TECHNOLOGY FOCUS - BIOTECHNOLOGY - Preferred Nucleic acid (claimed): (I) comprises (a) a NA sequence (NAS) which is at least 50 (preferably 98, especially 100)% identical to polynucleotide sequences selected from a group of 270 sequences as given in the specification e.g. odd number sequences from (SEQ ID NO:1) to (SEQ ID NO:370) (SEQ ID NO: not defined) over a region of at least about 20 (preferably 700, especially greater than or equal to 1150) residues, or the full length of a cDNA, transcript (mRNA) or gene, where the NA encodes a polypeptide (P1) having a cellulosic activity, or encodes a polypeptide capable of generating an antibody that specifically binds to a group of 341 polypeptide sequences as given in the specification e.g. even number sequences from (SEQ ID NO:2) to (SEQ ID NO:368) (SEQ ID NO: not defined) or their fragments; (b) NAS that hybridizes under stringent conditions to NA of (a); (c) NAS encoding a polypeptide (P1); (d) NAS of (a)/(b)/(c) and encoding a polypeptide having one conservative amino acid substitution and retaining its LA; (e) NAS of (a) to (d) encoding a polypeptide having LA but lacking a signal sequence, a prepro domain, a dockerin domain (DD), and/or a carbohydrate binding module (CBM); (f) NAS of (a) to (e) encoding a polypeptide having LA; (g) NAS of (f), where heterologous sequence comprises a sequence encoding: (i) a heterologous signal sequence, CBM, DD, and/or catalytic (CD); (ii) the sequence of (ii), where the heterologous signal sequence, CBM or CD is derived a heterologous LE; or, (iii) tag, epitope, targeting peptide, cleavable sequence, detectable moiety or enzyme; (h) NAS of (g), where the heterologous CBM comprises a CBM, a lignin BM, a xylose BM, mannanse BM, xyloglucan-specific module or arabinofuranosidase BM; (i) NAS of (g), where the heterologous signal targets the encoded protein to vacuole, endoplasmic reticulum, chloroplast or starch granule; or (j) NAS fully complementary to one of (a), (c) to (i). Preferred Polypeptide: The lignocellulosic activity in (P1) or recombinant LE comprises (a) a glycosyl hydrolase, cellulase, endocellulase, glucanase, cellobiohydrolase, beta -glucosidase and/or a mannanase activity; (b) an activity comprising hydrolyzing (degrading) soluble oligomers to fermentable, monomeric sugars; (c) an activity comprising hydrolyzing (degrading) soluble cellooligsaccharides and arabinoxylan oligomers into monomers, and optionally the monomers comprise xylose, arabinose or glucose; (d) catalyzing the hydrolysis of (degrading) plant biomass polysaccharides; (e) catalyzing the hydrolysis of (degrading) a glucan or lignin to produce a smaller molecular weight polysaccharides or oligomers or monomers; (f) catalyzing hydrolysis of 1,4-beta-D-glycosidic linkages; (g) an endocellulase activity comprising an endo-1,4-beta-endocellulase activity; (f) 1,4-beta-D-glycosidic linkage hydrolysis activity comprising hydrolysis of a 1,4-D-glycosidic linkage in a cellulose, its derivative, a lichenin or a cereal, where optionally the cellulose derivative comprises a carboxy methyl cellulose or a hydroxy ethyl cellulose, or the cereal comprises a beta-D-glucan or a xyloglucan; (g) catalyzing hydrolysis of glucanase linkages; (h) catalyzing hydrolysis of beta -1,4- and/or beta -1,3- glucanase linkages; (i) catalyzing hydrolysis of endo-glucan linkages; (j) catalyzing hydrolysis of endo-l,4-beta-D-glucan 4-glucano hydrolase activity; (k) catalyzing hydrolysis of internal endo- beta -1,4- glucanase linkages and/or beta -1,3-D-glucanase linkages; (l) catalyzing hydrolysis of internal beta -1,3-glucosidic linkages; (m) catalyzing hydrolysis of polysaccharides comprising glucopyranose; (n) catalyzing hydrolysis of polysaccharides comprising 1,4- beta -glycoside-linked D-pyranoses; (o) catalyzing hydrolysis of cellulose, a cellulose derivative or a hemicellulose; (p) the activity of (o), where the cellulase activity (hydrolysis of cellulose, a cellulose derivative or a hemicellulose) comprises hydrolyzing (degrading) a cellulose or a hemicellulose in sugar cane bagasse, corn fiber, corn seed fiber, wood, wood waste, wood pulp, paper pulp, a product or paper product, a plant biomass, a plant biomass comprising seeds, grains, s, plant