WO2006116658-A3  PFEIFFER F R ET AL: "Tri- and tetrapeptide analogues of kinins as potential renal vasodilators." JOURNAL OF MEDICINAL CHEMISTRY. MAR 1984, vol. 27, no. 3, March 1984 (1984-03), pages 325-341, XP002368169 ISSN: 0022-2623;  DATABASE REGISTRY Chem.Abstr.; RN=416977-96-3 16 May 2002 (2002-05-16), XP002351927 & WO 01/77384 A (EPIGENOMICS AG; OLEK, ALEXANDER; PIEPENBROCK, CHRISTIAN; BERLIN, KURT) 18 October 2001 (2001-10-18);  VILIM V ET AL: "CHARACTERIZATION OF MONOCLONAL ANTIBODIES RECOGNIZING DIFFERENT FRAGMENTS OF CARTILAGE OLIGOMERIC MATRIX PROTEIN IN HUMAN BODY FLUIDS" ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, NEW YORK, US, US, vol. 341, no. 1, 1 May 1997 (1997-05-01), pages 8-16, XP002050543 ISSN: 0003-9861 cited in the application;  STRACKE^A J O ET AL: "Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP)" FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 478, no. 1-2, 28 July 2000 (2000-07-28), pages 52-56, XP004337405 ISSN: 0014-5793;  FOSANG A J ET AL: "Neoepitopes as biomarkers of cartilage catabolism." INFLAMMATION RESEARCH : OFFICIAL JOURNAL OF THE EUROPEAN HISTAMINE RESEARCH SOCIETY ... [ET AL.]. JUN 2003, vol. 52, no. 7, June 2003 (2003-06), pages 277-282, XP002351924 ISSN: 1023-3830;  CARRINO DAVID A ET AL: "Age-related changes in the proteoglycans of human skin. Specific cleavage of decorin to yield a major catabolic fragment in adult skin." THE JOURNAL OF BIOLOGICAL CHEMISTRY. 9 MAY 2003, vol. 278, no. 19, 9 May 2003 (2003-05-09), pages 17566-17572, XP002351925 ISSN: 0021-9258;  PFEIFFER F R ET AL: "Tri- and tetrapeptide analogues of kinins as potential renal vasodilators.", JOURNAL OF MEDICINAL CHEMISTRY. MAR 1984, vol. 27, no. 3, March 1984 (1984-03-01), pages 325 - 341, XP002368169, ISSN: 0022-2623,relevantClaims[7,12-15],relevantPassages[See Table 1, compound 24];  DATABASE REGISTRY Chem.Abstr.; 16 May 2002 (2002-05-16), XP002351927,relevantClaims[9-11],relevantPassages[See sequence];  VILIM V ET AL: "CHARACTERIZATION OF MONOCLONAL ANTIBODIES RECOGNIZING DIFFERENT FRAGMENTS OF CARTILAGE OLIGOMERIC MATRIX PROTEIN IN HUMAN BODY FLUIDS", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, NEW YORK, US, US, vol. 341, no. 1, 1 May 1997 (1997-05-01), pages 8 - 16, XP002050543, ISSN: 0003-9861,relevantClaims[1-4,7-19],relevantPassages[&lt;pp&gt;W&lt;/pp&gt;];  STRACKE^A J O ET AL: "Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP)", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 478, no. 1-2, 28 July 2000 (2000-07-28), pages 52 - 56, XP004337405, ISSN: 0014-5793,relevantClaims[1-4,7-19],relevantPassages[&lt;pp&gt;W&lt;/pp&gt;];  FOSANG A J ET AL: "Neoepitopes as biomarkers of cartilage catabolism.", INFLAMMATION RESEARCH : OFFICIAL JOURNAL OF THE EUROPEAN HISTAMINE RESEARCH SOCIETY ... [ET AL.]. JUN 2003, vol. 52, no. 7, June 2003 (2003-06-01), pages 277 - 282, XP002351924, ISSN: 1023-3830,relevantClaims[1-4,7-19],relevantPassages[&lt;pp&gt;W&lt;/pp&gt;];  CARRINO DAVID A ET AL: "Age-related changes in the proteoglycans of human skin. Specific cleavage of decorin to yield a major catabolic fragment in adult skin.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. 9 MAY 2003, vol. 278, no. 19, 9 May 2003 (2003-05-09), pages 17566 - 17572, XP002351925, ISSN: 0021-9258,relevantClaims[1-4,7-19],relevantPassages[&lt;pp&gt;W&lt;/pp&gt;]