TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Method: The adsorbing and separating steps are performed at temperature ranging from 0 degrees C to normal temperature. The desorption of vitamin E from the anion exchanger is performed using weak acid or weak acid salt solution as supernatant liquor. The weak acid or weak acid salt solution is mixture of citric acid or sodium citrate and ethanol. The method further involves isolating tocotrienol from the separated vitamin E. The tocotrienol is separated from vitamin E by chromatographic separation method. The vitamin E contained in fat and oil is adsorbed to the anion exchanger, after converting the free fatty acid in the fat and oil to fatty acid ester using cation exchanger. The method involves producing fatty acid ester simultaneously as a byproduct by transesterification with the non-adsorbing fraction and alcohol obtained from fat and oil. The anion exchanger is anion exchange resin. The fat and oil is rice bran oil or palm oil. The adsorption and separation reaction is performed continuously using reactor filled with resin. Preferred Apparatus: The apparatus consists of reactor cooled with resin. ACTIVITY - Angiogenesis inhibitor; Ophthalmological; Antiarteriosclerotic. No biological data given.    MECHANISM OF ACTION - None given.    EXAMPLE - Rice bran crude oil and ethanol was treated with PK208 (RTM: cation exchange resin). Resin of 50 weight/weight% was supplied into the reaction liquid after completion of esterification experiment. PA306 (RTM: anion exchange resin) of 50 weight/weight% was injected into the reaction liquid, and stirred with the magnetic stirrer at 0 degrees C. Resin was collected from the solution by filtration after completion of adsorption. Recovered resin was filled into column and 5 weight% of citric acid ethanol solution was supplied at 1.25 cm3/minute as supernatant liquor, and treated at normal temperature. PA306 (RTM: anion exchange resin) of 50 weight/weight% was again injected to the solution and reacted by shaking at 150 rpm in 50 degrees C thermostat. Solution was extracted in each experiment and diluted with ethanol. The concentration of mono, di and tri glyceride, free fatty acid, fatty acid ester and vitamin E was measured by high performance liquid chromatography (HPLC). Results showed that the free fatty acids reduced with progress of reaction time and fatty acid ester concentration increased, and tocotrienol delta was recovered at a rate of 70%.