TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preparation (claimed): Compound (I) is prepared by:(A) synthesizing 1H-pyrrole-2,4-dicarboxylic acid of diethyl ester by dissolving ethyl isocyanoacetate and 1,8-diazabicyclo(5.4.0)undec-7-ene in tetrahydrofuran to form a solution, adding formaldehyde into the solution and stirring the reaction mixture at 54.5-55.5 degrees C; and when the reaction ends, cooling the reaction mixture to normal temperature, washing the reaction mixture with ethyl acetate, saturated sodium bicarbonate aqueous solution and sodium chloride aqueous solution respectively, mixing the ethyl acetate organic layers, dehydrating, drying and concentrating in vacuum;(B) synthesizing 1-aminodiethyl-1H-pyrrole-2,4-dicarboxylic acid by mixing the 1H-pyrrole-2,4-dicarboxylic acid of diethyl ester, ammonium chloride, trimethylammonium chloride and sodium hydroxide aqueous solution with methyl tert-butyl ether to form a solvent, adding ammonia into the solvent, adding bleaching water, and stirring the formed reaction mixture at room temperature to carry out a reaction; and when the reaction ends, filtering the reaction mixture, washing the filtrate using ethyl acetate, saturated sodium bicarbonate aqueous solution and a saturated sodium chloride aqueous solution respectively, mixing the ethyl acetate organic layers, dehydrating, drying and concentrating in vacuum;(C) synthesizing (1,2,4)triazine-6-carboxylic acid of diethylamino-4-4-hydropyrrolo(2,1-f) by mixing 1-aminodiethyl-1H-pyrrole-2,4-dicarboxylic acid and chloroformamidine hydrochloride with dimethylsulfoxide and stirring the mixture at 145.5-455.5 degrees C to react, cooling the reaction mixture to normal temperature, washing the reaction mixture using ethyl acetate, saturated sodium bicarbonate aqueous solution and saturated sodium chloride aqueous solution respectively, mixing the ethyl acetate organic layers, dehydrating, drying and concentrating in vacuum to obtain crude product of (1,2,4)triazine-6-carboxylic acid of diethylamino-4-4-hydropyrrolo(2,1-f), and purifying the crude product by recrystallization;(D) synthesizing (1,2,4)-triazine-6-carboxylic acid of ethyl-2-((penta)-((dimethylamino)methylene)amino)-4-hydropyrrolo(2,1-f) by mixing (1,2,4)triazine-6-carboxylic acid of diethylamino-4-4-hydropyrrolo(2,1-f) with dimethylformamide, thionyl chloride and dichloromethane to carry out reflux reaction, cooling the reaction mixture to normal temperature, washing the reaction mixture using ethyl acetate, saturated sodium bicarbonate aqueous solution and saturated sodium chloride aqueous solution respectively, mixing the ethyl acetate organic layers, dehydrating, drying and concentrating in vacuum to obtain crude product and purifying the crude product by recrystallization;(E) synthesizing ethyl 4-chloro-2-((penta)-((dimethylamino)methylene)amino)pyrrolo(2,1-f) (1,2,4)triazine-6-carboxylic acid by mixing (1,2,4)triazine-6-carboxylic acid of ethyl-2-((penta)-((dimethylamino)methylene)amino)-4-hydropyrrolo(2,1-f) with phosphorus oxychloride and stirring the mixture at 99.5-100.5 degrees C to react, preserving heat for 30 minutes when the reaction mixture turns brown, cooling the reaction mixture to 0 degrees C rapidly and adjusting pH of the reaction mixture to 7.2, filtering to obtain a white suspension, washing with ethyl acetate, taking out the organic layer of the filtrate using saline, dehydrating, drying and concentrating the organic layer in vacuum to obtain crude product, and purifying the crude product using a silica gel column;(F) synthesizing (1,2,4)triazine-6-carboxylic acid of 4-(2,4-dichloro-6-hydroxyphenyl)-2-((penta)-((dimethylamino)methylene)amino)pyrrolo(2,1-f) by