TECHNOLOGY FOCUS - POLYMERS - Preferred Polymer: (III) is not polydimethylsiloxane and is polyacrylate, polymethylacrylate, polycarbonate, polystyrene, polyhydroxy acid, polyanhydride, polyorthoester, polyphosphazene, polyphosphate, polyester, or their mixture. The polymeric substrate is preferably biodegradable. (III) is in the shape of a disc, sphere, tube, trough or dish.    TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Biological Molecule: (II) is a hormone, extracellular matrix molecule, cell adhesion molecule, natural polymer, enzyme, peptide, antibody, antigen, polynucleotide, growth factor, synthetic polymer, polylysine, drug, or its combination. (II) inhibits cell adhesion, growth or differentiation. (II) comprises a fully defined sequence of YIGSR, IKVAV, CSRARKNAASIKVAVSADR, REDV, RGDS, REDV, RGDV, LRGDN, PDSGR, RGDT, DGEA, VTXaaG (Xaa = any amino acid) or RNIAEIIK (S1-S13).    TECHNOLOGY FOCUS - INORGANIC CHEMISTRY - Preferred Method: The conditions that increase the polarity involves exposure to gaseous plasma, argon, nitrogen, or oxygen plasma. Preferably, for increasing polarity the surface of (III) is exposed to 1-10 cc/minute oxygen plasma for 5-120 seconds at 50-400 W and at room temperature. Preferred Preselected Pattern: The pre-selected pattern comprises a bound (III) surface having (II) stably absorbed to it and an unbound (III) surface having substantially no (II) adsorbed to it. The surface of the unbound (III) is hydrophobic before and after the (II) have been stably adsorbed to the bound (III) surface. Preferably, the pattern is micron-sized, the pattern preferably comprises 2-10 different types of (II). (I) comprises a line of (II). The line is 5-10 microns in length and 5-50 nm in width. The pattern comprises a line, circle, oval, square, rectangle, diamond or triangle. The preselected pattern in (IV) on the stamp is a raised surface. WIDER DISCLOSURE - The following are disclosed:    (1) polymeric substrates having a substrate patterned with micro sized features which is prepared by stamping the surface of the polymeric substrate with a natural or synthetic polymer-based ink or a biologically active molecule; and    (2) device for guided tissue regeneration which comprises a biodegradable or non-degradable polymeric substrate having a surface patterned with micron-sized features which is prepared by stamping the surface of the biodegradable or nondegradable polymeric substrate with a natural or synthetic polymer-based ink.    ACTIVITY - Vulnerary. No supporting data is given.    MECHANISM OF ACTION - Tissue regeneration template.    EXAMPLE - A non-degradable polymer, poly(methyl acrylate) (PMMA, MW 120,000, Aldrich) and a degradable polymer, poly(lactide-co-glycolide) were evaluated as polymeric substrates for micropatterning via the microcontact process. The polymers were compressed into thin films of 200 microm and cut to the size of cover slips. After activation, polymeric substrates were evaluated via x-ray photoelectron spectroscopy, atomic force microscopy, and near-field scanning optical microscopy, and it was observed that the polymeric surface was not significantly changed. After laminin absorption, its deposition was determined by incubating the prepared slips with rabbit anti-laminin affinity isolated antibody and fluorescein isothiocynate (FITC)-conjugated goat anti-rabbit IgG. Dorsal root ganglia dissected from seven day old chick embryos were either directly plated onto the patterned substrate or dissociated into individual neurons and plated. The prepared slips were imaged. alignment of neural cells on the patterned surface was observed via confocal microscopy.