TECHNOLOGY FOCUS - BIOLOGY - Preferred Process: The steps (b) and (c) are performed for essentially identical time periods of 10-15 (preferably 12) hours. The difference between the first and second temperature condition is 3-20 degrees C, preferably 5-15 degrees C. The process for producing an antibiotic using microorganisms comprises: (i) providing a microorganism capable of producing an antibiotic in cultivation medium; (ii) culturing the microorganism under a first temperature condition at 18-23 degrees C for 10-15 hours; (iii) culturing the microorganism under a second temperature condition at 27-32 degrees C for 10-15 hours; (iv) alternating steps (ii) and (iii) to generate a culture of the microorganism that exhibits a rhythmic production with circadian periodicity with respect to the antibiotic; and (v) arresting the cultivation of the microorganism during or after the rhythmic production, and (vi) recovering the antibiotic from the culture. The process for producing the beer using microorganisms comprises: (g) providing a culture of yeast suitable for making beer, preferably Saccharomyces cerevisiae, in a suitable cultivation medium; (h) culturing the yeast at 20-22 degrees C for 8-30 hours, preferably 10-15 hours; followed by (i) culturing the yeast at 27-29 degrees C for 8-30 (preferably 10-15) hours; (j) alternating steps (h) and (i) to generate a yeast culture that exhibits a rhythmic production with circadian periodicity with respect to the beer composition; (k) arresting the yeast cultivation during or after the rhythmic production; and (l) recovering the culture medium and preparing a beer. The first and/or second cultivation condition comprises continuous culture conditions. Preferred Components: The compound or composition is a constituent of the cells of the microorganism. The culture medium, optionally includes the microorganism. The microorganism is fungi, bacteria or microalgae, preferably yeast. The microorganism comprises Streptomyces, Penicillium sp. (both preferred), Saccharomyces cerevisiae, Penicillium chrysogenum, Lactococcus and Bacillus subtilis. EXAMPLE - No suitable example given.