wastes or byproducts of food or feed processing or industrial processing, stalks, cobs, stover, grasses, an Indian grass or a switch grass; (q) catalyzing hydrolysis of glucan in a feed, a food product or a beverage; (r) the activity of (q), where the feed, food product or beverage comprises a cereal-animal feed, a wort or a beer, a dough, a fruit or a vegetable; (s) catalyzing hydrolysis of a glucan in a microbial, fungal, mammalian, plant cell or any plant material comprising a cellulosic part; (t) the activity of any of (a) to (s). The chimeric polypeptide comprises (a) a first domain and at least a second domain, where the first domain comprises an enzyme corresponding to (P1) and the second domain comprises a heterologous or modified CBM, a heterologous or modified dockerin domain, a heterologous or modified prepro domain, or a heterologous or modified active site; (b) the chimeric polypeptide of (a), where CBM is cellulose-binding module or a lignin-binding domain; (c) the chimeric polypeptide of (a) or (b), where the CBM is approximate to the enzyme's catalytic domain; (d) the chimeric polypeptide of (a), (b) or (c), where the at least one CBM is positioned approximate to the polypeptide's catalytic domain; (e) the chimeric polypeptide of (d), where the CBM is positioned: proximate to the C-terminus of the polypeptide's catalytic domain, and/or, approximate to the N-terminus of the polypeptide's catalytic domain; or (f) the chimeric polypeptide of any of (a), (b), (c) or (e), where the chimeric eptide is a recombinant chimeric protein. Preferred Method: The method of isolating a polypeptide with a lignocellulosic activity involves contacting a sample comprising polypeptide (P1) with the antibody (AB) under conditions where (AB) specifically binds to (P1). The method of making an anti-cellulase or an anti-LE antibody involves administering to a non-human animal either (I) to generate a humoral immune response, to make an anti-cellulosic enzyme or an anti-cellulase antibody, or administering (P1) to generate a humoral immune response, to make an anti-LE or an anti-cellulase antibody. The method of producing a recombinant polypeptide involves providing a NA comprising (I) operably linked to a promoter; expressing it under conditions that allow expression of the peptide, to produce a recombinant polypeptide; further transforming a host cell with (I) followed by expressing it to form recombinant polypeptide in a transformed cell. The promoter (PR1) is or comprises: viral, bacterial, mammalian or plant promoter; potato, rice, corn, wheat, tobacco or barley promoter; or constitutive or CaMV35S promoter; inducible promoter; a tissue-specific or an environmentally regulated or a developmentally regulated promoter; seed-specific, leaf-specific, root-specific, stem-specific or an abscission-induced promoter; seed preferred promoter, maize gamma zein promoter or maize ADP-gpp promoter. The method for identifying a polypeptide having a lignocellulosic activity involves providing the polypeptide (P1) or LE; providing a substrate for a lignocellulosic enzyme; and contacting (P1) and detecting a decrease in amount of substrate or an increase in the amount of a reaction product, where a decrease amount of the substrate or an increase in the amount of the reaction product detects a peptide having a lignocellulosic activity. The method for identifying an lignocellulosic enzyme substrate involves contacting (P1) with the test substrate and detecting decrease in the amount of substrate or an increase in the amount of reaction product, where decrease in the amount of the substrate or an increase in the amount of a reaction product identifies the test substrate as a lignocellulosic enzyme substrate. The method of determining whether a test compound specifically binds to a polypeptide involves either expressing NA (I) or a vector comprising (I) under conditions permissive for translation of the NA to a polypeptide; providing a test compound; contacting the polypeptide with the test compound; and determining whether the test compound specifically binds to the polypeptide or it involves contacting polypeptide (P1) with the test compound; and determining whether the test compound