WO2006099207-A2  DIXON R.: 'Flavonoids and isoflavonoids - a goldmine for metabolic engineering' TRENDS IN PLANT SCIENCE vol. 4, 1999, pages 394 - 400US8735107-B2  Witkowski et al. Biochemistry. Sep. 7, 1999; 38(36): 11643-50.;  Seffernick et al. J Bacteriol. Apr. 2001; 183 (8): 2405-10.;  Baedeker_European Journal of Biochemistry (2002)-269-1790-1797.;  Baedeker_Structure (2002)-10-61-67.;  Calabrese_Biochemistry (2004)-43-11403-11416.;  CIPO_Nov. 20, 2012_Office Action_2,614,769.;  Daniel_Current Opinion in Biotechnology (2004)-15-199-204.;  Dixon_Trends in Plant Science (1999)-4-394-400.;  EMBL Accession No. AE017340, Idiomarina Ioihiensis L2TR (2004).;  EPO_EP 78735016_Extended EP Search Report_Oct. 22, 2009.;  EPO_EP675483487_Extended EP Search Report_Oct. 30, 2009.;  Ferrer_Current Opinion in Biotechnology (2005)-16-588-593.;  GenBank Accession No. CR378675, Photobacterium Profundum SS9, Vezzi et al. (2005).;  Geneseq Accession No. ADS24623, Protein (2004).;  Geneseq Accession No. ADS61699, cDNA (2004).;  Gloge_Chemistry_A European Journal (2000)-6-3386-3390.;  Hou_PNAS (2004)-101-18036-18041.;  Ikeda_Amino Acids (2005)-29-283-287.;  Kyndt_FEBS Letters (2002)-512-240-244.;  Levy_Structure (2002)-10-105-113.;  Lorenz_Current Opinion in Biotechnology (2002)-13-572-577.;  ISA/US_PCT/US2006/08722_International Search Report & Written Opinion_Aug. 18, 2008.;  ISA/US_PCT/US2007/69877_International Search Report & Written Opinion_Nov. 10, 2008.;  Poppe_Current Organic Chemistry (2003)-7-1297-1315.;  Rother_European Journal of Biochemistry (2002)-269-3065-3075.;  Schwede_Biochemistry (1999)-38-5355-5361.;  Shi_Biochemistry (1997)-36-9136-9144.;  Uniprot Accession No. Q5QXE5, Histidine ammonia-lyase (2005).;  Uniprot Accession No. Q7MMJ6-CHEN (2003).;  Uniprot Accession No. Q8DFZ8-RHEE_(2003).;  USPTO_Jun. 2, 2011_Office Action_U.S. Appl. No. 11/817,997.;  USPTO_Feb. 24, 2012_Restriction Requirement (Form 892)_U.S. Appl. No. 12/303,088.;  Valenzuela_Biotechnology Advances (2006)-24-197-211.;  Wang_Molecular Genetics and Metabolism (2005)-86-134-140.EP1869174-B1  DATABASE EMBL [Online] 4 December 2004 (2004-12-04), "Idiomarina loihiensis L2TR, complete genome." XP002551032 retrieved from EBI accession no. EMBL:AE017340 Database accession no. AE017340;  HOU SHAOBIN ET AL: "Genome sequence of the deep-sea gamma-proteobacterium Idiomarina loihiensis reveals amino acid fermentation as a source of carbon and energy." PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 28 DEC 2004, vol. 101, no. 52, 28 December 2004 (2004-12-28), pages 18036-18041, XP002356424 ISSN: 0027-8424;  DATABASE UniProt [Online] 4 January 2005 (2005-01-04), "SubName: Full=Histidine ammonia-lyase;" XP002551031 retrieved from EBI accession no. UNIPROT:Q5QXE5 Database accession no. Q5QXE5;  DIXON R.: 'Flavonoids and isoflavonoids - a goldmine for metabolic engineering' TRENDS IN PLANT SCIENCE vol. 4, 1999, pages 394 - 400, XP000949325EP2886658-A1  DATABASE UniProt [online] "SubName: Full=Probable histidine/phenylalanine ammonia-lyase {ECO:0000313|EMBL:AAG08478.1};", XP002737636, retrieved from EBI accession no. UNIPROT:Q9HU90 Database accession no. Q9HU90;  ;;;X;  KYNDT J A ET AL: "Characterization of a bacterial tyrosine ammonia lyase, a biosynthetic enzyme for the photoactive yellow protein", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 512, no. 1-3, 13 February 2002 (2002-02-13), pages 240 - 244, XP004341386, ISSN: 0014-5793, DOI: 10.1016/S0014-5793(02)02272-X;  ROESLER J ET AL: "Maize phenylalanine ammonia-lyase has tyrosine ammonia-lyase activity", PLANT PHYSIOLOGY, AMERICAN SOCIETY OF PLANT PHYSIOLOGISTS, ROCKVILLE, MD, US, vol. 