TECHNOLOGY FOCUS - INORGANIC CHEMISTRY - Preparation (Claimed): Procedure for obtaining synthetic monetite matrices involves synthesis of a brushite (CaHPO4-2H2O) matrix by setting of a cement resulting from mixing an aqueous phase and a solid phase comprising basic calcium salt and an acid calcium salt; manufacturing blocks, granules, rods or pellets; and converting the brushite matrix into monetite. The conversion of brushite into monetite is carried out by heat treatment at 80-300 degrees C (preferably 121-160 degrees C for 20 minutes to 2 hours). The procedure incorporates elements that increase the porosity of the cement; incorporates in the solid phase additives (a1) that control the cement setting time; and incorporate in the liquid phase a solution of acid (a2) at a concentration of 0.5-3.5 M. The liquid phase includes an additive (a3) to control cement rheology; an additive (a4) to control cement cohesion. The granules 0.2-2 mm in diameter are produced by pulverization of the set brushite/monetite cement. The brushite cement is set in a mold. The acid pH of the brushite or monetite matrix is neutralized by immersion or wash in water or buffered solutions. Preferred Components: The basic calcium salt is selected from alpha tricalcium phosphate, beta tricalcium phosphate, hydroxyapatite, tetracalcium phosphate, octacalcium phosphate and/or calcium oxide. The acid calcium salt is selected from monocalcium phosphate monohydrate, and/or monocalcium phosphate anhydrous. The additives (a1) are sodium pyrophosphate, calcium pyrophosphate, potassium pyrophosphate, strontium chloride, strontium renalate, strontium phosphate, strontium pyrophosphate, sodium acetate, potassium acetate, sodium citrate, potassium citrate, sodium phosphocitrate, potassium phosphocitrate, sodium sulfate, potassium sulfate, calcium sulfate hemihydrate, sodium dihydrogen pyrophosphate magnesium sulfate, sodium biphosphonates, potassium biphosphonates, chondroitin 4-sulfate, chondroitin 6-sulfate, glycolic acid, sodium glycolate, calcium glycolate, barium titanate, barium sulfate and/or barium fluoride. The acid (a2) is selected from phosphoric, glycolic, tartaric, citric, succinic, malic, lactic, chlorhydric and/or sulfuric acid. The additive (a3) is selected from chondroitin 4-sulfate, chondroitin 6-sulfate, silica gel, silica gel with chondroitin 4-sulfate, silica gel with chondroitin 6-sulfate, strontium chloride, strontium renalate, strontium salt, sodium pyrophosphate, calcium pyrophosphate, pyrophosphate salt or acid, collagen, chitosan, low molecular weight hyaluronic acid, hyaluronic acid, hyaluronate salts, dextran, alginate, xantham gum and/or hydroxypropyl cellulose. The additive (a4) is selected from chondroitin 4-sulfate, chondroitin 6-sulfate, silica gel, or a combination of silica gel with any of the other two. Preferred Matrix: The synthetic monetite matrices include at least one bioactive agent.    TECHNOLOGY FOCUS - PHARMACEUTICALS - Preferred Agent: The bioactive agents are selected from hormones, polysaccharides, proteins, peptides, growth factors, antibiotics, analgesics, antiinflamatories, and/or antigens. The growth factor is selected from: platelet derived growth factor (PDGF), vascular endothelial growth factor (VEGF), bone morphogenic protein (BMP), transforming growth factor- beta -1 (TGF- beta -1), growth hormone (GH), insulin like growth factor-1 (IGF1), insulin like growth factor-2 (IGF2), and/or fibroblast growth factor (FGF). The proteins are selected from collagen and/or fibronectin. ACTIVITY - Osteopathic. Test details are described but no results given.    MECHANISM OF ACTION - None given.    EXAMPLE - For the powder component of cement, calcium monophosphate anhydrous (0.8 g) and beta -tricalcium phosphate (1.4 g) were mixed. To the powder 1 M solution of phosphoric acid (1 ml/g) was added. Once the cement was set, the brushite solid was pulverized and sieved to obtain a particle size of 0.2-2 mm. The resulting brushite granules were treated for 30 minutes in the autoclave at 121 degrees C, 1 bar of pressure and a relative humidity of 100%. This resulted in the transformation of brushite into monetite and a change in its crystalline structure. The brushite and monetite granules obtained were applied separately to a bone regeneration model.