specifically binds to the polypeptide. The method for identifying a modulator of a lignocellulosic activity involves contacting polypeptide (P1) with a test compound; measuring an activity of the lignocellulosic enzyme, where a change in the lignocellulosic enzyme activity measured in the presence of the test compound compared to the activity in the absence of the test compound provides a determination that the test compound modulates the cellulosic enzyme activity. The method for identifying a feature in a sequence involves reading the sequence using a computer program which identifies at least one feature in the sequence where the sequence comprises (P1), (I), polypeptide encoded by (I). The method for comparing two sequences involves reading the first sequence and the second sequence using a computer program which compares the sequences, where the first sequence comprises a (P1) or (I); and determining differences between the first sequence and the second sequence with the computer program and optionally determining differences seen in the first sequence and the second sequence; identifying polymorphisms; using an identifier that identifies at least one feature in a sequence and reading the first sequence using a computer and identifying at least one feature in the sequence. The method for isolating or recovering a NA encoding a polypeptide with lignocellulosic activity from a sample involves either providing the amplification primer pair (AP1); isolating a NA from the sample or treating the sample such that NA sample is accessible for hybridization to (AP1); and, combining the NA with (AP1) to isolate or recover a NA encoding a polypeptide with a lignocellulosic activity from a sample; or it involves providing a polynucleotide probe comprising, or consisting of (I); isolating a NA from the sample or treating the sample such that NA sample is accessible for hybridization to a polynucleotide probe; combining the isolated NA or the treated sample with probe and isolating a NA that specifically hybridizes with the polynucleotide probe thereby isolating or recovering a NA encoding a polypeptide with a cellulosic activity from an sample. Optionally the sample is an environmental sample, or the sample comprises water, liquid, soil, air or a biological sample (optionally the biological sample is derived from bacterial, protozoan, insect, yeast, plant, fungal or a mammalian cell). The method of generating a variant of a NA encoding a polypeptide with a cellulosic activity involves providing a template NA comprising (I) and modifying, deleting or adding at least one nucleotide in the template sequence, or its combination to generate a variant of the template NA; optionally expressing the variant NA to generate a variant polypeptide with a lignocellulosic activity, and optionally the modifications, additions or deletions are introduced by a methods (M1) involving error-prone PCR, shuffling, oligonucleotide-directed mutagenesis, assembly PCR, sexual PCR mutagenesis, in vivo mutagenesis, cassette mutagenesis, recursive ensemble genesis, exponential ensemble mutagenesis, site-specific mutagenesis, gene reassembly, Site Saturation Mutagenesis (GSSM), synthetic ligation reassembly (SLR),recombination, recursive sequence recombination, phosphothioate-modified DNA mutagenesis, uracil-containing template mutagenesis, gapped duplex mutagenesis, point mismatch repair mutagenesis, repair-deficient host strain mutagenesis, chemical mutagenesis, radiogenic mutagenesis, deletion mutagenesis, restriction-selection mutagenesis, restriction-purification mutagenesis, artificial gene synthesis, ensemble mutagenesis and/or chimeric nucleic acid multimer creation and optionally the method is iteratively repeated until a lignocellulosic enzyme having altered or different activity or stability from that of a polypeptide encoded by the template nucleic acid is produced. The variant lignocellulosic enzyme is thermotolerant, and retains some activity being exposed to an elevated temperature; and has increased glycosylation as compared to lignocellulosic enzyme encoded by a template nucleic acid; or, it has a lignocellulosic activity under a high temperature, where the lignocellulosic enzyme encoded by the template