NOVELTY - The invention claims a biologic preparation of salubrious bacterial bacteriocin of professional aquiculture for sterilizing and germ-restraining. The main ingredients are hay bacillus gemma, lichen gemma bacillin, Bifidobacteria bacillin, lactobacillus bacteriocin and feedstuff blended according to proportion into powder agent via special biological technology. The hay bacillus gemma, lichen gemma bacillin, Bifidobacteria bacillin and lactobacillus bacteriocin are cultivated from purified bacterium seeds. The salubrious bacteria take part in competition between beneficial germ group and disease-causing germ group in cultivation environment and alimentary canal of animal for the space, time, habitat location and nutrients for survival and reproduction. It threats the survival, reproduction, habitat and attachment of the disease-causing germs. The beneficial germ group generate volatile fatty acid and lactic acid during metabolism, which decrease the ph and Eh of the growing environment due to the production of hydrogen peroxide that restrains the pathogeny. The growing and metabolic bacteriocin is antibiotic and bacteriocin that kill pathogenic germs. The feedstuff is algae containing various nutritious ingredients and being carrier for salubrious germs. The invention is suitable for the sterilization of various cultivated species in various aquiculture industries. It is effective and harmless to human body and cultivated species to be sterilized. It dos not pollute the water quality and environment. It is operationally simple for use. The bacteriocin of salubrious germ prepared by special technique is a new generation product for aquiculture industry. It is preeminent particularly in restraining harmful microorganism, preventing species of aquiculture from infecting diseases caused by germs, improving metabolism of the species of aquiculture, supplementing nutrients for organism, stimulating immune system of the organism in order to improve the immunity of the organism, taking part in biologic degradation and eliminating organic pollutants.