NOVELTY - A physiologically ingestible composition of matter comprises microstructured water consisting hydrogen and oxygen atoms, and having a negative oxidation reduction potential (ORP) made by the process of preconditioning water received from a water source for electrolysis; performing electrolysis on the preconditioned water; outputting alkaline water and/or acidic water with a stable negative ORP (negative ORP water); combining the negative ORP water with oxygen; and manipulating the combined negative ORP water and oxygen into a vortex to cause the oxygen to diffuse into the water.    USE - The physiologically ingestible composition of matter is used for inhibiting changes in the heart rate of a mammal (i.e. human or horse) undergoing stress (claimed); treatment of a variety of conditions associated and/or linked with low blood oxygen, e.g. altitude sickness; maintaining and normalizing, a reduced oxygenated blood level in an animal subsequent to a blood oxygen-lowering effect activity, after an oxygen-consuming activity, e.g. exercise; inhibiting and/or reducing the increase in levels of blood lactate attendant exercise in a human; reducing muscle soreness and lactic acid accumulation in muscle; inhibiting the onset of fatigue in a human; and reducing and/or inhibiting the significant and sudden increase on oxygen consumption attendant exercise in human. It is useful as a preferred beverage for consumption by professional athletes and/or those persons involved in any competitive sport. It is used for e.g. increasing the oxygen content of blood and tissues, oxygenation of wounds to increase the rate of healing and reduce infections, treatment of infections by anaerobic organisms, oxygenated organ transplant storage media, tumor oxygenation for radiation therapy and chemotherapy, lung bypass by oxygenated liquids in case of pulmonary deficiencies, carbon monoxide poisoning, mouthwashes, dentifrices, topical including cosmetic, treatment media, contact lens treating solutions, and cell level therapeutic applications. It is used as the fermentation liquor of all kinds of fermentation processes, such as drug production or food processing by microorganisms; as solvents for physiological saline isotonic solutions; and as food additive in e.g. agricultural food e.g. vegetables. It is useful during surgical manipulations in treatment for retinal detachments, diabetic retinopathy, or macular degenerations as an adjunct to the intraocular irrigation solution or applied directly to the vitreous during the surgical procedure.    ADVANTAGE - The physiologically ingestible composition of matter adequately and sufficiently oxygenates and structures water that when consumed, whether by internal or external absorption, there is a distinct and definite increase in hydration, oxygenation, and healthy metabolic changes regarding organic life processes. It achieves greater than or equal to 10% reduction in the changes of heart rate of mammal undergoing stress; provides for an enhancement of the persons endurance and performance as a result of the increase in available blood oxygen; lowers free radical levels; inhibits free radical damage in cells; and is capable of retaining a higher concentration and/or amount of oxygen under open-air (i.e. open container) conditions. The use of highly oxygenated water in aerobic processes is 5 times more efficient, and obtains a like extent of energy efficiency improvement. Subjects comprising a group of males and females of greater than or equal to 18 years in age in good physical condition were tested during a two-week period. The test subjects had been in physical training during the previous year, training greater than or equal to 2 times/week, during the time preceding the study. They were randomly assigned to a group to receive the oxygen enriched, structured and microstructured water preparation (500 ml) versus a preparation of conventional tap or bottled water (500 ml) (placebo). The total duration of the study was 14 days, comprising 4 evaluation visits. The mean (SD) percent change was 0.65, indicating that when subjects consumed the oxygen-enriched water, the change in heart rate during exercise to fatigue was reduced by 65% when compared to placebo.    DETAILED DESCRIPTION - An INDEPENDENT CLAIM is also included for a method of inhibiting changes in the heart rate of a mammal undergoing stress, comprising administering to the mammal an amount of physiologically ingestible composition of matter.    DESCRIPTION OF DRAWING(S) - The figure is a block diagram of a system for making and tuning super-oxygenated and structured water.