TECHNOLOGY FOCUS - INORGANIC CHEMISTRY - Preferred Components: The base is sodium hydroxide, ammonium hydroxide (both preferred), calcium hydroxide, and magnesium hydroxide. The sodium sulfite is 5-60 wt.%, while the base is 5-25 wt.%.    TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Process: The lignocellulosic biomass used in the process does not require mechanical (pre)treatment and/or the sulfite cooking step (a), which is the only chemical (pre)treatment prior to hydrolysis. The pH value at which the sulfite cook of the pretreatment step (a) is performed at higher than 5, preferably higher than 9. In the process, 80% or more, preferably 95% or more of the cellulose is initially present in the lignocellulosic biomass, which is present in the pulp after step (a). The acid cook is performed as only chemical pretreatment step (a), preferably 70% or more of the overall hemicellulose from the lignocellulosic biomass, which is hydrolyzed to monosaccharides. The sulfite pretreatment step is an acid cook at 125-160 degrees C. In the sulfite pretreatment step, the sulfur dioxide is present at 10-60 wt.% and base (hydroxide ion) is present at 1-10 wt.%, preferably 2-7%. The sulfite pretreatment step is a weak alkaline cook, and sodium sulfite is present at 10-60 (preferably 5-25) wt.%. The cook is performed for a time interval of 45-300 minutes. The hydrolysis step (c) is an enzymatic hydrolysis step, preferably employing extracellular or cell-membrane associated enzyme complexes, in particular mixture of cellulases and beta -glucosidases that can specifically hydrolyze the cellulose polymer into monosaccharides such as soluble glucose monomers. The hydrolysis step (c) is an enzymatic hydrolysis step and enzymes are recycled, by substrate adsorption and/or membrane separation. The bagasse is used as the raw material and fermentation step (d) comprises the metabolizing of the hydrolyzate of step (c) into biofuels such as ethanol and butanol, and into biomass proteins. In the process, an oxygen/alkali delignification step is part of the overall integrated process and is preferably performed after the (pre)treatment step (a) and before the separation step (b). The cook is performed for a time interval of 60-300 minutes. The sulfite pre-treatment step is an alkaline cook at 130-180 degrees C. The alkaline cook is performed as the pretreatment step (a) and 80% or more of the overall lignin from the lignocellulosic biomass is present in the liquid SSL phase. Preferred Components: The monosaccharides comprise hexoses and pentoses. The hexoses and pentoses comprise xylose and glucose. The lignocellulosic biomass comprises wood, annual plants, agricultural residues or waste, in particular bagasse or energy crops. The organic part of the liquid SSL phase predominantly comprises lignin (i.e. at least 50% of the lignin initially present in the lignocellulosic biomass, preferably more than 80%) in the form of sulfonated lignin. The enzymes comprise cellulases, hemicellulases and beta -glucosidases. EXAMPLE - Bagasse (82%) was mixed with a cooking liquor comprising sodium hydroxide (6%) and sodium sulfite (24%) with liquid to solid ratio of 6-1. The mixture was heated at 170 degrees C with the temperature increase of 1.6 degrees C/minute. The cook was kept at 170 degrees C for 60 minutes. After the cook, pulp (comprising cellulose corresponding to 57% of glucose, xylan corresponding to 24% of xylose, 2% other carbohydrates, 5% lignin, 4% ash and 8% undefined components) (51%) and the liquid (spent sulfite liquor, 49%) were separated by filtration, the pulp was enzymatically hydrolyzed with 0.7% of enzymes (comprising cellulase (0.5%), beta -glucosidase (0.05%), and xylanase (0.15%)) at 50 degrees C for 48 hours and to afford glucose (92%) and xylose (90%).