TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Method: The method involves milling biomass to a particle size of less than 1 mm to produce flour. The hull components are separated from the flour before performing the method, or separated from the mash before fermenting. The proteins present in the biomass are separated from the flour before performing the novel method or separated from the mash before fermenting, or separated from the clear phase of the pulp in the separation. The separation of the proteins before fermenting and separation is done via precipitation by cooling and separating the precipitate. The yeast, fibers, solid substances, fat and/or proteins present in the pulp are agglomerated by cooling and sedimented before separation of the pulp into solid phase and clear phase. The precipitation is done by cooling, sieving and drying. The separation of the solid phase and clear phase of the pulp is done using a decanter or a disk centrifuge. About 80 % of the liquid in the pulp is withdrawn with the clear phase. The fermentation is carried out in a batch process, cascading process or in a continuous process involving a recycling of yeast. The methane production in a high-performance methane reactor involves pre-acidification/conditioning. The method further involves rectification of crude ethanol and optional dehydration to obtain bioethanol or neutral ethanol, where more than 100 (preferably more than 300 m3) ethanol/day are produced. The clear phase of the pulp is aerobically purified after anaerobic purification in the methane reactor. The anaerobically/aerobically purified clear phase is added to the conversion process as water for dilution or is employed for the addition of water for liquefaction of the flour. The solid phase of the pulp is mixed with separated hull components and/or bran, or is mixed with separated proteins. The resultant mixture is further dried. The solid phase of the pulp is dried and burned for the generation of energy.Preferred Components: The biomass is grain (preferably wheat, rye, maize or triticale) and the bran is separated after milling. The particle size of the flour is less than 0.6 mm. The content of solid in the clear phase is less than 0.5 %.    TECHNOLOGY FOCUS - INSTRUMENTATION AND TESTING - Preferred Reactor: The reactor is high-performance methane reactor comprising beads with a diameter of 1-2 mm, in which methane bacteria are immobilized, where the immobilization of the methane bacteria in the beads increases the space time yield in the reactor and allows space time yield of at least 25 kg CSB/(m3+d); an Upflow Anaerobic Sludge Blanket (UASB)-reactor; and an Internal Circulation (IC)-reactor.