TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Components: The preparation further comprises heating 4-hydroxy-6-methyl-2-pyrone with dimethyl formamide dimethyl acetal in solvent. The preparation of 5-carboxy-4-hydroxy-2-methyl-pyridine (VI) comprises (wt.%) heating and agitating 3-((dimethylamino)methylene)-6-methyl-4-oxo-2-pyrone (10-30) with water, 30% ammonia (3-6) and dimethylamine (5-15), at 25-60 degrees C. The pyridine compound of formula (V) is prepared by reacting compound (VI) and 4-hydroxyphenyl glycine under the presence of ethyl chlorocarbonate. The pyridine compound (V) preparation further comprises reacting compound (VI) and ethyl chlorocarbonate in the presence of alkali catalyst in solvent, heating and agitating for 30-90 minutes, and adding 4-hydroxyphenyl glycine, with alkali having potassium carbonate, sodium carbonate, sodium hydroxide, pyridine, triethylamine and 4(N,N-dimethylpyridine); solvent having chloroform, methylene dichloride, tetrahydrofuran, methanol, ethanol and N, N-dimethylformamide; and reaction temperature at 0-25 degrees C. The method further comprises reacting compound (V) and ethyl chlorocarbonate in the presence of alkali catalyst in the solvent, heating and agitating for 30-90 minutes, and adding 7-ACA, with alkali of potassium carbonate, sodium carbonate, sodium hydroxide, pyridine, triethylamine and 4(N,N-dimethylpyridine); solvent having chloroform, methylene dichloride, tetrahydrofuran, methanol, ethanol and N,N-dimethylformamide; and reaction temperature at 0-25 degrees C. The cefpiramide sodium further comprises heating compound of formula (XVI) with 1-methyl-5-sulfhydryl-tetrazole in the presence of alkali catalyst in solvent, with alkali having sodium bicarbonate, potassium bicarbonate, sodium carbonate and potassium carbonate; at 10-60 degrees C. Preferred Content: The mol ratio of 4-hydroxy-6-methyl-2-pyrone to dimethyl formamide dimethyl acetal is 1:1.5-5; solvent is methanol, ethanol, water, acetonitrile and tetrahydrofuran; and heating at 50-100 degrees C.