NOVELTY - A solid acid and alkali bi-functional catalyst, and a reaction material containing low carbon alcohol and 0.1-20% of raw oil in mol ratio of 3:1-40:1, are subjected to a reaction device and reacted at temperature of 300 degrees C under pressure of 25 MPa. Then, the low carbon alcohol is vaporized, and the solid acid and alkali bi-functional catalyst are separated, to obtain biodiesel and glycerin.    USE - Manufacture of biodiesel.    ADVANTAGE - The biodiesel is efficiently manufactured using solid acid and alkali bi-functional catalyst having high catalytic activity, and has high industrial value.    DETAILED DESCRIPTION - A solid acid and alkali bi-functional catalyst, and a reaction material containing low carbon alcohol and 0.1-20% of raw oil in mol ratio of 3:1-40:1, are subjected to a reaction device and reacted at temperature of 300 degrees C under pressure of 25 MPa. Then, the low carbon alcohol is vaporized, and the solid acid and alkali bi-functional catalyst are separated, to obtain biodiesel and glycerin. The solid acid and alkali bi-functional catalyst is chosen from cesium-barium-phosphorus oxide/silica, copper-zinc oxide-alumina, copper-cobalt oxide-zinc oxide-alumina, copper-zinc oxide-cobalt oxide-alumina-titanium dioxide, copper-zinc oxide-cobalt oxide-alumina-zirconium oxide, copper-zinc oxide-cobalt oxide-alumina-titanium dioxide-zirconium oxide, zinc oxide-alumina-silicon oxide-sodium zeolite (ZnO-Al2O3-SiO2-NaZSM-5), zinc oxide-alumina-silica-tungsten oxide-manganese oxide, zinc oxide-alumina-silica-tungsten oxide-iron oxide, zinc oxide-alumina-silica-tungsten oxide-cobalt oxide, zinc oxide-alumina-silica-tungsten oxide-nickel oxide, zinc oxide-alumina-silica-tungsten oxide-copper oxide, zinc oxide-hydrogen zeolite (ZnO-HZSM-5), potassium oxide-boric acid-titanium dioxide-zirconia, metal oxide-sodium carbonate (MxOy-Na2CO3), metal oxide-sodium oxide (MxOy-Na2O), metal oxide-potassium carbonate (MxOy-K2CO3), metal oxide-potassium oxide (MxOy-K2O), metal oxide-silica-sodium carbonate (MxOy-SiO2-Na2CO3), metal oxide-silicon monoxide-sodium oxide (MxOy-SiO-Na2O), metal oxide-silica-potassium carbonate (MxOy-SiO2-K2CO3), metal oxide-silica-potassium oxide (MxOy-SiO2-K2O), metal oxide-silica-magnesium oxide (MxOy-SiO2-MgO), copper(II) sulfate-zirconia-metal oxide (CuSO4-ZrO2-MxOy), copper(II) sulfate-lanthanum oxide-zirconia, copper(II) sulfate-lanthanum oxide-metal oxide (CuSO4-LaO3-MxOy), copper oxide-zinc oxide-metal oxide (CuO-ZnO-MxOy), copper oxide-zinc oxide-zirconia, sodium carbonate-sodium chloride-metal oxide (Na2CO3-NaCl-AO), sodium oxide-sodium chloride-metal oxide (Na2CO3-KCl-AO), sodium carbonate-potassium chloride-metal oxide (Na3O2-KCl-AO), potassium carbonate-potassium chloride-metal oxide (K2CO3-KCl-AO), potassium oxide-potassium chloride-metal oxide (K2O-KCl-AO), potassium carbonate-sodium chloride-metal oxide (K2CO3-NaCl-AO), potassium oxide-sodium chloride-metal oxide (K2O-NaCl-AO), sodium chloride-metal oxide (NaCl-AO), potassium oxide-sodium chloride-metal oxide (K2O-NaCl-AO), sodium carbonate-potassium chloride-metal oxide (Na2CO3-KCl-AO), sodium oxide-potassium chloride-metal oxide (Na2O-KCl-AO), sodium oxide-potassium oxide-metal oxide (Na2O-K2O-AO), sodium