NOVELTY - A reactor (202) for detoxifying a fluid containing organophosphorus compounds comprises a vessel for holding the fluid, having a fluid contacting surface coated with a bioactive coating; and a bioactive support component (203) coated with a bioactive coating, disposed inside the vessel. The bioactive coating comprises a phosphoric triester hydrolase. The reactor is a column reactor; a packed bed reactor; a fluidized bed reactor; a tubular reactor; a stirred tank reactor; a batch reactor or a continuous reactor.    USE - For detoxification of fluid or fluid streams containing organophosphorus compounds, such as chemical weapons agents, chemical weapons agent analogs, chemical weapons agent surrogates, and pesticides (claimed).    ADVANTAGE - The bioactive coating comprising phosphoric triester hydrolase is capable of detoxifying organophosphorus compounds such as chemical weapons agents, particularly tabun, sarin, soman, cyclosarin, VX (nerve agent), and its isometric analog Russian VX; chemical weapons agent analogs, chemical weapons surrogates; and pesticides. The reactor can detoxify organophosphorus compounds continuously, semi-continuously and in batch operation. The bioactive coated support component may take any form of solid, flexible sheet for providing a surface or increasing surface area within a reactor for promoting chemical reaction, mass transfer operation, heat transfer operation or separation process.    DETAILED DESCRIPTION - INDEPENDENT CLAIMS are also included for:    (1) a bioactive support component for detoxifying a fluid stream containing organophosphorus compounds;    (2) a column comprising the bioactive support component coated with a bioactive coating disposed inside the column;    (3) preparing the bioactive support component; and    (4) a method of treating a fluid stream containing organophosphorus compound.    DESCRIPTION OF DRAWING(S) - The figure shows a simplified view of a column reactor having a bioactive support component.    column reactor (202)    inlet (201)    bioactive support component (203)    outlet. (204)