WO2006115305-A1  BARTROLI J. ET AL.: 'New Azole Antifungals. 2. Synthesis and Antifungal Activity of Heterocyclecarboxamide Derivatives of 3-Amino-2-aryl-1-azolyl-2-butanol' JOURNAL OF MEDICINAL CHEMISTRY vol. 41, no. 11, 1998, pages 1855 - 1868, XP001121008;  CAMAGGI C.M. ET AL.: 'Substituent effects in homolytic substitution reactions. The phenylation of some 3-substituted thiophenes' JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 2: PHYSICAL ORGANI CHEMISTRY no. 11, 1972, pages 1594 - 1597, XP003006950;  CHRISTOV V.C. ET AL.: 'Alkatrienyl sulfoxides and sulfones. Part II. 5-methyl-3-(methylsulfonyl)hexa-1,3,4-trien e. Synthesis and electrophile-induced cyclization reactions' HETEROCYCLIC COMMUNICATIONS vol. 9, no. 6, 2003, pages 629 - 634, XP003006938;  CHRZASZCZEWSKA A. ET AL.: 'Thiophenesulfonamides and their derivatives. I. Derivatives of 2,5-dibromo-3-thiophenesulfonic acid' LODZ. TOWARZ. NAUK., WYDZIAL III, ACTA CHIM. vol. 10, 1965, pages 65 - 69, XP003006953;  CONSIGLIO G. ET AL.: 'Linear free energy orthocorrelations in the thiophene series. Part 12. The kinetics of piperidinodebromination of some 2-bromo-3-X-4-methyl-5-nitrothiophenes in methanol' JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 2: PHYSICAL ORGANIC CHEMISTRY no. 4, 1985, pages 519 - 522, XP003006947;  GEORGIADIS T.M. ET AL.: 'Solid-phase synthesis of an oxalic acid amide library' JOURNAL OF COMBINATORIAL CHEMISTRY vol. 6, no. 2, 2004, pages 224 - 229, XP003006939;  GOL'DFARB Y.L. ET AL.: 'Reactions of tert-butyl 3-thienyl sulfide' IZVESTIYA AKADEMII NAUK SSSR no. 10, 1973, pages 2290 - 2295, XP003006948;  GRONOWITZ S. ET AL.: 'Inverted reactivity of aryllithium derivatives. V. On the syntheses of thiocyano, phenylsulfinyl, and phenoxy derivatives of thiophenes and furans' JOURNAL OF HETEROCYCLIC CHEMISTRY vol. 14, no. 2, 1977, pages 281 - 288, XP002191810;  HAGBERG E.C. ET AL.: 'Advances in Ni(0)-Catalyzed Coupling for the Synthesis of Polythiophenes and Polyphenylenes' MACROMOLECULES vol. 37, no. 13, 2004, pages 4748 - 4754, XP003006937;  HARTMAN G.D. ET AL.: 'Synthesis and derivatization of 4-(arylsulfonyl) thiophene- and furan-2-sulfonamides' JOURNAL OF HETEROCYCLIC CHEMISTRY vol. 27, no. 2, 1990, pages 127 - 134, XP003006935;  JEGANATHAN S. ET AL.: '2,3-Di(phenylsulfinyl)-1,3-butadiene via a double [2,3]-sigmatropic rearrangement of the bissulfenate ester of 2-butyne-1,4-diol' TETRAHEDRON LETTERS vol. 23, no. 46, 1982, pages 4763 - 4764, XP003006955;  JONES E. ET AL.: 'Di(thienylthio)thiophenes. Condensation of thiophene thiols with dibromothiophenes' JOURNAL OF THE CHEMICAL SOCIETY 1965, pages 7018 - 7019, XP003006933;  JONES E. ET AL.: 'The synthesis and absorption spectra of isomeric dithienyl sulfides' TETRAHEDRON vol. 21, no. 9, 1965, pages 2413 - 2420, XP003006954;  MIYAKE Y. ET AL.: 'Novel electron-transfer oxidation of Lipshutz cuprates with 1,4-benzoquinones: an efficient homo-coupling reaction of aryl halides and its applicatinon to the construction of macrocyclic systems' CHEMICAL COMMUNICATIONS no. 3, January 2005, pages 411 - 413, XP003006936;  NOTO R. ET AL.: 'An Analysis of 13C Nuclear Magnetic Resonance Substituent Chemical Shifts