TECHNOLOGY FOCUS - BIOLOGY - Preparation: No preparation method is given. Preferred Components: The microorganism grows on the carbon source, where the carbon source is 5-(hydroxymethyl)furfural (HMF), furfuryl alcohol, furfural and/or furoic acid. The microorganism expresses the enzymes including furoyl-CoA dehydrogenase, furoyl-CoA synthetase, 2-oxoglutaroyl-CoA hydrolase, 2,5-furan-dicarboxylic acid decarboxylase 1, 2,5-furan-dicarboxylic acid decarboxylase 2 and/or HMF/furfural oxidoreductase. The cell (I) is prokaryote, eukaryote, plant or animal cell. The cell (I) is a bacterium comprising Escherichia, Anabaena, Caulobacter, Gluconobacter, Rhodobacter, Pseudomonas, Paracoccus, Bacillus, Brevibacterium, Corynebacterium, Rhizobium (Sinorhizobium), Flavobacterium, Klebsiella, Enterobacter, Lactobacillus, Lactococcus, Methylobacterium, Staphylococcus or Streptomyces genus, preferably Bacillus subtilis, Bacillus amyloliquefaciens, Bacillus licheniformis, Bacillus lentus, Bacillus megaterium, Bacillus halodurans, Bacillus pumilus, G.oxydans, Caulobacter crescentus CB15, Methylobacterium extorquens, Rhodobacter sphaeroides, Pseudomonas zeaxanthinifaciens, Pseudomonas putida, Pseudomonas putida S12, Paracoccus denitrificans, E. coli, Corynebacterium glutamicum, Staphylococcus carnosus, Streptomyces lividans, Sinorhizobium meliloti or Rhizobium radiobacter species. The cell (I) is a yeast cell comprising: Candida, Hansenula, Kluyveromyces, Pichia, Saccharomyces, Schizosaccharomyces, or Yarrowia genus, preferably Kluyveromyces lactis, Saccharomyces cerevisiae, Hansenula polymorpha, Yarrowia lipolytica and Pichia pastoris species; or filamentous fungal cell including Aspergillus, Chrysosporium, Penicillium, Talaromyces or Trichoderma genus, preferably A. niger, A. awamori, A. foetidus, A. sojae, A. fumigatus, Talaromyces emersonii, A. oryzae, C. lucknowense, Trichoderma reesei or P. chrysogenum species. In the cell (I), at least gene is deleted, knocked-out or disrupted in full or in part, where optionally the gene encodes for a protease. The polypeptide (A3) having LysR family transcriptional regulator activity comprises: amino acid sequence containing SEQ ID NO: 17; or an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 18 or its variant polypeptide, where the variant has greater than or equal to 47% sequence identity with the sequence comprising SEQ ID NO: 17 (Sequences not defined here may be found at ftp://ftp.wipo.int/pub/published_pct_sequences/publication). The polynucleotide (A4) comprises: (b1) the nucleotide sequence containing SEQ ID NO: 18; (b2) a nucleotide sequence which hybridizes selectively with a polynucleotide being the reverse complement of SEQ ID NO: 18; (b3) a nucleotide sequence having at least greater than or equal to 72% sequence identity with the nucleotide sequence of SEQ ID NO: 18; (b4) a fragment of a nucleotide sequence of (b1), (b2) or (b3) which is at least 100 nucleotides in length; (b5) a sequence which is degenerate as a result of the genetic code to a sequence of (b1), (b2), (b3) or (b4); or (b6) a nucleotide sequence which is the reverse complement of a nucleotide sequence of (b1), (b2), (b3), (b4) or (b5). The polypeptide (A5) having 2,5-furan-dicarboxylic acid decarboxylase 1 activity comprises: the amino acid sequence containing SEQ ID NO: 19; or an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 20 or its variant polypeptide, where the variant has at least greater than or equal to 54% sequence identity with the sequence comprising SEQ ID NO: 19 (Sequences not defined here may be found at ftp://ftp.wipo.int/pub/published_pct_sequences/publication). The polynucleotide (A6) comprises: (c1) the nucleotide sequence containing SEQ ID NO: 20; (c2) a nucleotide sequence which hybridizes selectively with a polynucleotide being the reverse complement of SEQ ID NO: 20; (c3) a nucleotide sequence having at least greater than or equal to 66% sequence identity with the nucleotide sequence of SEQ ID NO: 20; (c4) a fragment of a nucleotide sequence of (c1), (c2) or (c3) which is at least 100 nucleotides in length; (c5) a sequence which is degenerate as a result of the genetic code to a sequence of (c1), (c2), (c3) or (c4); or (c6) a nucleotide sequence which is the reverse complement of a nucleotide sequence of (c1), (c2), (c3), (c4) or (c5). The polypeptide (A7) having 2,5-furan-dicarboxylic acid decarboxylase 2 activity comprises: the amino acid sequence containing SEQ ID NO: 21; or an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 22 or its variant polypeptide, where the variant has at least greater than or equal to 52% sequence identity with the sequence comprising SEQ ID NO: 21 (Sequences not defined here may be found at ftp://ftp.wipo.int/pub/published_pct_sequences/publication). The polynucleotide (A8) comprises: (d1) the nucleotide sequence containing SEQ ID NO: 22; (d2) a nucleotide sequence which hybridizes selectively with a polynucleotide