TECHNOLOGY FOCUS - BIOTECHNOLOGY - Preferred Method: The contacting step of fructose and alpha -D-glucose-containing solution with glucose isomerase further comprises stabilizing glucose isomerase with magnesium ion (Mg+) stabilizer. Preferred Components: Each of invertase, glucose isomerase and mutarotase is contained on separate solid substrates having aminated structures.    TECHNOLOGY FOCUS - INORGANIC CHEMISTRY - Preferred Component: The Mg+ stabilizer comprises magnesium chloride (MgCl2). The separate solid substrates comprise silica beads. Preferred Composition: The MgCl2 is present in a concentration of 20 mM.    TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Components: Each of aminated structures comprises amine functional group attached to native surface of silica beads, and amine group crosslinker attached to each of amine functional groups, where amine group crosslinker provides site for protein reaction. The amine functional group comprises amino alkyl alkyloxy silane including aminopropyltriethoxysilane, aminopropyltrimethoxysilane, aminopropylmethyldiethoxysilane, aminopropylmethyldimethoxysilane, aminoethylaminopropyltriethoxysilane, aminoethylaminopropyltrimethoxysilane, aminoethylaminopropylmethyldimethoxysilane, diethylenetriaminopropyltriethoxysilane, diethylenetriaminopropyltrimethoxysilane, diethylenetriaminopropylmethyldiethoxysilane, diethylenetriaminopropylmethyldimethoxysilane, cyclohexylaminopropyltrimethoxysilane, hexanediaminomethyltriethoxysilane, phenylaminomethyltriethoxysilane, phenylaminomethyltrimethoxysilane, diethylaminomethyltriethoxysilane, (dimethylaminomethyl)methyldimethoxysilane or methylaminopropyltrimethoxysilane, preferably 3-aminopropyltriethoxysilane. The amine group crosslinker comprises formaldehyde, glutaraldehyde, mono- and di-aldehyde polyethylene glycol, and bis(imido esters), bis(succinimidyl esters), diisocyanates or diacid chlorides, preferably mono- or di-aldehyde or glutaraldehyde. EXAMPLE - No suitable example given.