TECHNOLOGY FOCUS - BIOTECHNOLOGY - Preferred Protein: The parent polypeptide comprises an amino acid sequence with at least 60%, preferably 100% identity to a lipase chosen from lipase B comprising an amino acid sequence of SEQ ID NO: 2, and obtained from Candida antarctica, lipase comprising an amino acid sequence of SEQ ID NO: 3, and obtained from Hyphozyma sp., lipase comprising an amino acid sequence of SEQ ID NO: 4, and obtained from Ustilago maydis, lipase comprising an amino acid sequence of SEQ ID NO: 5, and obtained from Fusarium graminearum, lipase comprising an amino acid sequence of SEQ ID NO: 6, and obtained from Debaryomyces hansenii, lipase comprising an amino acid sequence of SEQ ID NO: 7, and obtained from Aspergillus fumigatus, lipase comprising an amino acid sequence of SEQ ID NO: 8, and obtained from A.oryzae, and lipase comprising an amino acid sequence of SEQ ID NO: 9, and obtained from Neurospora crassa. Preferred Method: The method involves substituting amino acid residues at positions chosen from 103, 197, 223 and 278 in the amino acid sequence of the parent polypeptide of SEQ ID NO: 2. Preferred Amino Acid: The amino acids substituted at positions 41, 83, 103, 129, 197, 207 or 223 of SEQ ID NO: 2 are alanine, leucine, glycine, leucine, glycine, alanine, glycine or alanine, respectively. Preferred Variant: The variant has substitutions chosen from 65 substitutions such as (e) G41A, (f) M83L, (g) M83L+T103G, (h) M83L+T103G +M129L, (i) M83L +T103G +M129L +G207A +D223G, (j) M83L+T103G +M129L+D223G, (k) T103G, (l) T103G+M129L, (m) T103G +M129L+S197G+G207A+D223G, (n) T103G +M129L+G207A, (o) T103G +M129L+G207A+D223G, (p) T103G +M129L+D223G, (q) M129L, (r) S197G, (s) G207A, (t) D223G, (u) M83L+T103G +M129L +A148P, (v) N97Q+T103G +M129L, (w) T103G +W104H +M129L, (x) T103G +M129L+A148P, (y) T103G+M129L+S197G+G207A+D223G+P303K, (z) T103G +M129L +G207A +P303K, (aa) T103G +M129L +D223G +P303K, (bb) T103G +M129L+P303K and (cc) T103G+P303K. EXAMPLE - No suitable example given.