mixing sodium carbonate aqueous solution with ethyl 4-chloro-2-((penta)-((dimethylamino)methylene)amino)pyrrolo(2,1-f) (1,2,4)triazine-6-carboxylic acid, (3,5-dichloro-2-(hydroxyboro)phenol) and 1,4 dioxane, blowing the mixture using nitrogen gas, adding tetra(triphenylphosphine)palladium and stirring at 79.5-80.5 degrees C to react; when the reaction ends, cooling to room temperature and adding water to form a water mixture, extracting the water mixture using ethyl acetate, and washing the organic layer using saturated sodium chloride aqueous solution; dehydrating, drying and concentrating to obtain crude product, and purifying the crude product using silica gel column;(G) synthesizing (1,2,4)triazine-6-carboxylic acid of diethylamino-4-(2,4-dichloro-6-hydroxyphenyl)pyrrolo(2,1-f) by mixing dioxane solution of 4 M hydrochloric acid with (1,2,4)triazine-6-carboxylic acid of 4-(2,4-dichloro-6-hydroxyphenyl)-2-((penta)-((dimethylamino)methylene)amino)pyrrolo(2,1-f) and methyl alcohol and stirring the mixture at room temperature to react; evaporating the reaction solution in vacuum and neutralizing using saturated sodium carbonate solution, and extracting using ethyl acetate; washing the organic layer using saturated sodium chloride solution, dehydrating, drying and concentrating in vacuum to obtain crude product, and purifying the crude product using silica gel column;(H) synthesizing (1,2,4)triazine-6-carboxylic acid of diethylamino-4-(2,4-dichloro-6-(2-(hydro-pyrazol-1-yl)ethoxy)phenyl)pyrrolo(2,1-f) by mixing potassium carbonate with 1-(2-chloroethyl)-1H-pyrrole, (1,2,4)triazine-6-carboxylic acid of diethylamino-4-(2,4-dichloro-6-hydroxyphenyl)pyrrolo(2,1-f) and dimethylformamide and stirring the mixture at 119.5-120.5 degrees C; when the reaction ends, cooling the reaction mixture to room temperature, adding water and ethyl acetate into the reaction mixture, and stirring for 30 minutes to obtain a water mixture; extracting the water mixture using ethyl acetate and washing the organic layer using saturated sodium chloride aqueous solution, dehydrating, drying and concentrating in vacuum to obtain crude product, and purifying the crude product using silica gel column;(I) synthesizing (1,2,4)triazine-6-carboxylic acid of 2-amino-4-(2,4-dichloro-6-(2-(1H-pyrazol-1-yl)ethoxy)phenyl)pyrrolo(2,1-f) by mixing a sodium hydroxide aqueous solution with (1,2,4)trazine-6-carboxylic acid of diethylamino-4-(2,4-dichloro-6-(2-(hydro-pyrazol-1-yl)ethoxy)phenyl)pyrrolo(2,1-f) and ethyl alcohol and stirring the mixture at 119.5-120.5 degrees C; when the reaction ends, adding hydrochloric acid aqueous solution to obtain mixture with pH of 6-8; extracting the mixture using ethyl acetate, extracting the organic layer using saturated sodium chloride aqueous solution, dehydrating, drying and concentrating in vacuum condition; and(J) synthesizing (1,2,4)triazine-6-formamide of 2-amino-N-cyclopropyl-4-(2,4-dichloro-6-(1H-pyrazol-1-yl)ethoxyphenyl)pyrrolo(2,1-f) by mixing 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride with (1,2,4)triazine-6-carboxylic acid of 2-amino-4-(2,4-dichloro-6-(2-(1H-pyrazole-1-yl)ethoxyl)phenyl)pyrrolo(2,1-f), cyclopropylamine, triethylamine and dimethylformamide and stirring the mixture at room temperature to react; when the reaction ends, extracting with ethyl acetate, washing the organic layer using saturated sodium bicarbonate aqueous solution and saturated sodium chloride aqueous solution, dehydrating, drying and concentrating in vacuum to obtain crude product and purifying the crude product using silica gel column. ACTIVITY - Cytostatic.    MECHANISM OF ACTION - Heat shock proteins (Hsp) inhibitor; Ubiquitin-proteasome pathway activator.