WO2007038564-A2  ALPER H. AND STEPHANOPOULOS G.: "Global transcription machinery enginering: a new approach for improving cellular phenotype" METABOLIC ENGINEERING, 8 January 2007 (2007-01-08), XP002428724;  ALPER HAL ET AL: "Engineering yeast transcription machinery for improved ethanol tolerance and production." SCIENCE (NEW YORK, N.Y.) 8 DEC 2006, vol. 314, no. 5805, 8 December 2006 (2006-12-08), pages 1565-1568, XP002428725 ISSN: 1095-9203;  ALPER HAL ET AL: "Tuning genetic control through promoter engineering." PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 6 SEP 2005, vol. 102, no. 36, 6 September 2005 (2005-09-06), pages 12678-12683, XP002428722 ISSN: 0027-8424;  GOWRISHANKAR J ET AL: "In vitro properties of RpoS (sigma(S)) mutants of Escherichia coli with postulated N-terminal subregion 1.1 or C-terminal region 4 deleted." JOURNAL OF BACTERIOLOGY APR 2003, vol. 185, no. 8, April 2003 (2003-04), pages 2673-2679, XP002430364 ISSN: 0021-9193;  MAHREN SUSANNE ET AL: "Functional interaction of region 4 of the extracytoplasmic function sigma factor FecI with the cytoplasmic portion of the FecR transmembrane protein of the Escherichia coli ferric citrate transport system." JOURNAL OF BACTERIOLOGY JUL 2002, vol. 184, no. 13, July 2002 (2002-07), pages 3704-3711, XP002430363 ISSN: 0021-9193;  WU WEI-HUA ET AL: "Mutational analysis of yeast TFIIB: A functional relationship between Ssu72 and sub1/tsp1 defined by allele-specific interactions with TFIIB" GENETICS, vol. 153, no. 2, October 1999 (1999-10), pages 643-652, XP002428723 ISSN: 0016-6731;  WU WEI-HUA ET AL: "Mutational analysis of yeast TFIIB: A functional relationship between Ssu72 and sub1tsp1 defined by allele-specific interactions with TFIIB" GENETICS, vol. 153, no. 2, October 1999 (1999-10), pages 643-652, XP002428723 ISSN: 0016-6731;  YURA T. AND OSAWA T.: ""Genetic studies of RNA polymerase sigma factor in Escherichia coli" in Genetics and Evolution of RNA Polymerase, tRNA and Ribosomes" 1980, UNIVERSITY OF TOKYO PRESS , TOKYO, JAPAN , XP001245627 pages 51-63;  ALPER H.: "Development of systematic and combinatorial approaches for the metabolic engineering of microorganisms" [Online] June 2006 (2006-06), MASSACHUSSET INSTITUTE OF TECHNOLOGY , BOSTON, USA , XP002429707 Retrieved from the Internet: URL:http://dspace.mit.edu/bitstream/1721.1 /35134/1/71825623.pdf [retrieved on 2007-04-05] PhD Thesis page 237 - page 242;  ALPER H.: "Development of systematic and combinatorial approaches for the metabolic engineering of microorganisms" [Online] June 2006 (2006-06), MASSACHUSSET INSTITUTE OF TECHNOLOGY , BOSTON, USA , XP002429707 Retrieved from the Internet: URL:http:dspace.mit.edubitstream1721.1 35134171825623.pdf [retrieved on 2007-04-05] PhD Thesis page 237 - page 242;  ALPER H.: "Development of systematic and combinatorial approaches for the metabolic engineering of microorganisms" [Online] June 2006 (2006-06), MASSACHUSSET INSTITUTE OF TECHNOLOGY , BOSTON, USA , XP002429707 Retrieved from the Internet: URL:http:dspace.mit.edubitstream1721.135134171825623.pdf [retrieved on 2007-04-05] PhD Thesis page 237 - page 242;  ALPER H.: "Development of systematic and combinatorial approaches for the metabolic engineering of microorganisms" [Online] June 2006 (2006-06), MASSACHUSSET INSTITUTE OF TECHNOLOGY , BOSTON, USA , XP002429707 Retrieved from the Internet: URL:http://dspace.mit.edu/bitstream/1721.1/35134/1/71825623.pdf [retrieved on 2007-04-05]PhD Thesis page 237 - page 242;  See also references of EP 1943343A2