TECHNOLOGY FOCUS - ELECTRONICS - Preferred Methods: The first step to made the anode current collection layer comprises drilling the flexible circuit substrate and plating the chemical copper with thickness of 10-50 inches to plate the gold with 3-10 inches on the whole substrate, and again plating the copper with 200-500 inches to plate the gold with 3-10 inches after film lamination, photo exposure and develop. The second step to make the membrane electrode assembly layer comprises using lamination mechanism to laminate proton exchange membrane, polymer catalyst layer, and carbon paper/cloth to form membrane electrode assembly layer. The third step comprises using the printed or prepreg laminating mechanism by the bonding medium laminate to form anode current collection layer, membrane electrode assembly layer, and cathode current collection layer; and compressing using thermal-pressure machine to produce fuel cell reactive layer. The fourth step uses thermal-pressure machine, laser machine, or CNC machine to form preset depth and flow recess(es) on the flexible substrate. The fifth step comprises printing or prepreg lamination mechanism using bonding medium by using lamination or bonding process to laminate the fuel cell reactive layer and flow layer together and compressing or high temperature curing using thermal-pressure machine to produce flexible substrate laminate integrated fuel cell.Preferred Components: The anode current collection layer includes anode current collection(s). Each anode current collection corresponds to one fuel cell unit of membrane electrode assembly layer. The anode current collection includes control circuit. The proton exchange membrane material is made of DuPont Nafion material. The flexible substrate is flexible and non-metallic substrate. The flexible circuit substrate is used as the printed circuit board. The thermal pressure machine operates in compression or curing environment to set at 80-200degreesC for compression or curing. The bonding medium is epoxy or prepreg. The flexible substrate laminate integrated fuel cell is flexible substrate integrated direct methanol fuel cell. The flexible circuit substrate is flexible circuit copper foil substrate.Preferred Properties: The preset