TECHNOLOGY FOCUS - FOOD - Preferred Component: The proanthocyanidin is originated from grape seed or its extract, which is extracted using, hydrated ethanol and fermented using microorganism. The proanthocyanidin is a water-soluble component. The grape seed extract contains 40-100% of proanthocyanidin. The formulation contains 10-500 mg of grape seed extract. The proanthocyanidin contains gallic acid ester. ACTIVITY - Thrombolytic; Cerebroprotective; Vasotropic; Neuroprotective; Cardiant; Antianginal; Auditory; Analgesic.    The thrombolytic activity of proanthocyanidin was evaluated using C57BL/6 (8-9 week-old) male mouse. The proanthocyanidin (95 wt.%) in dimethylsulfoxide (2 and 20 mg/ml) was poured in to the left femoral artery of the anesthetized mouse. The thrombophilia was measured after 5 minutes. 20 mg/ml of proanthocyanidin was orally administered twice after 60 minutes. The thrombophilia was performed 90 minutes after second time administration. A control group was maintained without administering proanthocyanidin. Polyethylene tube was detained in the left femoral artery of the anesthetized mouse, the neck was cut open and left common carotid artery was exposed. Then, the mouse carotid arteries were irradiated with He-Ne laser. The thrombosis was formed in 10 minutes and analysed using computer. Thrombosis size was calculated from the image taken. The fixed luminance threshold-value was given to the image and the area of thrombosis was measured. In the mice administered with proanthocyanidin through artery injection, the thrombophilia was suppressed significantly at a dose of 20 mg/kg. In the oral administration group, the thrombophilia was suppressed significantly.    MECHANISM OF ACTION - None given.    ADMINISTRATION - The proanthocyanidin is administered orally or parenterally at a dose of 0.1-600 mg/kg/day, preferably 0.1-200 mg/kg/day.    EXAMPLE - Grape seed (100 kg) was added to 75% ethanol aqueous solution (300 l) was added and extracted for 120 minutes. The extract was filtered, concentrated and proanthocyanidin (5 kg). The concentrated liquid was spray-dried and pulverized to obtain proanthocyanidin. The amount of proanthocyanidin in the sample was evaluated and was found to be 95%. Proanthocyanidin (in mg) (100), medium chain saturated fatty acid triglyceride (70), vitamin E (1), orange oil (20), decaglycerol mono stearate (30), glycerol (750), glucose (10), citric acid (1), ascorbic acid (500) and water were mixed and emulsified to obtain and emulsified liquid agent containing proanthocyanidin. The liquid agent can be used as internal agent or as functional food.