NOVELTY - Cryopreservative composition of a cell and tissue, obtained by dissolving high molecular compound containing polymer of carboxyl group containing unit chosen from poly-glutamic acid, poly(aspartic acid), other polyamino-acid, carboxylation polysaccharide, polyacrylic acid, ( alpha )-poly glutamic acid and ( gamma )-poly glutamic acid in a physiological medium, at a concentration of 1-50 weight/weight%.    USE - The composition is useful for cryopreservation of cell and tissue which is used for producing industrial commodities including pharmaceuticals, foodstuffs or fuel cells (all claimed), and in regeneration therapy. The cells include animal cell, plant cell, embryonic stem cell, mesenchymal stem cell, hematopoietic progenitors, neural stem cell, cord-blood cell, hepatocytes, nerve cell, cardiac myocyte, vascular endothelial cell, vascular smooth muscle cell or blood cell. The tissue includes tissue of skin, blood vessel, cartilage, cornea, liver, kidney or heart.    ADVANTAGE - The composition is highly safe, non-toxic, cost-effective, and maintains survival rate and bioactivation of cells and tissues.    DETAILED DESCRIPTION - Cryopreservative composition of a cell and tissue, obtained by (1) dissolving high molecular compound containing polymer of amino-group unit chosen from ( epsilon )-poly-L-lysine, ( alpha )-poly-L-lysine, poly arginine, other polyamino acids, aminated polysaccharide and polyallyl amine in a physiological medium, or (2) dissolving high molecular compound containing polymer of carboxyl group-containing unit chosen from poly-glutamic acid, poly(aspartic acid), other polyamino-acid, carboxylated polysaccharide, polyacrylic acid, ( alpha )-poly glutamic acid and ( gamma )-poly glutamic acid in a physiological medium, at a concentration of 1-50 weight/weight%. An INDEPENDENT CLAIM is included for method of producing industrial commodities including foodstuff, pharmaceutical or fuel cell, which involves mixing the additive composition with water-containing raw material composition for providing a hydrophilic surface layer in the water-containing composition of a foodstuff or pharmaceutical, such that the foodstuff and pharmaceutical contains 1-15 weight/weight% of the composition.