NOVELTY - Preparing clopidogrel chiral intermediate (S)-adjacent chlorobenzene glycine methyl comprises: (a) preparing (R,S)-N-phenylacetyl adjacent chlorobenzene glycine; (b) carrying out (R,S)-N-phenylacetyl adjacent chlorobenzene glycine enzyme hydrolysis; (c) preparing (S)-adjacent chlorobenzene glycine methyl ester hydrochloride; (d) preparing (S)-adjacent chlorobenzene glycine methyl ester; and (e) carrying out (R)-N-phenylacetyl adjacent chlorobenzene glycine racemization.    USE - The process is useful for preparing clopidogrel chiral intermediate (S)-adjacent chlorobenzene glycine methyl (claimed).    ADVANTAGE - The process is high in yield coefficient, high in purity of the product, and environment-friendly.    DETAILED DESCRIPTION - Preparing clopidogrel chiral intermediate (S)-adjacent chlorobenzene glycine methyl comprises: (a) preparing (R,S)-N-phenylacetyl adjacent chlorobenzene glycine: under the condition of -10 to 10 degrees C and pH of 8-10, stirring the (R,S)-adjacent chlorobenzene glycine in the sodium hydroxide (NaOH) solution to disperse, dropwise adding acylating agent with the ice-bath; where the mole ratio of the (R,S)-adjacent chlorobenzene glycine, NaOH, and acylating agent is 1:2-3:1-3; after finishing dropwise adding, reacting for 6-24 hours at room temperature; after finishing reaction, using hydrochloric acid to adjust pH to 1-2, and separating out (R,S)-N-phenylacetyl adjacent chlorobenzene glycine solid by stirring; (b) carrying out (R,S)-N-phenylacetyl adjacent chlorobenzene glycine enzyme hydrolysis: under the condition of 20-40 degrees C and pH of 8-10, hydrolyzing 0.1-0.5 mol of (R,S)-N-phenylacetyl adjacent chlorobenzene glycine in each liter of water for 10-20 hours by the catalysis of immobilized penicillin acylation enzymes; where the mass ratio of immobilized penicillin acylation enzymes and (R,S)-N-phenylacetyl adjacent chlorobenzene glycine is 1:3-10; finishing reaction, adjusting pH to 1-2 by using concentrated hydrochloric acid, separating out phenylacetic acid and (R)-N-phenylacetyl adjacent chlorobenzene glycine; concentrating filtrate, adjusting isoelectric point to separate (S)-adjacent chlorobenzene glycine; (c) preparing (S)-adjacent chlorobenzene glycine methyl ester hydrochloride: at 0-5 degrees C, adding the (S)-adjacent chlorobenzene glycine to absolute methanol, dropwise adding thionyl chloride (SOCl2), after dropwise adding, reacting for 5-24 hours at room temperature; where the mole ratio of the (S)-adjacent chlorobenzene glycine, SOCl2, and absolute methanol is 1:2-4:30-60; after finishing reaction, reducing pressure distillation at 60 degrees C to obtain the (S)-adjacent chlorobenzene glycine methyl ester hydrochloride; (d) preparing (S)-adjacent chlorobenzene glycine methyl ester: at 0-50 degrees C, stirring and adding 0.03-1.0 mol of (S)-adjacent chlorobenzene glycine methyl ester hydrochloride to each liter of alkaline solution with pH of 8.0-10 for extracting dichloromethane (CH2Cl2) of alkaline solution with the same volume; washing organic layer for 2-4 times with water, drying with absolute sodium sulfate (Na2SO4), reducing pressure distillation at 60 degrees C to remove CH2Cl2 for obtaining the (S)-adjacent chlorobenzene glycine methyl ester; and (e) carrying out (R)-N-phenylacetyl adjacent chlorobenzene glycine racemization: mixing the (R)-N-phenylacetyl adjacent chlorobenzene glycine and phenylacetic acid with a mole ratio 1:1, congruent melting and carrying out racemization for 10-60 minutes at 150-200 degrees C to obtain (R,S)-N-phenylacetyl adjacent chlorobenzene glycine for cycle splitting in (b).