TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Components: The first material and/or second material is a polymer and/or a non-polymeric organic compound. The first material or the second material comprises a polymer formed by at least one monomer of: L-lactic acid, saccharide, ethylene glycol oxalate, p-dioxanone, epsilon -caprolactone, ethylcyanoacrylate, butylcyanoacrylate, beta -hydroxybutyrate, 3-hydroxybutyrate, 4-hydroxyvalerate, 1,3-bis(carboxyphenoxy)propane, sebacic acid, D-glucose, acetate of glucose, glucose substituted with hydroxyl groups, glycolic acid, epsilon -caprolactone, 1,4-dioxan-2-one, sebacic anhydride, dodecanoic anhydride, ethylene glycol, oxyethylene, 1,3-bis(carboxyphenoxy)propane, 3-hydroxyvalerate, caprolactone, methyl methacrylate, gelatin, isoleucine, leucine, alanine, asparagine, lysine, methionine, aspartic acid, cysteine, tryptophan, valine, glycine, proline, serine, tyrosine, arginine, histidine, phenylalanine, glutamic acid, threonine, glutamine, adenine, guanine, thymine, cytosine or dimethyl siloxane. The first material or the second material is poly(L-lactic acid), dextran, poly(ethylene glycol oxalate), poly(p-dioxanone-co- epsilon -caprolactone), poly(ethylcyanoacrylate), poly(butylcyanoacrylate), poly( beta -hydroxybutyrate), poly(3-hydroxybutyrate-co-4-hydroxyvalerate), poly(1,3-bis(carboxyphenoxy)propane-co-sebacic acid), cholesterol, cellulose acetate, hydroxypropyl methyl cellulose phthalate, zein, poly(L-lactic-co-glycolic acid), poly( epsilon -caprolacton), poly(1,4-dioxan-2-one), poly(sebacic anhydride), poly(dodecanoic anhydride), poly(ethylene glycol), polyoxyethylene, stearic acid, stearyl alcohol, ethylene glycol palmitostearate, cetyl esters wax, poly(1,3-bis(carboxyphenoxy)propane-co-sebacic acid), poly(3-hydroxybutyrate-co-3-hydroxyvalerate), carnauba wax, ethyl cellulose, octadecanol, polycaprolactone, poly(methyl methacrylate), poly(gelatin) or silicone rubber. The first material is: (i) a combination of poly(L-lactic acid) and at least one compound of dextran, poly(ethylene glycol oxalate), poly(p-dioxanone-co- epsilon -caprolactone), poly(ethylcyanoacrylate), poly(butylcyanoacrylate), poly( beta -hydroxybutyrate), poly(3-hydroxybutyrate-co-4-hydroxyvalerate), poly(1,3-bis(carboxyphenoxy)propane-co-sebacic acid), cholesterol, cellulose acetate, hydroxypropyl methyl cellulose phthalate or zein; (ii) a combination of poly(ethylene glycol oxalate) and at least one compound of dextran, poly(p-dioxanone-co- epsilon -caprolactone), poly(ethylcyanoacrylate), poly(butylcyanoacrylate), poly( beta -hydroxybutyrate), poly(3-hydroxybutyrate-co-4-hydroxyvalerate), poly(1,3-bis(carboxyphenoxy)propane-co-sebacic acid), cholesterol, cellulose acetate, hydroxypropyl methyl cellulose phthalate or zein; (iii) a combination of poly( beta -hydroxybutyrate) and at least one compound of dextran, poly(p-dioxanone-co- epsilon -caprolactone), poly(ethylcyanoacrylate), poly(butylcyanoacrylate), poly(3-hydroxybutyrate-co-4-hydroxyvalerate), poly(1,3-bis(carboxyphenoxy)propane-co-sebacic acid), cholesterol, cellulose acetate, hydroxypropyl methyl cellulose phthalate or zein; (iv) a combination of poly(1,3-bis(carboxyphenoxy)propane-co-sebacic acid) and at least one compound of dextran, poly(p-dioxanone-co- epsilon -caprolactone), poly(ethylcyanoacrylate), poly(3-hydroxybutyrate-co-4-hydroxyvalerate), cholesterol, cellulose acetate, hydroxypropyl methyl cellulose phthalate or zein; and/or (v) a combination of poly(butylcyanoacrylate) and at least one compound of dextran, poly(p-dioxanone-co- epsilon -caprolactone), poly(ethylcyanoacrylate), poly(3-hydroxybutyrate-co-4-hydroxyvalerate), poly(1,3-bis(carboxyphenoxy)propane-co-sebacic acid), cholesterol, cellulose acetate, hydroxypropyl methyl cellulose phthalate or zein. The first material and the second material is a pair of materials consisting of: poly(L-lactic acid) and poly(L-lactic-co-glycolic acid); poly(L-lactic acid) and poly( epsilon -caprolacton); poly(L-lactic acid) and poly(1,4-dioxan-2-one); poly(L-lactic acid) and poly(sebacic anhydride); poly(L-lactic acid) and poly(dodecanoic anhydride); poly(L-lactic acid) and poly(1,3-bis(carboxyphenoxy)propane-co-sebacic acid); poly(1,3-bis(carboxyphenoxy)propane-co-sebacic acid) and poly(L-lactic-co-glycolic acid); poly(1,3-bis(carboxyphenoxy)propane-co-sebacic acid) and poly( epsilon -caprolacton); poly(1,3-bis(carboxyphenoxy)propane-co-sebacic acid) and poly(1,4-dioxan-2-one); poly(butylcyanoacrylate) and poly(L-lactic-co-glycolic acid); poly(butylcyanoacrylate) and poly(1,3-bis(carboxyphenoxy)propane-co-sebacic acid); poly(ethylcyanoacrylate) and poly(L-lactic-co-glycolic acid); poly(ethylcyanoacrylate) and poly(1,3-bis(carboxyphenoxy)propane-co-sebacic acid); poly(ethylene glycol oxalate) and poly(L-lactic-co-glycolic acid); poly(ethylene glycol oxalate) and poly( epsilon -caprolacton); poly(ethylene glycol oxalate) and poly(1,4-dioxan-2-one); poly(ethylene glycol