TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preparation (claimed): (I) is prepared by preparing thiazole non-amino acid salt type ionic liquid; converting thiazole non-amino acid salt type ionic liquid into thiazole hydroxide type ionic liquid through negative ion exchange reaction; and preparing compound (I) through neutralization reaction of amino acid and thiazole hydroxide type ionic liquid. Preferred Components: The amino acid negative ion is one or more of 76 compounds e.g. glycine negative ion, D-alanine negative ion, L-alanine negative ion, DL-alanine negative ion, and D-valine negative ion. The thiazole non-amino acid salt type ionic liquid comprises 3-butyl-4-methyl-5-(2-ethoxy) thiazole hydrochloride, 3-butyl-4-methyl thiazole hydrochloride, 3-ethoxyl-4-methyl thiazole hydrochloride, 3-vinyl-4-methyl thiazole hydrochloride, 3-butyl-4-methyl-5(2-ethoxy) thiazole bromate, 3-butyl-4-methyl thiazole bromate, 3-etyoxyl-4-methyl thiazole bromate, and 3-vinyl-4-methyl thiazole bromate. The thiazole hydroxide type ionic liquid comprises 3-butyl-4-methyl-5-(2-ethoxy) thiazole hydroxide type ionic liquid, 3-butyl-4-methyl thiazole hydroxide type ionic liquid, 3-etyoxyl-4-methyl thiazole hydroxide type ionic liquid and 3-vinyl-4-methyl thiazole hydroxide type ionic liquid. Preferred Method: The method comprises mixing 4-methylthiazole and 4-methyl-5-(2-ethoxy) thiazole respectively with 1-chlorobutane, 1-bromobutane, 2-chlorohydrin, 2-bromoethanol, allyl chloride and allyl bromine at molar ratio of 1:1-2:1; respectively adding 20-40 mL of acetonitrile as solvent into obtained mixed solutions, heating and uniformly stirring; keeping temperature at 40-90 degrees C, after reacting for 2-50 hours, steaming solutions to obtain compound (I); or mixing 3-butyl-4-methyl-5-(2-ethoxy) thiazole hydrochloride, 3-butyl-4-methyl thiazole hydrochloride, 3-ethoxy-4- methyl thiazole hydrochloride and 3-vinyl-4- methyl thiazole hydrochloride with purified water at mass ratio of 1:1-10:1; respectively making obtained mixed solutions flow through negative ion exchange column from top to bottom; after finishing adding, using purified water to wash, and collecting washing liquid to refine thiazole hydroxide type ionic liquids, until detecting that washing liquid is neutral. Preferred Definitions:    R1-R3=1-4C alkyl, straight-chain or branched chain alkyl, allyl, benzyl or ethoxy; and    M-=chloride ion, bromonium ion, iodide ion, acetate ion, sulfate radical ion, sulfite ion, nitrate ion, fluoroboric acid ion, thiocyanic acid, hexafluorophosphoric acid ion, p-toluenesulfonic acid ion or trifluoromethanesulfonic acid ion.    SPECIFIC COMPOUNDS - 4 Compounds (I) are specifically claimed namely 3-butyl-4-methyl-5-(2-ethoxy) thiazole glycinate type ionic liquid (Ia); 3-butyl-4-methyl thiazole glycinate type ionic liquid; 3-etyoxyl-4-methyl thiazole glycinate type ionic liquid; and 3-vinyl-4-methyl thiazole glycinate type ionic liquid.