TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preparation (Disclosed): Preparation of (I) comprises: fermenting Rhizobium meliloti strain in a medium containing yeast extract, potassium hydrogen phosphate, magnesium sulfate, Struktol J673 (RTM: Antifoaming agent) and a solution of sucrose at 28-30 degrees C, and pH of 6.5-8; aeration of the fermentor; after 42 hours, adding medium containing yeast extract and magnesium sulfate and allowing lysis by enzymatic polyglucuronanes oligoglucuronanes; fermenting for 72 hours to 13 days; separating bacteria; and isolating (I). Preferred Components: The acetyloxy function is localized in position 2, 3 and/or 6 of the glucuronic acid cycle. The acetylation occurs at the hydroxyl functions of the carbon in position 2 and/or 3. Preferred Composition: (I) is present at 0.00001-50 (preferably 1-5) wt.%. The composition comprises at least one additional active agent comprising moisturizer, which is guanidine, urea, glycolic acid salts, comprising glucolate ammonium salts of tetraalkylamine, salicylic acid, lactic acid, lactate salts comprising ammonium and alkyl quaternary ammonium salts, Aloe vera, sorbitol, mannitol, xylitol, erythritol, glycerol, hexanetriol, butanetriol, propylene glycol, butylene glycol, hexylene glycol, polyethylene glycol, sugars comprising melibiose, starch derivatives and starch sugar comprising glucose, fructose, glucosamine hydroxyalkyl, hyaluronic acid, lactamide monoethanolamine, acetamide monoethanolamine, panthenol, allantoin, petroleum and their mixtures, 1-30C propoxylated glycols, or polyesters of sugars and related materials, urea, guanidine, sucrose polyester, panthenol, dexpanthenol, allantoin, glycerol, glycerin, hexylene glycol, ethoxylated glucose, 1,2-hexanediol, dipropylene glycol, trehalose, diglycerol, maltitol, maltose, sodium chondroitin sulfate, sodium hyaluronate, sodium adenosine phosphate, sodium lactate, pyrrolidone carbonate, glucosamine, cyclodextrin, or their mixtures, polyethylene glycol (PEG), polypropylene glycols having a molecular weight of up to 1000 and comprising PEG-200, PEG-400, PEG-600, PEG-1000 or their mixtures. The composition comprises at least one additional active agent comprising anti-wrinkle agent, which is D and L amino acids containing sulfur, preferably N-acetylated derivatives, N-acetyl-L-cysteine, thiols, comprising ethane thiol, hydroxy acids comprising lactic acid and glycolic acid or beta-hydroxy acids comprising salicylic acid and its derivatives comprising octanoyl derivative, lactobionic acid, keto acid comprising pyruvic acid, phytic acid, lysophosphatidic acid, ascorbic acid (vitamin C), stilbenes, cinnamates, resveratrol, kinetin, zeatin, dimethylaminoethanol, natural peptides comprising soy peptides, manganese gluconate or zinc gluconate, lipoic acid, peeling agents comprising phenol and other derivatives of vitamin B3, retinoids, retinol comprising 2-22C alkyl esters of retinol, retinyl palmitate, retinyl acetate, retinyl propionate, retinal and/or retinoic acid, tocopheryl-retinoate, adapalene (6-(3-(1-adamantyl)-4-methoxyphenyl)-2-naphthoic acid), tazarotene (ethyl 6-(2-(4,4-dimethylthiochroman-6-yl)ethynyl)nicotinate), other compounds of vitamin B comprising thiamine (vitamin B1), pantothenic acid (vitamin B5), riboflavin (vitamin B2), their derivatives and salts (e.g. hydrochloride salts or calcium salts). The composition includes at least one additional active agent comprising antiinflammatory drugs, which is antiinflammatory steroids comprising corticosteroids preferably hydrocortisone, antiinflammatory non-steroids comprising oxicams such as piroxicam, salicylates such as aspirin, acetic acid derivatives, such as felbinac, fenamate group, such as etofenamate, mefenamic acid, meclofenamic acid, flufenamic acid, propionic acid derivatives, such as ibuprofen, naproxen, pyrazoles, candelilla wax, bisabolol comprising alpha bisabolol, Aloe vera, plant sterols such as phytosterols, Manjistha, Guggal, extracts of red clover, Kola or Chamomile, extract of Piper methysticum, extract of Bacopa moniere, allantoin, compounds of the family of liquorice, glycyrrhetic acid, glycyrrhizic acid, monoammonium glycyrrhizinate, monopotassium glycyrrhizinate, dipotassium