NOVELTY - Isolated microorganism, which is Cupriavidus basilensis strain HMF14 having a deposit number DSM 22875, is new.    USE - The microorganism is useful for: in-situ detoxification of a lignocellulose hydrolysate containing furanic compounds (e.g. at least one of HMF, furfuryl alcohol, furfural and/or furoic acid), which is useful in biocatalytic production of biofuels and producing second-generation biofuels from a lignocelluloses-containing material; and production of furoyl-CoA dehydrogenase, furoyl-CoA synthetase, 2-oxoglutaroyl-CoA hydrolase, 2,5-furan-dicarboxylic acid decarboxylase 1, 2,5-furan-dicarboxylic acid decarboxylase 2 and/or HMF/furfural oxidoreductase (all claimed).    DETAILED DESCRIPTION - INDEPENDENT CLAIMS are also included for:    (1) a bacterial culture comprising the isolated microorganism;    (2) a polypeptide (A1) having aldehyde dehydrogenase activity comprising: amino acid sequence containing SEQ ID NO: 15; or amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 16 or its variant polypeptide, where the variant has at least greater than or equal to 64% sequence identity with the sequence comprising SEQ ID NO: 16 (Sequences not defined here may be found at ftp://ftp.wipo.int/pub/published_pct_sequences/publication);    (3) a polynucleotide (A2) comprising: (a1) the nucleotide sequence containing SEQ ID NO: 16; (a2) a nucleotide sequence which hybridizes selectively with a polynucleotide being the reverse complement of SEQ ID NO: 16; (a3) a nucleotide sequence having at least greater than or equal to 64% sequence identity with the sequence comprising SEQ ID NO: 16; (a4) a fragment of the nucleotide sequence in (a1), (a2) or (a3) which is at least 100 nucleotides in length; (a5) a sequence which is degenerate as a result of the genetic code to a sequence of (a1), (a2), (a3) or (a4); or (a6) a nucleotide sequence which is the reverse complement of a nucleotide sequence of (a1), (a2), (a3), (a4), or (a5);    (4) a polypeptide (A3) having LysR family transcriptional regulator activity;    (5) a polynucleotide (A4);    (6) a polypeptide (A5) having 2,5-furan-dicarboxylic acid decarboxylase 1 activity;    (7) a polynucleotide (A6;    (8) a polypeptide (A7) having 2,5-furan-dicarboxylic acid decarboxylase 2 activity;    (9) a polynucleotide (A8);    (10) a polypeptide (A9) having HMF/furfural oxidoreductase activity;    (11) a polynucleotide (A10);    (12) a polypeptide (A11) having LysR type transcriptional regulator activity;    (13) a polynucleotide (A12);    (14) a polypeptide (A13) having furoyl-CoA dehydrogenase (large subunit) activity;    (15) a polynucleotide (A14);    (16) a polypeptide (A15) having furoyl-CoA dehydrogenase (flavin adenine dinucleotide (FAD) binding subunit) activity;    (17) a polynucleotide (A16);    (18) a polypeptide (A17) having furoyl-CoA dehydrogenase (2Fe-2S iron sulfur subunit) activity;    (19) a polynucleotide (A18);    (20) a polypeptide (A19) having furoyl-CoA synthetase activity;    (21) a polynucleotide (A20);    (22) a polypeptide (A21) having 2-oxoglutaroyl-CoA hydrolase activity;    (23) a polynucleotide (A22);    (24) a polynucleotide which encodes any one of the above polypeptides;    (25) a nucleic acid construct comprising any one of the above polynucleotides;    (26) a vector incorporating any one of the above polynucleotide sequences, or the nucleic acid construct;    (27) a cell comprising: any one of the above polypeptides; any one of the above polynucleotides; the nucleic acid construct; or the vector;    (28) a host microorganism cell (I) transformed or transfected by any one of the above polynucleotide sequence, or the nucleic acid construct, or by the vector under conditions conducive to express at least one of furoyl-CoA dehydrogenase, furoyl-CoA synthetase, 2-oxoglutaroyl-CoA hydrolase, 2,5-furan-dicarboxylic acid decarboxylase 1, 2,5-furan-dicarboxylic acid decarboxylase 2, or HMF/furfural oxidoreductase;    (29) a cell extract from the microorganism or the host cell (I), comprising furoyl-CoA dehydrogenase, furoyl-CoA synthetase, 2-oxoglutaroyl-CoA hydrolase, 2,5-furan-dicarboxylic acid decarboxylase 1, 2,5-furan-dicarboxylic acid decarboxylase 2 and/or HMF/furfural oxidoreductase;    (30) a process (IIa) for the in-situ detoxification of a lignocellulose hydrolysate containing furanic compounds (e.g. at least one of HMF, furfuryl alcohol, furfural and/or furoic acid), with a suitable host microorganism, comprising contacting the lignocellulose hydrolysate with the host microorganism (of the family Burkholderiaceae) under conditions facilitating the expression of at least one of furoyl-CoA dehydrogenase, furoyl-CoA synthetase, 2-oxoglutaroyl-CoA hydrolase, 2,5-furan-dicarboxylic acid decarboxylase 1, 2,5-furan-dicarboxylic acid decarboxylase 2 and/or HMF/furfural oxidoreductase from the host microorganism, to convert furanic compounds to non-toxic components, and obtain a detoxified lignocellulose hydrolysate;    (31) a process for the production of furoyl-CoA dehydrogenase, furoyl-CoA synthetase, 2-oxoglutaroyl-CoA hydrolase, 2,5-furan-dicarboxylic acid decarboxylase 1, 2,5-furan-dicarboxylic acid decarboxylase 2 and/or HMF/furfural oxidoreductase, which are at least 45% identical to those expressed by the microorganism, or the host microorganism cell (I) comprising: culturing the microorganism in a nutrient medium containing carbon and nitrogen sources, and inorganic salts; and isolating the enzymes produced from the microorganism;    (32) a process (IIb) for the conversion of 5-hydroxymethylfurfural (HMF), 2,5-dihydroxymethyl furan, 5-hydroxymethyl-2-furancarboxylic acid and/or 2,5-furandicarboxylic acid to 2-furoyl CoA, comprising contacting furfuryl alcohol and/or furfural with furoyl-CoA dehydrogenase, furoyl-CoA synthetase, 2-oxoglutaroyl-CoA hydrolase, and 2,5- furan-dicarboxylic acid decarboxylase catalyst in the presence of at least one coenzyme cofactor (s);    (33) a method for the biocatalytic production of biofuels (e.g. ethanol) in a suitable host microorganism of the enzymatic pathway of the microorganism, under conditions facilitating the expression of the activity of the enzymes in the enzymatic pathway; and    (34) a process (IIc) for producing second-generation biofuels from a lignocelluloses-containing material comprising: (m) pretreating and hydrolysis of the lignocellulose-containing material to prepare a lignocellulosic hydrolysate comprising at least one of the furanic compounds and at least one fermentable sugars; (n) the in-situ detoxification of the lignocellulose hydrolysate; and (o) conversion of the fermentable sugars from the lignocellulose hydrolysate or the detoxified lignocellulose hydrolysate to produce a biofuel.