113, no. 1, 1 January 1997 (1997-01-01), pages 175 - 179, XP002979322, ISSN: 0032-0889, DOI: 10.1104/PP.113.1.175;  HAVIR E A ET AL: "L-PHENYLALANINE AMMONIA-LYASE (MAIZE) EVIDENCE FOR A COMMON CATALYTIC SITE FOR L-PHENYLALANINE AND L-TYROSINE", PLANT PHYSIOLOGY, AMERICAN SOCIETY OF PLANT PHYSIOLOGISTS, ROCKVILLE, MD, US, vol. 48, 1 January 1971 (1971-01-01), pages 130 - 136, XP000944068, ISSN: 0032-0889;  BIRGID LANGER ET AL: "Identification of Essential Amino Acids in Phenylalanine Ammonia-Lyase by Site-Directed Mutagenesis", BIOCHEMISTRY, vol. 36, no. 36, 1 September 1997 (1997-09-01), pages 10867 - 10871, XP055178537, ISSN: 0006-2960, DOI: 10.1021/bi970699u;  WANG, MOL GENET METAB, vol. 86, no. 1-2, 1 July 2005 (2005-07-01), pages 134 - 140;  IKEDA, AMINO ACIDS, vol. 29, no. 3, 28 June 2005 (2005-06-28), pages 283 - 287;  BAEDEKER; SCHULZ, BUR. J.BIOCHEM, vol. 269, 2002, pages 1790 - 1797;  ROTHER; RETEY, BUR. J. BIOCHEM, vol. 269, 2002, pages 3065 - 3075;  KYNDT ET AL., FBBS LETTERS, vol. 512, 2002, pages 240 - 24;  J. MOL. CAT. B: ENZYMATIC, vol. 6, 1999, pages 29 - 39;  CHIVATA ET AL.: "Biocatalysis: Immobilized cells and enzymes", J MOL. CAT., vol. 37, 1986, pages 1 - 24;  SHANNA ET AL.: "Angew. Chern. Int. Ed. Engl.", vol. 21, 1982, article "Immobilized Biomaterials Techniques and Applications", pages: 837 - 54;  MATA, TOXICOL. APPL. PHARMACAL., vol. 144, 1997, pages 189 - 197;  STRAUSS-SOUKUP, BIOCHEMISTRY, vol. 36, 1997, pages 8692 - 8698;  SAMSTAG, ANTISENSE NUCLEIC ACID DRUG DEV, vol. 6, 1996, pages 153 - 156;  B. LEWIN: "Genes VI", 1997, OXFORD UNIVERSITY PRESS, pages: 214;  MERRIFIELD, R. B., J. AM. CHERN. SAC., vol. 85, 1963, pages 2149 - 2154;  STEWART, J. M.; YOUNG, J.D.: "Solid Phase Peptide Synthesis", PIERCE CHEMICAL CO., pages: 11 - 12;  H. M. GEYSEN ET AL., PROC. NATL. ACAD. SCI., USA, vol. 11, 1984, pages 3998;  ADAMS, J. AM. CHERN. SOC., vol. 105, 1983, pages 661;  BELOUSOV, NUCLEIC ACIDS RES., vol. 25, 1997, pages 3440 - 3444;  FRENKEL, FREE RADIC. BIOI. MED, vol. 19, 1995, pages 373 - 380;  BLOMMERS, BIOCHEMISTRY, vol. 33, 1994, pages 7886 - 7896;  NARANG, METH. ENZYMOL., vol. 68, 1979, pages 90;  BROWN, METH. ENZYMOL., vol. 68, 1979, pages 109;  BEAUCAGE, TETRA. LETT., vol. 22, 1981, pages 1859;  "MOLECULAR CLONING: A LABORATORY MANUAL", vol. 1-3, 1989, COLD SPRING HARBOR LABORATORY;  "CURRENT PROTOCOLS IN MOLECULAR BIOLOGY", 1997, JOHN WILEY & SONS, INC.;  "LABORATORY TECHNIQUES IN BIOCHEMISTRY AND MOLECULAR BIOLOGY: HYBRIDIZATION WITH NUCLEIC ACID PROBES", 1993, ELSEVER;  ROSENFELD, NAT. GENET., vol. 15, 1997, pages 333 - 335;  WOON, GENOMICS, vol. 50, 1998, pages 306 - 316;  KERN, BIOTECHNIQUES, vol. 23, 1997, pages 120 - 124;  WILLIAMS, BIOCHEMISTRY, vol. 34, 1995, pages 1787 - 1797;  DOBELI, PROTEIN EXPR. PURIF., vol. 12, 1998, pages 404 - 414;  KROLL, DNA CELL. BIOI., vol. 12, 1993, pages 441 - 53;  CREIGHTON, T.E.: "Proteins-Structure and Molecular Properties", 1993, W.H. FREEMAN AND COMPANY;  "Pasttranslational Covalent Modification of Proteins", 1983, ACADEMIC PRESS, pages: 1 - 12;  HUANG, PLANT MOL. BIOL., vol. 33, 1996, pages 125 - 139;  ZHONG, MOL. GEN. GENET., vol. 251, 1996, pages 196 - 203;  SOLOCOMBE, PLANT PHYSIOL, vol. 104, 1994, pages 1167 - 1176;  MARTINEZ, J. MOL. BIOL, vol. 208, 1989, pages 551 - 565;  MANJUNATH, PLANT MOL. BIOI., vol. 33, 1997, pages 97 - 112;  KUMAGAI, PROC. NATL. ACAD. SCI. USA, vol. 92, 1995, pages 1679 - 1683;  VERDAGUER, PLANT MOL. BIOL., vol. 31, 1996, pages 1129 - 1139;  KIRCH, PLANT MOL. BIOL., vol. 33, 1997, pages 897 - 909;  BLAZQUEZ, PLANT CELL, vol. 10, 1998, pages 791 - 800;  CARDON, PLANT J, vol. 12, 1997, pages 367 - 