being the reverse complement of SEQ ID NO: 22; (d3) a nucleotide sequence having at least greater than or equal to 67% sequence identity with the nucleotide sequence of SEQ ID NO: 22; (d4) a fragment of a nucleotide sequence of (d1), (d2) or (d3) which is at least 100 nucleotides in length; (d5) a sequence which is degenerate as a result of the genetic code to a sequence of (d1), (d2), (d3) or (d4); or (d6) a nucleotide sequence which is the reverse complement of a nucleotide sequence of (d1), (d2), (d3), (d4) or (d5). The polypeptide (A9) having HMF/furfural oxidoreductase activity comprises: the amino acid sequence containing SEQ ID NO: 25; or an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 26 or its variant polypeptide, where the variant has at least greater than or equal to 45% sequence identity with the sequence comprising SEQ ID NO: 25 (Sequences not defined here may be found at ftp://ftp.wipo.int/pub/published_pct_sequences/publication). The polynucleotide (A10) comprises: (e1) the nucleotide sequence containing SEQ ID NO: 26; (e2) a nucleotide sequence which hybridizes selectively with a polynucleotide being the reverse complement of SEQ ID NO: 26; (e3) a nucleotide sequence having at least greater than or equal to 66% sequence identity with the nucleotide sequence of SEQ ID NO: 26; (e4) a fragment of a nucleotide sequence of (e1), (e2) or (e3) which is at least 100 nucleotides in length; (e5) a sequence which is degenerate as a result of the genetic code to a sequence of (e1), (e2), (e3) or (e4); or (e6) a nucleotide sequence which is the reverse complement of a nucleotide sequence of (e1), (e2), (e3), (e4) or (e5). The polypeptide (A11) having LysR type transcriptional regulator activity comprises: the amino acid sequence containing SEQ ID NO: 33; or an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 34 or its variant polypeptide, where the variant has at least greater than or equal to 46% sequence identity with the sequence comprising SEQ ID NO: 33 (Sequences not defined here may be found at ftp://ftp.wipo.int/pub/published_pct_sequences/publication). The polynucleotide (A12) comprises: (f1) the nucleotide sequence containing SEQ ID NO: 34; (f2) a nucleotide sequence which hybridizes selectively with a polynucleotide being the reverse complement of SEQ ID NO: 34; (f3) a nucleotide sequence having at least greater than or equal to 65% sequence identity with the nucleotide sequence of SEQ ID NO: 34; (f4) a fragment of a nucleotide sequence of (f1), (f2) or (f3) which is at least 100 nucleotides in length; (f5) a sequence which is degenerate as a result of the genetic code to a sequence of (f1), (f2), (f3) or (f4); or (f6) a nucleotide sequence which is the reverse complement of a nucleotide sequence of (f1), (f2), (f3), (f4) or (f5). The polypeptide (A13) having furoyl-CoA dehydrogenase (large subunit) activity comprises: the amino acid sequence containing SEQ ID NO: 35; or an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 36 or its variant polypeptide, where the variant has at least greater than or equal to 54% sequence identity with the sequence comprising SEQ ID NO: 35 (Sequences not defined here may be found at ftp://ftp.wipo.int/pub/published_pct_sequences/publication). The polynucleotide (A14) comprises: (g1) the nucleotide sequence containing SEQ ID NO: 36; (g2) a nucleotide sequence which hybridizes selectively with a polynucleotide being the reverse complement of SEQ ID NO: 36; (g3) a nucleotide sequence having at least greater than or equal to 66% sequence identity with the nucleotide sequence of SEQ ID NO: 36; (g4) a fragment of a nucleotide sequence of (g1), (g2) or (g3) which is at least 100 nucleotides in length; (g5) a sequence which is degenerate as a result of the genetic code to a sequence of (g1), (g2), (g3) or (g4); or (g6) a nucleotide sequence which is the reverse complement of a nucleotide sequence of (g1), (g2), (g3), (g4) or (g5). The polypeptide (A15) having furoyl-CoA dehydrogenase (flavin adenine dinucleotide (FAD) binding subunit) activity comprises: the amino acid sequence containing SEQ ID NO: 37; or an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 38 or its variant polypeptide, where the variant has at least greater than or equal to 54% sequence identity with the sequence comprising SEQ ID NO: 37 (Sequences not defined here may be found at ftp://ftp.wipo.int/pub/published_pct_sequences/publication). The polynucleotide (A16) comprises: (h1) the nucleotide sequence containing SEQ ID NO: 38; (h2) a nucleotide sequence which hybridizes selectively with a polynucleotide being the reverse complement of SEQ ID NO: 38; (h3) a nucleotide sequence having at least greater than or equal to 71% sequence identity with the nucleotide sequence of SEQ ID NO: 38; (h4) a fragment of a nucleotide sequence of (h1), (h2) or (h3) which is at least 100 nucleotides in length; (h5) a sequence which is degenerate as a result of the genetic code to a