NOVELTY - Preparing resveratrol extract by using winery waste residue comprises processing winery waste material residue, rinsing, drying, and crushing, adding solvent e.g. methanol, performing reflux extraction or normal pressure ultrasonic extraction, extracting for two times, performing decompression heating reflux extraction, combining the extracts, concentrating, centrifuging, transferring the supernatant into a resin column, performing thin layer chromatography to obtain an eluent, rinsing with pure water, eluting with alcohol solution, collecting the eluent, concentrating and spray drying.    USE - The method is useful for preparing resveratrol extract by using winery waste residue.    ADVANTAGE - The method: produces higher amounts of resveratrol (more than 10%), which has mauve and bright color in comparison with resveratrol extract obtained by Polygonum cuspidatum, contains large amount of strong antioxidant polyphenols, has natural red pigment, which is harmless to human body, and does not contain Rheum emodi; is simple, convenient and economical; recycles winery waste residue; and maintains the medicinal value, completely utilizes grape, and can be used as a raw material of medicine or food.    DETAILED DESCRIPTION - Preparing resveratrol extract by using winery waste residue comprises: (a) processing winery waste material residue generated during the brewing process, rinsing, drying at 40-60 degrees C at normal pressure until the water content is not greater than 2%, and crushing; (b) crushing the dried wine material slag to small pieces of diameter 4-6 mm, adding solvent e.g. methanol or ethanol solution (50-95%), performing decompression heating reflux extraction method or normal pressure ultrasonic extraction, extracting for two times, performing decompression heating reflux extraction, extracting inside the tank under a vacuum degree of -0.09 to -0.1 MPa, extracting at 50-80 degrees C, refluxing and extracting every time for 90 minutes, where the amount is at least 4 times the raw material each time, performing normal pressure ultrasonic extraction at an ultrasonic output power of 1000-2000 W, extracting for 30 minutes, where the volume of extracting solvent is 2 times of the amount of raw material each time, extracting at 40-65 degrees C; (c) combining the extracted liquids after extracting for twice, concentrating the extract to 1 l equivalent to 0.5-1.5 kg/l crude drug; (d) centrifuging the concentrated liquid at 2000-4000 revolutions/minute for at least 40 minutes; (e) transferring the centrifugal liquid into a pre-treated macroporous adsorption resin column, where the amount of resin is 100kg/1000 kg raw material, performing thin layer chromatography to obtain eluent, where the resin adsorption is complete when there is appearance of resveratrol spot, stopping the column flow, adding 2-3 times of column volume of pure water into the column when the sample is absorbed completely, removing water after rinsing, firstly eluting with alcohol solution (50%), collecting the eluent by gradient elution 2-3 times the column volume of eluent, eluting with alcohol solution (85%) until the eluent liquid is purple, starting to collect 2-3 column volume of eluent; (f) eluting with alcohol solution (85%) at not greater than 70 degrees C, vacuum extracting and condensing at a vacuum degree of 0.09-0.1 MPa, concentrating to 11-15 Baume degrees; and (g) spray drying the concentrated liquid.