TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preparation (Disclosed): An oxime group-containing compound of formula (II) is halogenated using halogenating agent, to obtain halogen-containing compound of formula (III). The obtained compound (III) and substituted phenyl compound of formula (IV) are reacted in presence of base, to obtain compound (I).J5=halo, preferably chloro or bromo. Full Definitions:    A1-A3=C-Y2 or N;    X1=halo, -SF5, 1-6C haloalkyl, hydroxy 1-4C haloalkyl, 1-4C alkoxy 1-4C haloalkyl, 1-6C haloalkoxy, 1-4C haloalkoxy 1-4C haloalkoxy or 1-6C haloalkylthio;    X2=H, halo, cyano, nitro, 1-6C (halo)alkyl, -OR5 or -S(O)rR5;    X3=H, halo, 1-6C alkyl, 1-6C haloalkoxy or -NH2;    or X3+X1 or X2=-CF2OCF2-, -OCF2O-, -CF2OCF2O- or -OCF2CF2O-;    C+X3+X1 or X2=5-membered ring or 6-membered ring;    Y1=H, halo, cyano, nitro, 1-6C alkyl, 1-6C haloalkyl in which the 1-4C alkyl is optionally substituted by R6, 2-6C alkenyl, 2-6C alkynyl, -OR5, -S(O)rR5 or -N(R8)R7, -C(S)NH2 or group chosen from formulae (i)-(iv), (viii) and (x);    Y2=H, halo or methyl;    or 2 adjacent groups of Y2=-CH2CH2CH2-, -CH2CH2O-, -CH2OCH2-, -OCH2O-, -CH2CH2S-, -CH2SCH2-, -SCH2S-, -CH2CH2CH2CH2-, -CH2CH2CH2O-, -CH2CH2OCH2-, -CH2OCH2O-, - OCH2CH2O-, -OCH2CH2S-, -SCH2CH2S-, -OCH=N-, -SCH=N-, -CH=CHCH=CH-, -CH=CHCH=N-, -CH=CHN=CH-, -CH=NCH=CH- or -N=CHCH=CH-;    or Y2+C=5-membered ring or 6-membered ring;    R1=-C(O)R1a or -C(S)R1a;    R1a=-C(R9)(R9a)-S(O)r-R10, -C(R9)(R9a)-S(O)t(R10)=NR11 or sulfur-containing saturated heterocyclic ring of formula (xv-xx);    R2=H, cyano, 1-6C alkyl in which 1-4C alkyl is optionally substituted by R13, 3-6C cycloalkyl, 3-6C alkenyl, 3-6C alkynyl, 1-6C alkyl carbonyl, 1-6C alkoxycarbonyl or 1-6C alkoxy;    R3=1-6C haloalkyl or 3-8C halocycloalkyl;    R4=H, cyano, 1-6C (halo)alkyl, 3-6C cycloalkyl, 2-6C alkynyl, -C(O)NH2, -C(S)NH2, phenyl or aromatic heterocyclic group of formula (vi) or (vii);    R5=1-6C (halo)alkyl;    R6=-OH, 1-4C alkoxy, 1-4C alkylthio, 1-4C alkylsulfinyl, or 1-4C alkylsulfonyl;    R7=H, 1-6C alkyl, -CHO, 1-6C alkyl carbonyl or 1-6C alkoxycarbonyl;    R8=H or 1-6C alkyl;    R9=H, halo, 1-6C alkyl, 1-6C alkoxy, 1-6C alkylthio, 1-6C alkylsulfinyl or 1-6C alkylsulfonyl;    R9a=H, halo or 1-6C alkyl;    or R9a+R9=ethylene chain or cyclopropyl ring;    R10=cyano, 1-6C alkyl, 1-4C alkyl optionally substituted by R14, 3-6C cycloalkyl, 2-6C (halo)alkenyl, 2-6C (halo)alkynyl, -C(O)R15, -C(O)OR16, -C(O)SR16, -C(O)NH2, -C(O)N(R17)R16, -C(S)R15, -C(S)OR16, -C(S)SR16, -C(S)NH2, -C(S)N(R17)R16, partially saturated heterocyclic ring of formula (xxi)-(xxvi), phenyl or aromatic heterocyclic group chosen from formulae (vi), (vii), (ix), (xi) and (xii)-(xiv);    R11=H, cyano, nitro, 1-6C (halo)alkyl, -C(O)R15, -C(O)OR16 or 1-6C (halo)alkylsulfonyl;    R12=fluoro, nitro, -OH or 1-4C (halo)alkyl;    R13=halo, cyano, 3-6C cycloalkyl, -OR20, -S(O)rR21, -N(R23)R22, -C(O)R24, -C(O)OR25, -C(O)SR25, -C(O)NH2, -C(O)N(R26)R25, -C(S)OR25, -C(S)SR25, -C(S)NH2, -C(S)N(R26)R25, phenyl or group chosen from 14 aromatic heterocyclic groups e.g. groups of formulae (i)-(v);    R14=halo, cyano, 3-6C cycloalkyl, -OR20, -S(O)rR21, -C(O)R24, -C(O)OR25, -C(O)NH2, -C(O)N(R26)R25, -C(S)NH2, phenyl, or aromatic heterocyclic group of formula (xi);    R15=1-6C (halo)alkyl, 3-6C cycloalkyl, 2-6C alkenyl, 2-6C alkynyl, phenyl optionally substituted by (Z)p1 or aromatic heterocyclic group of formula (i), (ii), (iv), (v), (vii), (viii), (x) or (xi);    Z=halo, cyano, nitro, 1-6C (halo)alkyl, 1-4C (halo)alkoxy, 