TECHNOLOGY FOCUS - BIOTECHNOLOGY - Preferred Components: The ketoreductase enzyme is ES-KRED-104, ES-KRED-105, ES-KRED-106, ES-KRED-107, ES-KRED-1 15, ES-KRED-117, ES-KRED-118, ES-KRED-119, ES-KRED-120, ES-KRED-121, ES-KRED-125, ES-KRED-128, ES-KRED-133 and/or ES-KRED-42; or is associated with a co-factor selected from hydrogenated nicotinamide adenine dinucleotide, hydrogenated nicotinamide adenine dinucleotide phosphate, nicotinamide adenine dinucleotide ion, nicotinamide adenine dinucleotide phosphate ion, or their salts. The lipase is Porcine Pancreatic Lipase, Candida antartica lipase A, lyophilized Candida lipolytica Lipase, Geotrichum candidum Lipase, Pseudomonas aeruginosa Lipase, Aspergillus niger Lipase, Pseudomonas fluorescens Lipase, Candida rugosa Lipase, Rhizopus delemar Lipase, Rhizopus oryzae Lipase, Penicillium camembertii Lipase, Mucor javanicus Lipase, Penicillium roqueforti Lipase, Pseudomonas cepacia Lipase, P. cepacia D-1, C. antartica lipase B (CAL-B), lyophilized microbial, lyophilized Lipase, Thermomyces Lipase, Alcaligenes, Chromobacterium viscosum Lipase, Candida utilis Lipase, Rhizopus niveus Lipase, Pseudomonas Lipoprotein Lipase, Thermomyces lanuginosus Lipase, Rhizomucor miehei Lipase, Wheat Germ Lipase, Rhizopus arrhizus Lipase, Pancreatic Lipase 250, or C. antartica lipase B.    TECHNOLOGY FOCUS - INORGANIC CHEMISTRY - Preferred Component: The Lewis acid is titanium tetrachloride.    TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preparation (claimed): Compound (III) is prepared by protecting a hydroxy derivative of formula (IV) with a protecting agent, hydrolyzing obtained product, reacting obtained product with a pivaloyl chloride, acylating the product with a chiral auxiliary of formula (V), reacting obtained product with a protected amine of formula (VI) in a solvent in the presence of an organic amine base and Lewis acid to obtain (I), reacting (I) with an alkali metal oxide or aryloxide in a solvent to obtain (II), and cyclizing (II) in the presence of non-nucleophilic base to obtain (III). Preferred Components: The hydroxy protecting group is benzyl or silyl protecting group. The chiral auxiliary is (4S)-4-phenyl-2-oxazolidinone. The solvent is dichloromethane. The organic amine base is N,N-diisopropylethylamine. The alkali metal alkoxide is sodium methoxide. The non-nucleophilic base is lithium bis(trimethylsilyl)amide or bistrimethyl acetamide. The solvent is a water miscible organic solvent selected from 1-6C alcohol or dimethylsulfoxide; or toluene, hexane, cyclohexane, heptane, dimethylformamide and/or dichloromethane. The acylating agent is vinyl acetate, vinyl propionate, isopropenyl acetate, succinic anhydride or acetic anhydride. ACTIVITY - Antilipemic. No biological data given.    MECHANISM OF ACTION - None given.    SPECIFIC COMPOUNDS - 1 Compound (III) is specifically claimed, i.e. formula (IIIa).    EXAMPLE - No suitable example given.