NOVELTY - Synthesis of tazobactam comprises processing oxidizing 6,6-dibromo penicillanic acid diphenylmethyl ester in catalytic oxidation system; reducing 6,6-dibromopenam sulfoxide diphenylmethyl ester by zinc powder in the presence of ammonium chloride; reacting 6,6-dibromopenam sulfoxide diphenylmethyl ester with 2-triphenyl silicon-1,2,3-triazole; oxidizing 2( beta )-azidomethyl penicillanic acid diphenylmethyl ester by mixed oxidant phosphoric acid and potassium permanganate; and reducing 2( beta )-azidomethyl penicillanic acid diphenylmethyl ester dioxide by m-cresol.    USE - Synthesis of tazobactam.    ADVANTAGE - The method improves reaction yield and purity of product, and adopts environment-friendly hydrogen peroxide-cobalt acetate catalytic oxidation system that provides fine reaction selectivity, high yield, and recyclable catalyst. It is simple, safe, and reliable. It shortens reaction route and improves total yield. It improves production cost and environmental pollution, and has larger implementation value and economic benefit.    DETAILED DESCRIPTION - Synthesis of tazobactam comprises:    (1) generating 6,6-dibromo penicillanic acid by diazotization-bromination reaction at 0-5 degrees C using 6-amino penicillinic acid (6-APA) as raw material in the presence of sodium nitrite, sulfuric acid, bromine and quat. ammonium salt type phase transfer catalyst, in which molar ratio of 6-APA, sodium nitrite, and bromine is 1:1-2:1.5-3 and dosage of quat. ammonium salt type phase transfer catalyst is 1-5 mass% of 6-APA;    (2) processing catalytic esterification to 6,6-dibromo penicillanic acid and diphenyl methanol using concentrated sulfuric acid as catalyst in the presence of dehydrating agent N,N'-dicyclohexylcarbodiimide (DCC), in which dosage of catalyst concentrated sulfuric acid is 1-5 mass% of raw material diphenyl methanol;    (3) oxidizing 6,6-dibromo penicillanic acid diphenylmethyl ester in catalytic oxidation system composed of hydrogen peroxide-cobalt acetate to prepare 6,6-dibromopenam sulfoxide diphenylmethyl ester, in which weight to volume ratio of cocatalyst cobalt acetate to 30% hydrogen peroxide is 1:100;    (4) reducing 6,6-dibromopenam sulfoxide diphenylmethyl ester by zinc powder in the presence of ammonium chloride to obtain 6,6-dihydropenam sulfoxide diphenylmethyl ester, in which molar ratio of 6-APA to zinc powder is 1:2-5; and adding zinc powder in batches and reacting for 30 minutes at 0-10 degrees C;    (5) reacting 6,6-dibromopenam sulfoxide diphenylmethyl ester with 2-triphenyl silicon-1,2,3-triazole in solvent at 110-120 degrees C for 3-5 hours to obtain 2( alpha )-methyl 2( beta )-(1,2,3-triazol-1-yl)methylpenam-3( alpha )-carboxylic diphenylmethyl ester;    (6) oxidizing 2( beta )-azidomethyl penicillanic acid diphenylmethyl ester by mixed oxidant phosphoric acid and potassium permanganate at 1:1.5 molar ratio in the presence of phosphoric acid to generate 2( beta )-azidomethyl penicillanic acid diphenylmethyl ester dioxide; and controlling pH of reaction liquid to 6.5;and    (7) reducing 2( beta )-azidomethyl penicillanic acid diphenylmethyl ester dioxide by m-cresol to remove carboxyl protection group dimethylphenyl on 4-site of aromatic heterocyclic and to obtain tazobactam, such that reaction is carried out at 80 degrees C for 4 hours, and pH of system is controlled at 1-1.8 during crystallization.