NOVELTY - A method (M1) for synthesizing colloidal superparticles (SPs) involves mixing a first solution comprising ligand-functionalized nanoparticles with a surfactant under aqueous conditions to form a second solution containing nanoparticle-micelles; and mixing the second solution with a solvent to form a third solution having colloidal SPs.    USE - For synthesizing colloidal superparticles (SPs), which is useful for making articles of manufacture such as medical device, light emitting diode (LED), solar cell, magnetic resonance imaging (MRI) contrast reagent, fluorescent label and gas sensor; for coating on the article of manufacture; for preparing film, pharmaceutical composition and stacked SP; for delivering a drug or biologically active molecule to a person or animal (claimed) or also to the environment (e.g. superparticles bearing fertilizing agents is applied to plants and soil for fertilization purposes); for making batteries; and as a catalyst for photochemical and other chemical reactions, or as a colored sensitizers ink or dye to label products and vehicles in commerce or for military applications (e.g. functioning as a bar code). The medical devices prepared from the SPs are extracorporeal devices such as blood oxygenators, blood pumps, blood sensors, tubing used to carry blood and implantable devices such as vascular grafts, stents, electrical stimulation leads, heart valves, orthopedic devices, catheters, shunts, sensors, replacement devices for nucleus pulposus, cochlear or middle ear implants and intraocular lenses.    ADVANTAGE - The method (M1) permits efficient control of size- and shape-distributions and long-range ordering of SPs, thereby the SPs can be produced in any shape such as rod-shaped, cube-shaped, sphere-shaped or prism-shaped. The method (M1) provides the SPs that are self-assemble and monodisperse. The deformation of superparticles is reversible, thus used as drug delivery vehicles that can be degraded in vivo. The SP has excellent colloidal stability in polar solvents, and single supercrystalline colloidal SPs can also be assembled into more complex and hierarchically ordered materials in which new properties may occur.    DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for a colloidal superparticle (SP) comprising an aggregate of nanoparticles, where adjacent nanoparticles are bound together through non-covalent interactions.