WO2003062380-A2  See also references of EP 1530631A2EP1530631-A2  See also references of WO 03062380A2EP2287320-A1  DATABASE Geneseq [Online] EBI, Hinxton, Cambridgeshire, U.K.; 23 May 1991 (1991-05-23), Wilson CR, et al: "Pre-pro alkaline protease enzyme", XP002613313, Database accession no. AAR11190&WO 91/02792 A1 (HENKEL RESEARCH CORP [US]) 7 March 1991 (1991-03-07);  DATABASE Geneseq [Online] EBI, Hinxton, Cambridgeshire, U.K.; 1 November 1989 (1989-11-01), Hastrup S, et al.,: "Subtilisin 309 from Bacillus lentus", XP002613314, Database accession no. AAP90374&WO 89/06279 A1 (NOVO INDUSTRI AS [DK]) 13 July 1989 (1989-07-13);  DATABASE Geneseq [Online] EBI, Hinxton, Cambridgeshire, U.K.; 1 November 1989 (1989-11-01), Hastrup S, et al.,: "Subtilisin BPN' from Bacillus spp.", XP002613315, Database accession no. AAP90376;  STROUD, R. SCI. AMER. vol. 131, pages 74 - 88;  KRAUT, J. ANNU. REV. BIOCHEM. vol. 46, 19 May 0006, pages 331 - 358;  MARKLAND, F.S. ET AL. HOPPE-SEYLER'S Z. 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GANSHAWV. SCHELLENBERGER: 'Selection of a subtilisin-hyperproducing Bacillus in a highly structured environment' APPL MICROBIOL BIOTECHNOL vol. 49, 19 February 0008, pages 290 - 294;  ANAGNOSTOPOULOS, C.SPIZIZEN, J.: 'Requirements for transformation in Bacillus subtilis' J. BACTERIOL. vol. 81, 19 January 0005, pages 741 - 746;  FREDERICK C. NEIDHARDTPHILIP L. BLOCHDAVID F. SMITH: 'Culture Medium for Enterobacteria' JOURNAL OF BACTERIOLOGY vol. 119, no. 3, 19 February 0906, pages 736 - 747;  DELMAR, E.G. ET AL. ANAL. BIOCHEM. vol. 94, 19 July 0006, pages 316 - 320;  ACHTSTETTER ARCH. BIOCHEM. BIOPHYS vol. 207, 19 September 0006, pages 445 - 54EP2287321-A1  DATABASE Geneseq [Online] EBI, Hinxton, Cambridgeshire, U.K.; 23 May 1991 (1991-05-23), Wilson, CR, et al.,: "Pre-pro alkaline protease enzyme", XP002613313, Database accession no. AAR11190&WO 91/02792 A1 (HENKEL RESEARCH CORP [US]) 7 March 1991 (1991-03-07);  DATABASE Geneseq [Online] EBI, Hinxton, Cambridgeshire, U.K.; 1 November 1989 (1989-11-01), Hastrup, S. et al.,: "Subtilisin 309 from Bacillus lentus.", XP002613314, Database accession no. AAP90374&WO 89/06279 A1 (NOVO INDUSTRI AS [DK]) 13 July 1989 (1989-07-13);  DATABASE Geneseq [Online] EBI, Hinxton, Cambridgeshire, U.K.; 1 November 1989 (1989-11-01), Hastrup, S. et al.,: "Subtilisin BPN' from Bacillus spp.", XP002613315, Database accession no. AAP90376;  STROUD, R. SCI. AMER., vol. 131, pages 74 - 88;  KRAUT, J. ANNU. REV. BIOCHEM. vol. 46, 19 May 0006, pages 331 - 358;  MARKLAND, F.S. ET AL.: 'Hoope-Sev tor's Z' PHVSIOL. CHEM. vol. 364, 19 November 0006, pages 1537 - 1540;  ROBERTUS, J.D. ET AL. BIOCHEMISTRY vol. 11, 19 December 0005, pages 2439 - 2449;  ROBERTUS, J.D. ET AL. J. BIOL. CHEM. vol. 251, 19 April 0006, pages 1097 - 1103;  SVENDSEN, B. CARLSBERQ RES. COMMUN. vol. 41, 19 April 0006, pages 237 - 291;  STAUFFER, D.C. ET AL. J. BIOL. CHEM. vol. 244, 19 May 0005, pages 5333 - 5338;  WELLSESTELL TIBS vol. 13, 19 April 0007, pages 291 - 297;  DALE, M.W.: 'Molecular Genetics of Bacteria', 19 May 0007, JOHN WILEY&SONS, LTD.;  SIEZEN ET AL. PROTEIN ENG. vol. 4, no. 7, 19 July 0007, pages 719 - 737;  D. NAKIC. PAECHG. GANSHAWV. SCHELLENBERGER APPL MICROBIOL BIOTECHNOL vol. 49, 19 February 0008, pages 290 - 294;  K. M. KALISZ: 'Advances in Biochemical Enqineerinq/Biotechnotoqy', 19 April 0007 article 'Microbial Proteinases';  TEPLYAKOV, AV ET AL. PROTEIN ENG. no. 5, 19 August 0712, pages 413 - 20;  TEPLYAKOV AVVAN DER LAAN JMLAMMERS AAKELDERS HKALK KHMISSET OMULLENERS LJDIJKSTRA BW: 'Protein engineering of the high-alkaline serine protease P892 from Bacillus alcalophilus: functional and structural consequences of mutation at the S4 substrate binding pocket' PROTEIN ENG. vol. 5, no. 5, 19 August 0707, pages 413 - 20;  D. NAKIC. PAECHG. GANSHAWV. SCHELLENBERGER: 'Selection of a subtilisin-hyperproducing Bacillus in a highly structured environment' APPL MICROBIOL BIOTECHNOL vol. 49, 19 February 0008, pages 290 - 294;  ANAGNOSTOPOULOS, C.SPIZIZEN, J.: 'Requirements for transformation in Bacillus subtilis' J. BACTERIOL. vol. 81, 19 January 0005, pages 741 - 746;  FREDERICK C. NEIDHARDTPHILIP L. BLOCHDAVID F. SMITH: 'Culture Medium for Enterobacteria' JOURNAL OF BACTERIOLOGY vol. 119, no. 3, 19 February 0906, pages 736 - 747;  DELMAR, E.G. ET AL. ANAL. BIOCHEM. vol. 94, 19 July 0006, pages 316 - 320;  ACHTSTETTER ARCH. BIOCHEM. BIOPHYS vol. 207, 19 September 0006, pages 445 - 54WO2003062380-A3  ZHOU L ET AL: "ON THE ORIGIN OF MEMBRANE VESICLES IN GRAM-NEGATIVE BACTERIA" FEMS MICROBIOLOGY LETTERS, AMSTERDAM, NL, vol. 163, no. 2, 15 June 1998 (1998-06-15), pages 223-228, XP001007553 ISSN: 0378-1097;  WYLLIE S ET AL: "Single channel analysis of recombinant major outer membrane protein porins from Chlamydia psittaci and Chlamydia pneumoniae" FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 445, no. 1, 19 February 1999 (1999-02-19), pages 192-196, XP004259874 ISSN: 0014-5793