77;  MANDEL, PLANT MOLECULAR BIOLOGY, vol. 29, 1995, pages 995 - 1004;  JOHN, PROC. NATL. ACAD. SCI. USA, vol. 89, 1997, pages 5769 - 5773;  DELISLE, INT. REV. CYTOL., vol. 123, 1990, pages 39 - 60;  BUSK, PLANT J., vol. 11, 1997, pages 1285 - 1295;  GUERRERO, MOL. GEN. GENET., vol. 224, 1990, pages 161 - 168;  BLUME, PLANT J, vol. 12, 1997, pages 731 - 746;  FICKER, PLANT MOL. BIOL., vol. 35, 1997, pages 425 - 431;  REISER, CELL, vol. 83, 1995, pages 735 - 742;  LIU, PLANT PHYSIOL., vol. 115, 1997, pages 397 - 407;  CHEN, PLANT J., vol. 10, 1996, pages 955 - 966;  STREIT, MOL. PLANT MICROBE INTERACT., vol. 10, 1997, pages 933 - 937;  SHEEN, SCIENCE, vol. 274, 1996, pages 1900 - 1902;  DE VEYLDER, PLANT CELL PHYSIOL., vol. 38, 1997, pages 568 - 577;  MASGRAU, PLANT J., vol. 11, 1997, pages 465 - 473;  STANGE, PLANT J., vol. 11, 1997, pages 1315 - 1324;  STAGE, PLANT J., vol. 11, 1997, pages 1315 - 1324;  COVEY, PROC. NATL. ACAD. SCI. USA, vol. 87, 1990, pages 1633 - 1637;  ANGELL, EMBO J., vol. 16, 1997, pages 3675 - 3684;  CASPER, GENE, vol. 173, 1996, pages 69 - 73;  HILLMAN, VIROLOGY, vol. 169, 1989, pages 42 - 50;  DOLJA, VIROLOGY, vol. 234, 1997, pages 243 - 252;  MORINAGA, MICROBIAL IMMUNOL., vol. 37, 1993, pages 471 - 476;  CECCHINI, MOL. PLANT MICROBE INTERACT., vol. 10, 1997, pages 1094 - 1101;  RUBIN, MOL. CELL. BIOI., vol. 17, 1997, pages 6294 - 6302;  KUNZE, CURR. TOP. MICROBIAL. IMMUNOL., vol. 204, 1996, pages 161 - 194;  SCHLAPPI, PLANT MOL. BIOI., vol. 32, 1996, pages 717 - 725;  AUSUBEL ET AL.: "Cun&#183;ent Protocols in Molecular Biology", 1997, JOHN WILEY 503 SONS, INC;  SAMBROOK: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS;  SAMBROOK ET AL.: "Molecular (cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR;  WEISING, ANN. REV. GENET., vol. 22, 1988, pages 421 - 477;  DAVIS, L.; DIBNER, M.; BATTEY, I., BASIC METHODS IN MOLECULAR BIOLOGY, 1986;  GURTU, BIOCHEM. BIOPHYS. RES. COMMUN, vol. 229, 1996, pages 295 - 8;  SANDERS, DEV. BIOL. STAND., vol. 66, 1987, pages 55 - 63;  GLUZMAN, CELL, vol. 23, 1981, pages 175;  "PCR PROTOCOLS, A GUIDE TO METHODS AND APPLICATIONS", 1990, ACADEMIC PRESS;  "PCR STRATEGIES", 1995, ACADEMIC PRESS, INC.;  WU, GENOMICS, vol. 4, 1989, pages 560;  LANDEGREN, SCIENCE, vol. 241, 1988, pages 1077;  BARRINGER, GENE, vol. 89, 1990, pages 117;  KWOH, PROC. NATL. ACAD. SCI. USA, vol. 86, 1989, pages 1173;  GUATELLI, PROC. NATL. ACAD. SCI. USA, vol. 87, 1990, pages 1874;  SMITH, J. CLIN. MICROBIAL., vol. 35, 1997, pages 1477 - 1491;  BURG, MOL. CELL. PROBES, vol. 10, 1996, pages 257 - 271;  BERGER, METHODS ENZYMOL., vol. 152, 1987, pages 307 - 316;  SOOKNANAN, BIOTECHNOLOGY, vol. 13, 1995, pages 563 - 564;  PEARSON; LIPMAN, PROC. NATL. ACAD. SCI. USA, vol. 85, no. 8, 1988, pages 2444 - 2448;  ALTSCHUL ET AL., J. MOL. BIOI., vol. 215, no. 3, 1990, pages 403 - 410;  THOMPSON, NUCLEIC ACIDS RES., vol. 22, no. 2, 1994, pages 4673 - 4680;  HIGGINS ET AL., METHODS ENZYMOL., vol. 266, 1996, pages 383 - 402;  ALTSCHUL, NATURE GENETICS, vol. 1, 1993, pages 266 - 272;  SMITH; WATERMAN, ADV. APPL. MATH., 1981, pages 482;  NEEDLEMAN; WUNSCH, J. MOL. BIOI, vol. 48, 1970, pages 443;  PERSON; LIPMAN, PROC. NAT'L. ACAD. SCI. USA, vol. 85, 1988, pages 2444;  ALTSCHUL ET AL., NUC. ACIDS RES., vol. 25, 1977, pages 3389 - 3402;  ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 410;  HENIKOFF; HENIKAFF, PROC. NATL. ACAD. SCI. USA, vol. 89, 1989, pages 10915;  KARLIN; ALTSCHUL, PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5873;  GONNET, SCIENCE, vol. 256, 1992, pages 1443 - 1445;  HENIKOFF; HENIKOFF, PROTEINS, vol. 17, 1993, pages 49 - 61;  "Matrices for Detecting Distance Relationships: Atlas of Protein Sequence and Structure", 1978, NATIONAL BIOMEDICAL RESEARCH FOUNDATION;  ALTSCHUL ET AL., J. MOL. BIOI., vol. 215, 1990, pages 403;  PEARSON; LIPMAN, PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 2444;  BRUTLAG, COMP. APP. BIOSCI..