NOVELTY - An article (I) comprising a pre-selected pattern of biologically active molecules (II) stably adsorbed on a polymeric substrate (III).    USE - (I) is useful for spatially modulating the growth of a cell such as an epithelial cell, a mesenchymal cell, a fibroblast cell, preferably a nerve cell. The method involves contacting a cell with (I) such that the cell adheres to (II) and grows along the micron-sized pattern of (II) on (III). The method further involves implanting the article in a mammal, preferably a human. (I) is also useful for regenerating a tissue which involves contacting cells such as an epithelial cell, a mesenchymal cell, a fibroblast cell, preferably a nerve cell, of the tissue with (I) such that the cells adhere to (II) stably adsorbed to (III) surface of (I) and grow in a preselected pattern of (II) on (III). The cells grow in a pre-selected pattern in a shape that is missing from the tissue and in normal shape for the tissue. The method further involves implanting the article into a mammal, preferably a human (claimed). The article is implanted at a site for repairing injuries, regenerating skin, vascular, or neural tissues, and directionally guiding cellular growth. (I) is also useful for modulating cell-substrate interactions, combinatorial screening strategies and multiple analytical biosensors. Cell growth can be modulated spatially both in vivo and in vitro, e.g., an injured tissue can be regenerated into an appropriate, functional shape and a severed nerve cell connection can be repaired by encouraging nerve cells to grow across the gap in the connection. (I) is used as a tissue regeneration template, and articles prepared with particular cell adhesion proteins, growth factors and other biologically active molecules is useful for promoting neurite extension. The nerve cells are removed from the patient, seeded onto the article, grown, divided, and/or differentiated to form a tissue in culture, and then implanted into the body. The article has tissue engineering applications and may be used for directed nerve regeneration and new blood vessel formation (vasculogenesis). Articles comprising patterned polymeric surfaces, can mimic cues for directed growth of neurons, necessary for repair of peripheral nerve damage, thereby encouraging nerve cell alignment and growth.    ADVANTAGE - (II) adsorbed onto a polymeric substrate, is stable. The functional groups and active sites of adsorbed (II) also remain free to interact with other molecular species, macromolecules, biomolecules, cells and tissues. Linker molecules between the polymeric substrate and (II), are not needed. The article has fewer components and will generate fewer immunogenic responses and fewer side effects. Manufacturing procedures are simple, fast, inexpensive and avoid coupling agents and other harsh chemicals which may create negative side effects when left in the article in even small amounts. There is no need for UV exposure, high processing temperatures, organic solvents, expensive equipment, extensive manufacturing space and/or lengthy production times. The methods produce a polymeric substrate surface which is only transiently polar and which can return to being hydrophobic. Hence, articles with patterns of (II) that are surrounded by regions of hydrophobicity encourage specific interaction of biomolecules and cells with the stably adsorbed (II).    DETAILED DESCRIPTION - INDEPENDENT CLAIMS are also included for:    (1) an apparatus (IV) comprising a stamp coated with (II) and (I), where the stamp has pre-selected pattern;    (2) preparing (M1) a pattern of (II) on the surface of a (III), involves exposing the surface of a (III) to conditions that increase the polarity of the surface, and contacting the surface with a pre-selected pattern of (II);    (3) preparing (M2) a pattern of (II) on a hydrophobic (III) involves exposing a stamp and a hydrophobic (III) to conditions that increase the polarity, to a polar surface on (III), coating a stamp with (II) to generate a coated stamp, contacting the coated stamp with the polar surface under conditions sufficient to transfer the (II) to the polar surface and thereby creating a pattern of (II) on a hydrophobic (III);    (4) an article made by (M1) or (M2); and    (5) a method of regenerating tissue comprising contacting the tissue cells with (I); and    (6) a method of spatially modulating the growth of a cell comprising contacting the cell with (I).    DESCRIPTION OF DRAWING(S) - The figure shows the method of making an article comprising a pre-selected pattern of biological molecules stably adsorbed onto a polymeric substrate.