TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Components: In method (M1), the organic solvent solution further comprises additional nucleophile selected from NH3, at least one alkylamines, NaOH, polysulfide, and/or hydropolysulfide reagents. The additional nucleophile is at least one alkylamine which is at concentration of up to 20 wt.% of dry biomass. The target product is selected from alcohols, organic acids, amino acids and gases. In method (M1) and (M2), the organic solvent solution further comprises one or additional component selected from alkali or alkaline earth hydroxides or carbonates, ammonia, thiols, polysulfides, and/or hydropolysulfides. The organic solvent solution comprises a solvent selected from alcohols, diols and aprotic solvents (preferably methanol, ethanol, propanol, butanol, pentanol and hexanol, isomers, and diols). The alkylamines is selected from R-NH2, R2-NH, R3N, (H2N-R-NH2), (H2N-R(NH2)2), (HO-R-NH2), ((HO)2-R-NH2), (HO-R-(NH2)2), (HS-R-NH2), ((HS)2-R-NH2), (HS-R-(NH2)2) and/or H2N-R(OH)(SH). The alkylamine is methylamine. The sulfide salt is selected from alkali metal and alkaline earth sulfides (e.g. Na2S), alkali metal and alkaline earth hydrosulfides (e.g. NaHS), alkali metal and alkaline earth polysulfides (e.g. Na2Sn), alkali metal and alkaline earth hydropolysulfides (e.g. NaHSn), ammonium sulfide, hydrosulfide, polysulfides, and hydropolysulfides, alkylammonium sulfide, hydrosulfide, polysulfides, and hydropolysulfides.R=monovalent, divalent or trivalent 1-6C alkane, alkene or alkyne (preferably methyl, ethyl, propyl or butyl).    TECHNOLOGY FOCUS - PHARMACEUTICALS - Preferred Method: The method (M1) further involves e) washing the biomass produced in step d) with solvent solution. The method (M1) further involves f) washing the biomass produced in step e) with water to produce readily saccharifiable carbohydrate-enriched biomass. The method (M1) further involves drying biomass produced in step e) to produce readily saccharifiable carbohydrate-enriched biomass. The method (M1) further involves repeating steps e) and f) at least one times. The heating step of c) occurs in sealed pressure vessel. The filtering step of d) occurs under pressure. The solvent solution to biomass in step b) has a weight ratio of 10:1-0.5:1. The heated suspension of step c) is cooled to room temperature before filtering in step d). The method (M1) further involves evaporating off the solvent under vacuum of the filtered and washed biomass after step e). The method (M1) further involves saccharifying the biomass with enzyme consortium where fermentable sugars are produced. The method (M1) further involves saccharifying the biomass without drying by contacting the biomass with enzyme consortium after washing in step f), where fermentable sugars are produced. The method (M1) further involves fermenting the sugars to produce a target product. In method (M2), the solvent at step e1) may contain water. The lignin-free biomass is 60-100% original weight of the biomass. In method (M1) and (M2), the solvent solution, and any unreacted sulfide salts or other unreacted components are recyclable. The lignocellulosic biomass of step a) or a1) has carbohydrate content that is highly conserved through steps a) or a1) through d) or d1). The temperature of step c) or c1) is 165-195 degrees C. Preferred Components: In method (M1), the biomass is selected from switch grass, waste paper, sludge from paper manufacture, corn fiber, corn cobs, corn husks, corn stover, grasses, wheat, wheat straw, hay, barley, barley straw, rice straw, sugar cane bagasse, sugar cane straw, yellow poplar, sorghum, soy, components obtained from processing of grains, trees, branches, roots, leaves, wood chips, sawdust, shrubs and bushes, vegetables, fruits, flowers, and/or animal manure. EXAMPLE - No suitable example given.