WO2003097861-A1  CHAN C.M. ET AL.: 'Monitoring the toxicity of phenolic chemicals to activated sludge using a novel optical scanning respirometer' CHEMOSPHERE vol. 39, no. 9, 1999, pages 1421 - 1432, XP002985132;  CHITI G. ET AL.: 'Electrochemical DNA biosensor for environmental monitoring' ANALYTICA CHIMICA ACTA vol. 427, no. 2, 2001, pages 155 - 164, XP002985116;  LAYTON A.C. ET AL.: 'Validation of genetically engineered bioluminescent surfactant resistant bacteria as toxicity assessment tools' ECOTOXICOL. ENVIRON. SAF. vol. 43, no. 2, 1999, pages 222 - 228, XP002985118;  MARRAZZA G. ET AL.: 'Disposable DNA electrochemical biosensors for environmental monitoring' ANALYTICA CHIMICA ACTA vol. 387, no. 3, 1999, pages 297 - 307, XP002985117;  MASCINI M. ET AL.: 'DNA electrochemical biosensors' FRESENIUS' JOURNAL OF ANALYTICAL CHEMISTRY vol. 369, no. 1, 2001, pages 15 - 22;  MASCINI M. ET AL.: 'DNA electrochemical biosensors' FRESENIUS' JOURNAL OF ANALYTICAL CHEMISTRY vol. 369, no. 1, 2001, pages 15 - 22, XP002999800;  CHAN C.M. ET AL.: 'Monitoring the toxicity of phenolic chemicals to activated sludge using a novel optical scanning respirometer' CHEMOSPHERE vol. 39, no. 9, 1999, pages 1421 - 1432;  CHITI G. ET AL.: 'Electrochemical DNA biosensor for environmental monitoring' ANALYTICA CHIMICA ACTA vol. 427, no. 2, 2001, pages 155 - 164;  LAYTON A.C. ET AL.: 'Validation of genetically engineered bioluminescent surfactant resistant bacteria as toxicity assessment tools' ECOTOXICOL. ENVIRON. SAF. vol. 43, no. 2, 1999, pages 222 - 228;  MARRAZZA G. ET AL.: 'Disposable DNA electrochemical biosensors for environmental monitoring' ANALYTICA CHIMICA ACTA vol. 387, no. 3, 1999, pages 297 - 307;  See also references of EP 1497451A1;  MICHAEL R. ET AL.: 'Biosensors for the measurement of toxicity of wastewaters to activated sludge' PESTICIDE SCIENCE vol. 54, no. 4, December 1998, pages 447 - 452;  KONG, Z. ET AL.: 'An activated sludge-based biosensor for rapid IC-50 estimation and online toxicity monitoring' BIOSENSORS AND BIOELECTRONICS vol. 8, no. 1, 1993, pages 49 - 58EP1497451-A1  HYUNG JOO KIM ET AL: "A MEDIATOR-LESS MICROBIAL FUEL CELL USING A METAL REDUCING BACTERIUM, SHEWANELLA PUTREFACIENS" ENZYME AND MICROBIAL TECHNOLOGY, STONEHAM, MA, US, vol. 30, no. 2, 14 February 2002 (2002-02-14), pages 145-152, XP001156325 ISSN: 0141-0229;  EVANS MICHAEL R ET AL: "Biosensors for the measurement of toxicity of wastewaters to activated sludge" PESTICIDE SCIENCE, vol. 54, no. 4, December 1998 (1998-12), pages 447-452, XP002379862 ISSN: 0031-613X;  KIM B H ET AL: "A MICROBIAL FUEL CELL TYPE LACTATE BIOSENSOR USING A METAL-REDUCING BACTERIUM, SHEWANELLA PUTREFACIENS" JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, SEOUL, KR, vol. 9, no. 3, June 1999 (1999-06), pages 365-367, XP000862875 ISSN: 1017-7825;  KONG Z ET AL: "An activated sludge-based biosensor for rapid IC-50 estimation and on-line toxicity monitoring" BIOSENSORS AND BIOELECTRONICS, vol. 8, no. 1, 1993, pages 49-58, XP002379863 ISSN: 0956-5663;  See also references of WO 03097861A1;  See references of WO 03097861A1EP1497451-B1  EVANS MICHAEL R ET AL: "Biosensors for the measurement of toxicity of wastewaters to activated sludge" PESTICIDE SCIENCE, vol. 54, no. 4, December 1998 (1998-12), pages 447-452, XP002379862 ISSN: 0031-613X;  KONG Z ET AL: "An activated sludge-based biosensor for rapid IC-50 estimation and on-line toxicity monitoring" BIOSENSORS AND BIOELECTRONICS, vol. 8, no. 1, 1993, pages 49-58, XP002379863 ISSN: 0956-5663;  KIM B H ET AL: "A MICROBIAL FUEL CELL TYPE LACTATE BIOSENSOR USING A METAL-REDUCING BACTERIUM, SHEWANELLA PUTREFACIENS" JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, SEOUL, KR, vol. 9, no. 3, June 1999 (1999-06), pages 365-367, XP000862875 ISSN: 1017-7825;  HYUNG JOO KIM ET AL: "A MEDIATOR-LESS MICROBIAL FUEL CELL USING A METAL REDUCING BACTERIUM, SHEWANELLA PUTREFACIENS" ENZYME AND MICROBIAL TECHNOLOGY, STONEHAM, MA, US, vol. 30, no. 2, 14 February 2002 (2002-02-14), pages 145-152, XP001156325 ISSN: 0141-0229;  MASCINI M. ET AL.: 'DNA electrochemical biosensors' FRESENIUS' JOURNAL OF ANALYTICAL CHEMISTRY vol. 369, no. 1, 2001, pages 15 - 22, XP002999800;  CHITI G. ET AL.: 'Electrochemical DNA biosensor for environmental monitoring' ANALYTICA CHIMICA ACTA vol. 427, no. 2, 2001, pages 155 - 164, XP002985116;  MARRAZZA G. ET AL.: 'Disposable DNA electrochemical biosensors for environmental monitoring' ANALYTICA CHIMICA ACTA vol. 387, no. 3, 1999, pages 297 - 307, XP002985117;  CHAN C.M. ET AL.: 'Monitoring the toxicity of phenolic chemicals to activated sludge using a novel optical scanning respirometer' CHEMOSPHERE vol. 39, no. 9, 1999, pages 1421 - 1432, XP002985132;  LAYTON A.C. ET AL.: 'Validation of genetically engineered bioluminescent surfactant resistant bacteria as toxicity assessment tools' ECOTOXICOL. ENVIRON. SAF. vol. 43, no. 2, 1999, pages 222 - 228, XP002985118