TECHNOLOGY FOCUS - BIOLOGY - Preferred Components: The biological molecule comprises: amino acids, peptides, proteins, glycoproteins, lipoproteins, nucleotides, oligonucleotides, nucleic acids, lipids and/or carbohydrates; drug or its target; antibodies, immunoglobulins, receptors, enzymes, neurotransmitters, cytokines, hormones, complimentarity determining proteins, DNA, RNA or their active fragments; or one or more molecules that are integral to or attached to cells or cellular components.    TECHNOLOGY FOCUS - INORGANIC CHEMISTRY - Preferred Components: (I) comprises: metal or its alloy; a semiconductor; ceramic; and a composite material. The metal or its alloy comprises iron, copper, zinc, lead, aluminum, titanium, gold, platinum, silver, cobalt, chromium, vanadium, tantalum, nickel, magnesium or manganese. The metal alloy is cobalt chrome, nickel titanium, titanium vanadium aluminum or stainless steel. The semiconductor comprises silicon, germanium, gallium arsenide, indium antimonide, diamond, amorphous carbon or amorphous silicon. The ceramic comprises an oxide, a silicate, a silicide, a nitride, a carbide or a phosphate, preferably magnesium oxide, aluminum oxide, hydroxyapatite, titanium nitride, titanium carbide, aluminum nitride, silicon oxide, zinc oxide or indium tin oxide. The composite material comprises a metal ceramic composite, an oxide composite or a ceramic polymer composite.    TECHNOLOGY FOCUS - POLYMERS - Preferred Components: (I) takes the form of a block, sheet, film, tube, strand, fiber, piece or particle, powder, shaped article, woven fabric or massed fiber pressed into a sheet. The plasma polymer is generated from monomer units comprising n-hexane, allylamine, acetylene, ethylene methane or ethanol. The plasma polymer surface has a thickness of 0.3-1000 nm. The cross-linked regions are located at 0.3-1000 nm beneath the plasma polymer surface. The mixed or graded interface is generated by varying composition of gases supplied to the process chamber so that deposited and/or implanted material changes progressively from more metallic to more polymeric. The presence of many sub-surface cross-linked regions results in delay of plasma polymer surface hydrophobic recovery. EXAMPLE - Titanium was connected to a pulsed bias power supply capable of delivering 20kV pulses for 20 microseconds. Acetylene was introduced into an argon plasma created by a parallel plate capacitor to which a radiofrequency field was applied. The bias pulses were applied during the operation of the radiofrequency plasma and ions from the carbon containing gas were implanted into the metal to produce a graded interface. Then the metal was incubated with the protein horseradish peroxidase in 10 mM phosphate buffer having pH of 7 overnight to give functionalized titanium substrate.