&#167;, 1990, pages 237 - 245;  AUSUBEL: "Current Protocols in Molecular Biology", 1997, JOHN WILEY 503 SONS, INC.;  BARANY, F.: "The Ligase Chain Reaction in a PCR World", PCR METHODS AND APPLICATIONS, vol. 1, 1991, pages 5 - 16;  E. FAHY ET AL.: "Self-sustained Sequence Replication (3SR): An Isothermal Transcription-based Amplification System Alternative to PCR", PCR MLETHODS AND APPLICATIONS, vol. 1, 1991, pages 25 - 33;  WALKERG.T.: "Strand Displacement Amplification-an Isothermal in vitro DNA Amplification Technique", NUCLEIC ACID RESEARCH, vol. 20, 1992, pages 1691 - 1696;  HO, METHODS ENZYMOL., vol. 314, 2000, pages 168 - 183;  SMITH, EUR. J. PHARM. SCI., vol. 11, 2000, pages 191 - 198;  MATA: "Toxicol Appl Pharmaco1", vol. 144, 1997, pages: 189 - 197;  "Antisense Therapeutics", 1996, HUMANA PRESS;  GOLD, J. OFBIOL. CHEM., vol. 270, 1995, pages 13581 - 13584;  ROSSI, AIDS RESEARCH AND HUMAN RETROVIRUSES, vol. 8, 1992, pages 183;  HAMPEL, BIOCHEMISTRY, vol. 28, 1989, pages 4929;  HAMPEL, NUC. ACIDS RES., vol. 18, 1990, pages 299;  PERROTTA, BIOCHEMISTRY, vol. 31, 1992, pages 16;  GUERRIER-TAKADA, CELL, vol. 35, 1983, pages 849;  SHUEY, DRUG DISCOV . TODAY, vol. 7, 2002, pages 1040 - 1046;  RICE, PROC. NATL. ACAD. SCI. USA, vol. 89, 1992, pages 5467 - 5471;  CRAMERI, BIOTECHNIQUES, vol. 18, 1995, pages 194 - 196;  STEMMER: "Molecular breeding of viruses for targeting and other clinical properties", TUMOR TARGETING, vol. 4, 1999, pages 1 - 4;  NESS, NATURE BIOTECHNOLOGY, vol. 17, 1999, pages 893 - 896;  CHANG: "Evolution of a cytokine using DNA family shuffling", NATURE BIOTECHNOLOGY, vol. 17, 1999, pages 793 - 797;  MINSHULL: "Protein evolution by molecular breeding", CURRENT OPINION IN CHEMICAL BIOLOGY, vol. 3, 1999, pages 284 - 290;  CHRISTIANS: "Directed evolution of thymidine kinase for AZT phosphorylation using DNA family shuffling", NATURE BIOTECHNOLOGY, vol. 17, 1999, pages 259 - 264;  CRAMERI: "DNA shuffling of a family of genes from diverse species accelerates directed evolution", NATURE, vol. 391, 1998, pages 288 - 291;  CRAMERI: "Molecular evolution of an arsenate detoxification pathway by DNA shuffling", NATURE BIOTECHNOLOGY, vol. 15, 1997, pages 436 - 438;  ZHANG: "Directed evolution of an effective fucosidase from a galactosidase by DNA shuffling and screening", PROC. NATL. ACAD. SCI. USA, vol. 94, 1997, pages 4504 - 4509;  PATTEN ET AL.: "Applications of DNA Shuffling to Pharmaceuticals and Vaccines", CURRENT OPINION IN BIOTECHNOLOGY, vol. 8, 1997, pages 724 - 733;  CRAMERI ET AL.: "Construction and evolution of antibody-phage libraries by DNA shuffling", NATURE MEDICINE, vol. 2, 1996, pages 100 - 103;  GATES ET AL.: "Affinity selective isolation ofligands from peptide libraries through display on a lac repressor 'headpiece dimer", JOURNAL OF MOLECULAR BIOLOGY, vol. 255, 1996, pages 373 - 386;  STEMMER: "The Encyclopedia ofMolecular Biology", 1996, VCH PUBLISHERS, article "Sexual PCR and Assembly PCR", pages: 447 - 457;  CRAMERI; STEMMER: "Combinatorial multiple cassette mutagenesis creates all the permutations ofmutant and wildtype cassettes", BIOTECLMIQUES, vol. 18, 1995, pages 194 - 195;  STEMMER ET AL.: "Single-step assembly of a gene and entire plasmid form large numbers of oligodeoxyribonucleotides", GENE, vol. 164, 1995, pages 49 - 53;  STEMMER: "The Evolution of Molecular Computation", SCIENCE, vol. 270, 