(DE19507103-C1)      In fermenter 1, for mutation, which contains the growth-stimulating, nutrient-enriched solution, medium no. 1, microorganisms are cultivated under stable conditions, and also exposed to chemical and/or physical mutagenic influences. In fermenter 2, for selection, they meet a pollutant-enriched solution, medium no. 2 where they are influenced by the pollutant, under growth limiting conditions. They are then recycled to the start of the process.    Small quantities of biomass released from medium 1 in the mutation fermenter are continuously transferred to no. 2, selection. Similarly, small quantities of biomass from no. 2, selection, are transferred continuously to no. 1, mutation. Thus selection and mutation alternate continuously.    The fermenters are computer controlled; their individual fermentation parameters may be adjusted in inter-dependence.    USE -   The process is used to culture microorganisms with voracious appetite for specific pollutants, and to dispose of the pollutants through metabolism, breaking them down repeatedly to more simple molecules, hence rendering them harmless. These organisms are used to clean up abandoned polluted areas, waste water, and in the purificn. of polluted air.    ADVANTAGE -   The method combines growth and mutation conditions, with cyclic exposure to selection and limitation in a double fermenter, encouraging the two fundamental principles of mutation and selection. Continuous alternation between the two generates tolerance and specificity, combined with rapid breakdown ability.    The computer maintains conditions both constant and reproducible; the constant toxicity level allowing the growth of resistance to the pollutant, encouraging genetic stability.    (JP9509577-W)      In fermenter 1, for mutation, which contains the growth-stimulating, nutrient-enriched solution, medium no. 1, microorganisms are cultivated under stable conditions, and also exposed to chemical and/or physical mutagenic influences. In fermenter 2, for selection, they meet a pollutant-enriched solution, medium no. 2 where they are influenced by the pollutant, under growth limiting conditions. They are then recycled to the start of the process.    Small quantities of biomass released from medium 1 in the mutation fermenter are continuously transferred to no. 2, selection. Similarly, small quantities of biomass from no. 2, selection, are transferred continuously to no. 1, mutation. Thus selection and mutation alternate continuously.    The fermenters are computer controlled; their individual fermentation parameters may be adjusted in inter-dependence.    USE -   The process is used to culture microorganisms with voracious appetite for specific pollutants, and to dispose of the pollutants through metabolism, breaking them down repeatedly to more simple molecules, hence rendering them harmless. These organisms are used to clean up abandoned polluted areas, waste water, and in the purificn. of polluted air.    ADVANTAGE -   The method combines growth and mutation conditions, with cyclic exposure to selection and limitation in a double fermenter, encouraging the two fundamental principles of mutation and selection. Continuous alternation between the two generates tolerance and specificity, combined with rapid breakdown ability.    The computer maintains conditions both constant and reproducible; the constant toxicity level allowing the growth of resistance to the pollutant, encouraging genetic stability.    (US5798253-A)      In fermenter 1, for mutation, which contains the growth-stimulating, nutrient-enriched solution, medium no. 1, microorganisms are cultivated under stable conditions, and also exposed to chemical and/or physical mutagenic influences. In fermenter 2, for selection, they meet a pollutant-enriched solution, medium no. 2 where they are influenced by the pollutant, under growth limiting conditions. They are then recycled to the start of the process.    Small quantities of biomass released from medium 1 in the mutation fermenter are continuously transferred to no. 2, selection. Similarly, small quantities of biomass from no. 2, selection, are transferred continuously to no. 1, mutation. Thus selection and mutation alternate continuously.    The fermenters are computer controlled; their individual fermentation parameters may be adjusted in inter-dependence.    USE -   The process is used to culture microorganisms with voracious appetite for specific pollutants, and to dispose of the pollutants through metabolism, breaking them down repeatedly to more simple molecules, hence rendering them harmless. These organisms are used to clean up abandoned polluted areas, waste water, and in the purificn. of polluted air.    ADVANTAGE -   The method combines growth and mutation conditions, with cyclic exposure to selection and limitation in a double fermenter, encouraging the two fundamental principles of mutation and selection. Continuous alternation between the two generates tolerance and specificity, combined with rapid breakdown ability.    The computer maintains conditions both constant and reproducible; the constant toxicity level allowing the growth of resistance to the pollutant, encouraging genetic stability.    (CN1144535-A)      In fermenter 1, for mutation, which contains the growth-stimulating, nutrient-enriched solution, medium no. 1, microorganisms are cultivated under stable conditions, and also exposed to chemical and/or physical mutagenic influences. In fermenter 2, for selection, they meet a pollutant-enriched solution, medium no. 2 where they are influenced by the pollutant, under growth limiting conditions. They are then recycled to the start of the process.    Small quantities of biomass released from medium 1 in the mutation fermenter are continuously transferred to no. 2, selection. Similarly, small quantities of biomass from no. 2, selection, are transferred continuously to no. 1, mutation. Thus selection and mutation alternate continuously.    The fermenters are computer controlled; their individual fermentation parameters may be adjusted in inter-dependence.    USE -   The process is used to culture microorganisms with voracious appetite for specific pollutants, and to dispose of the pollutants through metabolism, breaking them down repeatedly to more simple molecules, hence rendering them harmless. These organisms are used to clean up abandoned polluted areas, waste water, and in the purificn. of polluted air.    ADVANTAGE -   The method combines growth and mutation conditions, with cyclic exposure to selection and limitation in a double fermenter, encouraging the two fundamental principles of mutation and selection. Continuous alternation between the two generates tolerance and specificity, combined with rapid breakdown ability.    The computer maintains conditions both constant and reproducible; the constant toxicity level allowing the growth of resistance to the pollutant, encouraging genetic stability.    (EP748373-B1)      In fermenter 1, for mutation, which contains the growth-stimulating, nutrient-enriched solution, medium no. 1, microorganisms are cultivated under stable conditions, and also exposed to chemical and/or physical mutagenic influences. In fermenter 2, for selection, they meet a pollutant-enriched solution, medium no. 2 where they are influenced by the pollutant, under growth limiting conditions. They are then recycled to the start of the process.    Small quantities of biomass released from medium 1 in the mutation fermenter are continuously transferred to no. 2, selection. Similarly, small quantities of biomass from no. 2, selection, are transferred continuously to no. 1, mutation. Thus selection and mutation alternate continuously.    The fermenters are computer controlled; their individual fermentation parameters may be adjusted in inter-dependence.    USE -   The process is used to culture microorganisms with voracious appetite for specific pollutants, and to dispose of the pollutants through metabolism, breaking them down repeatedly to more simple molecules, hence rendering them harmless. These organisms are used to clean up abandoned polluted areas, waste water, and in the purificn. of polluted air.    ADVANTAGE -   The method combines growth and mutation conditions, with cyclic exposure to selection and limitation in a double fermenter, encouraging the two fundamental principles of mutation and selection. Continuous alternation between the two generates tolerance and specificity, combined with rapid breakdown ability.    The computer maintains conditions both constant and reproducible; the constant toxicity level allowing the growth of resistance to the pollutant, encouraging genetic stability.