oxalate) and poly(sebacic anhydride); poly(ethylene glycol oxalate) and poly(dodecanoic anhydride); poly(ethylene glycol oxalate) and poly(1,3-bis(carboxyphenoxy)propane-co-sebacic acid); dextran and poly(butylcyanoacrylate); dextran and poly(ethylcyanoacrylate); dextran and poly(L-lactic acid); dextran and poly(L-lactic-co-glycolic acid); dextran and poly(1,3-bis(carboxyphenoxy)propane-co-sebacic acid); dextran and poly(sebacic anhydride); cellulose acetate and poly(L-lactic acid); cellulose acetate and poly(butylcyanoacrylate); cellulose acetate and poly(L-lactic-co-glycolic acid); cellulose acetate and poly(sebacic anhydride); and cellulose acetate and poly(dodecanoic anhydride); Carnauba wax and poly(lactide-co-glycolide); ethyl cellulose and octadecanol; Carnauba wax and polycaprolactone; poly(methyl methacrylate) and poly(L-lactide); poly(lactide-co-glycolide) and poly(gelatin); silicone rubber and poly(L-lactide); ethyl cellulose and a combination of poly(L-lactic-co-glycolic acid) and poly(ethylene glycol); a combination of poly(L-lactic acid) and dextran and a combination of poly(L-lactic-co-glycolic acid) and poly(ethylene glycol); and dextran and a combination of poly(L-lactide) and poly(L-lactic-co-glycolic acid) (preferred). The second material degrades faster than the first material.    TECHNOLOGY FOCUS - PHARMACEUTICALS - Preferred Composition: (I) comprises: 1-95% of the microparticles; and a coating. (I) has a size of 0.2-200 (preferably 0.5-20) mm. (I) is a pharmaceutical composition (implantable). (I) is formed by using a method of extrusion method, extrusion molding method, injection molding method, compression molding method, casting method, coating method or calendaring method. Preferred Components: The first active agent or second active agent are local anesthetics, antiepileptic drugs and anticonvulsants, anti Alzheimer's disease drugs, analgesics, antipodagric, antihypertensive drugs, antiarrhythmic drugs, diuretic drugs, drugs for treating liver diseases, drugs for treating pancreatic diseases, antihistamine drugs, antiallergic drugs, glucocorticoid drugs, sex hormone drugs and contraceptive drugs, hypoglycemic drugs, antiosteoporosis drugs, antibiotics, sulfonamides, quinolones, and other synthetic antibacterial drugs, antituberculous drugs, antiviral drugs, antineoplasm drugs, immunomodulators or cosmetically active agents. The microparticles comprise 2-98 wt.% of the first material, and 2-98 wt.% of the first active agent. The microparticles further comprise a first additive. The first additive is present at 0-30 wt.%. The matrix further comprises: a second active agent; and a second additive. The second active agent is present at 0-70 wt.%. The second additive is present at 0-30 wt.%. The microparticles are uniformly distributed or embedded in the matrix. The microparticles are distributed or embedded in the matrix in accordance with a predetermined pattern. The microparticles have a size of 1-5000 (preferably 20-1000) mu m. Preferred Method: The melting temperature is greater than or equal to 2 degrees C, preferably greater than or equal to 50 degrees C. The method further comprises heating the matrix-forming composition to a melting temperature (Tm) (where Tm is greater than TH and less than TL); providing a coating to (I); and dissolving the matrix-forming composition in a solvent, where the matrix-forming composition is soluble in the solvent while the first material or the microparticles comprising the first material is substantially insoluble in the solvent. ACTIVITY - Nootropic; Dermatological; Antianginal; Thrombolytic; Antiarrhythmic; Antiarteriosclerotic; Anticoagulant; Hemostatic; Cardiant; Vasotropic; Cardiovascular-Gen.; Analgesic; Antidiabetic; Hypotensive; Antilipemic; Vulnerary; Cytostatic; Antiinflammatory; Immunomodulator; Hypertensive; Antismoking; Antiulcer; Antiseborrheic; Endocrine-Gen.; Anesthetic; Fungicide; Virucide; Immunosuppressive; Metabolic; Antiallergic; Keratolytic; Antipsoriatic; Antiarthritic; Antibacterial; Antidote; Osteopathic; Nephrotropic; Neuroprotective; Ophthalmological; Antipyretic; Antithyroid; Anorectic; Gastrointestinal-Gen.; Antiinfertility; CNS-Gen.; Muscle relaxant; Antidiarrheic; Laxative; Uropathic.    MECHANISM OF ACTION - None given.    ADMINISTRATION - Administration of (I) is 5 mg/kg, subcutaneously, intraperitoneally, intramuscularly, intradermally, intranasally or intraocularly.    EXAMPLE - Fluorouracil (6 g) and poly(L-lactic acid) with molecular weight of 20000 and melting temperature of 162-168 degrees C (4 g) were mixed and melted at 170 degrees C. The melted mixture was cooled and the resulting solid was grinded to yield the fluorouracil microparticles (size of 180 mu m). Poly(L-lactic-glycolic acid) with molecular weight of 16000 and melting temperature of 68-76 degrees C (20 g), fluorouracil (12 g), and fluorouracil microparticles (8 g) were mixed and extruded at 110 degrees C to give the fluorouracil implants.