TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Process: The process is characterized by either one or a combination of the following structural features, which are: -OR1, at the benzene ring of the benzo(b)thiophene moiety is located at the 6-position of the benzo(b)thiophene moiety; R6 is -phenyl (Ph)-OR1 preferably, -OR1, is located at the 4-position of the phenyl moiety of the R6; and/or R7 is -Ph-OR2 preferably, -OR2 is located at the 4-position of the phenyl moiety of the R7. In the process, (VIIa) is prepared from 2-phenyl-benzo(b)thiophene compound of formula (VIa), which is reacted with phenyl keto compound of formula (Va), in the presence of a Lewis acid and a solvent. In the process, one of the hydroxy protecting groups R1 and R2 is stable under basic conditions and cleavable under acidic conditions but substantially not cleavable in the presence of a Lewis acid at Friedel-Crafts acylation conditions, while the other hydroxy protecting group is cleavable under basic conditions and stable under acidic conditions, preferably R1 is stable under basic conditions and cleavable under acidic conditions but substantially not cleavable in the presence of a Lewis acid at Friedel-Crafts acylation conditions, and R2 is cleavable under basic conditions and stable under acidic conditions. The Lewis acid is used in substoichiometric amounts, which is 0.004-0.07 times molar amounts, preferably 0.01-0.02, relative to (VI) and (VIa) respectively. In the process, (VIII) is prepared from (VIIa), where the process comprises selective deprotection of the -OR2 group. In the process, (XX) is prepared from (VIII) by O-alkylation with alkyl compound of formula (Y1-R3) (IX). In the process, (XI) or their salts is prepared from (XX) by deprotection of the -OR1 groups. In the process, (X1a) or 1-(2-(4-(6-methoxy-2-(4-methoxy-phenyl)-benzo(b)thiophene-3-carbonyl)-phenoxy)-ethyl)-piperidinium chloride (X1aa) is provided. (X1a) is provided in crystalline form, preferably (X1aa) and whose X-ray diffraction (XRD) pattern has at least signals at the following 2 theta values ( plus minus 0.5 degrees C respectively), which are 11.41, 113.07, 116.74, 19.27, 19.39, 21.56, 23.42, 24, 124.631 or 26.05, or (X1a) and whose XRD pattern has at least signals at the following 2 theta values ( plus minus 0.5 degrees respectively), which are 7.41, 13.05, 16.64, 19.07, 19.22, 21.45, 23.31, 24.34, 25.81 or 26.62. The process is characterized by following procedural features: the azeotrope forms under normal or reduced pressure, preferably under reduced pressure; in the dissolving step, the resulting mixture is heated prior to step seeding step, preferably heating is under reflux conditions; and/or solvent(s) incorporated into the solvate form of a salt of (XI) is/are removed by azeotropic distillation of the mixture, preferably the azeotropic distillation is carried out at reduced pressure. The process is characterized by following features, which are: the acid forming the salt of (XI) whereupon the solvate form is based is organic or inorganic acids, preferably oxalic acid, succinic acid, lactic acid, malonic acid, HCl, HBr and H2SO4, preferably HBr; and the salt of (XI) obtained in separating step has a purity of greater than 98%, preferably greater than 99.6%, as measured by HPLC.X1 = Cl, Br, I or phenyl ester group of formula (a); andY1 = Cl, Br or I.Preferred Components: The crystalline solvate is characterized by following features, which are: the salt is derived from an organic or inorganic acid comprising oxalic acid, succinic acid, lactic acid, malonic acid, hydrochloric acid (HCl), hydrobromic acid (HBr) and sulfuric acid (H2SO4), preferably HBr; the first solvent is incorporated into the salt of (XI) in an amount of percent by weight which is lower than the amount of percent by weight of the second solvent and/or the crystalline solvate form of a salt of (XI) comprises the first solvent in an amount of 0.1-8 wt% and the second solvent in an amount of 3-15 wt% relative to the solvate form of a salt of (XI); or the first solvent is an alcohol and the second solvent is a hydrocarbon or halocarbon, where the first solvent is a 1-4C alcohol and the second solvent is a 1-10C halocarbon optionally comprising a benzene ring or 6-10C hydrocarbon comprising a benzene moiety, preferably the first solvent is methanol (preferred) or ethanol and the second solvent is methylene chloride (preferred), toluene, chloroform or chlorobenzene. The organic solvent is an alcohol, a water-miscible alcohol, which is 1-4C alcohol. The organic solvent of dissolving step comprises a predetermined amount of water, preferably the amount of water is predetermined by a volume ratio of water and organic solvent of 0-0.5, preferably 0.29-0.38. The water used in dissolving step is potable water, preferably reverse osmosis water. EXAMPLE - No suitable example given.