TECHNOLOGY FOCUS - INORGANIC CHEMISTRY - Preferred Oxidant: The oxidant is oxygen-rich air, oxygen-depleted air, pure oxygen, or preferably air.    TECHNOLOGY FOCUS - MECHANICAL ENGINEERING - Preferred Components: The mixed reforming zone is CPO or ATR zone. The system comprises a heat exchange zone (153), a shift reaction zone, and a purification system to generate an off-gas and a hydrogen-rich product gas. The off-gas is recycled to a steam generator to generate steam and produce a cooled off-gas. The heat exchange zone comprises heat exchanger(s). It includes a first heat exchanger to receive the first portion of steam and second reformate stream, where heat is transferred from the second reformate gas stream to the first portion of steam to generate a heated steam and a first cooled second reformate stream; a second heat exchanger to receive the first and second fuels and the first cooled second reformate stream, where heat is transferred from the first cooled second reformate stream to the first and second fuels to generate heated first and second fuels and a second cooled second reformate; and a third heat exchanger to receive the oxidant and second cooled second reformate gas stream, where heat is transferred from the second cooled second reformate gas stream to the oxidant to generate a heated oxidant and a third cooled second reformate stream. The shift reaction zone receives the third cooled second reformate stream and steam to generate a third reformate stream rich in hydrogen. A fourth heat exchanger receives the third reformate stream and water, where heat is extracted from the third reformate stream to produce steam and a cooled third reformate gas stream. Pre-reformer reforms the second fuel before the second fuel is introduced into the reforming zone. The pre-reformer utilizes the heat from off-gas to reform the second fuel. The steam reforming, CPO, heat exchange and shift reaction zones are placed in a vessel (82). The purification system comprises chemical absorber, pressure swing adsorber, cryogenic separator, membrane separator, and/or liquefier.Preferred Parameters: The steam reforming zone operates at 500-1200degreesC. When the second fuel is ethanol, the steam reforming zone operates at 350-850degreesC. When the second fuel is methanol, the steam reforming zone operates at 200-400degreesC.    TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Fuel: The first and second fuels are methane, methanol, ethanol, a stream comprising naphtha, butane, propane, diesel, kerosene, aviation fuel, coal-derived fuel, bio-fuel, oxygenated hydrocarbon feedstock, and/or preferably natural gas.