1995, pages 1510;  STEMMER, BIO/TECHNOLOGY, vol. 13, 1995, pages 549 - 553;  STEMMER: "Rapid evolution of a protein in vitro by DNA shuffling", NATURE, vol. 370, 1994, pages 389 - 391;  STEMMER: "DNA shuffling by random fragmentation and reassembly: In vitro recombination for molecular evolution", PROC. NATL. ACAD. SCI. USA, vol. 91, 1994, pages 10747 - 10751;  LING ET AL.: "approaches to DNA mutagenesis: an overview", ANAL BIOCHEM., vol. 254, no. 2, 1997, pages 157 - 178;  DALE ET AL.: "Oligonucleotide-directed random mutagenesis using the phosphorothioate method", METHODS MOL. BIOL., vol. 57, 1996, pages 369 - 374;  SMITH: "In vitro mutagenesis", ANN. REV. GENET., vol. 19, 1985, pages 423 - 462;  BOTSTEIN SHORTIE: "Strategies and applications of in vitro mutagenesis", SCIENCE, vol. 229, 1985, pages 1193 - 1201;  CARTER: "Site-directed mutagenesis", BIOCHEM. J., vol. 237, 1986, pages 1 - 7;  KUNKEL: "Nucleic Acids & Molecular Biology", 1987, SPRINGER VERLAG, article "The efficiency of oligonucleotide directed mutagenesis";  KUN EL: "Rapid and efficient site-specific mutagenesis without phenotypic selection", PROC. NATL. ACAD. SCI. USA, vol. 82, 1985, pages 488 - 492;  KUNKEL ET AL.: "Rapid and efficient site-specific mutagenesis without phenotypic selection", METHODS IN ENZYMOL., vol. 154, 1987, pages 367 - 382;  BASSET: "Mutant Trp repressors with new DNA-binding specificities", SCIENCE, vol. 242, 1988, pages 240 - 245;  METHODS IN ENZYMOL., vol. 100, 1983, pages 468 - 500;  METHODS IN ENZYMOL., vol. 154, 1987, pages 329 - 350;  ZOLLER: "Oliganucleotide-directed mutagenesis using M13-derived vectors: an efficient and general procedure for the production of point mutations in any DNA fragment", NUCLEIC ACIDS RES., vol. 10, 1982, pages 6487 - 6500;  ZOLLER; SMITH: "Oligonucleotide-directed mutagenesis of DNA fragments cloned into M13 vectors", METHODS IN ENZYMOL., vol. 100, 1983, pages 468 - 500;  ZOLLER: "ligonucleotide-directed mutagenesis: a simple method using two oligonucleotide primers and a single-stranded DNA template", METHODS IN ENZYMOL., vol. 154, 1987, pages 329 - 350;  TAYLOR: "The use ofphosphorothioate-modified DNA in restriction enzyme reactions to prepare nicked DNA", NUCL. ACIDS RES., vol. 13, 1985, pages 8749 - 8764;  TAYLOR: "The rapid generation of oligonucleotide-directed mutations at high frequency using phosphorothioate-modified DNN", NUCL. ACIDS RES., vol. 13, 1985, pages 8765 - 8787;  NAKAMAYE: "Inhibition of restriction endonuclease Nci I cleavage by phosphorothioate groups and its application to oligonucleotide-directed mutagenesis", NUCL. ACIDS RES., vol. 14, 1986, pages 9679 - 9698;  SAYERS: "Y-T Exonucleases in phosphorothioate-based oligonucleotide-directed mutagenesis", NUCL. ACIDS RES., vol. 16, 1988, pages 791 - 802;  SAYERS ET AL.: "Strand specific cleavage ofphosphorothioate-containing DNA by reaction with restriction endonucleases in the presence of ethidium bromide", NUCL. ACIDS RES., vol. 16, 1988, pages 803 - 814;  KRAMER ET AL.: "The gapped duplex DNA approach to oligonticleotide-directed mutation construction", NUCL. ACIDS RES., vol. 12, 1984, pages 9441 - 9456;  KRAMER; FRITZ: "Oligonucleotide-directed construction of mutations via gapped duplex DNA", METHODS IN ENZYMOL., vol. 154, 1987, pages 350 - 367;  KRAMER: "Improved enzymatic in Vitro reactions in the gapped duplex DNA approach to oligonucleotide-directed construction of mutations", NUCL. ACIDS RES., vol. 16, 1988, pages 7207;  FRITZ: "Oligonucleotide-directed construction of mutations: a gapped duplex DNA procedure without enzymatic reactions in vitro", NVCL. ACIDS RES., vol. 16, 1988, pages 6987 - 