NOVELTY - Chemical conversion process that converts a bioprocess output stream to higher-value liquids involves: introducing the bioprocess output stream into a reactive separation unit; introducing a second stream into the reactive separation unit; combining the output stream and the second stream; and subjecting the combined streams to reactive separation to convert portion of the bioprocess output stream to higher value liquid fuels/chemicals by reaction and separation of selected size fractions/boiling point product fractions of bioprocess output stream.    USE - For converting a bioprocess output stream to higher-value liquids (claimed) used as chemicals, chemical intermediates, or alternative (non-fossil-based) liquid transportation fuels; for upgrading bioprocess intermediates into higher value liquid fuels or chemicals.    ADVANTAGE - The method uses a reactive separation unit to upgrade a bioprocess intermediate stream to higher value liquid fuels or chemicals. The reactive separation unit simultaneously enables molecular weight and density increases, oxygen content reduction, efficient process energy integration, optional water separation for potential reuse, and incorporation of additional hydrocarbons or oxygenated hydrocarbons as co-feed(s). The use and selection of particular co-feed(s) for this purpose enables tailoring of the intended product composition. The process yields a product of higher alcohols and/or liquid hydrocarbons. The process split into at least two boiling point fractions by the same reactive separations unit operation resulting in product(s) that can be used as chemicals, chemical intermediates, or alternative (non-fossil-based) liquid transportation fuels. The method incorporates an interstage pressure drop, nozzle arrangement, or isenthalpic flash that facilitates aqueous-organic phase separation and removal of water or a water-rich phase from the reactive separation operation; incorporates interstage pressure drops, and an overall pressure profile over the path of the reactive separation stages, which facilitates removal of water or a water-rich phase from intermediate stage in the reactive separation operation, i.e. in tandem with organic phase rectification; incorporates interstage pressure drops, water takeoff(s), and overall pressure and temperature profiles over the path of the reactive separation stages that yield the intended product stream(s) at the design product take-off location(s), on the basis of the tendency toward vapor-liquid equilibrium at each of the stages within the reactive separations operation.    DETAILED DESCRIPTION - A chemical conversion process that converts a bioprocess output stream to higher-valve liquids involves: introducing the bioprocess output stream comprising at least one component selected from hydrocarbon product and/or oxygenated hydrocarbon product into a reactive separation unit; introducing a second stream comprising at least one component selected from carbon monoxide (CO), hydrogen (H2), syngas, alcohol and/or oxygenated hydrocarbons into the reactive separation unit; combining the bioprocess output stream and the second stream; and subjecting the combined streams to reactive separation to produce at least one product selected from higher alcohol and/or higher aliphatic hydrocarbon, thus converting at least a portion of the bioprocess output stream to higher value liquid fuels or chemicals by reaction and separation of selected size fractions or boiling point product fractions of the bioprocess output stream.