TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Process: The aniline compound (III) is obtained by reacting a N-(4-nitroanilino)-N-methyl-2-chloro-acetamide (IV) with a 1-methyl-piperazine (V) and subsequent hydrogenation of the nitro group in an amino group. The acetamide compound (IV) is obtained by reacting a N-methyl-4-nitroaniline (VI) with a compound Cl-CH2-C(=O)-O-C(=O)-CH2-Cl (VII). The compound (II) is obtained by base catalyzed dechloroacetylation of a methyl-1-(chloroacetyl)-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate) (VIII). The compound (VIII) is obtained by reacting methyl-1-(chloroacetyl)-2-oxoindoline-6-carboxylate (IX) with a trimethyl orthobenzoate (X). The compound (IX) is obtained by reacting 6-methoxycarbonyl-2-oxindol (XI) with the compound (VII). The compound (XI) is obtained by esterifying 4-chloro-3-nitro-benzoic acid (I') to obtain 4-chloro-3-nitro-benzoic acid methyl ester (II'); reacting the product (II') with malonic acid dimethylester to obtain 2-(4-methoxycarbonyl-2-nitro-phenyl)-malonic acid dimethyl ester (III'); and performing a cyclization of the product (III') by a reaction of hydrogenation. The compound (I) is reacted with EtSO3H to obtain a monoethanesulfonate salt of the compound (I). The process further involves milling of the monoethanesulfonate salt of the compound (I). ACTIVITY - Cytostatic.    MECHANISM OF ACTION - Tyrosine kinase receptor inhibitor; and Vascular endothelial growth factor receptor (VEGFR) inhibitor. No biological data is given.    EXAMPLE - A suspension of methyl-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate (10 g) and N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide (8.6 g) in a mixture of methanol (72 ml) and N,N-dimethylformamide (18 ml) was heated to reflux. After 7 hours of refluxing the suspension was cooled down to 0 degrees C and stirred for 2 hours and after work up, (3-Z-(1-(4-(N-((4-methyl-piperazin-1-yl)- methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene)-6-methoxycarbonyl-2-indolinone) (15.4 g, 88.1%) as yellow crystals was obtained.