TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Process: The method for manufacturing biofuel by trans-esterification process involves mixing the triglyceride and alcohol to form a reaction mixture; transferring the reaction mixture to at least a distal pre-heater (24) to heat the mixture to a temperature below 180 degrees C and at a pressure below 1450 psi; transferring the pre-heated reaction mixture to a reactor (36) maintained at a temperature of greater than 180 degrees C and at a pressure of greater than 1450 psi to form a liquid biofuel, and a glycerin and excess alcohol gaseous mixture; collecting the so-produced biofuel; collecting the glycerin; and recycling the excess alcohol to the alcohol source. The method further involves providing a proximal pre-heater (34) in fluid communication with the distal pre-heater and the reactor and a first flash reactor, transferring the reaction mixture from the first pre-heater to the proximal pre-heater and then to the reactor; and after the reaction is complete, recycling the reaction products to the proximal pre-heater and to a first flash reactor drum. The proximal pre-heater is interposed between the first pre-heater and the reactor, the second pre-heater is at a temperature and pressure greater than that of the first pre-heater but below 180 degrees C and 1450 psi. The method further involves providing a first intermediate pre-heater and a second intermediate pre-heater, where the first intermediate pre-heater is in fluid communication with the distal pre-heater, and the second intermediate pre-heater is in fluid communication with the first intermediate pre-heater and the proximal pre-heater; transferring the biofuel from the first flash drum to the first intermediate pre-heater to heat the reaction mixture to a temperature and pressure above the distal pre-heater but below that of the second intermediate pre-heater, transferring the alcohol and glycerin gaseous mixture from the first flash drum to the second intermediate pre-heater to pre-heat the reaction mixture to a temperature and pressure above that of the first intermediate pre-heater but below that of the proximal pre-heater, and collecting the biofuel from the first intermediate pre-heater. The method additionally involves providing a second flash drum; transferring the glycerin and alcohol mixture from the second intermediate pre-heater to the second flash drum to condense the glycerin; collecting the glycerin; transferring the remaining gaseous alcohol to the distal pre-heater to pre-heat the reaction mixture; delivering the so-recycled alcohol from the distal pre-heater to the source of alcohol; and mixing the recycled alcohol with the alcohol source. The method is a continuous process. Each of the pre-heaters is a counter-current flow heat exchanger. Preferred Components: The reactants are an alcohol (preferably of formula Cn-H2n-1(OH), especially methanol) and an oil (preferably vegetable oil).n=1-10. EXAMPLE - No suitable example given.