TECHNOLOGY FOCUS - BIOTECHNOLOGY - Preferred Method: The method further involves fermenting hexose and pentose saccharides using second microorganism. The method further involves adding one or more medium supplements comprising hexose or pentose saccharides to the medium during the growth of the first microorganism. The method further involves pretreatment of biomass. The pretreatment involves steam explosion or hot water extraction, or exposure to acid or alkaline conditions. The method further involves adding fermentation medium supplement chosen from fatty acid, surfactant, chelating agent, vitamins, minerals, pH modifiers, yeast extract and salts. The method further involves adding one or more enzymes, where the enzymes are not derived from first microorganism. The method further involves fed-batch fermentation of biomass with bolus addition of biomass solids. The biomass solids are recovered using sieve. The sieve comprises several apertures of 150-250 microns in diameter. Preferred Components: The hexose saccharides are chosen from cellulose, hemicellulose, starch, mannan, fructose, glucose, galactose, rhamnose and mannose. The pentose saccharides are chosen from xylan, hemicellulose, xylose and arabinose. The hexose or pentose saccharides are added in relation to amount of sugar converted by the first microorganism to other compounds. The hexose and pentose saccharides comprise malt syrup, corn steep liquor, distillers dried grains or corn steep solids. Preferred Microorganism: The first microorganism is Clostridium strain, preferably C.phytofermentans. The second microorganism is Saccharomyces cerevisiae, C.thermocellum, C.acetobutylicum, C.cellulovorans, or Zymomonas mobilis. The C.phytofermentans is nonrecombinant or recombinant microorganism. The C.phytofermentans comprises one or more heterologous polynucleotides. The first microorganism simultaneously ferments the hexose and pentose saccharides. Preferred Enzymes: The enzymes are chosen from cellulase, hemicellulase, galacturonase, pectate lyase, carbohydrase, xylanase, glucanase, endoglucanase, exoglucanase, glucosidase, amylase, phytase and laccase. EXAMPLE - No suitable example given.