NOVELTY - Solid phase/submerged multicomponent culture system (A) and corresponding culture method.    USE - (A) is used for preparation and in situ performance testing of generated high capacity strains and for scale-up of corresponding solid-state/substrate methods, e.g. for optimizing production of (particularly) enzymes; for decomposition/modification of organic solid and liquid substrates (e.g. wood, plant materials, humus, organic waste of animal or plant origin); to produce hydrolyzates of these materials in optimal yields (for subsequent fermentation); for improving metabolic capacity (e.g. in decomposition of pollutants) and for improving production of spores for starter cultures (all claimed).    ADVANTAGE - The combination of trickle bed/fluidized bed reactors with solid state/submerged reactors overcomes the problem, encountered in trickle bed reactors, that some fungi form thick, leathery growths on solid substrates that make it difficult to switch from trickle bed to fluidized bed modes. By using several solid substrates, the performance of native and mutant strains may be compared directly and selection pressure can be maintained throughout the process, eliminating the need for time-consuming precultures and preparations.    DETAILED DESCRIPTION - Solid phase/submerged multicomponent culture system (A) and corresponding culture method comprises:    (i) one or more trickle bed/fluidized bed solid-state fermenters with, additionally in the trickle bed, stirrers that, before switching to fluidized bed mode, homogenize the mycelium formed (or the mycelial coating), either stepwise or, for fungi, continuosly, e.g to inhibit undesirable sporulation of strongly sporulating fungi; and    (ii) one or more submerged fermenters in which, either with or after milling (using an Ultra-Turrax) of the mycelium transferred to them (after switching from trickle bed to to fluidized bed mode in the solid-substrate culture), the mycelium is cultured in batch or (semi) continuous mode. To generate stable, high capacity strains, the submerged fermenter comprises a quartz tube and closure plate (with standard fittings) and also includes a UV source and one or more solid-state cultures, particularly culture is on inert carriers.    DESCRIPTION OF DRAWING(S) - Schematic diagram of the system.    Reactor (A)    Trickle nozzles (1)    Aeration frits (5)    Storage tank (6)    Sterile filter (7)    Recycle line for fluidized bed (15)    Recycle line for trickle flow bed (16)    Fixed bed (18)    Submerged fermenter (23)    Solid-state fermenter (24)    Ultra-Turrax (25)    UV source. (26)