TECHNOLOGY FOCUS - BIOTECHNOLOGY - Preferred Method: In the method above, the mixture in (a) further comprises at least one of furfural, phenolics compounds and acetic acid. The mixture in (a) is obtained from a biomass, where the biomass is a plant biomass. The biomass is obtained from plant or animal waste. The plant biomass undergoes pretreatment by acid hydrolysis and heat treatment to produce the mixture inoculated in (a). It comprises: 5-35% lignin; 10-35% hemicellulose; and 10-60% cellulose. The plant biomass is obtained from at least one selected from switchgrass, corn stover, and mixed waste of plant. The at least one microorganism strain is an extracellular and/or intracellular cellulase, hemicellulase, and laccase enzyme producer microorganism, where the extracellular and/or intracellular cellulase, hemicellulase, and laccase enzyme producer is selected from prokaryote, bacteria, archaea, eukaryote, yeast and fungi. Preferably, the extracellular and or intracellular cellulase producer is a fungus or bacteria selected from Humicola, Trichoderma, Penicillium, Ruminococcus, Bacillus, Cytophaga and Sporocytophaga, Humicola grisea, Trichoderma harzianum, Trichoderma lignorum, Trichoderma reesei, Penicillium verruculosum, Ruminococcus albus, Bacillus subtilis, Bacillus thermoglucosidasius, Cytophaga spp., Sporocytophaga spp. and Clostridium lentocellum. The at least one microorganism strain is a bacteria. The at least one microorganism strain is Clostridium lentocellum. Additionally, the at least one microorganism strain produces at least one fermentation product selected from acetate, acetone, 2,3-butanediol, butanol, butyrate, carbon dioxide (CO2), ethanol, formate, glycolate, lactate, malate, propionate, pyruvate, and succinate, and other fermentation products. At least one microorganism strain has been evolutionarily modified to metabolize pretreated biomass targeted more efficiently. At least one evolutionarily modified microorganism strain produces one or more cellulases, hemicellulases and/or laccases so that the evolutionarily modified microorganism strain has greater capacity to metabolize cellulose and hemicelluloses with lignin as compared to the unmodified wild-type version of the microorganism. At least one microorganism strain has been evolutionarily modified by at least one method selected from serial transfer, serial dilution, genetic engine, continuous culture, and chemostat. The method is continuous culture. The at least one evolutionarily modified microorganism strain is an anaerobic bacteria strict or not. The at least one microorganism strain is Clostridium lentocellum and has been evolutionarily modified by continuous culture. At least one microorganism strain has been evolutionary modified for a specific biomass plant. The one or more cellulases is at least one selected from endoglucanase, exoglucanase, and beta-glucosidase, hemicellulases, and optionally laccase. The method further comprises measuring cellulase activity and/or the amount of fermentation products in (a), and depending on the quantity of the fermentation product in the supernatant, proceeding to (b). At the start of (b), the mixture is filtered and transferred to another bio-reactor. In (c), the mixture is also filtered to separate solid components and the microorganism strain inoculated in the first bio-reactor from the fermentation products. In (b), a portion of the at least one fermentation product is removed and transferred to another bio-reactor. The portion of the at least one fermentation product in (b) comprises one or more alcohol. The one or more alcohols is removed from the portion of the at least one fermentation product by a distillation process. The remaining portion of the mixture without the removed alcohol from the bio-reactor in (b) is transferred in (c) to the second bio-reactor. At least one algae strain in (d) is selected from green algae, red algae, blue-green algae, cyanobacteria and diatoms. The at least one algae strain in (d) is selected from Monalanthus salina; Botryococcus braunii; Chlorella prototecoides; Outirococcus sp.; Scenedesmus obliquus; Nannochloris sp.; Dunaliella bardawil (Dunaliella salina); Navicula pelliculosa; Radiosphaera negevensis; Biddulphia aurita; Chlorella vulgaris; Nitzschia palea; Ochromonas dannica; Chrorella pyrenoidosa; Peridinium cinctum; Neochloris oleabundans; Oocystis polymorpha; Chrysochromulina spp.; Scenedesmus acutus; Scenedesmus spp.; Chlorella minutissima; Prymnesium parvum; Navicula pelliculosa; Scenedesmus dimorphus; Scotiella sp.; Chorella spp.; Euglena gracilis; and Porphyridium cruentum. The at least one algae strain in (d) has been evolutionarily modified to metabolize the at least one fermentation product. Growth of the at least one algae strain in (d)is not inhibited by the presence of one or more of lignin, furfural, phenolics compounds, salts, cellulase enzymes and hemicellulase enzymes. The at one algae strain in (d) can grow in one or more conditions selected from aerobic, anaerobic, phototrophic, and heterotrophic. Additionally, the at least one algae strain in (d) has been evolutionarily modified to heterotrophically and/or phototrophically metabolize as a carbon source the at least one fermentation products (secondary metabolite) and the at least one algae strain can optionally metabolize as a carbon source soluble sugars released by a pretreatment of the mixture prior to (a) and soluble sugars released by the enzymatic activity of the microorganism strain during (a). The at least one algae strain in (d) has been evolutionarily modified by at least one method selected from serial transfer, serial dilution, genetic engine, continuous culture, and chemostat. At least one algae strain is Chlorella protothecoides which has been evolutionarily modified by the continuous culture method. At least one algae strain in (d) further metabolizes at least one of glucose, cellobiose, xylose, mannose, galactose, rhamnose, arabinose or other hemicellulose sugars, and waste glycerol. At least one algae strain in (d) uses acetic acid as a carbon source. Culturing in (d) is under heterotrophic conditions. At least one algae strain in (d) produces no inhibitory by-product that inhibits growth of the algae. The method further comprises: (v) recovering the one or more fatty acids from the at least one algae strain. Recovering step (v) comprises at least one selected from filtration-centrifugation, flocculation, solvent extraction, ultrasonication, microwave, pressing, distillation, thermal evaporation, homogenization, hydrocracking (fluid catalytic cracking), and drying of the at least one algae strain containing fatty acids. Supernatant recovered in (e) is reused. Step (d) further comprises culturing and growing the at least one algae strain under conditions for extracellular and/or intracellular production of at least one compound selected from fatty acids, hydrocarbons, proteins, pigments, sugars, such as polysaccharides and monosaccharides, and glycerol. The at least one compound can be used for biofuel, cosmetic, alimentary, mechanical grease, pigmentation, and medical use production. At least one algae strain produces hydrocarbon chains which can be used as feedstock for hydrocracking in an oil refinery to produce one or more compounds selected from octane, gasoline, petrol, kerosene, diesel and other petroleum product as solvent, plastic, oil, grease and fibers. The method also comprises, after step (d), direct transesterification of cells of the at least one algae strain to produce fatty acids for biodiesel fuel, where direct transesterification comprises breaking the algae cells, releasing fatty acids and transesterification through a base or acid method with methanol or ethanol to produce biodiesel fuel. At least one algae strain is adapted to use waste glycerol, as carbon source, produced by the transesterification reaction without pretreatment or refinement to produce fatty acids for biodiesel production. EXAMPLE - No suitable example given.