TECHNOLOGY FOCUS - BIOLOGY - Preferred Components: The metal reducing bacteria belongs to the genus Shewanella.    TECHNOLOGY FOCUS - INORGANIC CHEMISTRY - Preferred Process: The chalcogen element of the electron acceptor is incorporated into the chalcogenic nanostructure by partially replacing sulfur through replacement rather than through deposition. The chalcogen element-containing salt is incorporated into the chalcogenic nanostructure by partially replacing arsenic through cation-exchange reaction. The method further comprises after performing either the metal reduction reaction or ion-exchange reaction: adding a medium containing metal-reducing bacteria, an electron donor and a chalcogen element-containing electron acceptor to the prepared chalcogenic hybrid nanostructure to prepare a reaction mixture; and performing a metal reduction reaction to prepare a second chalcogenic hybrid nanostructure with the chalcogen element of the electron acceptor incorporated. Preferred Components: The chalcogenic nanostructure comprises at least one chalcogen element comprising arsenic, cadmium, zinc, sulfur, selenium or tellurium. The chalcogenic nanostructure is a binary nanostructure comprising arsenic and sulfur. The electron acceptor comprising a chalcogen element is: a salt comprising a chalcogen element in oxidized state; or a salt of selenium and the prepared chalcogenic hybrid nanostructure is a ternary nanostructure comprising arsenic, sulfur and selenium. In the method, either or both of the chalcogenic nanostructure and the chalcogenic hybrid nanostructure or second chalcogenic hybrid nanostructure is(are) a nanotube or nanowire. The chalcogenic hybrid nanostructure is of formula (As2SxSe3-x) or (As2-yCdyS3) (optionally having p-type semiconductor properties) or (As2-cCdcS3-dSed). The chalcogenic nanostructure is one synthesized biogenically using metal-reducing bacteria. The chalcogen element-containing salt is: a salt comprising chalcogen element in oxidized state; or a salt of cadmium, and the prepared chalcogenic hybrid nanostructure is a ternary nanostructure comprising arsenic, cadmium or sulfur. The chalcogen element-containing electron acceptor is a salt of selenium and the prepared chalcogenic hybrid nanostructure is a quaternary nanostructure comprising arsenic, cadmium, sulfur and selenium. The second chalcogenic hybrid nanostructure is of formula (As2CdaS3-bSeb).x, d = 0-3;y, c = 0-2;a = 0-2 or 0-5; andb = 0-3 or 0-5. EXAMPLE - The arsenic-sulfur nanotubes were produced by Shewanella sp. HN-41 in the dark at 30 degrees C for 7 days. The nanotubes were collected from culture medium, washed 3 times in anaerobic deionized water, and then injected into the (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES)-buffered basal medium which supplemented with sodium lactate (10 mM) as the electron donor and sodium selenite (2 mM) as the electron acceptor to produce the ternary arsenic-sulfur-selenium nanotubes. Inoculation of bacteria was performed as same as producing arsenic-sulfur, followed by incubation in the dark at 30 degrees C for 24 hour.