TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Process: The protection of hydroxy group in step (c) is carried out in the presence of base comprising potassium carbonate, sodium carbonate, potassium hydroxide, sodium hydroxide, triethylamine, trimethylamine and/or pyridine and solvent comprising dioxane, tetrahydrofuran, ethylene glycol dimethyl ether, acetone, dichloromethane, toluene, xylene, methanol, ethanol, isopropanol, dimethylformamide, dimethyl sulfoxide, acetonitrile and/or dimethylacetamide. The conversion of hydroxy group in step (c) into leaving group is carried out by using p-toluene sulfonyl chloride, methanesulfonyl chloride or p-nitrobenzenesulfonyl chloride. The conversion in step (e) is carried out at 45-60 degrees C by using organic acid comprising oxalic acid, acetic acid, formic acid, malic acid, maleic acid, malonic acid, succinic acid, fumaric acid, phthalic acid, terephthalic acid, citric acid, tartaric acid, methanesulfonic acid, ethanesulfonic acid, p-toluenesulfonic acid, trifluoroacetic acid, and ascorbic acid in the presence of the solvent. Preferred Components: The alcohol is methanol, ethanol, n-propanol, isopropyl alcohol, n-butanol and/or isobutanol. ACTIVITY - Uropathic.    MECHANISM OF ACTION - Muscarinic receptor antagonist.    EXAMPLE - Solution of 3-(2-methoxy-5-methylphenyl)-3-phenyl propyl-p-toluene sulfonate (0.100 kg) in water (0.250 l) and diisopropyl amine (0.123 kg) was stirred at 80-100 degrees C for 130-150 hours. The obtained product was extracted with dichloromethane (0.200 lx 2). The organic layers were washed with demineralized water (1 l) and worked up to give crude N,N-diisopropyl-3-(2-methoxy-5-methylphenyl)-3-phenylpropylamine (a1). The obtained (a1) (0.080 kg) was dissolved in acetone (0.160 l) and fumaric acid (0.041 kg) was added portion-wise within 30 minutes and heated up to 50-55 degrees C for 1-2 hours and worked up to give fumarate salt of N,N-diisopropyl-3-(2-methoxy-5-ethylphenyl)-3-phenylpropylamine (a2). The obtained (a2) (0.050 kg) was added to aqueous hydrobromic acid (0.111 l) and acetic acid (0.66 l), and stirred at 100-125 degrees C for 12-16 hours till completion of reaction. The reaction mixture was cooled to room temperature to obtain a solid. The solid was filtered and washed with demineralized water till washing of cake was neutral and to afford hydrobromic salt of N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropyl amine (a3). The obtained (a3) was stirred with 2N sodium hydroxide (0.030 l), demineralized water (0.675 l) and dichloromethane (1.5 l) and worked up to give crude (+)-(R)-tolterodine-L-tartrate. Then the crude (+)-(R)-tolterodine-L-tartrate was dissolved in ethanol (3.2 l) and refluxed at 80-85 degrees C for 2-3 hours to obtain a solution. The solution was concentrated to half the initial volume by distilling ethanol (1.6 l) and gradually cooled and worked up to give (+)-(R)-tolterodine-L-tartrate.