TECHNOLOGY FOCUS - PHARMACEUTICALS - Preferred Composition: The coating comprises natural or synthetic polymer, metal, metal oxide, metal nitride, borate, ceramic, zirconia, allograft hard tissue, allograft soft tissue, xenograft hard tissue, xenograft soft tissue, carbon nanostructure, carbon, glasses, and natural or biocompatible material. The coating comprises one or more layers of nanoparticles and/or microparticles. Preferred Components: The micro and/or nano material contains a material of 0.5 nm-50 mm size. The one or more layer comprises a single type of nanoparticle and/or microparticle or a combination of more than one type of nanoparticle and/or microparticle. The one or more layers comprise combination of metal nanoparticles, metal oxides, carbon nanotubes, polymeric nanoparticles, ceramics, calcium phosphate, collagen and/or hydroxyapatite nanoparticles. The nanoparticle comprises gold, silver, metal, oxides, carbon nanostructures (single, double, multilayered nanotubes, graphene, fullerenes and nanofibers), hydroxyapatite, zirconia, natural or synthetic polymers, ceramics or metal oxide. The one or more layer comprises protein, amino acid, collagen, enzyme, nucleic acid, bioactive agent, growth factor, drug, antibiotic, nucleic acid, hormone, antibody or biofilm inhibiting agent. The bioactive agent is in or on the surface coating of medical device and affects adjacent tissue or cells in at least one or more of bone formation, protein synthesis, gene expression, cell proliferation, mitosis, DNA transcription, hormone production, enzyme production, cell death, gene delivery or drug delivery. The bioactive agent is linked to nanoparticle. The linkage is chosen from covalent, ionic, hydrogen bond, sulfide bond and polar covalent bond. Preferred Method: The method further involves heating the surface to alter the crystallinity of film. The coating is produced by self assembly and self formation during deposition. The structured surface is prepared by flame spraying, acid etching, grit blasting, casting-in, forging-in, laser texturing, micromachining, plasma treatment, ion bombardment, physical vapor deposition or chemical vapor deposition. ACTIVITY - Osteopathic; Antibacterial; Fungicide; Antidote.    MECHANISM OF ACTION - Gene therapy.    EXAMPLE - No suitable example given.