TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preparation: No general method for the preparation of compound (V) is given. Preferred Process: In the process, purification involves distillation of impurities. The reaction of the compound (IV) occurs in the presence of a solvent, in an amount less than 3 (preferably less than 2) ml, per gram of the compound (IV). The purification is done by chromatography. Preferred Compound: The compound (IV) has an enantiomeric purity of greater than 97 wt.% as determined using high performance liquid chromatography. The compound (V) has a powder X-ray diffraction pattern as given in the specification of fig. 1, and has an infrared absorption spectrum as given in the specification of fig. 2. Preferred Dispersion: The dispersion (D1) comprises naproxcinod and lactose. The dispersion (D1) has a powder X-ray diffraction pattern having specific peak locations as given in specification of fig. 3. The dispersion (D1) comprises naproxcinod and microcrystalline cellulose. The dispersion (D1) has a powder X-ray diffraction pattern having specific peak locations as given in specification of fig. 4. Preferred Components: The molar ratio of a compound (III) to the compound (II) is 8:1 to 3:1, or 8:1 to 4:1, or 8:1 to 5:1. The nitrating agent comprises silver nitrate. ACTIVITY - Analgesic; Osteopathic; Antiinflammatory.    MECHANISM OF ACTION - Cycloxygenase inhibitor. No biological data given.    EXAMPLE - Naproxen (20 g) and acetonitrile (300 ml) are charged into a round bottom flask and heated to 50 degrees C to dissolve naproxen completely, then the solution was cooled to 25-35 degrees C and potassium carbonate (14.3 g) was added. The mixture was heated to 55-60 degrees C and aged for 2 hours. The mixture was cooled to 25-35 degrees C, 1-bromo-4-chlorobutane (17.8 g) was added, and the mixture was stirred for 5-10 minutes. The mixture was heated to 60 degrees C and maintained for 7-8 hours. The mixture was filtered at 25-35 degrees C and the filtrate was distilled completely under vacuum at 48-52 degrees C. The residue (30 g) was dissolved in toluene (100 ml). 10% sodium hydroxide solution (50 ml) was added and the mixture was stirred for 10-20 minutes. After work up, 2-(S)-(4-chlorobutyl)-2-(6-methoxy-2-naphthyl)-propanoate (25.6 g, 96.26%) was obtained.