NOVELTY - An aqueous halogen-substituted saccharide solution is obtained by carrying out synthesis reaction (AA) of leaving group-substituted saccharide or leaving group-substituted protected saccharide (BB) with halide salt in presence of aprotic organic solvent containing halogen-substituted reaction material or halogen-substituted saccharide and in absence of catalyst which is harmful to human and biological component.    USE - The aqueous halogen-substituted saccharide is useful in pharmaceuticals and as tracer in positron emission tomography.    ADVANTAGE - The aqueous halogen-substituted saccharide is continuously, selectively, safely, easily and economically manufactured within a short period of time, without causing environmental pollution.    DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for the following:    (1) manufacture of halogen-substituted saccharide, which involves reacting leaving group-substituted protected saccharide or leaving group-substituted saccharide and halide salt in presence of supercritical fluid or subcritical fluid (DD) as reaction solvent having high-temperature high-pressure state, carrying out halogen substitution reaction (EE) and deprotecting reaction. The reaction solvent is non-catalytic solvent. The solvent substitution reaction is not carried out during manufacture of halogen-substituted saccharide;    (2) halogen-substituted saccharide synthesizing apparatus, which is a micro reaction system whose channel space is micro space. The micro reaction system consists of back pressure valve for controlling aqueous liquid feed through pump, a coil for heating water, a high-temperature high-pressure flow cell, a reaction material-liquid feeding pump, a furnace, a reaction material inlet tube for introducing reaction material into furnace, a reaction-solution discharge liquid line, and a cooling flange; and    (3) simple solid-liquid continuous extraction of solid containing halogen-substituted saccharide, which involves injecting water into a recycled water solution after performing the synthesis reaction, decanting, separating to solid-liquid bilayer solution and recovering the solid containing halogen-substituted saccharide.    DESCRIPTION OF DRAWING(S) - The drawing shows flowchart of manufacturing process of halogen-substituted saccharide. (Drawing includes non-English language text)    Catalyst-free synthesis of halogen-substituted saccharide in high-temperature high-pressure water (AA)    Leaving group-substituted saccharide or leaving group-substituted protected saccharide (BB)    Dissolution in aqueous ethanol solution (CC)    Supercritical fluid or subcritical fluid (DD)    Halogen substitution (EE)