TECHNOLOGY FOCUS - INORGANIC CHEMISTRY - Preferred Method: The step of forming the flow-channel/liquid-trench layer further comprises forming the flow channels in a PCB substrate using a heat press machine, a laser molding equipment, and/or a CNC molding equipment; forming the liquid trenches in another PCB substrate by using a heat press machine, a laser molding equipment, and/or a CNC (sic) molding equipment; bonding the substrate with flow channels and the substrate with liquid trenches by an adhesive material; and pressing the two substrates by a heat press machine.The step of pressing is performed at 130-200 degrees C under a pressure of 5-50 kg/cm2. The step of forming the membrane electrode assembly layer further comprises coating a material comprising platinum (Pt) and/or ruthenium (Ru) on a proton exchange membrane and a polymer material; and bonding the proton exchange membrane, the polymer catalytic layer, and a carbon paper or a carbon cloth by a glue to form the membrane electrode assembly layer.The step of joining further comprises stacking the flow-channel/liquid-trench layer, the membrane electrode assembly layer, and the controlling circuit layer by a glue or an adhesive material to form a stacked layer lamination; and pressing the stacked layer lamination by the heat press machine to form the layer lamination integrated direct methanol fuel cell.The method further comprises forming at least one fixing hole, the flow-channel/liquid-trench layer, the membrane electrode assembly layer, and the controlling circuit layer, respectively; and bonding the flow-channel/liquid-trench layer, the membrane electrode assembly layer, and the controlling circuit layer by a glue, a screw, or a nail via the fixing holes.Preferred Parameter: The depth of the flow channel is 1-10 mm.Preferred Composition: The concentration of Pt material is 1-5 mg/cm2. The concentration of the material comprising Pt and Ru is l-10 mg/cm2.    TECHNOLOGY FOCUS - POLYMERS - Preferred Component: The materials of the PCB comprise FR4. The adhesive material comprises a glass fiber reinforced epoxy resin. The material of the proton exchange membrane comprises Nafion (TM).    TECHNOLOGY FOCUS - ELECTRONICS - Preferred Component: The controlling circuit layer is a double-side or multi-layer PCB. The controlling circuit layer further comprises at least one PCB and at least one electric device posited on the PCB.