glycyrrhizinate, 1-beta glycyrrhetic acid, stearyl glycyrrhetinate, 3-stearyloxy glycyrrhetinic acid, and disodium 3-beta-succinyloxy glycyrrhetinate, diosgenol, saponins, sapogenins, lignans, triterpenes, saponins or aglycon. The composition includes at least one additional active agent comprising bleaching agents, which is kojic acid, arbutin, hydroquinone, aminophenol derivatives, N-cholesteryloxycarbonyl-para-aminophenol or N-ethyloxycarbonyl-para-aminophenol; iminophenol derivatives, L-2-oxothiazolidine-4-carboxylic acid or procysteine and its salts and esters, tranexamic acid, ascorbic acid or its derivatives comprising magnesium ascorbyl phosphate, sodium ascorbyl phosphate or ascorbyl glucoside; extract of mulberry, placenta, Scutellaria or Broussonetia, oil soluble liquorice, glycyrrhiza extract, camomile, m-tranexamic acid/ethyl vitamin C, disodium adenosine monophosphate, ellagic acid, rucinol, ethyl ascorbyl ether. The composition comprises at least one additional active agents comprising antioxidant, which is ascorbic acid (vitamin C) and its salts, ascorbyl esters of fatty acids, ascorbic acid derivatives (e.g. magnesium ascorbyl phosphate, sodium ascorbyl phosphate or ascorbyl sorbate), tocopherol (vitamin E), tocopherol sorbate, tocopherol acetate, other esters of tocopherol, butylated hydroxy benzoic acids and their salts, peroxides including hydrogen peroxide, perborate, the thioglycolates, persulfate salts, acid 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid, gallic or its alkyl esters, preferably propyl gallate, uric acid or its salts and alkyl esters, sorbic acid or its salts, lipoic acid, amines (e.g. N,N-diethylhydroxylamine, amino-guanidine), sulfhydryl compounds (e.g. glutathione), dihydroxy fumaric acid or its salts, lysine pidolate, amino acids, silymarin, lysine, 1-methionine, proline, superoxide dismutase, olive extracts, tea extracts, polyphenols comprising proanthocyanidins from bark of pine, carotenoids, curcumin compounds comprising tetrahydrocurcumin, L-2-oxo-4-thiazolidine carboxylic acid, glutathione, melanin, rosemary extracts, extracts of skin/grains of grapes or tocopherol sorbate. The composition comprises at least one additional active agents comprising sunscreen active agent, e.g. derivatives of para-aminobenzoic acid (PABA) comprising PABA, ethyl PABA, ethyl dihydroxypropyl PABA, ethylhexyl dimethyl PABA, glyceryl PABA or PEG-25 PABA; salicylic derivatives comprising homosalate, ethylhexyl salicylate or dipropylene salicylate; dibenzoylmethane derivatives comprising butyl methoxydibenzoylmethane or isopropyl dibenzoylmethane; cinnamic acid derivatives comprising ethylhexyl methoxycinnamate, isopropyl methoxycinnamate, isoamyl methoxycinnamate, diisopropyl methyl cinnamate, glyceryl dimethoxycinnamate ethylhexanoate, beta , beta '-diphenylacrylate derivatives comprising octocrylene or etocrylene; benzylidene camphor derivatives comprising 3-benzylidene camphor, 4-methylbenzylidene camphor, benzylidene camphor sulfonic acid, camphor benzalkonium methosulfate, terephthalylidene dicamphor sulfonic acid, polyacrylamidomethyl benzylidene camphor; phenyl-benzimidazole derivatives comprising phenylbenzimidazole sulfonic acid, derivatives of triazine comprising anisotriazine, ethylhexyl triazone, diethylhexyl butamido triazone; phenyl benzotriazole derivatives comprising drometrizole trisiloxane; anthranilic acid derivatives comprising menthyl anthranilate; or benzalmalonate comprising polyorganosiloxane with benzalmalonate functions. (I) is used in the form of a solution, dispersion, emulsion, paste or powder, individually or in pre-mixed form or is conveyed individually or premixed by vectors comprising macrocapsules, microcapsules or nanocapsules, macrospheres, microspheres or nanospheres, liposomes, oleosomes or chylomicrons, macroparticles, microparticles or nanoparticles, macrosponges, microsponges or nanosponges, microemulsions, or nanoemulsions, or adsorbed on powdered organic polymers, talcs, bentonites and other minerals or organic material, preferably liposomes. ACTIVITY - Dermatological.    MECHANISM OF ACTION - Cluster of differentiation-44 (CD44) receptor stimulator.    EXAMPLE - No preparative example given.