6999;  KRAMER: "Point Mismatch Repair", CELL, vol. 38, 1984, pages 879 - 887;  CARTERET: "Improved oligonucleotide site-directed mutagenesis using M13 vector", NUCL. ACIDS RES., vol. 13, 1985, pages 4431 - 4443;  "Improved oligonucleotide-directed mutagenesis using M13 vectors", METHODS IN ENZYMOL., vol. 154, 1987, pages 382 - 403;  EGHTEDARZADEH: "Use of oligonucleotides to generate large deletions", NUCL. ACIDS RES., vol. 14, 1986, pages 5115;  "Importance ofhydrogen-bond formation in stabilizing the transition state of subtilisin", PHIL. TRANS. R. SOC. LOND. A, vol. 317, 1986, pages 415 - 423;  NAMBIAR ET AL.: "Total synthesis and cloning of a gene coding for the ribonuclease S protein", SCIENCE, vol. 223, 1984, pages 1299 - 1301;  SAKAMAR; KHORANA: "Total synthesis and expression of a gene for the a-subunit of bovine rod outer segment guanine nucleotide-binding protein (transducin", NUCL. ACIDS RES., vol. 14, 1988, pages 6361 - 6372;  WELLS ET AL.: "Cassette mutagenesis: an efficient method for generation of multiple mutations at defined sites", GENE, vol. 34, 1985, pages 315 - 323;  GRUNDSTROM ET AL.: "Oligonucleotide-directed mutagenesis bymieroscale'shot-gun' gene synthesis", NUCL. ACIDS RES., vol. 13, 1985, pages 3305 - 3316;  ARNOLD: "Protein engineering for unusual environments", CURRENT OPINION IN BIOTECHNOLOGY, vol. 4, 1993, pages 450 - 455;  "Oligonucleotide-directed double-strand break repair in plasmids of Escherichia coli: a method for site-specific mutagenesis", PROC. NATL. ACAD. SCI. USA, vol. 83, pages 7177 - 7181;  LEUNG, TECHNIQUE, vol. 1, 1989, pages 11 - 15;  CALDWELL, PCR METHODS APPLIC., vol. 2, 1992, pages 28 - 33;  REIDHAAR-OLSON, SCIENCE, vol. 241, 1988, pages 53 - 57;  STEMMER, PROC. NATL. ACAD. SCI. USA, vol. 91, 1994, pages 10747 - 10751;  ARKIN, PROC. NATL. ACAD. SCI. USA, vol. 89, pages 7811 - 7815;  DELEGRAVE, BIOTECHNOLOGY RES., vol. 11, 1993, pages 1548 - 1552;  ARNOLD, CURRENT OPINION IN BIOTECHNOLOGY, vol. 4, 1993, pages 450 - 455;  BEN-BASSAT ET AL., J BACTERIAL., vol. 169, 1987, pages 751 - 7;  O'REGAN ET AL., GENE, vol. 77, 1989, pages 237 - 51;  PROTEIN SCI., vol. 3, 1994, pages 240 - 7;  HOCHULI, BIO/TECHNOLOGY, vol. 6, 1988, pages 1321 - 5;  BACA, INT. J. PARASITOL., vol. 30, 2000, pages 113 - 118;  HALE, PROTEIN EXPR. PURIF., vol. 12, 1998, pages 185 - 188;  NARUM, INFECT. HNMUN., vol. 69, 2001, pages 7250 - 7253;  NARUM, INFECT. IMMUN., vol. 69, 2001, pages 7250 - 7253;  OUTCHKOUROV, PROTEIN EXPR. PURIF., vol. 24, 2002, pages 18 - 24;  FENG, BIOCHEMISTRY, vol. 39, 2000, pages 15399 - 15409;  HUMPHREYS, PROTEIN EXPR. PURIF., vol. 20, 2000, pages 252 - 264;  POLLOCK, J. IMMUNOL. METHODS, vol. 231, 1999, pages 147 - 157;  BAGUISI, NAT. BIOTECHNOL., vol. 17, 1999, pages 456 - 461;  STREPP, PROC NATL. ACAD. SCI. USA, vol. 95, 1998, pages 4368 - 4373;  MIAO, PLANT J, vol. 7, 1995, pages 359 - 365;  CHRISTOU, PLANT MOL. BIOI., vol. 35, 1997, pages 197 - 203;  PAWLOWSKI, MOL. BIOTECHNOL., vol. 6, 1996, pages 17 - 30;  KLEIN, NATURE, vol. 327, 1987, pages 70 - 73;  TAKUMI, GENES GENET. SYST., vol. 72, 1997, pages 63 - 69;  ROUWENDAL, PLANT MOL. BIOI., vol. 33, 1997, pages 989 - 999;  PORTA: "Use of viral replicons for the expression of genes in plants", MOL. BIOTECHNOL., vol. 5, 1996, pages 209 - 221;  HORSCH, SCIENCE, vol. 233, 1984, pages 496 - 498;  FRALEY, PROC. NATL. ACAD. SCI. USA, vol. 80, 1983, pages 4803;  "Gene Transfer to Plants, Potrykus", 1995, SPRINGER-VERLAG;  HIEI, PLANT MOL. BIOI., vol. 35, 1997, pages 205 - 218;  HORSCH, SCIENCE, vol. 233, 1984, pages 496;  FRALEY, PROC. NATL. ACAD. SCI USA, vol. 80, 1983, pages 4803;  PARK, PLANT MOL. BIOI., vol. 32, 