NA is not active under the high temperature; or the method is iteratively repeated until a lignocellulosic enzyme-coding sequence having an altered codon usage from that of the template NA is produced, or a cellulosic enzyme gene having higher or lower level of message expression or stability that of the template nucleic acid is produced. The method for modifying codons in a NA encoding a polypeptide with a cellulosic activity to increase its expression in a host cell, involves providing a (I) encoding a polypeptide with a lignocellulosic activity and identifying a non-preferred or a less preferred codon in the NA by replacing it with a preferred or neutrally used codon encoding the same amino acid as the replaced codon, thereby modifying NA to increase its expression in a host cell. The preferred codon is a codon over-represented in coding sequences in the host cell and a non-preferred or less preferred codon is a codon under-represented in coding sequences in genes in the host cell. The method for modifying codons in a NA encoding a lignocellulosic enzyme involves identifying a codon in the nucleic acid (I) and replacing it with a different codon encoding the same amino acid as the replaced codon, thereby modifying codons in NA encoding a lignocellulosic enzyme (preferably identifying a non-preferred or a less preferred codon in (I) and replacing it with a preferred or neutrally used codon encoding the same amino acid as the replaced codon). The method for producing a library of NA encoding several modified LE active sites or substrate binding derived from a first NA comprising a sequence encoding a first active site or a first substrate binding site, involves providing a first NA encoding a first active site or first substrate binding where the first NA sequence comprises a sequence that hybridizes under stringent conditions to (I), which encodes a LE active site or LE substrate binding site; providing a set of mutagenic oligonucleotides that encode naturally-occurring amino variants at several targeted codons in the first NA; and using the set of mutagenic oligonucleotides to generate a set of active site-encoding substrate binding site-encoding variant NA encoding a range of amino acid ions at each amino acid codon that was mutagenized, to produce the library of NA. Optionally a mutagenic oligonucleotide or a variant nucleic acid is generated by methods (M1). The method for making a small molecule involves providing several biosynthetic enzymes capable of synthesizing or modifying a molecule, where one of the enzymes comprises a LE encoded by (I); providing a substrate for at least one of the enzymes; and reacting the substrate with the enzymes under conditions that facilitate biocatalytic reactions to generate a small molecule by a series of biocatalytic reactions. The method for modifying a small molecule involves reacting a LE comprising (P1) or a polypeptide encoded by (I) with the small molecule under conditions to facilitate an enzymatic reaction catalyzed by the LE, to modify a small molecule by a lignocellulosic enzymatic reaction. The method further involves providing several small molecule substrates for LE to generate a library of modified small molecules produced by at least one enzymatic reaction catalyzed by LE; providing several additional enzymes under conditions that facilitate biocatalytic reactions by the enzymes to form a library of modified small molecules; further testing the library to determine if a particular modified small molecule which exhibit a desired activity is present within the library, where optionally the step of testing the library further involves systematically eliminating all but one of the biocatalytic reactions used to produce a portion of the modified small molecules within the library by testing the portion of the modified small molecule for the presence or absence of the particular modified small molecule with a desired activity, and identifying at least one specific biocatalytic reaction that produces the particular modified small molecule of desired activity. The method for determining a functional fragment of a LE involves deleting several amino acid residues from LE comprising (P1) or a polypeptide encoded by (I) and