TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preparation (disclosed): 3 Methods for the preparation of (I) are given e.g. preparation of (I) involves reacting an amino alcohol of formula NH2-C(R1)(R2)-CH2-OH with a compound of formula A1-CO-Hal (Hal stands for halogen), in presence of a base such as triethylamine, in a solvent such as diethylether, for 12-24 hours at 20-25 degrees C, to form a compound of formula A1-CO-NH-C(R1)(R2)-CH2OH, which is treated with SOCl2, followed by oxidation provides cyclic sulfamidites of formula (VII), which is reacted with compound of formula H-S-B1, to form (I) (where R3 is H and G1 is CH2S). Preferred Definitions:    R10=difluoromethyl or trifluoromethyl;    R1=H;and    R2=H or methyl.    ACTIVITY - Fungicide; Antibacterial; Virucide. The activity of a composition comprising 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (3-(2,4-dichloro-phenyl)-2-((E or Z)-methoxyimino)-1,1-dimethyl-propyl)-amide against Botrytis cinerea was tested as follows. Conidia of the fungus from cryogenic storage were directly mixed into nutrient broth (potato dextrose broth). After placing the composition into a microtiter plate (96-well format) the nutrient broth containing the fungal spores was added. The test plate was incubated at 24 degrees C and the inhibition of growth measured after 3-4 days. The composition showed at least 50% fungal growth inhibition.    MECHANISM OF ACTION - None given.    ADMINISTRATION - The composition comprising (I) is applied by foliar application. The rate of application is 5 g to 2 kg of active ingredient (a.i.) per hectare (ha), preferably 10 g to 1 kg a.i./ha, especially 20-600 g a.i./ha. When used as seed drenching agent, convenient rates of application are 10 mg to 1 g of active substance per kg of seeds. The pharmaceutical composition comprising (I) for treating and/or preventing microbial infection in animals is administered orally, topically, parenterally, by inhalation, or as an aerosol spray. No dosage details given.    SPECIFIC COMPOUNDS - 156 Compounds are disclosed as (I) e.g. 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (2-(2,6-dichloro-phenylsulfanyl)-1-methyl-ethyl)-amide (IA); 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid ((S)-3-(2,4-dichloro-phenyl)-1-methyl-2-oxo-propyl)-amide; 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (3- (2,4-dichloro-phenyl)-1,1-dimethyl-2-oxo-propyl)-amide; 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (1-(2-(2,4-dichloro-phenyl)-acetyl)-cyclopropyl)-amide; and 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid ((S)-3-(2,4-dichloro-phenyl)-2-((E or Z)-methoxyimino)-1-methyl-propyl)-amide.    EXAMPLE - To a solution of 2,6-dichloro-benzenethiol (0.448 g) in dimethylformamide (10 ml) sodium hydride 50% in oil (0.12 g) was added portion wise. The reaction mixture was stirred for 20 minutes at ambient temperature followed by the addition of 3-difluoromethyl-1-methyl-1H-pyrazol-4-yl)-4-methyl-2,2-dioxo-2- lambda -asterisk6asterisk-(1,2,3)oxathiazolidin-3-yl)-methanone (0.800 g), in dimethylformamide (6 ml). The reaction mixture was stirred for 5 hours at ambient temperature then poured onto 1M hydrochloric acid (HCl) (50 ml) and extracted with ethyl acetate (2x 50 ml). After work-up, 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (2-(2,6-dichloro-phenylsulfanyl)-1-methyl-ethyl)-amide (0.88 g, 88%) was obtained in form of a solid (melting point 103-106 degrees C).