NOVELTY - Composition comprises extract of one or more of crude drug as an active ingredient chosen from Euphorbia, Euphorbia helioscopia, Alocasia odora, Spirodela, Artemisia apiacea, folium artemisiae, Ailanthus altissima, Evodia rutaecarpa Bentham, Veratrum nigrum, Japanese Angelica root, Ledebouriella seseloides, Amomum xanthioides, Alpinia officinarum, Quisqualis indica, Carpesium abrotanoides, water caltrop and Dichroa febrifuga.    USE - The composition is useful for controlling insects and plant disease (claimed) caused by pathogenic microbe such as bacteria, fungi or virus e.g. cucumber, anthracnose microbe, Pyricularia oryzae, potato powder form scab disease microbe, wheat powdery mildew, garden pea Phomopsis-leaf-spot microbe, Puccinia recondita, potato mole pathogenic microbe, potato early blight microbe, sweet potato vine decline (Phomopsis viticola) microbe, tomato half body wilting pathogenic microbe, tomato anthracnose microbe, potato black root and crown rot microbe, soil borne wheat mosaic virus and potato lea roll virus. The insects are chosen from agriculture insect pests such as various aphids, locust, planthopper, fruit fly, stink bug, spider mites and deathwatch beetle, unpleasant harmful insects and unsanitary insect pests, such as mosquito, cockroach, centipede, Gryllotalpa, mites, house ticks, louse, bedbug, flea and grub.    ADVANTAGE - The composition exhibits high antibacterial effect, is safe, less toxic and harmless to human, and does not cause environmental pollution.    DETAILED DESCRIPTION - Composition comprises extract of one or more of crude drug as an active ingredient chosen from Euphorbia,Euphorbia helioscopia, Alocasia odora, Euphorbia helioscopia, seed of Datura tatula, Arisaema, Spirodela, Artemisia apiacea, folium artemisiae, achyranthis radix, caulis spatholobi, Ailanthus altissima, Ilex cornuta, Polygonum flaccidum (Meissn.) Steud, Veratrum nigrum, semen persicae, citrus unshiu peel, Cortex dictamni radicis, scutellaria root, portion of Agastache rugosa, Glycyrrhiza uralensis, flower bud of Sophora japonica, Glycyrrhiza glabra var.glandulifera, rhubarb, Aster tataricus, thoroughwort, Cirsium japonicum, Bupleurum root, Holland Amaranthus tricolor ssp. Amaranthus mangostanus, cortex erythrinae, Millettia pachycarpa, Cassia seed, radix angelicae, angelicae tuhou radix, tobacco, dandelion, cortex fraxinus, Forsythia suspensa, Zanthoxylum bungeanum, phellodendron bark, Evodia rutaecarpa Bentham, mint, Perilla, herba schizonepetae, Prunella vulgaris, Salvia miltiorrhiza, clove, cinnamon branch, Cinnamomum camphora, cinnamon, fennel, Japanese Angelica root, cnidii monnieri fructus, Ledebouriella seseloides, notopterygii rhizoma, cnidii rhizome, rose, fructus mume, radix sanguisorbae, Atractylodes lancea rhizome, Atractylodes rhizome, fructus arctii, Senecio nemorensis, magnolia bark, Schisadra fruit, ginger, Amomum xanthioides, Alpinia officinarum, pepper, nutmeg, hawthorn, Curcuma wenyujin rhizome, frutus rosae laevigatae, Acorus gramineus, peony root bark, Paeonia lactiflora, rhizoma cimicifugae, rhizoma coptidis, radix clematidis, Celosia cristata, Anemarrhena rhizome, Ephedra sinica, Arisarum root, rhizome polygonati, semen pharbitidis, Isatis tinctoria, Portulaca oleracea, semen plantaginis, kochiae fructus, sinomeni, Aquilaria agallocha, Althaea bark, Petaurista xanthotis, Bletilla striata, thujae orientalis folium, semen raphani, Trichosanthes kirilowii Maxim, Aristolochia debilis, Rhododendron dauricum, Paeonia lactiflora, ophiopogon tuber, radix asparagi, Cornus officinalis, meliae cortex, Quisqualis indica, betel palm, Daemonorops, Carpesium abrotanoides, water caltrop, turnip, Acacia catechu tea, Dichroa febrifuga, Akebia stem, and Brassica alba (L.)Boiss.