TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Process: In the process, the stirring step is carried out at 20-35 degrees C for 15-75 minutes. Preferred Components: The solvent is methylene chloride. ACTIVITY - Gastrointestinal-Gen.. No biological data given.    MECHANISM OF ACTION - Gastric proton pump inhibitor. No biological data given.    EXAMPLE - 2-(((4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl)methyl)thio)-1H-benzimidazole (130 kg) was dissolved in methylene chloride (780 l) stirred at 25-35 degrees C and cooled the reaction mass to 0-5 degrees C. Sodium hypochlorite solution (975 l) was added to the reaction mass for 1 hour 30 minutes at 0-5 degrees C and stirred. Ammonium sulphate (122 kg), water (1000 l), methylene chloride (250 l) and sodium chloride (130 kg) were added to the reaction mass, stirred for 30 minutes at 5-10 degrees C and allowed to settle for 15 minutes. The bottom organic layer was separated twice by treating with methylene chloride, stirred and allowed to settle for 15 minutes. Water (1300 l) and sodium hydroxide flakes (50 kg) were added to the reactor cooled to 20- 25 degrees C and then added the methylene chloride layer to the reactor. Sodium chloride (50 kg) was added to the reaction mixture, stirred for 20 minutes and allowed to settle for 20 minutes. The bottom organic layer was separated. The pH of the aqueous layer was adjusted to 9.2-9.4 with ammonium acetate solution and acetic acid solution. The bottom organic layer was separated twice by treating with methylene chloride, stirred and allowed to settle for 15 minutes. The organic layer was given carbon treatment, filtered and washed the filtrate with methylene chloride (50 L). Dried the total organic layers with sodium sulfate (20 kg) and 2-Amino ethanol (1.8 l) was added. The organic layer was concentrated until the mass temperature reached to 40- 45 degrees C. Acetonitrile (50 l) was added to the reaction mass and acetonitrile was distilled off from the reaction mass until the mass temperature reached to 40-45 degrees C. Acetonitrile (600 l) was added to the reaction mass, stirred for 2 hours at room temperature and cooled to 0-5 degrees C. Centrifuged the material twice, washed with acetonitrile and dried to give crude rabeprazole. Monomethylamine (135 l) in water (765 l) was cooled to 10-20 degrees C, added crude rabeprazole and stirred for dissolution. The bottom organic layer was separated twice by treating with methylene chloride, stirred and allowed to settle for 15 minutes. The pH of the aqueous layer was adjusted to 9.6-9.8 with ammonium acetate solution. The bottom organic layer was separated twice by treating with methylene chloride, stirred and allowed to settle for 15 minutes. The total organic layer was washed with sodium chloride solution, given carbon treatment, filtered, washed the filtrate with methylene chloride (50 l) and 2-amino ethanol (0.54 l) was added. The organic layer was concentrated until the mass temperature reached to 35-40 degrees C. Acetonitrile (90 l) was added to the reaction mass and acetonitrile was distilled off from the reaction mass until the mass temperature reached to 35-40 degrees C. Acetonitrile (270 l) was added to the reaction mass, cooled to 25-35 degrees C, stirred for 1 hour and 30 minutes, cooled to 0-5 degrees C and stirred for 1 hour. Centrifuged the material, washed with acetonitrile (50 l) and dried the material to obtain rabeprazole. Rabeprazole was added to the solution and stirred at 25-35 degrees C for 1 hour. Methanol was distilled off from the reaction mass, dichloromethane (150 l) was added to the residual mass and the contents were stirred to obtain solution. The solution was added to cyclohexane (1080 l). The contents were stirred at 25-35 degrees C for 30 minutes, centrifuged the material and washed at 60-65 degrees C to obtain amorphous rabeprazole sodium (69 kg).