in 3-Substituted Thiophene-2-carboxylic and 2-Substituted Benzoic Acids by Linear Free Energy Relationships' JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 2: PHYSICAL ORGANIC CHEMISTRY vol. 6, 1988, pages 887 - 892, XP003006943;  NOTO R. ET AL.: 'An analysis of 13C nuclear magnetic resonance substituent chemical shifts in 4- and 5-substituted thiophene-2-carboxylic acids by linear free energy relationships' JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 2: PHYSICAL ORGANIC CHEMISTRY no. 6, 1987, pages 689 - 694, XP003006945;  PADWA A. ET AL.: 'A [4+1] annulation approach to nitrogen heterocycles using 2,3-bis(phenylsulfonyl)-1,3-butadiene and primary amines' JOURNAL OF ORGANIC CHEMISTRY vol. 55, no. 16, 1990, pages 480 - 4807, XP003006958;  PADWA A. ET AL.: 'Formation of polysubstituted 1,2,5,6-tetrahydropyridines from the 4+2 cycloaddition reaction of bis (phenylsulfonyl)butadienes with aryl imines' JOURNAL OF ORGANIC CHEMISTRY vol. 56, no. 8, 1991, pages 2713 - 2720, XP003006957;  PADWA A. ET AL.: '[3+2]-Anionic electrocyclization using 2,3-bis(phenylsulfonyl)-1,3-butadiene: trans-4,7,7-tricarbomethoxy-2-phenylsulfony lbicyclo[3.3.0]oct-1-ene' ORGANIC SYNTHESES vol. 74, 1997, pages 147 - 157, XP003006956;  SHERMOLOVICH Y.G. ET AL.: '1-(Alkylthio)polyfluoroalkynes. Reactions with mercaptans and thermal transformations' HETEROATOM CHEMISTRY vol. 9, no. 2, 1998, pages 151 - 154, XP003006934;  SIMONNIN M.P. ET AL.: '19F and 1H NMR study of five-membered ring triflones and related sigma-adducts. Long range fluorine-proton spin spin coupling' JOURNAL OF FLUORINE CHEMISTRY vol. 36, no. 4, 1987, pages 439 - 448, XP003006944;  SPINELLI D. ET AL.: 'Transmission of substituent effects in systems with bonds of different order. Kinetics of the reactions of 3-bromo-2-nitro-4-X-thiophenes and 3-bromo-4-nitro-2-X-thiophenes with Sodium benzenethiolate in methanol' JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 2: PHYSICAL ORGANIC CHEMISTRY no. 4, 1972, pages 441 - 445, XP003006951;  STEPHENS C.E. ET AL.: 'Synthesis and antiviral/antitumor evaluation of 2-amino- and 2-carboxamido-3-arylsulfonylthiophenes and related compounds as a new class of diarylsulfones' BIOORGANIC & MEDICINAL CHEMISTRY vol. 9, no. 5, 2001, pages 1123 - 1132, XP003006940;  STEPHENS C.E. ET AL.: 'Synthesis and antiviralantitumor evaluation of 2-amino- and 2-carboxamido-3-arylsulfonylthiophenes and related compounds as a new class of diarylsulfones' BIOORGANIC & MEDICINAL CHEMISTRY vol. 9, no. 5, 2001, pages 1123 - 1132, XP003006940;  STEPHENS C.E. ET AL.: 'Synthesis and antiviralantitumor evaluation of 2-amino- and 2-carboxamido-3-arylsulfonylthiophenes and related compounds as a new class of diarylsulfones' BIOORGANIC 0x26 MEDICINAL CHEMISTRY vol. 9, no. 5, 2001, pages 1123 - 1132, XP003006940;  STEPHENS C.E. ET AL.: 'Synthesis of methyl 3-amino-4-aryl(or methyl)sulfonyl-2-thiophenecarboxylates from 3-alkoxy-2-aryl(or methyl-sulfonylacrylonitriles' JOURNAL OF HETEROCYCLIC CHEMISTRY vol. 36, no. 3, 1999, pages 659 - 665, XP003006941;  STEPHENS C.E. ET AL.: 'Synthesis of novel heterocycles from 2-amino-3-(cyanomethylsulfonyl)thiophene' JOURNAL OF HETEROCYCLIC CHEMISTRY vol. 35, no. 4, 1998, pages 927 - 931, XP003006942;  STOYANOVICH F.M. ET AL.: 'Nucleophilic substitution of the tert-butylsulfonyl group on the thiophene series' KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII no. 5, 1967, pages 823 - 826, XP003006952;  STOYANOVICH F.M. ET AL.: 'Reaction of arylsulfonyl compounds with an excess of an organolithium reagent. 