TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Composition: The amount of alcohol with respect to oil and fat at the time of reaction is more than triple the theoretical chemistry equivalent. Preferred Container: Reaction of oil and fat and alcohol is performed in a reaction container having metal lead on the inner surface, or a reaction container having a structure with many slits consisting of lead and/or lead compound, in a portion or whole of the reaction container. The reaction container further has a filled layer containing grain, fragment or ring shaped lead and/or lead compound as filler, supported by a shelf, a pore board or a net-like material. Preferred Method: The oil and fat, and the alcohol are reacted in the presence of lead and/or lead compound, at 350degreesC or less, preferably 350-250degreesC, and pressure of 5 MPa or less, preferably atmospheric pressure of 0.101-0.15 MPa. The manufacturing method involves forming a fluid bed with the grain or fragment shaped lead and/or lead compound, and passing the mixture of oil and fat and alcohol as flow medium through the fluid bed, or adding and stirring the grain or fragment shaped lead and/or lead compound to the mixture of oil and fat and alcohol. The vaporized alcohol is supplied to the oil and fat in reaction container through cellular miniaturization unit, such as nozzle, pore board or pore component, to gas-liquid mixing unit, such as gas-liquid mixing pump, and then supplied to the reaction container. Oil and fat are supplied to the reaction container as microparticles having aerosol particle size with a proper atomization apparatus. Unreacted substance is separated by a gravity-separation method from the mixture of the reaction-product and unreacted substance obtained from the reaction container. The incomplete reaction material or unreacted substance is again supplied to the reaction container. The reaction product or reaction product and unreacted oil and fat with excess vaporized alcohol as air-fuel mixture phase or dispersed phase in excess of vaporized alcohol, is separated utilizing the boiling point difference of alcohol and reaction product, and recovered as condensate. The condensate is further separated to glycerol, fatty acid ester or glycerol, oil and fat and fatty acid ester and unreacted oil and fat are sequentially separated from excess vaporization alcohol by the specific gravity difference method. Alternately, the reaction product or reaction product and unreacted oil and fat with excess vaporized alcohol, is fractionated in a distilling column having required number of section, and is directly coupled with the reaction container. Preferred Compound: The alcohol is of formula: R-OH, where R is 1-5C alkyl, preferably methyl. Preferred Oil and Fat: The oil and fat is waste oil and fat, waste edible oil, animal fat and oil and/or vegetable oil. The vegetable oil is palm oil and/or rapeseed oil, preferably rough palm oil obtained by pressing oil from raw material.