1-4C (halo)alkylthio, 1-4C (halo)alkylsulfinyl or 1-4C (halo)alkylsulfonyl;    R16=1-6C (halo)alkyl, 3-6C cycloalkyl, 2-6C alkenyl or 2-6C alkynyl;    R17=H or 1-6C alkyl;    or R17+R16+N=4-6 membered ring;    or R16+R17=3-5C alkylene chain optionally having oxygen, sulfur or nitrogen, and 1-4C alkyl, -CHO, 1-4C alkyl carbonyl, 1-4C alkoxycarbonyl or oxo;    R18=H or 1-4C (halo)alkyl;    R19=fluoro or 1-4C (halo)alkyl;    R20=1-4C (halo)alkyl, -C(O)R27 or -C(O)OR28;    R21,R24,R28=1-4C (halo)alkyl;    R22=1-4C alkyl, -C(O)R27 or -C(O)OR28;    R23=H or 1-4C alkyl;    R25=1-4C (halo)alkyl or 3-6C cycloalkyl;    R26=H or 1-4C alkyl;    or R26+R25+N=4-6 membered ring;    or R25+R26=3-5C alkylene chain optionally having oxygen, sulfur or nitrogen, and 1-4C alkyl, -CHO, 1-4C alkyl carbonyl, 1-4C alkoxycarbonyl or oxo;    R27=1-4C (halo)alkyl, 3-6C cycloalkyl, phenyl optionally substituted by (Z)p1, group of formula (i), (ii), (v), (vii) or (xi);    p1=1-3;    p2,q4,q5,r=0-2;    p3,p4,t=0 or 1;    q1=0-7;    q2=0-9;and    q3=0-5.    When X1 and X2 are chloro simultaneously, X3 is halo, 1-6C alkyl, 1-6C haloalkoxy or -NH2. Preferred Definitions:    X1=bromo or trifluoromethyl;    X2=chloro, bromo, iodo or trifluoromethyl;    X3=H or fluoro;    Y1=chloro, bromo or iodo;    R9=H;    R1a=-C(R9)(R9a)-S(O)r-R10, -C(R9)(R9a)-S(O)t-(R10)=NR11 or group of formula (xv);    R2=H, methyl, ethyl, methyl substituted by R13, allyl or propargyl;    R3=1-2C haloalkyl;    R4=H, cyano, methyl, ethynyl or -C(S)NH2;    R9=H, fluoro, methyl, ethyl, 1-2C alkylthio or 1-2C alkylsulfinyl;    R9a=H or fluoro;    R10=methyl, ethyl, 1-2C haloalkyl or cyanomethyl;    R11=H or 1-2C haloalkyl carbonyl;    R13=cyano, cyclopropyl, 1-2C alkoxy, -C(O)OR25, -C(O)NH2, -C(O)N(R26)R25 or -C(S)NH2;    R25=methyl or ethyl;and    R26=H or methyl.    ACTIVITY - Insecticide; Acaricide; Antiparasitic. In a test for measuring insecticidal activity with respect to Plutella xylostella using Canarium album leaf, the N-(2-chloro-(4-(5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl)phenyl)methyl)-2-(methylthio)acetamide exhibited an insecticidal rate of 80% or more.    MECHANISM OF ACTION - None given.    SPECIFIC COMPOUNDS - Approximately 2494 substituted isoxazoline compounds are disclosed, e.g. N-(2-chloro-(4-(5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl)phenyl)methyl)-2-(methylthio)acetamide of formula (Ia), N-(1-(4-(5-(3,5-bis(trifluoromethyl)phenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl)phenyl)ethyl)-2-(methylthio)acetamide, N-(4-(5-(3,5-bis(trifluoromethyl)phenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl)phenyl)cyano)methyl-2-(ethylthio)acetamide, N-(2-chloro-(4-(5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl)phenyl)methyl)-2-(ethylthio)-N-methyl acetamide and N-(4-(5-(3-bromo-5-(trifluoromethyl)phenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl)-2-chlorophenyl)methyl-2-(methylsulfonyl)acetamide.    EXAMPLE - 3-(4-Aminophenyl-3-chlorophenyl)-5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole (in g) (0.11), 1-(3-(dimethylamino)propyl)-3-ethyl(methylthio)carbodiimide (0.092), acetic acid (0.051) and chloroform solution (2 ml) of triethylamine (0.048) were mixed at room temperature for 15 hours and reacted. Aqueous saturated sodium hydrogencarbonate solution (2 ml) was then added to the resultant reaction mixture, fractionated and purified, to obtain N-(2-chloro-(4-(5-(3,4,5-trichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl)phenyl)methyl)-2-(methylthio)acetamide (0.12) (Ia).