6. Metalation of tert-butyl 3-thienyl sulfone' IZVESTIYA AKADEMII NAUK SSSR, SERIYA KHIMICHESKAYA vol. 10, 1973, pages 2285 - 2290, XP003006949;  STOYANOVICH F.M. ET AL.: 'Reactions of arylsulfonyl compounds with an excess of organolithium reagent. 16. Selectivity of metalation of phenyl thienyl sulfones and relative reactivity of benzene and thiophene rings' IZVESTIYA AKADEMII NAUK SSSR, SERIYA KHIMICHESKAYA no. 4, 1985, pages 868 - 874, XP003006946;  YAKUBOV A.P. ET AL.: 'Stable heteroarenium ions. III. Isomerization of 2,5-bis(alkylthio)thiophenes under C-protonation conditions' ZHURNAL ORGANICHESKOI KHIMII vol. 14, no. 3, 1978, pages 641 - 650, XP003006932;  STEPHENS C.E. ET AL.: 'Synthesis and antiviral/antitumor evaluation of 2-amino- and 2-carboxamido-3-arylsulfonylthiophenes and related compounds as a new class of diarylsulfones' BIOORGANIC&MEDICINAL CHEMISTRY vol. 9, no. 5, 2001, pages 1123 - 1132, XP003006940;  See also references of EP 1916244A1US8008425-B2  Yakubov, A. P. et al., Zhurnal Organicheskoi Khimii, 1978, vol. 14, No. 3, pp. 641-650.;  Jones, E. et al., Journal of the Chemical Society, 1965, pp. 7018-7019.;  Shermolovich, Y. G. et al., Heteroatom Chemistry, 1998, vol. 9, No. 2 pp. 151-154.;  Hartman, G. D. et al., Journal of Heterocyclic Chemistry, 1990, vol. 27, No. 2, pp. 127-134.;  Miyake, Y. et al., Chemical Communications, Jan. 2005, No. 3, pp. 411-413.;  Hagberg, E. C. et al., Macromolecules, 2004, vol. 37, No. 13, pp. 4748-4754.;  Christov, V. C. et al., Heterocyclic Communications, 2003, vol. 9, No. 6, pp. 629-634.;  Georgiadis, T. M. et al., Journal of Combinatorial Chemistry, 2004, vol. 6, No. 2, pp. 224-229.;  Stephens, C. 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Nauk., Wydzial III, Acta Chim., 1965, vol. 10, pp. 65-69.;  Jones, E. et al., Tetrahedron, 1965, vol. 21, pp. 2413-2420.;  Jeganathan, S. et al., Tetrahedron Letters, 1982, vol. 23, No. 46, pp. 4763-4764.;  Padwa, A. et al., Organic Syntheses, 1997, vol. 74, pp. 147-157.;  Padwa, A. et al., Journal of Organic Chemistry, 1991, vol. 56, No. 8, pp. 2713-2720.;  Padwa, A. et al., Journal of Organic Chemistry, 1990, vol. 55, No. 16, pp. 4801-4807.EP1916244-B1  YAKUBOV A.P. ET AL.: 'Stable heteroarenium ions. III. Isomerization of 2,5-bis(alkylthio)thiophenes under C-protonation conditions' ZHURNAL ORGANICHESKOI KHIMII vol. 14, no. 3, 1978, pages 641 - 650, XP003006932;  JONES E. ET AL.: 'Di(thienylthio)thiophenes. Condensation of thiophene thiols with dibromothiophenes' JOURNAL OF THE CHEMICAL SOCIETY 1965, pages 7018 - 7019, XP003006933;  SHERMOLOVICH Y.G. ET AL.: '1-(Alkylthio)polyfluoroalkynes. Reactions with mercaptans and thermal transformations' HETEROATOM CHEMISTRY vol. 9, no. 2, 1998, pages 151 - 154, XP003006934;  HARTMAN G.D. ET AL.: 'Synthesis and derivatization of 