sequence of (h1), (h2), (h3) or (h4); or (h6) a nucleotide sequence which is the reverse complement of a nucleotide sequence of (h1), (h2), (h3), (h4) or (h5). The polypeptide (A17) having furoyl-CoA dehydrogenase (2Fe-2S iron sulfur subunit) activity comprises: the amino acid sequence containing SEQ ID NO: 39; or an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 40 or its variant polypeptide, where the variant has at least greater than or equal to 54% sequence identity with the sequence comprising SEQ ID NO: 39 (Sequences not defined here may be found at ftp://ftp.wipo.int/pub/published_pct_sequences/publication). The polynucleotide (A18) comprises: (i1) the nucleotide sequence containing SEQ ID NO: 40; (i2) a nucleotide sequence which hybridizes selectively with a polynucleotide being the reverse complement of SEQ ID NO: 40; (i3) a nucleotide sequence having at least greater than or equal to 70% sequence identity with the nucleotide sequence of SEQ ID NO: 40; (i4) a fragment of a nucleotide sequence of (i1), (i2) or (i3) which is at least 100 nucleotides in length; (i5) a sequence which is degenerate as a result of the genetic code to a sequence of (i1), (i2), (i3) or (i4); or (i6) a nucleotide sequence which is the reverse complement of a nucleotide sequence of (i1), (i2), (i3), (i4) or (i5). The polypeptide (A19) having furoyl-CoA synthetase activity comprises: the amino acid sequence containing SEQ ID NO: 41; or an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 42 or its variant polypeptide, where the variant has at least greater than or equal to 57% sequence identity with the sequence comprising SEQ ID NO: 41 (Sequences not defined here may be found at ftp://ftp.wipo.int/pub/published_pct_sequences/publication). The polynucleotide (A20) comprises: (k1) the nucleotide sequence containing SEQ ID NO: 42; (k2) a nucleotide sequence which hybridizes selectively with a polynucleotide being the reverse complement of SEQ ID NO: 42; (k3) a nucleotide sequence having at least greater than or equal to 68% sequence identity with the nucleotide sequence of SEQ ID NO: 42; (k4) a fragment of a nucleotide sequence of (k1), (k2) or (k3) which is at least 100 nucleotides in length; (k5) a sequence which is degenerate as a result of the genetic code to a sequence of (k1), (k2), (k3) or (k4); or (k6) a nucleotide sequence which is the reverse complement of a nucleotide sequence of (k1), (k2), (k3), (k4) or (k5). The polypeptide (A21) having 2-oxoglutaroyl-CoA hydrolase activity comprises: the amino acid sequence containing SEQ ID NO: 43; or an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 44 or its variant polypeptide, where the variant has at least greater than or equal to 72% sequence identity with the sequence comprising SEQ ID NO: 43 (Sequences not defined here may be found at ftp://ftp.wipo.int/pub/published_pct_sequences/publication). The polynucleotide (A22) comprises: (l1) the nucleotide sequence containing SEQ ID NO: 44; (l2) a nucleotide sequence which hybridizes selectively with a polynucleotide being the reverse complement of SEQ ID NO: 44; (l3) a nucleotide sequence having at least greater than or equal to 74% sequence identity with the nucleotide sequence of SEQ ID NO: 44; (l4) a fragment of a nucleotide sequence of (l1), (l2) or (l3) which is at least 100 nucleotides in length; (l5) a sequence which is degenerate as a result of the genetic code to a sequence of (l1), (l2), (l3) or (l4); or (l6) a nucleotide sequence which is the reverse complement of a nucleotide sequence of (l1), (l2), (l3), (l4) or (l5). Preferred Process: In the process (IIa): the microorganism is the Cupriavidus basilensis, preferably Cupriavidus basilensis HMF14 DSM 22875; and the host microorganism cell is the microorganism cell (I). The process (IIa) further comprises: subjecting the detoxified lignocellulose hydrolysate to a simultaneous or subsequent fermentation step; and pre-treating lignocellulose-containing material to obtain a lignocellulose hydrolysate, preferably under acidic conditions. The process (IIa) comprises: introducing any one of the above polynucleotides in an appropriate host cell; cultivating the obtained host cell under conditions conducive to the detoxification of lignocelluloses hydrolysate; and recovering a detoxified lignocelluloses hydrolysate from the culture. In the process (IIb), the catalyst comprises any one of the polypeptides. In the process (IIc): the conversion of fermentable sugars comprises fermentation of the fermentable sugars; and in step (n) a stable fermentable sugar concentration is maintained before all furanic compounds are converted. The process (IIc) further comprises: the step of catalytic cracking and/or hydrotreating of the biofuel to prepare a cracked and/or hydrotreated biofuel; and blending the, optionally cracked or hydrotreated, biofuel with at least one of the other components to produce an automotive fuel. EXAMPLE - No suitable example given.