WO200042621-A3  DATABASE CHEMICAL ABSTRACTS [Online] abstr. no. 92401, 18 August 1997 (1997-08-18) SCZAKIEL G. ET AL.: "Computer-aided calculation of the local folding potential of target RNA and its use for ribozyme design " XP002110004 & METHODS MOL. BIOL., vol. 74, 1997, pages 11-15, US;  DATABASE CHEMICAL ABSTRACTS [Online] Accession no. 119:132896, SZAKIEL G. ET AL.: "Computer-aided search for effective antisense RNA target sequences of the human immunodeficiency virus type 1" XP002110005 & ANTISENSE RES.DEV., vol. 3, no. 1, 1993, pages 45-52,;  DATABASE MEDLINE [Online] us national library of medicine Accession Number: 96374653, HYNDMAN D. ET AL.: "Software to detewrmine optimal oligonucleotide sequences based on hybridization simulation data" XP002110006 & BIOTECHNIQUES, vol. 20, no. 6, June 1996 (1996-06), pages 1090-1097,;  BRUICE T W ET AL: "Control of complexity constraints on combinatorial screening for preferred oligonucleotide hybridisation sites on structured RNA" BIOCHEMISTRY,US,AMERICAN CHEMICAL SOCIETY. EASTON, PA, vol. 36, no. 16, page 5004-5019-5019 XP002110003 ISSN: 0006-2960;  DATABASE CHEMABS [Online] Chemical Abstracts Service, Columbus, Ohio, US Accession Number 117:105283, STULL, R.A. ET AL.: "Predicting antisense oligonucleotide inhibitory efficacy: a computational approach using histograms and thermodynamic indices" XP002110007 & NUCLEIC ACIDS RES., vol. 20, no. 13, 1992, pages 3501-3508,;  DATABASE CHEMICAL ABSTRACTS 18 August 1997 (1997-08-18), SCZAKIEL G. ET AL.: "Computer-aided calculation of the local folding potential of target RNA and its use for ribozyme design", XP002110004,relevantClaims[1],relevantPassages[&lt;pp&gt;A&lt;/pp&gt;];  DATABASE CHEMICAL ABSTRACTS SZAKIEL G. ET AL.: "Computer-aided search for effective antisense RNA target sequences of the human immunodeficiency virus type 1", XP002110005,relevantClaims[1],relevantPassages[&lt;pp&gt;A&lt;/pp&gt;];  DATABASE MEDLINE us national library of medicine; HYNDMAN D. ET AL.: "Software to detewrmine optimal oligonucleotide sequences based on hybridization simulation data", XP002110006,relevantClaims[1],relevantPassages[&lt;pp&gt;A&lt;/pp&gt;];  BRUICE T W ET AL: "Control of complexity constraints on combinatorial screening for preferred oligonucleotide hybridisation sites on structured RNA", BIOCHEMISTRY,US,AMERICAN CHEMICAL SOCIETY. EASTON, PA, vol. 36, no. 16, pages 5004-5019-5019, XP002110003, ISSN: 0006-2960,relevantClaims[1,3,5],relevantPassages[abstract,discussion];  DATABASE CHEMABS Chemical Abstracts Service, Columbus, Ohio, US; STULL, R.A. ET AL.: "Predicting antisense oligonucleotide inhibitory efficacy: a computational approach using histograms and thermodynamic indices", XP002110007,relevantClaims[1],relevantPassages[&lt;pp&gt;A&lt;/pp&gt;]