TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preparation (claimed): The preparation method of the compound containing crosswise biphenyl center comprises: (a) adding 1 pts.wt. of 2,2',5,5'-biphenyl tetracarboxylic acid, 1.3-3.1 pts.wt. of compound A, and 30-80 pts.wt. of polyphosphoric acid to a reactor having stirrer, thermometer, and nitrogen replaceable device; at the protection of the nitrogen gas, reacting the materials for 2-6 hours at 60-70 degrees C, for 2-10 hours at 90-100 degrees C, for 4-6 hours at 120-140 degrees C, and for 5-16 hours at 150-180 degrees C; after the reaction, pouring the reaction liquid to the ice water, precipitating the reaction liquid, neutralizing it by the alkali substance, filtering and drying; (b) adding 1 pts.wt. of 2,2',5,5'-biphenyl tetraformyl chloride, 1.2-2.8 pts.wt. of compound B, 10-20 pts.wt. of solvent, and 1-2 pts.wt. of catalyst to a reactor having stirrer, thermometer, and nitrogen replaceable device; at the protection of the nitrogen gas, reacting the components for 1-3 hours at 0 degrees C and for 10-20 hours at room temperature; after the reaction, pouring the reaction solution to water, precipitating the reaction solution, filtering and drying; and (c) preparing benzyltributyl ammonium chloride and ferric chloride with mole ratio of 1:1 into ionic solution, adding 1 pts.wt. of 2',5,5'-biphenyl tetraformyl chloride, 4.7 pts.wt. of ionic solution of benzyltributyl ammonium chloride and ferric chloride, and 0.78-1 pts.wt. of compound C to a reactor having stirrer, thermometer and nitrogen replaceable device; at the protection of the nitrogen gas, reacting the components for 10-60 minutes at 50-70 degrees C; after the reaction, pouring the reaction solution to water, extracting the reaction solution with ether, and drying it by anhydrous magnesium sulfate to obtain the product. Preferred Components: The compound A is R2-group containing o-aminophenol, o-amino thiophenol, or o-phenylenediamine derivate. The compound B is R4-group containing aminobenzene or phenol derivative. The compound C is R5-group containing benzene or toluene derivative. The solvent is N,N-dimethyl fomamide, N,N-dimethyl acetamide, dimethyl sulfoxide, N-methylpyrrolidone, dioxane, or methylene dichloride. The catalyst is pyridine or propylene epoxide. The alkali substance is sodium carbonate, sodium bicarbonate, potassium bicarbonate, potassium carbonate, or sodium hydroxide.