1996, pages 1135 - 1148;  EVANS ET AL.: "ProtoplastsIsolation and Culture, Handbook of Plant Cell Culture", 1983, MACMILLILAN PUBLISHING COMPANY, pages: 124 - 176;  BINDING: "Regeneration of Plants, Plant Protoplasts", 1985, CRC PRESS, pages: 21 - 73;  KLEE, ANN. REV. OF PLANT PHYS., vol. 38, 1987, pages 467 - 486;  PALMGREN, TRENDS GENET., vol. 13, 1997, pages 348;  CHONG, TRANSGENIC RES., vol. 6, 1997, pages 289 - 296;  "Posttranslational Covalent Modification of Proteins", 1983, ACADEMIC PRESS, pages: 1 - 12;  MERRIFIELD, R. B., J. AM. CHERN. SOC., vol. 85, 1963, pages 2149 - 2154;  H. M. GEYSEN ET AL., PROC. NATL. ACAD. SCI., USA, vol. 81, 1984, pages 3998;  CALABRESE ET AL.: "Crystal structure of phenylalanine ammonia lyase: multiple helix dipoles implicated in catalysis", BIOCHEMISTRY, vol. 43, no. 36, 2004, pages 11403 - 16;  LEVY ET AL.: "Insights into enzyme evolution revealed by the structure ofmethylaspartate ammonia lyase", STRUCTURE (CAROB, vol. 10, no. 1, 2002, pages 105 - 13;  BAEDEKER ET AL.: "Autocatalytic peptide cyclization during chain folding of histidine ammonia-lyase", STRUCTURE (CAROB, vol. 10, no. 1, 2002, pages 61 - 7;  SCHWEDE ET AL.: "crystal structure ofhistidine ammonia-lyase revealing a novel polypeptide modification as the catalytic electrophile", BIOCHEMISTRY, vol. 38, no. 17, 27 December 1998 (1998-12-27), pages 5355 - 61;  SHI ET AL.: "The structure ofL-aspartate ammonia-lyase from Escherichia coli", BIOCHEMISTRY, vol. 36, no. 30, 1997, pages 9136 - 44;  CAMTHERS, NUCLEIC ACIDS RES. SYMP. SER., 1980, pages 215 - 223;  HOM, NUCLEIC ACIDS RES. SYMP. SER., 1980, pages 225 - 232;  BANGA, A.K.: "Therapeutic Peptides and Proteins, Formulation, Processing and Delivery Systems", 1995, TECHNOMIC PUBLISHING CO.;  ROBERGE, SCIENCE, vol. 269, 1995, pages 202;  MERRIFIELD, METHODS ENZYMOL., vol. 289, 1997, pages 3 - 13;  SPATOLA: "Peptide Backbone Modifications", vol. 7, 1983, MARCELL DEKKER, article "Chemistry and Biochemistry of Amino Acids, Peptides and Proteins", pages: 267 - 357;  CREIGHTON, T.E.: "Proteins- Structure and MolecularProperties", 1993, W.H. FREEMAN AND COMPANY;  "Posttranslational Covalent Modification ofproteins", 1983, ACADEMIC PRESS, pages: 1 - 12;  VAN DE VEN, CRIT. REV. ONCOG., vol. 4, no. 2, 1993, pages 115 - 136;  NIELSEN: "Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites", PROTEIN ENGINEERING, vol. 10, 1997, pages 1 - 6;  SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS;  NIELSEN: "Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites", PROTEIN ENGINEERING, vol. 10, no. 1, 1997, pages 1 - 6;  JOHNSTON, CURR. BIOI., vol. 8, 1998, pages R171 - R174;  SCHUMMER, BIOTECHNIQUES, vol. 23, 1997, pages 1087 - 1092;  SOLINAS-TOLDO, GENES, CHROMOSOMES & CANCER, vol. 20, 1997, pages 399 - 407;  BOWTELL, NATURE GENETICS, vol. 21, 1999, pages 25 - 32;  "Fundamental Immunology", 1993, RAVEN PRESS;  WILSON, J. IMMUNOL. METHODS, vol. 175, 1994, pages 267 - 273;  YARMUSH, J. BIOCHEM. BIOPHYS. METHODS, vol. 25, 1992, pages 85 - 97;  WARD ET AL., NATURE, vol. 341, 1989, pages 544 - 546;  COLIGAN: "CURRENT PROTOCOLS IN IMMUNOLOGY", 1991, WILEY 'GREENE;  "BASIC AND CLINICAL IMMUNOLOGY", LANGE MEDICAL PUBLICATIONS;  CODING: "MONOCLONAL ANTIBODIES: PRINCIPLES AND PRACTISE", 1986, ACADEMIC PRESS;  KOHLER, NATURE, vol. 256, 1975, pages 495;  HARLOW: "ANTIBODIES, A LABORATORY MANUAL", 1988, COLD SPRING HARBOR PUBLICATIONS;  HOOGENBOOM, TRENDS BIOTECHNOL., vol. 15, 1997, pages 62 - 70;  KATZ, ANNU. REV. BIOPHYS. BIOMOL. STNICT., vol. 26, 1997, pages 27 - 45;  KOHLER; MILSTEIN, NATURE, vol. 256, 1975, pages 495 - 497;  KOZBOR ET AL., IMMUNOLOGY TODAY, vol. 1, 1983, pages 