NOVELTY - Preparation of zaltoprofen comprises: (i) adding 5-(1-propionyl)-2-phenylthiophenylacetic acid, iodine, triethyl ortho-formate, cuprous oxide, blending, adding sodium thiosulfate, neutralizing, drying and concentrating to obtain 2-(3-(carboxymethyl)-4-(phenylthio)phenyl)propanoic acid; (ii) adding the obtained product, polyphosphoric acid and dichloromethane, reacting, separating dichloromethane layer, adding n-hexane and filtering to obtain the crude product; (iii) adding the crude product in an organic solvent, adding active carbon, crystallizing by n-hexane and drying to obtain zaltoprofen.    USE - Zaltoprofen is non-steroid anti-inflammation drug used as antiphlogistic, demulcent and antidotic drug.    ADVANTAGE - The method is simple, environmental-friendly and suitable for industrialized mass-production.    DETAILED DESCRIPTION - Preparation of zaltoprofen comprises: (i) adding 5-(1-propionyl)-2-phenylthiophenylacetic acid, iodine, triethyl ortho-formate and cuprous oxide in a three-opening reaction bottle, blending for 2 hours at 55 degrees C, reducing to room temperature, adding 25% sodium thiosulfate and blending for 4 hours, extracting by ethyl acetate, combining the extracted liquid, washing with water, drying, reducing the pressure to recover solvent, adding solvent and alkaline solution into the residue, reflowing to react for 5 hours, neutralizing by hydrochloric acid, extracting by ethyl acetate, washing the extracted liquid by water, drying, reducing the pressure to concentrate to obtain 2-(3-(carboxymethyl)-4-(phenylthio)phenyl)propanoic acid, which is a white solid; (ii) adding 2-(3-(carboxymethyl)-4-(phenylthio)phenyl)propanoic acid, polyphosphoric acid and dichloromethane in a three-opening reaction bottle, reacting for 1 hour at 33-53 degrees C, pouring the reaction system into ice water, separating the dichloromethane layer, washing with sodium bicarbonate solution and brine in turns, drying and reducing the pressure to concentrate to 1/4 of the volume, adding n-hexane, precipitating the crystals and filtering to obtain zaltoprofen crude product, which is a bright yellow solid; and (iii) adding zaltoprofen crude product in an organic solvent, heating to reflow and dissolve, adding required amount of active carbon to decolor, thermally filtering and adding n-hexane to crystallize, freezing, filtering and drying to obtain zaltoprofen, which is a white solid.