NOVELTY - An organic solvent containing alkaline substance is added to reactor, and p-chloro-o-nitro-acetanilide is added. Reaction is carried out at 20-30 degrees C for 2.5-3.5 hours, and temperature is raised to 50 degrees C. The closed cycle reaction is performed at solvent boiling point temperature. The content of p-chloro-o-nitro-acetanilide is tracked by liquid chromatogram. A reducing agent is added to reactor, and temperature is increased to 50-150 degrees C. Cooling water and cold salt are added, and crystallization is carried out. Thus, 2-chloro-6-hydroxy quinoxaline is produced.    USE - Synthesis of 2-chloro-6-hydroxy quinoxaline.    ADVANTAGE - The hydroxy quinoxaline compound is manufactured with high yield by a simple method, without affecting the environment.    DETAILED DESCRIPTION - An organic solvent containing an alkaline substance is added to a reactor, and p-chloro-o-nitro-acetanilide is added. Reaction is carried out at 20-30 degrees C for 2.5-3.5 hours, and temperature is raised to 50 degrees C. The closed cycle reaction is performed at solvent boiling point temperature for 2.5-3.5 hours. The content of the p-chloro-o-nitro-acetanilide is tracked by liquid chromatogram. The processing is continued, when content of p-chloro-o-nitro-acetanilide is less than 1%. The reaction time is delayed, when content of p-chloro-o-nitro-acetanilide is more than 0.1%. A reducing agent is added to the reactor, and temperature is increased to 50-150 degrees C for 5-15 hours. Liquid chromatogram is used to analyze complete reaction. The processing is continued, when content of nitric oxide is less than 0.1%. The reaction time is delayed, when content of nitric oxide is more than 0.1%. Cooling water is added to reduce the temperature to room temperature, and cold salt is added to reduce the temperature to 5 degrees C. The heat is preserved for 2 hours such that crystallization is carried out. The molar ratio of p-chloro-o-nitro-acetanilide, alkali and reducing agent is 1:3-6:1-2. The molar number of alkali is calculated according to hydroxy radical number. Thus, 2-chloro-6-hydroxy quinoxaline is produced.