TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preparation (disclosed): 3 Methods for the preparation of (I) are given e.g. preparation of (I) involves reacting an amino alcohol of formula NH2-C-(R1)(R2)-CH2-OH with a compound of formula A1-CO-Hal (Hal stands for halogen), in presence of a base such as triethylamine, in a solvent such as diethylether, for 12-24 hours at 20-25 degrees C, to form a compound of formula A1-CO-NH-C(R1)(R2)-CH2OH, which is treated with SOCl2, followed by oxidation provides cyclic sulfamidites of formula (VII), which is reacted with compound of formula HO-N=C(CH3)-B1 to form (I) (where R3 is H and G1 is CH2ON=C(CH3)). ACTIVITY - Fungicide; Antibacterial; Virucide. The activity of a composition comprising 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (1-(2,4,6-trichloro-phenylcarbamoyl)-ethyl)-amide against Botrytis cinerea was tested as follows. Conidia of the fungus from cryogenic storage were directly mixed into nutrient broth (potato dextrose broth). After placing the composition into a microtiter plate (96-well format) the nutrient broth containing the fungal spores was added. The test plate was incubated at 24 degrees C and the inhibition of growth measured after 3-4 days. The composition showed at least 50% fungal growth inhibition.    MECHANISM OF ACTION - None given.    ADMINISTRATION - The composition comprising (I) is applied by foliar application. The rate of application is 5 g to 2 kg of active ingredient (a.i.) per hectare (ha), preferably 10 g to 1 kg a.i./ha, especially 20-600 g a.i./ha. When used as seed drenching agent, convenient rates of application are 10 mg to 1 g of active substance per kg of seeds. The pharmaceutical composition comprising (I) for treating and/or preventing microbial infection in animals is administered orally, topically, parenterally, by inhalation, or as an aerosol spray. No dosage details given.    SPECIFIC COMPOUNDS - 104 Compounds are disclosed as (I) e.g. 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (1-(2,4,6-trichloro-phenylcarbamoyl)-ethyl)-amide (IA); 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid cyclopropyl-(1-(2,4,6-trichloro-phenylcarbamoyl)-ethyl)-amide; 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (2-(2- chloro-6-fluoro-benzyloxyimino)-1-methyl-ethyl)-amide; 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (2-(1-(2,4-dichloro-phenyl)-meth-(E)-ylideneaminooxy)-1-methyl-ethyl)-amide; and 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (2-(1-(2,4-dichloro-phenyl)-eth-(E)-ylideneaminooxy)-1-methyl-ethyl)-amide.    EXAMPLE - A solution of 3-difluoromethyl-1-methyl-1H-pyrazole-4-carbonyl chloride (0.194 g) in dichloromethane (3 ml) was added dropwise at 0 degrees C under a nitrogen atmosphere to a stirred solution of 2-amino-N-(2,4,6-trichloro-phenyl)-propionamide (0.267 g) and triethylamine (0.22 ml) in dichloromethane (7 ml). The reaction mixture was stirred for 2 hours at ambient temperature then washed with 1M sodium hydroxide (5 ml), 1M hydrochloric acid (HCl) (5 ml), brine (10 ml) and then dried over sodium sulfate. The raw material was then purified by flash chromatography over silica gel to obtain 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (1-(2,4,6-trichloro-phenylcarbamoyl)-ethyl)-amide (230 mg, 54%) in the form of a resin.