TECHNOLOGY FOCUS - INORGANIC CHEMISTRY - Preferred Components: The alkali is potassium hydroxide, sodium hydroxide, sodium hydride, potassium hydride or potassium carbonate. Preferred Process: The methylation reaction is carried out at 5-20 degrees C for 0.5-4 hours. The silane reaction of methyl tert-butyl ether and ethyl acetate is carried out at 0-100 degrees C, preferably 15-40 degrees C for 12-48 hours. The clarithromycin preparation method further involves using compound (II), which is obtained by reacting solvent with (3R,4S,6R)-4-dimethylamino-6-methyl -tetrahydro-pyran-3-ol substituted (3R,5S,7R,9R,11S,12R,13S,14R)-14-ethyl-7,12,13-trihydroxy-10-imino-3,5,7,9,11,13-hexamethyl-oxacyclotetradecan-2-one compound of formula (I), which is a fine sugar type compound. The silanization reagent is processed.R1= oxime hydroxyl protecting group;andR 2=trimethyl alkyl, catalytic amount of saccharin and/or N-trimethyl silicon based saccharin.    TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Components: The other polar inert solvent is N, N-dimethyl formamide, N, N-dimethyl acetamide, dimethyl sulfoxide, 1, 2-dimethoxyl ethane and/or hexamethyl phosphoric triamide. The methylation reagent is toluene sulfonic acid methyl ester, methyl sulfonic acid methyl ester, chloromethane, methyl bromide, iodide or sulfate. The clarithromycin preparation method enables utilizing silylation reagent, which is hexamethyl disilazane, trimethyl silicon imidazole, N, N-bis (trimethylsilyl) acetamide or N, N'-di (trimethyl silicon based) carbamide, and the solvent is dichloromethane, 1, 2-dichloroethane, acetonitrile, N, N-dimethyl formamide or N, N-dimethyl acetamide. The molar weight of compound (I) is 10 times of the solvent. Preferred Composition: The mole amount of the compound (II) is 1-10 times mole amount of the methylated reagent. The molar weight of the compound (II) is 10 times molar weight of the alkali. The volume ratio of 2-methyl tetrahydrofuran and other polar inert solvent is 1: 1. The mole weight of fine sugar compound utilized in a compound (I) is 0.1-10% preferably 0.5 to 5%. Preferred Definitions:    R1=trityl, benzyl, 2-chlorobenzyl, 1-methoxy-1-methyl ethyl, 1-ethoxy-1-methyl ethyl, 1-methoxy-1-cyclohexyl, 1-ethoxy-l-cyclohexyl or 1-isopropoxy-l-cyclohexyl;and    R2=phenyl, methyl, ethyl, isopropyl, cyclohexyl, silicane, carbonyl or carbonyl.    SPECIFIC COMPOUNDS - 1 compound (II) is specifically claimed i.e. (2S,3R)-3-tert-Butyl-2,4,4-trimethy-l-tetrahydro-pyran substituted 1-isopropoxy1-cyclohexyl of formula (IIa)