4-(arylsulfonyl) thiophene- and furan-2-sulfonamides' JOURNAL OF HETEROCYCLIC CHEMISTRY vol. 27, no. 2, 1990, pages 127 - 134, XP003006935;  MIYAKE Y. ET AL.: 'Novel electron-transfer oxidation of Lipshutz cuprates with 1,4-benzoquinones: an efficient homo-coupling reaction of aryl halides and its applicatinon to the construction of macrocyclic systems' CHEMICAL COMMUNICATIONS no. 3, January 2005, pages 411 - 413, XP003006936;  HAGBERG E.C. ET AL.: 'Advances in Ni(0)-Catalyzed Coupling for the Synthesis of Polythiophenes and Polyphenylenes' MACROMOLECULES vol. 37, no. 13, 2004, pages 4748 - 4754, XP003006937;  CHRISTOV V.C. ET AL.: 'Alkatrienyl sulfoxides and sulfones. Part II. 5-methyl-3-(methylsulfonyl)hexa-1,3,4-trien e. Synthesis and electrophile-induced cyclization reactions' HETEROCYCLIC COMMUNICATIONS vol. 9, no. 6, 2003, pages 629 - 634, XP003006938;  GEORGIADIS T.M. ET AL.: 'Solid-phase synthesis of an oxalic acid amide library' JOURNAL OF COMBINATORIAL CHEMISTRY vol. 6, no. 2, 2004, pages 224 - 229, XP003006939;  STEPHENS C.E. ET AL.: 'Synthesis and antiviral/antitumor evaluation of 2-amino- and 2-carboxamido-3-arylsulfonylthiophenes and related compounds as a new class of diarylsulfones' BIOORGANIC & MEDICINAL CHEMISTRY vol. 9, no. 5, 2001, pages 1123 - 1132, XP003006940;  STEPHENS C.E. ET AL.: 'Synthesis of methyl 3-amino-4-aryl(or methyl)sulfonyl-2-thiophenecarboxylates from 3-alkoxy-2-aryl(or methyl-sulfonylacrylonitriles' JOURNAL OF HETEROCYCLIC CHEMISTRY vol. 36, no. 3, 1999, pages 659 - 665, XP003006941;  STEPHENS C.E. ET AL.: 'Synthesis of novel heterocycles from 2-amino-3-(cyanomethylsulfonyl)thiophene' JOURNAL OF HETEROCYCLIC CHEMISTRY vol. 35, no. 4, 1998, pages 927 - 931, XP003006942;  BARTROLI J. ET AL.: 'New Azole Antifungals. 2. Synthesis and Antifungal Activity of Heterocyclecarboxamide Derivatives of 3-Amino-2-aryl-1-azolyl-2-butanol' JOURNAL OF MEDICINAL CHEMISTRY vol. 41, no. 11, 1998, pages 1855 - 1868, XP001121008;  NOTO R. ET AL.: 'An Analysis of 13C Nuclear Magnetic Resonance Substituent Chemical Shifts in 3-Substituted Thiophene-2-carboxylic and 2-Substituted Benzoic Acids by Linear Free Energy Relationships' JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 2: PHYSICAL ORGANIC CHEMISTRY vol. 6, 1988, pages 887 - 892, XP003006943;  SIMONNIN M.P. ET AL.: '19F and 1H NMR study of five-membered ring triflones and related sigma-adducts. Long range fluorine-proton spin spin coupling' JOURNAL OF FLUORINE CHEMISTRY vol. 36, no. 4, 1987, pages 439 - 448, XP003006944;  NOTO R. ET AL.: 'An analysis of 13C nuclear magnetic resonance substituent chemical shifts in 4- and 5-substituted thiophene-2-carboxylic acids by linear free energy relationships' JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 2: PHYSICAL ORGANIC CHEMISTRY no. 6, 1987, pages 689 - 694, XP003006945;  STOYANOVICH F.M. ET AL.: 'Reactions of arylsulfonyl compounds with an excess of organolithium reagent. 