TECHNOLOGY FOCUS - BIOTECHNOLOGY - Preferred System: The bio-organic compound production system comprises: (1) a vessel having a capacity of at least 100 liters; (2) an aqueous medium, within the vessel, forming a first phase; (3) host cells, within the aqueous medium, capable of making at least one bio-organic compound; and (4) a liquid organic second phase, comprising the at least one bio-organic compound, in contact with the first phase. The at least one bio-organic compound is a C5, C10, C15, C20 or C20+ bio-organic compound. The bio-organic compound is an isoprenoid compound. The vessel has a capacity of at least 1000, 10000, 50000, 100000, 500000 or 1000000 liters. The organic second phase comprises the bio-organic compound. The organic second phase comprises at least 90% bio-organic compound. The system is for making C5-C20 isoprenoid compounds and comprises:(1) a vessel having a capacity of at least 100 liters;(2) an aqueous medium, within the vessel, comprising a first phase;(3) host cells, within the aqueous medium, capable of making at least one isoprenoid; and(4) a liquid organic second phase, comprising the at least one isoprenoid, in contact with the first phase.The isoprenoid compound is a hemiterpene, monoterpene, sesquiterpene or diterpene. The system is a fuel composition production system comprising: (a) one or more fermentation systems comprising: (i) at least one vessel having a capacity of at least 100 liters; (ii) an aqueous medium, within the at least one vessel, comprising a first phase; (iii) host cells, within the aqueous medium, capable of making, producing or synthesizing at least one bio-organic compound; and (iv) a liquid organic second phase comprising the at least one bio-organic compound in contact with the first phase; (b) one or more first phase separation systems where the first phase and the second organic phase or one or more components of the second organic phase are separated; (c) optionally one or more second phase separation systems where the at least one bio-organic compound is separated from the second organic phase; (d) optionally one or more reactors or vessels, where the at least one bio-organic compound is chemically or biologically modified; (e) optionally one or more purification systems, where the bio-organic compound or the modified bio-organic compound is purified or further purified; (f) optionally one or more blending vessels or systems for blending the at least one bio-organic compound with one or more additional fuel components; and (g) optionally one or more further purification systems, where the blend of the at least one bio-organic compound and the one or more additional fuel components is purified or further purified. Preferred Method: Producing a bio-organic compound comprises:(1) culturing in an aqueous medium host cells that produce at least one bio-organic compound where the aqueous medium and host cells comprise a first phase;(2) forming a liquid organic second phase comprising the at least one bio-organic compound in contact with the second phase;(3) separating at least a portion of the second phase from the first phase; and(4) isolating the at least one bio-organic compound from the second phase.The organic second phase is formed by induction. The organic second phase is separated by decanting the second phase from the first phase. The isolation step comprises adsorption, distillation, gas-liquid extraction, liquid-liquid extraction or ultrafiltration. The bio-organic compound is an isoprenoid compound. Producing a C5-C20 isoprenoid compound comprises:(1) culturing in an aqueous medium host cells that produce at least one C5-C20 isoprenoid compound in a vessel having a capacity of at least 100 liters;(2) forming an organic phase comprising the at least one C5-C20 isoprenoid compound;(3) separating at least a portion of the organic phase from the aqueous medium; and(4) isolating the at least one C5-C20 isoprenoid compound from the organic phase.The organic phase is formed by induction. The organic phase is separated by decanting the organic phase from the aqueous phase. The isolation step comprises adsorption. The isolation step comprises distillation. The isolation step comprises gas-liquid extraction. The isolation step comprises liquid-liquid extraction. The isolation step comprises ultrafiltration. Making a fuel composition comprises:(1) culturing in an aqueous medium host cells that produce, make or synthesize at least one bio-organic compound where the aqueous medium comprises a first phase;(2) forming a liquid organic second phase comprising the at least one bio-organic compound in contact with the first phase;(3) separating at least a portion of the second phase from the first phase;(4) isolating the at least one bio-organic compound from the second phase;(5) optionally chemically or biologically modifying the at least one bio-organic compound;(6) optionally purifying the bio-organic compound or the modified bio-organic compound;(7) optionally blending the at least one bio-organic compound with one or more additional fuel components; and(8) optionally purifying the blend of the one or more bio-organic compounds and the one or more additional fuel components. EXAMPLE - No suitable example given.