TECHNOLOGY FOCUS - BIOTECHNOLOGY - Preferred Method: Amplifying a nucleic acid encoding a polypeptide having a cellulase activity comprises amplification of a template nucleic acid with an amplification primer pair. Inhibiting the translation of a cellulase message in a cell comprises administering to the cell or expressing in the cell an antisense oligonucleotide comprising a nucleic acid sequence complementary to or capable of hybridizing under stringent conditions to a sequence ODD SEQ ID NOS: 1-165. Inhibiting the expression of a cellulase in a cell comprises administering to the cell or expressing in the cell a double-stranded interference RNA (RNAi) molecule. Isolating or identifying a polypeptide with a cellulase activity comprises providing an antibody, providing a sample comprising polypeptides, and contacting the sample with the antibody under conditions where the antibody can specifically bind to the polypeptide, thus isolating or identifying a polypeptide having a cellulase activity. Making an anti-cellulase antibody comprises administering to a non-human animal a nucleic acid or its subsequence in an amount to generate a humoral immune response, thus making an anti-cellulase antibody, or administering to a non-human animal a polypeptide or its subsequence in an amount to generate a humoral immune response, thus making an anti-cellulase antibody. Producing a recombinant polypeptide comprises providing a nucleic acid operably linked to a promoter, and expressing the nucleic acid under conditions that allow expression of the polypeptide, thus producing a recombinant polypeptide, where optionally the method further comprises transforming a host cell with the nucleic acid followed by expressing the nucleic acid, thus producing a recombinant polypeptide in a transformed cell. Identifying a polypeptide having a cellulase activity comprises providing a polypeptide, providing a cellulase substrate, and contacting the polypeptide with the substrate and detecting a decrease in the amount of substrate or an increase in the amount of a reaction product, where a decrease in the amount of the substrate or an increase in the amount of the reaction product detects a polypeptide having a cellulase activity. Identifying a cellulase substrate comprises providing a polypeptide, providing a test substrate, and contacting the polypeptide with the test substrate and detecting a decrease in the amount of substrate or an increase in the amount of reaction product, where a decrease in the amount of the substrate or an increase in the amount of a reaction product identifies the test substrate as a cellulase substrate. Determining whether a test compound specifically binds to a polypeptide comprises expressing a nucleic acid or a vector comprising the nucleic acid under conditions permissive for translation of the nucleic acid to a polypeptide, providing a test compound, contacting the polypeptide with the test compound, and determining whether the test compound specifically binds to the polypeptide. Identifying a modulator of a cellulase activity comprises providing a polypeptide, providing a test compound, contacting the polypeptide with the test compound and measuring an activity of the glucanase, where a change in the cellulase activity measured in the presence of the test compound compared to the activity in the absence of the test compound provides a determination that the test compound modulates the cellulase activity. Identifying a feature in a sequence comprises reading the sequence using a computer program, which identifies one or more features in a sequence, where the sequence comprises a polypeptide sequence or a nucleic acid sequence, and identifying one or more features in the sequence with the computer program. Comparing a first sequence to a second sequence comprises reading the first sequence and the second sequence through use of a computer program which compares sequences, where the first sequence comprises a polypeptide sequence or a nucleic acid sequence, and determining differences between the first sequence and the second sequence with the computer program. Isolating or recovering a nucleic acid encoding a polypeptide with a cellulase activity from an environmental sample comprises providing an amplification primer pair, isolating a nucleic acid from the environmental sample or treating the environmental sample such that nucleic acid in the sample is accessible for hybridization to the amplification primer pair, and combining the nucleic acid with the amplification primer pair and amplifying nucleic acid from the environmental sample, thus isolating or recovering a nucleic acid encoding a polypeptide with a cellulase activity from an environmental sample. Generating a variant of a nucleic acid encoding a polypeptide with