TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Process: Acetal and ester of quarter pyridine derivative are hydrolyzed to form formyl group and carboxyl group, respectively. The formyl group is oxidized to carboxyl group and quarter pyridine derivative of formula (4) is obtained.Z,R1-R4=same as defined above. EXAMPLE - 2-(N,N-dimethylamino)ethanol (5 ml) and t-butyl methyl ether (30 ml) were stirred under nitrogen stream. Hexane solution (63 ml) of n-butyl lithium (1.6 mol/l) was added and stirred at 0 degrees C for 15 minutes, and the mixture was cooled at -78 degrees C. Tertiary butyl methyl ether solution (30 ml) of 4-(4,4-dimethyl-2,6-dioxanyl)pyridine (in g) (4.83) was added to the cooled mixture and stirred. Chlorinated tributyl tin (14 ml) was added and the mixture was heated to room temperature and stirred. Water was added to the reaction mixture and extracted with ethyl acetate. The organic phase was dried to obtain 2-tributyl stannyl-4-(4,4-dimethyl-2,6-dioxanyl)pyridine. The obtained compound, 2,6-bis(trifluoromethane sulfonyloxy)-4-isopropoxy carbonyl pyridine (11.7) and toluene (75 ml) were mixed and deaerated. Tetrakis (triphenylphosphine) palladium (0.87) and lithium chloride (3.18) were mixed, and added to the deaerated solution. The mixture was refluxed at 110 degrees C under nitrogen stream for 8 hours, cooled to room temperature and concentrated to obtain yellow solid of 4-isopropoxy carbonyl-4'-(4,4-dimethyl-2,6-dioxanyl)-6-(trifluoromethane sulfonyloxy)-2,2'-bipyridine (3.40) with yield of 26%. The bipyridine (390 mg) in tetrahydrofuran solution (10 ml) was added to anhydrous tetrahydrofuran solution of 6-bromo-2,2'-bipyridine (200 mg) and zinc chloride. Tetrakis (triphenylphosphine) palladium (92 mg) was added and refluxed, and the mixture was extracted with ethyl acetate. The organic phase was dried and concentrated to obtain yellow solid of 4'-isopropoxy carbonyl-4-(4,4-dimethyl-2,6-dioxanyl)-2-, 2':6,2":6",2"' quarter pyridine (12 mg) with yield of 3%.