NOVELTY - An isolated polypeptide having alpha-xylosidase, activity is new.    USE - The therapeutic protein expressed in a mammal host is useful for preparing a medicament, where the O-glycosylations of the therapeutic protein have been completely or partially removed (claimed). The polypeptide is useful for degradation of biomass containing xylose residues and as an additive for a detergent composition.    DETAILED DESCRIPTION - An isolated polypeptide having alpha-xylosidase activity selected from:    (a) a polypeptide having an amino acid sequence which has at least 99.5% identity with amino acids 1-769 of a sequence comprising 769 bp (SEQ ID NO: 2);    (b) a polypeptide which is encoded by a polynucleotide which hybridizes under at least high stringency conditions with:    (i) nucleotides 1-2310 of a sequence comprising 2310 bp (SEQ ID NO: 1); or    (ii) a complementary strand of (i); or    (c) a variant comprising a conservative substitution, deletion, and/or insertion of one or more amino acids of amino acids 1-769 of SEQ ID NO: 2.    INDEPENDENT CLAIMS are also included for:    (1) an isolated polynucleotide comprising a nucleotide sequence which encodes the polypeptide above;    (2) a nucleic acid construct comprising the polynucleotide operably linked to one or more control sequences that direct the production of the polypeptide in an expression host;    (3) a recombinant expression vector comprising the nucleic acid construct of (2);    (4) a recombinant host cell comprising the nucleic acid construct of (2);    (5) a method for producing the polypeptide;    (6) a method for producing a polynucleotide having a mutant nucleotide sequence;    (7) a mutant polynucleotide produced by the method of (6);    (8) a transgenic plant, plant part or plant cell, which has been transformed with a polynucleotide encoding the polypeptide above;    (9) a method for the complete or partial removal of O-glycosylations of proteins within the epidermal growth factor-like (EGF) modules;    (10) a method for producing a therapeutic protein;    (11) a detergent composition comprising a polypeptide above; and    (12) a method for degrading biomass.