16. Selectivity of metalation of phenyl thienyl sulfones and relative reactivity of benzene and thiophene rings' IZVESTIYA AKADEMII NAUK SSSR, SERIYA KHIMICHESKAYA no. 4, 1985, pages 868 - 874, XP003006946;  CONSIGLIO G. ET AL.: 'Linear free energy orthocorrelations in the thiophene series. Part 12. The kinetics of piperidinodebromination of some 2-bromo-3-X-4-methyl-5-nitrothiophenes in methanol' JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 2: PHYSICAL ORGANIC CHEMISTRY no. 4, 1985, pages 519 - 522, XP003006947;  GRONOWITZ S. ET AL.: 'Inverted reactivity of aryllithium derivatives. V. On the syntheses of thiocyano, phenylsulfinyl, and phenoxy derivatives of thiophenes and furans' JOURNAL OF HETEROCYCLIC CHEMISTRY vol. 14, no. 2, 1977, pages 281 - 288, XP002191810;  GOL'DFARB Y.L. ET AL.: 'Reactions of tert-butyl 3-thienyl sulfide' IZVESTIYA AKADEMII NAUK SSSR no. 10, 1973, pages 2290 - 2295, XP003006948;  STOYANOVICH F.M. ET AL.: 'Reaction of arylsulfonyl compounds with an excess of an organolithium reagent. 6. Metalation of tert-butyl 3-thienyl sulfone' IZVESTIYA AKADEMII NAUK SSSR, SERIYA KHIMICHESKAYA vol. 10, 1973, pages 2285 - 2290, XP003006949;  CAMAGGI C.M. ET AL.: 'Substituent effects in homolytic substitution reactions. The phenylation of some 3-substituted thiophenes' JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 2: PHYSICAL ORGANI CHEMISTRY no. 11, 1972, pages 1594 - 1597, XP003006950;  SPINELLI D. ET AL.: 'Transmission of substituent effects in systems with bonds of different order. Kinetics of the reactions of 3-bromo-2-nitro-4-X-thiophenes and 3-bromo-4-nitro-2-X-thiophenes with Sodium benzenethiolate in methanol' JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 2: PHYSICAL ORGANIC CHEMISTRY no. 4, 1972, pages 441 - 445, XP003006951;  STOYANOVICH F.M. ET AL.: 'Nucleophilic substitution of the tert-butylsulfonyl group on the thiophene series' KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII no. 5, 1967, pages 823 - 826, XP003006952;  CHRZASZCZEWSKA A. ET AL.: 'Thiophenesulfonamides and their derivatives. I. Derivatives of 2,5-dibromo-3-thiophenesulfonic acid' LODZ. TOWARZ. NAUK., WYDZIAL III, ACTA CHIM. vol. 10, 1965, pages 65 - 69, XP003006953;  JONES E. ET AL.: 'The synthesis and absorption spectra of isomeric dithienyl sulfides' TETRAHEDRON vol. 21, no. 9, 1965, pages 2413 - 2420, XP003006954;  JEGANATHAN S. ET AL.: '2,3-Di(phenylsulfinyl)-1,3-butadiene via a double [2,3]-sigmatropic rearrangement of the bissulfenate ester of 2-butyne-1,4-diol' TETRAHEDRON LETTERS vol. 23, no. 46, 1982, pages 4763 - 4764, XP003006955;  PADWA A. ET AL.: '[3+2]-Anionic electrocyclization using 2,3-bis(phenylsulfonyl)-1,3-butadiene: trans-4,7,7-tricarbomethoxy-2-phenylsulfony lbicyclo[3.3.0]oct-1-ene' ORGANIC SYNTHESES vol. 74, 1997, pages 147 - 157, XP003006956;  PADWA A. ET AL.: 'Formation of polysubstituted 1,2,5,6-tetrahydropyridines from the 4+2 cycloaddition reaction of bis (phenylsulfonyl)butadienes with aryl imines' JOURNAL OF ORGANIC CHEMISTRY vol. 56, no. 8, 1991, pages 2713 - 2720, XP003006957;  PADWA A. ET AL.: 'A [4+1] annulation approach to nitrogen heterocycles using 2,3-bis(phenylsulfonyl)-1,3-butadiene and primary amines' JOURNAL OF ORGANIC CHEMISTRY vol. 55, no. 16, 1990, pages 480 - 4807, XP003006958KR1484741-B1  The Macromolecules, the Vol. 37, and the pp. 4748~ 4754 (2004 year) *.;  Macromolecules, Vol. 37, pp. 4748~4754(2004&#45380;)