TECHNOLOGY FOCUS - BIOTECHNOLOGY - Preferred Components: The polypeptide (P1) comprises a substitution or deletion at a position corresponding to at least one residues Gln37, Asn38, Tyr53, Ser54, Ala65, Ala66 and/or His438 in CBHII from Trichoderma reesei (SEQ ID NO: 1). The polypeptide (P1) comprises a substitution at a position corresponding to at least one residue Gln37Ile, Asn38Lys, Tyr53(Ala/Gln), Ser54Val, Ala65Pro, Ala66tyr and/or His438(Ser/Asn) in CBHII from Trichoderma reesei (SEQ ID NO: 1). The polypeptide (P1) consists essentially of the substitutions selected from a) Gln37Ile, Asn38lys; b) Tyr53Ala, Ser54Val; c) Ala65Pro, Ala66Tyr; d) His438Ser; e) His438Asn; f) Tyr53Ala, Ser54Val, His438Asn; h) Tyr53Gln, Ser54Val, His438Ser; i) Tyr53Gln, Ser54Val; j) Gln37Ile, Asn38Lys, Ala65Pro, Ala66Tyr, His438Ser; k) Gln37Ile, Asn38Lys, Tyr53Ala, Ser54Val, Ala65Pro, Ala66Tyr and His438Ser. The variation comprises a variation of one-seven positions selected from: Gln37, Asn38, Tyr53, Ser54, Ala65, Ala66 and/or His438. The variation comprises a variation selected from Gln37Ile, Asn38Lys, Tyr53Ala, Ser54Val, Ala65Pro, Ala66tyr and/or His438Ser. The polypeptide (P1) has at least a minimum percent sequence identity and/or percent homology to the polypeptide, where the minimum percent identity and/or homology is selected from at least 50%, at least 60%, at least 75%, at least 80%, at least 85%, at least 90%, at least 93%, at least 95%, at least 96%, at least 97%, at least 98%, and at least 99%. Preferred Definitions:    X=Gln, Asn, Ala or Ser;    X2=Asn, Gly, Ser or Asp;    X12=Tyr, Thr, Glu, Lys, Ala or Val;    X13=Ser, Gln, Leu, Val, Ile or Thr;    X20=Ala, Thr, Gly, Ser or Asn;    X21=Ala, Thr, Gly, Gln or Ser;    X3-X11 and X13-X19=any amino acid;    X'1=Thr or Val;    X'2=Ser or Thr;    X'3=Asp, Asn or Val;    X'4=Asn, Pro, Gln; Ser or Thr;    X'5=Ser or Thr;    X6=Ala or Ser;    X'7=any amino acid;    X'8=Phe or Tyr;    X'9=any amino acid;    X'10=Ser or Asn.    Where the amino acid sequence motif comprises at least one variation in the amino acid sequence motif, the variation is selected from X1 is Ile, X2 is Lys; X12 is Ala or Gln; X13 is Val; X20 is Pro; X21 is Tyr, and each of at least one variations can be the same or different and can comprise a substitution, deletion or insertion.    EXAMPLE - No suitable example given.