NOVELTY - Deterring (M1) biofouling of a surface involves attaching noradrenalin an adduct (I) to the surface.    USE - For deterring biofouling of a surface which is a surface exposed to a marine environment; preventing the settling of and cementation of a mollusk on a surface; and preventing the settling of and cementation of a crustacean on a surface. The mollusk is selected from oysters. The crustacean is selected from barnacles. Also useful in marine paint, and varnish to inhibit attachment of biofouling organisms on a surface. The surface is selected from hull of ship, propeller, seismic streamer, dock, oil rig, gas rig, pipeline, power plant water intake system, heat exchanger, grid, fish net, and cage (claimed).    ADVANTAGE - The present method is effective to deter biofouling include surfaces e.g. hull of ship. The present method deters biofouling longer than other antifouling methods and compositions.    DETAILED DESCRIPTION - Deterring (M1) biofouling of a surface involves attaching noradrenalin an adduct of formula (I) to the surface.    A1=6C or 10C substituted aryl ring or 1-9C optionally substituted heteroaryl ring (disclosed);    L1=linking group (disclosed);    R=primary amino moiety comprising unit (disclosed).    INDEPENDENT CLAIMS are included for the following:    (1) a non-toxic biofouling deterrence system comprising: a polymer-based coating disposed on a submarine surface, where the coating comprises the adduct of formula (I);    (2) a composition comprising the noradrenalin linked to a polymer;    (3) a non-toxic coating composition (C1) comprising the adduct (I); and a film forming agent, where the noradrenalin is present in the composition in an amount to inhibit the attachment of biofouling organisms on a surface to which the composition is applied;    (4) a paint comprising the composition (C1);    (5) a varnish comprising the composition (C1);    (6) an anti-fouling surface comprising the adduct (I), where the compound or its biologically active fragment is released from the surface; and    (7) preparing (M2) an anti-fouling surface involving attaching the adduct (I) to the surface.