NOVELTY - Replicable artificial composition (I) comprises: at least two particles, P1 and P2, bound together; a surface-exposed first and second chemical moieties A1 and A2, which are able to specifically and reversibly interact with chemical moieties B1 and B2; where one of A1-B1 and A2-B2 interactions can be modified to make A1-B1 interaction irreversible under conditions in which the A2-B2 interaction is reversible.    USE - The method is useful for producing more copies of the seed. (I) is useful for: creating designed components for nano- and micro-scaled machines, and materials comprising crystals and silicon wafers; and personal products and pharmaceuticals. (I) is useful in sensors, solar cells, microelectronics, battery and fuel cell components.    ADVANTAGE - (I) is self-replicable and produces macroscopic number of copies of the original after a relatively short time.    DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for:    (1) making a copy of (I) comprising: constructing a seed particle comprising the particles P1 and P2, and the surface-exposed first and second chemical moiety, at least one third particle P3 comprising (i) at least a third surface-exposed chemical moiety B1, where A1B3 specifically and reversibly interact, and (ii) at least a fourth surface-exposed chemical moiety C1, where C1 specifically and reversibly interacts with a fourth chemical moiety D1, at least one fourth P4 particle comprising the (i) surface-exposed chemical moiety D1, and (ii) a surface-exposed chemical moiety F1, where F1 specifically and reversibly interacts with A2; mixing the seed of P1 and P2 and P3 and P4 particles under a first condition favorable for specific and reversible A1-B3, A2-F1, and C1-D1 interactions; providing a second condition that causes C1-D1 interactions to become irreversible under at least a third condition, where the third condition reverses A1-B3 and A2-F1 interactions; and providing the third condition to create P3-P4, which is a copy of P1-P2; and    (2) a material made by the method.