NOVELTY - Controlled release composition (I) comprises many microparticles operably linked to a matrix, where: the microparticles comprise a first material and a first active agent; the matrix comprises a second material; the first material comprises an initial melting temperature (TH); the second material comprises a complete melting temperature (TL), where Delta T is equal to TH-TL and the Delta T is greater than 0.    USE - (I) is useful for treating condition, which is a pathological condition e.g. aging, angina, antithrombin deficiency, arrhythmia, atherosclerosis, artrial fibrillation, atrial flutter, blood clots, cardiac ischemia, cardiac surgery, cardiomyopathy, cardiovascular abnormalities, carotid artery disease, chest pain, circulation disorders, claudication, collagen vascular diseases, congenital heart diseases, congestive heart failure, coronary artery disease, type I and II diabetes mellitus, diabetes and hypertension, dyslipidemia, dysrhythmia, elevated triglycerides, heart disease, heart failure, heart valve disease, hemangioma, high chlolesterol, hypertriglyceridemia, intermittent claudication, hypertension, Kawasaki disease, heart attack, myocardial ischemia, orthostatic hypotension, peripheral arterial disease, peripheral arterial occlusive disease, peripheral vascular disease, Raynaud's disease, smoking cessation, tachycardia (fast heart rate), varicose veins, vascular diseases, venous leg ulcers, gingivitis, gum diseases, halitosis, oral cancer, periodontal disease, temporomandibular disorders, temporomandibular joint syndrome, sunburn, acne, skin aging, alopecia, anesthesia, athlete's foot, atopic dermatitis, bed sores (decubitus ulcers), bunions, burns, burn infections, cold sores (herpes labialis infections), congenital skin diseases, contact dermatitis, cutaneous lupus erythematosus, diabetic foot ulcers, eczema, excessive sweating, fabry disease, fungal infections, genital herpes, genital warts, hair loss, hair removal, hand dermatitis, head lice, hemangioma, hereditary angioedema, herpes simplex infections, herpes Zoster infections, herpetic neuralgia, hives, ichthyosis, ischemic foot ulcers, keratoses, lupus, male pattern baldness, malignant melanoma, medical prosthetics, melanoma, molluscum contagiosum, mycosis fungoides, onychomycosis, pemphigus vulgaris, post-herpetic neuralgia, pressure ulcers, psoriasis and psoriatic disorders, psoriatic arthritis, razor bumps, rosacea, sarcoidosis, scalp disorders, scar tissue, scleroderma, seborrhea, seborrheic dermatitis, shingles, skin cancer, skin infections, skin lipomas, skin wounds, solar lentigines, sporotrichosis, staphylococci skin infections, stasis dermatitis, stretch marks, systemic fungal infections, sun poisoning, ringworm, tinea capitis, tinea versicolor, urticaria, vitiligo, warts, acromegaly, adrenal cancer, congenital adrenal hyperplasia, diabetic gastroparesis, diabetic kidney disease, diabetic macular edema, diabetic neuropathy, diabetic retinopathy, diabetic vitreous hemorrhage, dyslipidemia, female hormonal deficiencies/abnormalities, Fredrickson type III, hyperlipoproteinemia, growth hormone deficiencies/abnormalities, gynecomastia, hot flush, hyperparathyroidism, idiopathic short stature, indication, male hormonal deficiencies/abnormalities, menopause disorders, metabolic syndrome, obesity, pancreatic cancer, pancreatic disorders, pancreatitis, parathyroid cancer, parathyroid disease, perimenopause, pituitary disorders, polycystic ovarian syndrome, post menopause disorders, post menopause osteopenia, precocious puberty, primary insulin hypersecretion, severe short stature, sexual dysfunction, thyroid disease, thyroid disorders, Turner syndrome, Wilms' tumor, Wilson's disease, abdominal cancer, achalasia, alpha -1 antitrypsin deficiency, anal fissures, appendicitis, Barrett's esophagus, biliary tract cancer, bowel dysfunction, celiac disease, chronic diarrhea, clostridium difficile-associated diarrhea, colon cancer, colon polyps, colorectal cancer, constipation, Crohn's disease, diabetic gastroparesis, digestive system neoplasms, duodenal ulcers, fecal incontinence, functional dyspepsia, gall bladder disorders, gastric cancer, gastric ulcers, gastroenteritis, gastroesophageal reflux disease, gastrointestinal disease and disorders, heart burn, helicobacter pylori and hemorrhoids; and the condition is cosmetic condition e.g. skin aging (e.g. wrinkling, loss of elasticity, sagging, uneven pigmentation, and loss of underlying tissue mass), undesired pigmentation, or post-cosmetic procedure damage resulted from e.g. chemical peel, dermabrasion, laser resurfacing, ablative resurfacing, nonablative resurfacing, photodynamic therapy, noncoherent light photo therapy, breast lift, face lift, eyelid lift, forehead lift, neck lift, thigh lift, buttock lift, tummy tuck, and scar revision (all claimed). The ability of (I) to inhibit tumor growth was tested in d7 H22 passage mice. The result showed that (I) (5 mg/kg) exhibited the 20.43% of tumor growth inhibition.    ADVANTAGE - (I) has improved physical, chemical, and/or pharmaceutical properties e.g. more stable, has longer shelf life, require no solvent reconstitution, and is less prone to leaking when implanted (such as, when implanted into a solid tumor). The first and second materials are biodegradable materials, which are break down or degrade into non-toxic components in vivo, without causing harm to the body. (I) can be easily taken out from the subject after a period of time. (I) can be administered in a significantly lower dosing frequency. The release period of the active agent in (I) reaches weeks, months or even years, and thus reduce the necessity of frequent dosing and improve patient's compliance.    DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for making (I) comprising: preparing microparticles comprising a first material and a first active agent; and applying the microparticles to a matrix-forming composition.