a cellulase activity comprises providing a template nucleic acid, and modifying, deleting or adding one or more nucleotides in the template sequence, or their combination, to generate a variant of the template nucleic acid where optionally the method further comprises expressing the variant nucleic acid to generate a variant cellulase polypeptide, and optionally the modifications, additions or deletions are introduced. Modifying codons in a nucleic acid encoding a polypeptide with a cellulase activity to increase its expression in a host cell comprises providing a nucleic acid encoding a polypeptide with a cellulase activity, and identifying a non-preferred or a less preferred codon in the nucleic acid and replacing it with a preferred or neutrally used codon encoding the same amino acid as the replaced codon, where a preferred codon is a codon over-represented in coding sequences in genes in the host cell and a non- preferred or less preferred codon is a codon under-represented in coding sequences in genes in the host cell, thus modifying the nucleic acid to increase its expression in a host cell. Producing a library of nucleic acids encoding modified cellulase active sites or substrate binding sites, where the modified active sites or substrate binding sites are derived from a first nucleic acid comprising a sequence encoding a first active site or a first substrate binding site the method comprises providing a first nucleic acid encoding a first active site or first substrate binding site, where the first nucleic acid sequence comprises a sequence that hybridizes under stringent conditions to a sequence of ODD SEQ ID NOS: 1-165, or its subsequence, and the nucleic acid encodes a cellulase active site or a cellulase substrate binding site, providing a set of mutagenic oligonucleotides that encode naturally-occurring amino acid variants at targeted codons in the first nucleic acid, and using the set of mutagenic oligonucleotides to generate a set of active site-encoding or substrate binding site-encoding variant nucleic acids encoding a range of amino acid variations at each amino acid codon that was mutagenized, thus producing a library of nucleic acids encoding a plurality of modified cellulase active sites or substrate binding sites. Making a small molecule comprises providing biosynthetic enzymes capable of synthesizing or modifying a small molecule, providing a substrate for at least one of the enzymes, and reacting the substrate with the enzymes under conditions that facilitate biocatalytic reactions to generate a small molecule by a series of biocatalytic reactions. Modifying a small molecule comprises providing a cellulase enzyme, providing a small molecule, and reacting the enzyme with the small molecule under conditions that facilitate an enzymatic reaction catalyzed by the cellulase enzyme, thus modifying a small molecule by a cellulase enzymatic reaction. Determining a functional fragment of a cellulase enzyme comprises providing a cellulase enzyme, and deleting amino acid residues from the sequence and testing the remaining subsequence for a cellulase activity, thus determining a functional fragment of a cellulase enzyme. Whole cell engineering of new or modified phenotypes by using real-time metabolic flux analysis, the method comprises making a modified cell by modifying the genetic composition of a cell, culturing the modified cell to generate a plurality of modified cells, measuring at least one metabolic parameter of the cell by monitoring the cell culture in real time, and analyzing the data to determine if the measured parameter differs from a comparable measurement in an unmodified cell under similar conditions, thus identifying an engineered phenotype in the cell using real-time metabolic flux analysis. Increasing thermotolerance or thermostability of a cellulase polypeptide comprises glycosylating a cellulase, thus increasing the thermotolerance or thermostability of the cellulase. Overexpressing a recombinant cellulase in a cell comprises expressing a vector comprising a nucleic acid sequence, where overexpression is effected by use of a high activity promoter, a dicistronic vector or by gene amplification of the vector. Making a transgenic plant comprises introducing a heterologous nucleic acid sequence into the cell, thus producing a transformed plant cell, producing a transgenic plant from the transformed cell. Expressing a heterologous nucleic acid sequence in a plant cell comprises transforming the plant cell with a heterologous nucleic acid sequence operably linked to a promoter, and growing the plant under conditions where the heterologous nucleic acids sequence is expressed in the plant cell. Hydrolyzing, breaking up or disrupting a glucan- or cellulose- comprising composition comprises