TECHNOLOGY FOCUS - POLYMERS - Preferred Monomer: The alkylene oxide monomer is ethylene oxide.The polymer is polymerized from ethylene oxide and one or more alkylene oxides other than ethylene oxide.Preferred Particle: The particle is in the form of powders, tablets, pellets, granules and extrudates.Preferred Properties: The powders have an average particle size of less than 40-1000 microns. The extrudates have an average diameter of 2-10 mm. The polymer has weight average molecular weight of 300000-1000000 g/gmole.Preferred Polymer: The poly(alkylene oxide) polymer is polyethylene oxide.Preferred Composition: The concentration gradient has less than 5 weight% of the total amount of formic compound contained in the outermost 10% along a radial cross-section of the particle.    TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Compound: The particle further comprise a compound having amine functionality which is a pharmaceutically active compound containing secondary amine functionality.Preferred Composition: The composition comprises 10-150 ppmw of the formic compound, based on the total weight of the composition.Preferred Acid: The acid is chosen from hydrofluoric acid, sulfuric acid, nitric acid, thiosulfuric acid, phosphoric acid, citraconic acid, citric acid, dichloroacetic acid, oxalic acid, methanesulfonic acid and/or malonic acid, preferably methane sulfonic acid.Preferred Secondary Amine: The secondary amine is a drug chosen from enalapril maleate, famotidine, metformin hydrochloride, nifedipine, buspirone hydrochloride, glipizide, bupropion hydrochloride, omeprazole, fluoxetine hydrochloride, lisinopril, lovastatin, isotretinoin, amoxicillin with clavulanate, interferon, imipenem and cilastatin, tamoxifen citrate, nabumetone, nizatidine, alprazolam, ciprofloxacin hydrochloride, clarithromycin, fluticasone propionate, doxazosin mesylate, benazepril hydrochloride, fluticasone, nefazodone hydrochloride, tolcapone, tolterodine tartrate, isradipine, naratriptan hydrochloride, candesartan cilexetil, paclitaxel, fluconazole, recombinant DNA HepB, carboplatin, simvastatin, sertraline hydrochloride, paroxetine hydrochloride, pravastatin sodium, azithromycin, ondansetron hydrochloride, goserelin acetate, sumatriptan succinate, amlodipine besylate, cetirizine hydrochloride, losartan potassium, losartan potassium-hydrochlorothiazide, atorvastatin calcium, olanzapine, and Ioratadine, preferably reboxetine.Preferred Method: Release of reboxetine is achieved through one or more methods associated with the group of methods including osmotic methods, diffusion methods, dissolution methods and ion-exchange methods. EXAMPLE - A slurry containing (in grams) POLYOX WSR N80 NF (RTM; poly(ethylene oxide) (100) with molecular weight of 300000, methane sulfonic acid (21.75) and distilled water (19), was stirred at room temperature for 2 hours. The resulting polymer was collected by filtration using a vacuum filter, and rinsed twice with 70 ml of isopropyl alcohol. The polymer was then dried at 40 degrees C under vacuum over a weekend. The resulting finished polymer was a free-flowing solid. The inorganic formate in the polymer was analyzed with an ion chromatography instrument and the value was found to be 48 ppmw. The unwashed poly(ethylene oxide) had an inorganic formate level of over 500 ppmw.