TECHNOLOGY FOCUS - BIOTECHNOLOGY - Preferred Coating: In the coating above, the active biomolecule comprises a proteinaceous molecule. The proteinaceous molecule binds a ligand and/or contacts a living organism. Preferably, the proteinaceous molecule binds a ligand, where the ligand comprises an antigen, a substrate, and/or an inhibitor. The ligand also comprises a chemical toxic to humans. It also comprises an organophosphorus compound. The proteinaceous molecule comprises a peptide, a polypeptide, and/or a protein. It also comprises an enzyme, an antibody, a receptor, a transport protein, and/or structural protein. Preferably, the proteinaceous molecule comprises an enzyme such as an oxidoreductase, a transferase, a hydrolase, a lyase, an isomerase, and/or a ligase. The enzyme comprises a hydrolase, where the hydrolase comprises an esterase. The esterase comprises a phosphoric triester hydrolase. The phosphoric triester hydrolase comprises an aryldialkylphosphatase and/or a diisopropyl-fluorophosphatase. It also comprises a combination of phosphoric triester hydrolases. The aryldialkylphosphatase comprises an organophosphorus hydrolase, a human paraoxonase, an animal carboxylase, or a functional equivalent. The organophosphorus hydrolase comprises an Agrobacterium radiobacter P230 organophosphate hydrolase, a Flavobacterium balustinum parathion hydrolase, a Pseudomonas diminuta phosphotriesterase, a Flavobacterium opd gene product, a Flavobacterium parathion hydrolase opd gene product, or a functional equivalent. The functional equivalent is a structural analog comprising a cobalt (Co2+), iron (Fe2+), copper (Cu2+), manganese (Mn2+), cadmium (Cd2+), or nickel (Ni2+) at the enzyme active site. The functional equivalent is also a sequence analog, where the sequence analog is an alteration in sequence length or a fusion protein. The sequence analog lacks a leader peptide sequence. Preferably, the organophosphorus hydrolase comprises a Pseudomonas diminuta phosphotriesterase or a functional equivalent comprising a sequence analog comprising an amino acid substitution. The sequence analog is His55Cys, His57Cys, Cys59Ala, Gly60Ala, Ser61Ala, Ile106Ala, Ile106Gly, Trp131Ala, Trp131Phe, Trp131Lys, Phe132Ala, Phe132His, Phe132Tyr, Leu136Tyr, Leu140Tyr, His201Cys, His230Cys, His254Ala, His254Arg, His254Ser, His257Ala, His257Leu, His257Tyr, Leu271Ala, Leu271Tyr, Leu303Ala, Phe306Ala, Phe306Glu, Phe306His, Phe306Lys, Phe306Tyr, Ser308Ala, Ser308Gly, Tyr309Ala, Met317Ala, Met317His, Met317Lys, Met317Arg, His55Cys/His57Cys, His55Cys/His201Cys, His55Cys/His230Cys, His57Cys/His201Cys, His57Cys/His230Cys, Ala80Val/Ser365Pro, Ile106Ala/Phe132Ala, Ile106Ala/Ser308Ala, Ile106Gly/Phe132Gly, Ile106Gly/Ser308Gly, Phe132Tyr/Phe306His, Phe132His/Phe306His, Phe132His/Phe306Tyr, Phe132Tyr/Phe306Tyr, Phe132Ala/Ser308Ala, Phe132Gly/Ser308Gly, Leu182Ser/Val310Ala, His201Cys/His230Cys, His254Arg/His257Leu, His55Cys/His57Cys/His201Cys, His55Cys/His57Cys/His230Cys, His55Cys/His201Cys/His230Cys, Ile106Ala/Phe132Ala/His257Tyr, Ile106Ala/Phe132Ala/His257Trp, Ile106Gly/Phe132Gly/Ser308Gly, Leu130Met/His257Tyr/Ile274Asn, His257Tyr/Ile274Asn/Ser365Pro, His55Cys/His57Cys/His201Cys/His230Cys, Ile106Gly/Phe132Gly/His257Tyr/Ser308Gly, or Ala14Thr/Ala80Val/Leu185Arg/His257Tyr/Ile274Asn. The aryldialkylphosphatase comprises a human paraoxonase or a functional equivalent. The human paraoxonase comprises an HPON1 gene product or a functional equivalent, which comprises a sequence analog comprising an amino acid substitution. The sequence analog is E32A, E48A, E52A, D53A, D88A, D107A, H114N, D121A, H133N, H154N, H160N, W193A, W193F, W201A, W201F, H242N, H245N, H250N, W253A, W253F, D273A, W280A, W280F, H284N, or H347N. The aryldialkylphosphatase comprises an animal carboxylase, where the animal carboxylase comprises an insect carboxylase or a functional equivalent. The insect carboxylase comprises a Flodia interpunctella carboxylase, Chrysomya putoria carboxylase, Lucilia cuprina carboxylase, Musca domestica carboxylase, or a functional equivalent. The phosphoric triester hydrolase comprises a diisopropyl-fluorophosphatase (DFP). Preferably, the diisopropyl-fluorophosphatase comprises an organophosphorus acid anhydrolase, a squid-type DFPase, a Mazur-type DFPase, or a functional equivalent. The diisopropyl-fluorophosphatase comprises an organophosphorus acid anhydrolase or a functional equivalent. The organophosphorus acid anhydrolase comprises an Altermonas organophosphorus acid anhydrolase, a prolidase, or a functional equivalent. Preferably, the Alteromonas organophosphorus acid anhydrolase comprises an Alteromonas sp JD6.5 organophosphorus acid anhydrolase, an Alteromonas haloplanktis organophosphorus acid anhydrolase, an Altermonas undina organophosphorus acid anhydrolase, or a functional equivalent. The organophosphorus acid anhydrolase also comprises a prolidase or a functional equivalent. The prolidase comprises a human prolidase, a Mus musculus prolidase, a Lactobacillus helveticus prolidase, an Escherichia coli prolidase, an Escherichia coli aminopeptidase P, or a functional equivalent. EXAMPLE - No example given.