TECHNOLOGY FOCUS - INORGANIC CHEMISTRY - Preferred Components: The base is butyl lithium, isopropyl magnesium chloride or magnesium.    TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preparation (Claimed): Preparation of (I) comprises: conducting a cross-coupling reaction of bromine, iodine or chlorine substituted fluoride compound of formula (a) (preferably 1-bromo-2-fluoro-benzene) and a fluorine substituted amine compound of formula (b) (preferably 2-fluoro-phenylamine) to form a multiple fluorine substituted amine compound of formula (a1), or conducting a cross-coupling reaction of an iodine chlorine substituted bromide compound of formula (c) (preferably 1-bromo-2-iodo-benzene) and a bromine substituted amine compound of formula (d) (preferably 2-bromo-phenylamine) to form a multiple bromine substituted amine compound of formula (a2), and conducting a nucleophilic reaction of (a1) or (a2), and metal containing compounds (A) of formula (M2X(n)) (Aa) and (M2Y1) (Ab) to form (I); or conducting a cross-coupling reaction of a bromine, iodine or chlorine substituted fluoride compound formula (IX) (preferably 1-bromo-2-flurobenzene) and a substituted amine compound formula (X) (preferably N,N-dimethylethylenediamine) to form a substituted amine compound of formula (XI) (preferably N-(dimethylaminoethyl)-2-fluoroaniline), and conducting a nucleophilic reaction of (XI) and (A) (preferably potassium diphenylphosphide) to form (I) (preferably N-(dimethylaminoethyl)-2-diphenylphosphinoaniline); or conducting a cross-coupling reaction of an amine compound of formula (XII) and a halo compound of formula (XIII) to form a substituted amine compound of formula (XIV), and conducting a nucleophilic reaction of (XIV) and (Ab) to form (I); or conducting a cross-coupling reaction of (X) and a halo compound of formula (XV) to form an amine compound of formula (XVI), and reacting (XVI) with a base and then with a halo compound of formula (Hal5X(n)) to form (I); or reaction of a bromide compound of formula ((CH?=C-CH2-Y1+)(Br-)) (where Y1+ is P(C6H5)3+) with an amine compound of formula (DNH2) (where D is R8, which is 2,6-C6H3-(isopropyl)2, 2,6-C6H3(CH3)2, phenyl or tert-butyl) to give a substituted amine compound of formula ((D-NH-C(CH3)=CH-Y1+)(Br-)) (b1), and reaction of (b1) with sodium hydride to give a substituted amine compound of formula (CH3-C(=ND)-CH=Y1) (representative compound of (I)).M2 = Li, Na or K (preferred); andHal5 = halo.Where the linkage between fluorine and bromine, iodine or chlorine of (a), or the linkage between iodine or chlorine substituted bromide in (c), or the linkage between Y1 and NH2 of (X), or the linkage between F and NH2 of (XII) is optionally saturated hydrocarbon or aromatic group (optionally substituted). Preferred Definitions:    D = ring A;    A = phenyl (optionally substituted by halo);    X = PR1R2 or OR1;    Y1 = PR1R2 or NR1R2;    R1, R2, R9 = phenyl (substituted by halo) or alkyl; and    n = 1, where the linkage between N-Y1 is ethyl, propyl or phenyl (all substituted by halo), and the ligand is a monoanion, when B1 is bond.    SPECIFIC COMPOUNDS - 16 Compounds (I) are specifically claimed e.g. N-(dimethylaminoethyl)-2-diphenylphosphinoaniline of formula (Ia), bis(2-diisopropylphosphinophenyl)amine, bis(2-dicyclohexylphosphinophenyl)amine, (2-diphenylphosphanyl-4-fluoro-phenyl)-(2,4,6-trimethyl-phenyl)-amine and (2-diphenylphosphanyl-phenyl)-(2-methoxy-phenyl)-amine.    EXAMPLE - A flask was sequentially charged with tris(dibenzylideneacetone)dipalladium (26 mg), racemic-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl (27 mg), sodium tert-butoxide (0.770 g), N,N-dimethylethylenediamine (0.503 g), 1-bromo-2-fluorobenzene (1 g), and toluene (25 ml) under nitrogen. The reaction mixture was heated to reflux with stirring for 2 days and worked up to give N-(dimethylaminoethyl)-2-fluoroaniline. Potassium diphenylphosphide (89 ml, 0.5M in tetrahydrofuran (THF) solution) was added to a flask. THF was removed in vacuo and a solution of N-(dimethylaminoethyl)-2-fluoroaniline (8.119 g) in 1,4-dioxane (60 ml) was added to the mixture. The reaction solution was heated to reflux for 7 days, and worked up to give N-(dimethylaminoethyl)-2-diphenylphosphinoaniline (1.237 g, 79.8%).