TECHNOLOGY FOCUS - IMAGING AND COMMUNICATION - Preferred Components: Many customized anisotropic particles utilizes at least one of lithographic method, templating method, imprinting method, stamping method, extrusion method, relief deposition templating method, pillar deposition templating method, well deposition templating method, spatially patterned radiation exposure method, etching method, relief radiation templating method, particle templating method, two-patterned surface imprinting method, bottom-up solution synthesis method or patterned deposition method.    TECHNOLOGY FOCUS - INORGANIC CHEMISTRY - Preferred Method: The method further comprises: modifying rheological property of the dispersion by adding a rheological modifier to increase at least one of viscosity, resistance to stress, elastic shear modulus, yield stress or magnitude of viscoelastic complex shear modulus of the dispersion. At least one of the particle shape, volume and composition is designed to provide a predetermined time-release profile of the loading material, over at least duration of three days, subsequent to the embedding. Many customized anisotropic particles in the fluid material remains stable against at least one of separation, aggregation, agglomeration or degradation prior to the embedding. The embedding causes at least one of customized anisotropic particles to substantially penetrate and remain within at least one of layer of a epidermis, layer of a dermis, layer of a subcutaneous tissue, stratum corneum, stratum lucidum, stratum granulosum, stratum germinativum, dermal papilla, papillary dermis, reticular dermis, follicle, pore, ocular membrane, nasal membrane, oral membrane, aural membrane, vaginal membrane, labial tissue, intestinal membrane, anal membrane, urethral membrane or mucosal membrane. Preferred Components: The particle volume of each of many customized anisotropic particles is less than 1 cubic mm. The maximum spatial dimension of each of many customized anisotropic particles is less than 1 mm. The particle material comprises at least one of a carrier material and loading material. The carrier material is at least one of bio-compatible material, bio-degradable material, bio-inert material, bio-polymer material, bioerodable material, bio-nutrient material, bio-inhibitor material, bio-catalytic material, bio-reactive material, bio-digestible material, bio-absorbable material, bio-derived material, protein, enzyme, vitamin, nutrient, collagen, gelatin, albumin, actin, tubulin, polypeptide, copolypeptide, polysaccharide, starch, modified starch, porous material, elastic material or biopolymer. The loading material is at least one of therapeutic material, anti-fungal material, anti-viral material, anti-bacterial material, anti-microbial material, anti-wart material, anti-blemish material, anti-cancer material, anti-irritation material, anti-scar material, anti-inflammatory material, anesthetic material, antiseptic material or anti-bum material. At least a feature of the particle shape is at least one of point, comer, edge, barb, spike, protuberance, blade, sliver, acute angle, hook or needle. The volume fraction of customized anisotropic particles in the dispersion is 0.01-30%. The first material component is at least one of fluid, liquid, polymeric solution, biopolymer solution, dispersion, mixture, gel, emulsion, nanoemulsion or solution, such that the multi-component composition is a topical scrub.    TECHNOLOGY FOCUS - POLYMERS - Preferred Components: The rheological modifier is at least one of polymer, biopolymer, copolymer, diblock co-polymer, star polymer, high molecular weight polymer, surfactant, amphiphilic material, hydrogel, polypeptide, co-polypeptide, dendrimer, starch, modified starch, emulsion, nanoemulsion, nanoparticulate dispersion, cream, foam, jelly, lyotropic liquid crystal, microgel particle, micellar solution, thickener, gel, thermo-responsive gelling material, thermo-reversible gelling material, crosslinker or crosslinking agent. ACTIVITY - Dermatological.    MECHANISM OF ACTION - None given.    ADMINISTRATION - Administration of the scrub is topical (claimed). No dosage details given.    EXAMPLE - Customized anisotropic particles were mass-produced using pillar deposition templating, a form of relief deposition templating. A portion of a solid pillar template was created (using a material e.g. silicon), typically by a lithographic process. The triangular cross-sectional shapes of the pillars on the template were designed to impart pointed shape features to the customized anisotropic particles. A pillar template typically had a spatial dimension of 100 mm or larger and a maximum cross-sectional dimension less than 1 mm, where optionally the surfaces of a pillar template were coated with a release agent. Onto at least the top surfaces of the pillars on the pillar template, a particle material containing therapeutic drug molecules was deposited (e.g. using a coating process e.g. spin coating or spray-coating) and solidified (e.g. using heating or evaporation) to form many customized anisotropic particles containing therapeutic drug molecules. Subsequently, customized anisotropic particles containing therapeutic drug molecules were released from the pillar template into a fluid material e.g. simple viscous liquid. The customized anisotropic particles was produced in a manner that does not alter the pillar template, thus pillar template could be repeatedly re-used to make additional customized anisotropic particles. In order to provide desired gel-like rheological properties to the topical scrub, a high molecular weight polymer material was added in sufficient quantity and mixed with the simple viscous liquid containing customized anisotropic particles, yielding a topical scrub which is a liquid gel-like material within which customized anisotropic particles containing drug molecules were dispersed.