providing a polypeptide having a cellulase activity, providing a composition comprising a cellulose or a glucan, and contacting the polypeptide with the composition under conditions where the cellulase hydrolyzes, breaks up or disrupts the glucan- or cellulose- comprising composition. Dough conditioning comprises contacting dough or a bread product with at least one polypeptide, under conditions for conditioning the dough. Beverage production comprises administration of at least one polypeptide, to a beverage or a beverage precursor under conditions for decreasing the viscosity of the beverage, where optionally the beverage or beverage precursor is wort or a beer. Utilizing a cellulase as a nutritional supplement in an animal diet comprises preparing a nutritional supplement containing a cellulase enzyme comprising at least thirty contiguous amino acids of a polypeptide, and administering the nutritional supplement to an animal to increase utilization of a xylan contained in a feed or a food ingested by the animal. Delivering a cellulase supplement to an animal comprises preparing an edible enzyme delivery matrix or pellets comprising a granulate edible carrier and a thermostable recombinant cellulase enzyme, where the pellets readily disperse the cellulase enzyme contained therein into aqueous media, and the recombinant cellulase enzyme comprises a polypeptide, and administering the edible enzyme delivery matrix or pellet to the animal. Reducing the amount of cellulose in a paper, a wood or wood product comprises contacting the paper, wood or wood product with a cellulase, where optionally the cellulase activity comprises endoglucanase, cellobiohydrolase, mannanase and/or beta-glucosidase activity. Making a fuel comprises contacting a composition comprising a cellulose or a fermentable sugar with a polypeptide, where optionally the composition comprising a cellulose or a fermentable sugar comprises a plant, plant product or plant derivative, and optionally the plant or plant product comprises cane sugar plants or plant products, beets or sugarbeets, wheat, corn, soybeans, potato, rice or barley, and optionally the polypeptide has activity comprising cellulase, endoglucanase, cellobiohydrolase, mannanase and/or beta-glucosidase activity, and optionally the fuel comprises a bioethanol or a gasoline-ethanol mix. Making bioethanol comprises contacting a composition comprising a cellulose or a fermentable sugar with a polypeptide, where optionally the composition comprising a cellulose or a fermentable sugar comprises a plant, plant product or plant derivative, and optionally the plant or plant product comprises cane sugar plants or plant products, beets or sugarbeets, wheat, corn, soybeans, potato, rice or barley, and optionally the polypeptide has activity comprising cellulase, endoglucanase, cellobiohydrolase, mannanase and/or beta-glucosidase activity. Processing a biomass material comprising lignocellulose comprises contacting a composition comprising a cellulose or a fermentable sugar with a polypeptide, where optionally the biomass material comprising lignocellulose is derived from an agricultural crop, is a byproduct of a food or a feed production, is a lignocellulosic waste product, or is a plant residue or a waste paper or waste paper product, and optionally the polypeptide has activity comprising cellulase, endoglucanase, cellobiohydrolase, mannanase and/or beta-glucosidase activity, and optionally the plant residue comprise stems, leaves, hulls, husks, cobs, wood, wood chips, wood pulp and sawdust, and optionally the paper waste comprises discarded or used photocopy paper, computer printer paper, notebook paper, notepad paper, typewriter paper, newspapers, magazines, cardboard and paper-based packaging materials, and optionally the processing of the biomass material generates a bioethanol. Improving texture and flavor of a dairy product comprises providing a polypeptide, providing a dairy product, and contacting the polypeptide and the dairy product under conditions where the cellulase can improve the texture or flavor of the dairy product. Treating solid or liquid animal waste products comprises providing a polypeptide, where optionally the polypeptide has activity comprising cellulase, endoglucanase, cellobiohydrolase, mannanase and/or beta-glucosidase activity, providing a solid or a liquid animal waste, and contacting the polypeptide and the solid or liquid waste under conditions where the protease can treat the waste. SPECIFIC SEQUENCES - The nucleic acid comprises a nucleotide sequence of ODD SEQ ID NOS: 1-165 encoding a polypeptide having a cellulase activity, which comprises an amino acid sequence of EVEN SEQ ID NOS: 2-166. All sequences are fully defined in the specification.    EXAMPLE - No suitable example given.