TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Components: The first stream is an aqueous solution comprising at least one alcohol or poly-alcohol. The aqueous solution is an intermediate product of fermentation or other bioprocessing operations. The second stream is a syngas stream comprising CO and H2. The relative molar concentration of H2 and CO in the syngas (H2 to CO ratio) is 1-3. The bioprocess output stream comprises at least dilute bioethanol. Preferred Method: The reactive separation is accomplished by reactive distillation. Subjecting the combined streams to reactive separation step produces an oxygenated hydrocarbon product by at least one process selected from catalytic alcohol condensation with dehydration, and catalytic aldol coupling reaction. Higher aliphatic hydrocarbons are produced by catalytic Fischer-Tropsch reaction. Both higher alcohols and higher aliphatic hydrocarbons are produced through parallel reactive separation schemes, in which first reactive separation yields primarily liquid aliphatic hydrocarbons, and a second reactive separation yields primarily liquid higher alcohols. The primarily liquid aliphatic hydrocarbons from the first reactive separation and the primarily liquid higher alcohols from the second reactive separation are combined in a desired ratio. The method further involves: operating slurry-phase, multiphase, or other well-mixed heterogeneous catalytic liquid upgrading reactions in a region in the reactive separation unit in tandem with the remaining portions of the process; operating phase separation in a region in the reactive separation unit, where the phase separation facilitates removal of a water-rich phase from reactive slurry and return of organic-rich phase for continued reaction or rectification; separating an aqueous-organic phase mixture and removing water or a water-rich phase from the reactive separation unit through at least one process selected from an interstage pressure drop, nozzle arrangement, and isenthalpic flash; removing water or water-rich phase from the reactive separation unit during an intermediate stage in which the interstage pressure drops and the overall pressure profile over the path of the reactive separations facilitates the removal. EXAMPLE - Isobutanol was produced as follows: Isobutanol (i-BuOH) was produced from aqueous unrefined ethanol intermediate stream, and syngas. A 41% aqueous ethanol was typically generated from corn-based carbohydrate fermentation via alcohol generation and primary separation of some water and dried distiller's grains and solubles (DDGS) in a separations unit was available as a feedstock at a nominal quantity of 50 Mgpy 50000000 gallons per year, on an ethanol-only basis. This liquid solution was introduced to the reactive separation operation. Syngas stream was generated separately and also introduced to the reactive separation operation, at a H2/CO ratio of 2, and two molar equivalents relative to the feed EtOH. Thus the starting materials had the relative mole ratio: 1 ethanol/2 CO/4 H2. On this basis, the combined feed to the reactive separation unit was as follows: EtOH (17046 kg/hour) with water (24,529 kg/hour) at 7 degrees C and 1 atmosphere (atm), pumpable to the pressure of the reactive separations operation (60 atm); H2 (2987 kg/hour) at 40 degrees C and 60 atm; CO (20728 kg/hour) at 40 degrees C and 60 atm. The reactive separations unit was operated at 30 degrees C and 60 atm. Product stream of 26,055 kg/hour i-BuOH with 43860 kg/hour water, corresponding to 37.3% i-BuOH was obtained.