NOVELTY - An improved process for the preparation of ceftriaxone disodium hemiheptahydrate (I) involves: condensing 7-amino-3-(((2,5-dihydro-6-hydroxy-2-methyl-5-oxo-1,2,4-triazin-3-yl)thio) methyl)-3-cephem-4-carboxylic acid (II) with 2-mercaptobenzothiazole 2-(2-aminothiazol-4-yl)-2-syn-methoxyiminoacetate (III) in presence of a base in alcoholic solvent; adding water and organic solvent, followed by separating, adding and isolating step.    USE - For preparation of ceftriaxone disodium hemiheptahydrate (claimed) for the treatment of several infections.    ADVANTAGE - The method prepares good quality ceftriaxone disodium hemiheptahydrate in a very safe, simple, economical, user-friendly and in an industrially viable manner or in greater yield with higher chemical purity; is easy to implement on commercial scale and avoid excessive use of reagents and organic solvents to avoid hazardous and risky solvents which makes the method more safe and eco-friendly. The alcoholic solvent used during the reaction, can be reusable and thus recyclable, which makes the process industrially more suitable. The condensation is accomplished relatively in a shorter time, which makes the process more useful against the prior art processes. The method is a simple method, which avoids more number of operations, thus resulting in shortening of reaction time and lowering of labor.    DETAILED DESCRIPTION - An improved process for the preparation of ceftriaxone disodium hemiheptahydrate (disodium salt of 7-((2-(2-aminothiazol-4-yl)-2-syn-methoxyimino)acetamido)-3-(((2,5-dihydro-6-hydroxy-2-methyl-5-oxo-1,2,4-triazin-3-yl)thio)methyl)-3-cephem-4-carboxylic acid) (I) involves: condensing 7-amino-3-(((2,5-dihydro-6-hydroxy-2-methyl-5-oxo-1,2,4-triazin-3-yl)thio) methyl)-3-cephem-4-carboxylic acid (II) with 2-mercaptobenzothiazole 2-(2-aminothiazol-4-yl)-2-syn-methoxyiminoacetate (III) in presence of a base in an alcoholic solvent; adding water and an organic solvent; separating the organic layer and aqueous layer; adjusting the pH of the aqueous layer as obtained from third step with an acid; adding sodium ion source and an organic solvent to the aqueous layer as obtained from fourth step; and isolating the ceftriaxone disodium hemiheptahydrate (I) in pure form.