NOVELTY - The thermally-induced phase separation (TIPS) micro-porous membrane useful as a single layer/multi layers to form multi-layered articles, comprises a first layer comprising a poly(vinylidene fluoride) polymeric matrix and a nucleating agent uniformly dispersed throughout the polymeric matrix, a second layer on an outer surface of the first layer, and an imbibing material within a portion of first layer pores. The first layer has a diluent and a uniform distribution of first layer pores having an average pore size of greater than of 6-15 mu m. The polymeric matrix comprises polymer spherulites.    USE - The thermally-induced phase separation (TIPS) micro-porous membrane is useful as a single layer or multi layers for forming multi-layered articles, for micro-filtration and particle filtration e.g., red blood cells and yeast, and in fuel cell applications.    ADVANTAGE - The micro-porous membrane has a large average pore size and improved porosity, strength and stretchability, and is capable of filtering large particulates such as red blood cells and yeast.    DETAILED DESCRIPTION - The thermally-induced phase separation (TIPS) micro-porous membrane useful as a single layer/multi layers to form multi-layered articles, comprises a first layer comprising a poly(vinylidene fluoride) polymeric matrix and a nucleating agent uniformly dispersed throughout the polymeric matrix, a second layer on an outer surface of the first layer, and an imbibing material within a portion of first layer pores. The first layer has a diluent and a uniform distribution of first layer pores having an average pore size of greater than of 6-15 mu m. The polymeric matrix comprises polymer spherulites. The nucleating agent is present within the polymer spherulites of the polymer matrix. The second layer comprises a polymeric matrix having a uniform distribution of second layer pores having an average pore size of 0.05-15 mu m, and an adhesive layer, a coating composition, a woven layer, a non-woven layer, a knitted layer, a mesh fabric layer, a polymeric film layer, a metal foil layer and/or a foam layer. An INDEPENDENT CLAIM is included for a method of making a micro-porous membrane.    DESCRIPTION OF DRAWING(S) - The diagram shows a cross-sectional view of a micro-porous membrane.