NOVELTY - Selectively hydrogenating process stream involves use of catalyst composition to hydrogenate portion of process stream. The catalyst composition comprises nonmicroporous substrate having mesopores, macropores, external surface, open pore wall surface, surface region and subsurface region; catalytic constituent; and catalytically-active region comprising the constituent. The nonmicroporous substrate has total surface area determined by N2-BET and/or Kr-BET measurements of 5-300 m2/g, and predetermined isoelectric point (IEP) obtained in pH greater than 0 to less than or equal to 14.    USE - For hydrogenating process stream (claimed), e.g. alkenes, dienes, polyenes, alkynes, polyynes, cyclenes, aromatics, unsaturated vegetable oils, hydrogenatable oxygenates, ketones, aldehydes, carboxylic acids, quinones. Also useful for emission control processes e.g. auto emissions, refinery emissions, utility plant emissions.    ADVANTAGE - The substrate is a glass composition having a sodium surface area rate of change (SARC-Na) of less than or equal to 0.5. The nonmicroporous substrate has total surface area determined by N2-BET and/or Kr-BET measurements of 5-300 m2/g, predetermined isoelectric point (IEP) obtained in pH greater than 0 to less than or equal to 14. The catalyst composition provides improvements across a relatively diverse set of process conditions and requirements, while maintaining a relatively higher life cycle with improved robustness and durability. The catalyst composition effectively improves the reaction selectivity, reaction rate, product yield and energy efficiency of hydrocarbon, hetero-hydrocarbon and/or non-hydrocarbon treatment, conversion, refining and/or emission control and treatment processes. The functional surface active nature of the catalyst compositions allows the charge and/or geometric orientation of the catalytic constituents integrated with the substrate to vary significantly as the catalyst composition facilitates its intended process reaction.    DETAILED DESCRIPTION - Selectively hydrogenating process stream comprising at least one compound having at least one targeted hydrogenatable site involves use of a catalyst composition to hydrogenate at least a portion of the process stream. The catalyst composition comprises nonmicroporous substrate having mesopores, macropores, external surface, open pore wall surface, surface region and subsurface region; catalytic constituent; and catalytically-active region comprising the constituent. The nonmicroporous substrate has total surface area determined by N2-BET and/or Kr-BET measurements of 5-300 m2/g, and predetermined isoelectric point (IEP) obtained in pH greater than 0 to less than or equal to 14. The catalytically-active region may be contiguous or discontiguous having mean thickness of less than or equal to 30 nm, and at least one catalytic constituent. The location of the catalytically-active region is on the external surface, on the open pore wall surface, in the surface region and/or on the external surface in part, on the open pore wall surface in part and/or in the surface region in part.