TECHNOLOGY FOCUS - INORGANIC CHEMISTRY - Preferred Components: The alkali is sodium hydroxide, potassium hydroxide or sodium hydride. The additive is sulfuric acid. The oxidizing agent is chromium oxide. The halogen is selected from chlorine, bromine or iodine.    TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preparation (claimed): Compound (I) is prepared by mixing steroid sapogenin and 20-30% carboxyl derivative of formula (II), adding concentrated hydrochloric acid to adjust pH of the solution to 1-3, stirring at - 10 degrees C to room temperature, filtering distilling the filtrate, adding non-protonic solvent, drying using anhydrous sodium sulfate, and evaporating to remove the solvent to obtain black oily liquid; adding aryl halide and alkali to the liquid, adding non-protonic solvent, heating at 70 degrees C for 5-20 hours, adding concentrated sulfuric acid and alcohol, and reacting at - 10 degrees C to room temperature to obtain a hydroxyl derivative of formula (III); and adding non-protonic solvent and oxidizing agent, adding additive, and reacting at - 78 to 60 degrees C for 0.1-5 hours. Preferred Components: The mole ratio of black oily liquid, alkali, aryl halide and concentrated sulfuric acid is 1:1-5:1-5:0.01-0.2. The aryl halide agent is halogenated benzyl; p-methoxy-benzyl halide; 2-nitro benzyl halide; p-nitro benzyl halide; 2,4,6-trimethyl benzyl halide; 2,4-dimethoxy benzyl halide; or 3, 4-dimethoxy benzyl halide. The mole ratio of compound (II), compound (III), and mixture of oxidizing agent and additive is 1:1-10:0-15. The oxidizing agent is dichromate pyridine, dimethyl sulfoxide or Dyess-Martin oxidizing agent. The additive is oxalyl chloride and/or triethylamine. The non-protonic solvent is methylbenzene, benzene, N, N-dimethylformamide, diethyl ether, ethyl acetate, acetone and/or dichloromethane. The alcohol is methanol, alcohol or propanol. The mole ratio of compound (I), organic alkali and carbonyl protecting agent is 1:1-3:1-3. The carbonyl protecting agent is trimethyl silica-based halogen, triethyl silica-based halogen or dimethyl tertiary butyl silica-based halogen. The mole ratio of blue solution, organic alkali and dimethyl sulfide is 1:1-3:3-6. The non-protonic solvent A is dichloromethane, tetrahydrofuran, benzene, ethyl acetate and/or diethyl ether. The organic alkali is pyridine, 1,8-diazabicyclo (5,4,0)-11-7-alkene or imidazole.