TECHNOLOGY FOCUS - BIOLOGY - Preferred Method: The crude bacteria in the first culture is under organic cultivation executed under the condition of 25-40 weight% of water content at 25-30 degreesC for 4-5 days under agitating several times/day. The culture medium in the second culture is made by adding 10-20 parts by weight of a combined nutrient to 100 parts by weight of crushed soil from volcanic rocks mineral and blending together them under controlling the water content to reach 30-40% by weight.The method further comprises granulating the cultured material after the second step. The granulation step is executed simultaneously with a drying process comprising evaporating moisture and forcibly drying the base material in order to have 4-5 weight% of a controlled water content. EXAMPLE - An organic medium containing rice bran as a principle ingredient, a mixture of native microbes including Streptomyces griseus, Actinomycetes, Corynebacterium, Aspergillus versicolor filamentous fungi and Saccharomyces cerevisiae yeast as main components was inoculated to obtain crude bacteria by subculture. Crushed soil (100 kg), kanigara powder (2 kg), rice bran (5 kg) and morocone powder (5 kg) were introduced in combination and added with water to form a medium having 25% of water content. The medium was inoculated by previously cultured soil microbes, then was subject to a secondary culture of such microbes at 28-30 degrees Centigrade.    When the culture process progressed from the induction period to the culture increasing period, the temperature of medium sharply increased. By air-ventilating the cultured material under agitating after passing the normal state period and immediately before entering into the destruction period, it was accomplished to protect it from overheating.    After completing the culture process, the produced material was cultured on albumin agar culture medium in order to counter the numbers of bacteria based on genus of such bacteria. Such cultured material was water-evaporated in order for 3-4 days, then controlled to have 4-5% by weight of final water content by forced drying operation.    A raising outdoor test for Southern Blight disease was carried out by using the microbe base material. 20 kg of the high density antagonist base material was mixed with other components such as sesame dregs, powdered fish, powdered cones, rice bran and chemical fertilizer to form a 500 kg self-prepared organic compound fertilizer.    As the compost, 10 ton of the self-prepared manure fermented by the base material and 100 kg of commercial organic fertilizer (7-6-2) were added to 150 kg of the self-prepared fertilizer. The combined fertilizer was scattered over the area to be further under cultivation process. After the treatment, the area was under additional manuring for 3 times by 45 days with 110 kg, 100 kg and 50 kg of the self-prepared fertilizer, respectively.    The result showed that the induction of the Southern blight disease was sharply reduced even it had a great amount of rainfall and rained near the harvesting season, and ensured about 97% of shipping rate of vegetables. In addition to the above, it was found that the weight of one head increased 20% than last year and for its quality, sugar content of 14.2 L class product reached about 80%.