carbonate-metal oxide (Na2CO3-AO), sodium oxide-metal oxide (Na2O-AO), potassium carbonate-metal oxide (K2CO3-AO), potassium oxide-metal oxide (K2O-AO), potassium carbonate-potassium oxide-metal oxide (K2CO3-KCl-MxOy), potassium oxide-potassium chloride-metal oxide (K2O-KCl-MxOy), potassium carbonate-sodium chloride-metal oxide (K2CO3-NaCl-MxOy), potassium oxide-sodium chloride-metal oxide (K2O-NaCl-MxOy), sodium carbonate-potassium chloride metal oxide (Na2CO3-KCl-MxOy), sodium oxide-sodium chloride-metal oxide (Na2O-NaCl-MxOy), sodium carbonate-potassium chloride-metal oxide (Na2CO3-KCl-MxOy), sodium oxide-potassium chloride-metal oxide (Na2O-KCl-MxOy), sodium oxide-potassium chloride-metal oxide (Na2O-K2O-MxOy), potassium carbonate-potassium oxide-metal oxide (K2CO3-K2O-MxOy), metal oxide-sodium carbonate (MxOy-AO-Na2CO3), metal oxide-sodium oxide (MxOy-AO-Na2O), metal oxide-potassium oxide (MxOy-AO-K2O), sodium carbonate-potassium chloride oxide-zinc oxide, sodium carbonate-potassium oxide-zinc oxide, potassium carbonate-potassium chloride-zinc oxide, potassium carbonate-potassium oxide-zinc oxide, sodium carbonate-sodium chloride-zinc oxide, sodium oxide-sodium chloride-zinc oxide, potassium carbonate-sodium chloride-zinc oxide, potassium carbonate-potassium chloride-zinc oxide, potassium oxide-potassium chloride-zinc oxide, potassium oxide-sodium chloride-zinc oxide, sodium oxide-potassium chloride-zinc oxide, sodium oxide-potassium-zinc oxide, potassium carbonate-potassium chloride-silica, potassium carbonate-sodium chloride-silica, sodium carbonate-sodium chloride-silica, sodium carbonate-potassium chloride-silica, potassium oxide-potassium chloride-silica, potassium oxide-sodium chloride-silica, sodium oxide-sodium chloride-silica, sodium oxide-potassium chloride-silica, sodium oxide-potassium oxide-silica, copper oxide-zinc oxide-metal oxide (CuO-ZnO-MxOy), sodium oxide-metal oxide-titanium dioxide-zirconia (Na2O-MxOy-TiO2-ZrO2), potassium oxide-metal oxide-titanium dioxide-zirconia (K2O-MxOy-TiO2-ZrO2), sodium carbonate-metal oxide-titanium dioxide-zirconia (Na2CO3-MxOy-TiO2-ZrO2), potassium carbonate-metal oxide-titanium dioxide-zirconia (K2CO3-MxOy-TiO2-ZrO2), sodium chloride-metal oxide-titanium dioxide-zirconia (NaCl-MxOy-TiO2-ZrO2), potassium chloride-metal oxide-titanium dioxide-zirconia (KCl-MxOy-TiO2-ZrO2), platinum-silica-metal oxide (Pt-SiO2-MxOy), sodium chloride-copper(II) chloride-metal oxide (NaCl-CuCl2-MxOy), potassium chloride-copper(II) chloride-metal oxide (KCl-CuCl2-MxOy), sodium oxide-copper(II) chloride-metal oxide (Na2O-CuCl2-MxOy), potassium oxide-copper(II) chloride-metal oxide (K2O-CuCl2-MxOy), sodium oxide-copper(II) chloride-metal oxide (Na2O-CuCl2-MxOy), potassium oxide-copper oxide-metal oxide (K2O-CuO-MxOy), metal oxide-palladium-silica (MxOy-Pd-SiO2), iron oxide-chromium oxide, cobalt-molybdenum oxide-metal oxide (Co-MoO3-MxOy), and/or cobalt-molybdenum-zirconium oxide-metal oxide (CoMo-ZrO2-MxOy), where A is element of group II in a periodic table, M is element of group III in periodic table, rare earth metals, silicon, germanium, tin, lead, manganese, zinc, phosphorus, arsenic, antimony, selenium, tellurium, polonium or bismuth, x is 1 or 2, and y is 1, 2, 3, 4, 5, 6 or 7.