testing remaining subsequence for a lignocellulosic activity, to determine a functional element of LE, where optionally the LE activity is measured by providing a cellulosic enzyme substrate and detecting a decrease in the amount of the substrate or an increase in the amount of a reaction product. The method for whole cell engineering of new or modified phenotypes by using real-time metabolic flux analysis involves making a modified cell by modifying the genetic composition of a cell by addition of (I) to the cells; culturing the modified cell to generate a several modified cells; measuring at least one metabolic parameter of the cell by monitoring the cell culture in real time; and analyzing the data to determine if the measured parameter differs from a comparable measurement in an unmodified cell under similar conditions, to identify an engineered phenotype in the cell. Optionally the genetic composition of the cell is modified by a method involving deletion of a sequence or modification of a sequence in the cell; or knocking out expression of a gene, and optionally the method further involves selecting a cell comprising a newly engineered phenotype, and optionally culturing the selected cell, to generate a new cell strain comprising a newly engineered phenotype. The method of increasing thermotolerance or thermostability of a lignocellulosic polypeptide involves glycosylating a lignocellulosic enzyme, where the polypeptide comprises at least thirty contiguous amino acids of (P1) or polyypeptide encoded by (I). The method for overexpressing a recombinant LE in a cell involves expressing a vector comprising (I) by use of a high activity promoter, a dicistronic vector or by gene amplification of the vector. The high activity promoter is (PR1). The method of making a transgenic plant involves introducing a heterologous NA comprising (I) into the cell, to produce a transformed plant cell; and producing a transgenic plant from the transformed cell. The first step further involves introducing the heterologous NA sequence by electroporation or microinjection of plant cell plasts or introducing the heterologous NA sequence directly to plant tissue by DNA particle bombardment or by using an Agrobacterium faciens host. The method of expressing a heterologous NA sequence in a plant cell involves transforming the plant cell with a heterologous NA sequence comprising (I), operably linked to a promoter (PR1); and growing the plant under conditions where the heterologous NA sequence is expressed in the plant cell. The method for hydrolyzing, breaking up or disrupting a cellooligsaccharide, arabinoxylan oligomer, or a lignocellulose-, lignin-, xylan-, glucan- or cellulose- comprising composition (C1) involves providing a polypeptide having a lignocellulosic activity or polypeptide encoded by (I) and contacting it with (C1) under conditions where the LE hydrolyzes, breaks up or disrupts the lignin-, cellooligsaccharide, arabinoxylan oligomer, or glucan- or cellulose in (C1). The polypeptide has glycosyl hydrolase, endo-glucanase, cellobiohydrolase, beta-glucosidase, xylanase, mannanse, beta -xylosidase and/or arabinofuranosidase activity and is a recombinant polypeptide (produced as a heterologous recombinant polypeptide within the composition to be hydrolyzed or produced by expression heterologous polynucleotide encoding the recombinant polypeptide in a bacterium, a yeast, insect, a fungus or an animal, and optionally the organism is selected from S. pombe S. cerevisiae, Pichia pastoris, E. coli, Streptomyces, Bacillus or Lactobacillus). (C1) comprises plant, bacterial, yeast, insect cell, or animal cell (preferably monocot or dicot plant or plant product; or corn, sugarcane, rice, wheat, barley, switchgrass or Miscanthus or a dicot oilseed soy, canola, rapeseed, flax, cotton, palm oil, sugar beet, peanut, tree, poplar or lupine). The method of beverage production involves administration (P1), polypeptide encoded by (I) or a mixture of cocktail of enzymes to a beverage or a beverage precursor under conditions sufficient for decreasing the viscosity of the beverage, where optionally the beverage or beverage precursor is wort or beer. The method for making a fuel involving contacting composition (C2) comprising a cellooligsaccharide, arabinoxylan oligomer, lignin, lignocellulose, xylan, glucan, cellulose or fermentable sugar with polypeptide (P1) or a polypeptide encoded by (I) or a mixture of cocktail of enzymes. The method further involves processing and/or formulating bioethanol, biomethanol, biopropanol and/or, bio-butanol as a liquid fuel and/or a gas fuel. (C2) comprises a plant, plant product or plant derivative (preferably cane sugars or plant products, beets or sugarbeets, wheat, corn, soybeans, potato, rice, barley, switchgrass, Miscanthus, oilseed soy, canola, rapeseed, flax, cotton, palm oil, sugar beet, peanut, tree, poplar or lupine). The method for processing a biomass material comprising lignocellulose involves contacting a composition comprising a cellulose or a fermentable sugar with the polypeptide (P1) or a polypeptide encoded by (I) or a mixture of cocktail of enzymes; and optionally processing the biomass material to generate a bioalcohol, bioethanol, biomethanol, biobutanol or biopropanol. The plant residue comprise stems, leaves, hulls, husks, corn or corn cobs, stover, hay, straw, wood, wood chips, wood pulp, wood waste and sawdust. The paper waste comprises discarded or used photocopy paper, computer printer paper, notebook paper, notepad paper, typewriter paper, newspapers, magazines, board and paper-based packaging materials. Preferred Composition: The mixture of cocktail of enzymes comprises (a) at least one LE corresponding to (P1); a combination of enzymes as set forth in Table 4 of the specification; at least one of (i) each of a endoglucanase, cellobiohydrolase I (CBH I), biohydrolase II (CBH II) or beta -glucosidase; (ii) at least one of each of an xylanase, beta -glucosidase or arabinofuranosidase; or, (iii) a combination of at least one of (i) or (ii); where mixture comprises at least one enzyme corresponding to (P1); at least one hemicellulose- and/or cellulose-hydrolyzing enzyme comprising: (i) at one of each of a endoglucanase, glucose oxidase, (CBH I), (CBH II), arabinofuranosidase or xylanase; (ii) mixture of (i), where the glucose oxidase is a glucose oxidase-1 or beta -glucosidase; and/or (iii) the mixture of (i) or (ii), where the glucose oxidase is a glucose oxidase-2 or beta -xylosidase; where the mixture comprises at least one enzyme corresponding to (P1); (e) at least one hemicellulose- and/or cellulose-hydrolyzing enzyme comprising: at least of each of a endoglucanase; CBH I; CBH II; abinofuranosidase; xylanase; glucose oxidase-1 (a beta -glucosidase); and/or, a glucose oxidase-2 or beta -xylosidase; where the mixture of (c) comprises at least one enzyme corresponding to (P1); (f) at least one (1) endoglucanase which cleaves internal beta -1,4 linkages resulting in shorter glucooligosaccharides, (2) cellobiohydrolase which acts in an ''exo'' manner processively releasing cellobiose units ( beta -1,4 glucose-glucose disaccharide), and/or (3) beta -glucosidase for releasing glucose monomer from short cellooligosaccharides (e.g. cellobiose), where the mixture of (d) comprises at least one enzyme corresponding to (P1); (g) the enzyme combination selected from a group of 13 polypeptides as given in the specification e.g. (SEQ ID NO:34), (SEQ ID NO:360), (SEQ ID NO:358), and (SEQ ID NO:371); or (SEQ ID NO:358) (SEQ ID NO: not defined). The enzyme cocktail for depolymerization of cellulosic polymers comprises the polypeptide (P1); a polypeptide encoded by (I) or mixture of cocktail of enzymes. The isolated, synthetic and/or recombinant CBM comprises or consists of 1) a carbohydrate binding domain-module (CBM) motif rising, or consisting of, a subsequence of the polypeptide (P1) or a polypeptide encoded by (I) where the carbohydrate binding domain module (CBM) comprises or consists of a CBM1, CBM2, CBM2a, CBM2b, CBM3, CBM3a, CBM3b, CBM3c, CBM4, CBM5, CBM512, CBM6, CBM7, CBM8, CBM9, CBM10, CBM11, CBM12, CBM13, CBM14, CBM15, CBM16 or any of the CBMs from a CMB family of CBM1 to CBM48; and/or at least one carbohydrate binding domain-module (CBM) as set forth in Table 5 and Table 6 of the specification. ACTIVITY - Anabolic. No biological data is given.    MECHANISM OF ACTION - None given.    EXAMPLE - No suitable example given.