72;  COLE ET AL.: "Monoclonal Antibodies and Cancer Therapy", 1985, ALAN R. LISS, INC., pages: 77 - 96;  "Methods for Measuring Cellulase Activities", METHODS IN ENZYMOLOGY, vol. 160, pages 87 - 116;  KREUZER, BR. J. HAEMATOL., vol. 114, 2001, pages 313 - 318;  XIA, TRANSPLANTATION, vol. 72, 2001, pages 907 - 914;  "Remington's Pharmaceutical Sciences", MAACK PUBLISHING CO;  "Remington, The Science and Practice of Pharmacy";  MINTO, J. PHARMACAL. EXP. THER., vol. 281, 1997, pages 93 - 102;  ROHATAGI, J. CLIN. PHARMACAL., vol. 35, 1995, pages 1187 - 1193;  TJWA, ANN. ALLERGY ASTHMA IMMUNOL., vol. 75, 1995, pages 107 - 111;  RAO, J. BIOMATER SCI. POLYM. ED., vol. 7, 1995, pages 623 - 645;  GAO, PHARM. RES., vol. 12, 1995, pages 857 - 863;  BYLES, J. PHARM. PHARMACAL., vol. 49, 1997, pages 669 - 674;  AL-MUHAMMED, J. MICROENCAPSUL., vol. 13, 1996, pages 293 - 306;  CHONN, CURR. OPIN. BIOTECHNOL., vol. 6, 1995, pages 698 - 708;  OSTRO, AM. J. HOSP. PHARM., vol. 46, 1989, pages 1576 - 1587;  HIDALGO-ARAGONES, J. STEROID BIOCHEM. MOL. BIOL., vol. 58, 1996, pages 611 - 617;  GRONING, PBARMAZIE, vol. 51, 1996, pages 337 - 341;  FOTHERBY, CONTRACEPTION, vol. 54, 1996, pages 59 - 69;  JOHNSON, J. PHARM. SCI, vol. 84, 1995, pages 1144 - 1146;  ROHATAGI, PHAMIAZIE, vol. 50, 1995, pages 610 - 613;  BROPHY, BUR. J. CLIN. PHARMACOL., vol. 24, 1983, pages 103 - 108;  KIRKMAN, AM. J. HUM. GENET., vol. 34, no. 5, 1982, pages 743 - 752;  GERASIMOVA, CLINICAL CHEMISTRY, vol. 35, 1989, pages 2112 - 2115;  BAEDEKER; SCHULZ, EUR. J. BIOCHEM, vol. 269, 2002, pages 1790 - 1797;  KYNDT ET AL., FEBS LETTERS, vol. 512, 2002, pages 240 - 24;  MANN ET AL., ANNUAL REVIEW OF BIOCHEMISTRY, vol. 70, July 2001 (2001-07-01), pages 437 - 473US9150845-B2  Seffernick et al. J Bacteriol. Apr. 2001; 183 (8): 2405-10.;  Witkowski et al. Biochemistry. Sep. 7, 1999; 38(36): 11643-50.;  Baedeker_European Journal of Biochemistry (2002)_269_1790-1797.;  Baedeker_Structure (2002)_10_61-67.;  Calabrese_Biochemistry (2004)_43_11403-11416.;  CIPO_Nov. 20, 2012_Office Action_2,614,769.;  Daniel_Current Opinion in Biotechnology (2004)_15_199-204.;  Dixon_Trends in Plant Science (1999)_4_394-400.;  EMBL Accession No. AE017340, Idiomarina loihiensis L2TR (2004).;  EPO_EP 78735016_Extended EP Search Report_Oct. 22, 2009.;  EPO_EP675483487_Extended EP Search Report_Oct. 30, 2009.;  Ferrer_Current Opinion in Biotechnology (2005)_16_588-593.;  GenBank Accession No. CR378675, Photobacterium Profundum SS9, Vezzi et al. (2005).;  Geneseq Accession No. ADS24623, Protein (2004).;  Geneseq Accession No. ADS61699, cDNA (2004).;  Gloge_Chemistry_A European Journal (2000)_6_3386-3390.;  Hou_PNAS (2004)_101_18036-18041.;  Ikeda_Amino Acids (2005)_29_283-287.;  KYNDT_FEBS Letters (2002)_512_240-244.;  Levy_Structure (2002)_10_105-113.;  Lorenz_Current Opinion in Biotechnology (2002)_13_572-577.;  ISA/US_PCT/US2006/08722_International Search Report & Written Opinion_Aug. 18, 2008.;  ISA/US_PCT/US2007/69877_International Search Report & Written Opinion_Nov. 10, 2008.;  Poppe_Current Organic Chemistry (2003)_7_1297-1315.;  Rother_European Journal of Biochemistry (2002)_269_3065-3075.;  Schwede_Biochemistry (1999)_38_5355-5361.;  Shi_Biochemistry (1997)_36_9136-9144.;  Uniprot Accession No. Q5QXE5, Histidine ammonia-lyase (2005).;  Uniprot Accession No. Q7MMJ6_Chen (2003).;  Uniprot Accession No. Q8DFZ8_Rhee_(2003).;  USPTO_Jun. 6, 2011_Office Action_U.S. Appl. No. 11/817,997.;  USPTO_Feb. 24, 2012_Restriction Requirement (Form 892)_U.S. Appl. No. 12/303,088.;  Valenzuela_Biotechnology Advances (2006)_24_197-211.;  Wang_Molecular Genetics and Metabolism (2005)_86_134-140.