TECHNOLOGY FOCUS - INORGANIC CHEMISTRY - Preferred Component: The strong acid is sulfuric acid, muriatic acid, hydrobromic acid, hydroiodic acid and/or perchloric acid. The strong base is sodium hydroxide, calcium hydride, and/or potassium hydroxide.    TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Component: The ratio of 1-bromo-4-isobutyl benzene and compound (I) is 1.1-1.5. The mmole ratio of solvent to 1-bromo-4-isobutyl benzene is 0.5-2. The palladium catalytic agent is used at 0.1-0.4 mol% of quantity of 1-bromo-4-isobutyl benzene. The ratio of organic phosphorus ligand to palladium catalytic agent is 1:1-3:1. The solvent is benzene, methylbenzene, dimethylbenzene, trimethylbenzene, dimethyl sulfoxide, dimethylformamide, dimethylacetylamide, N-methyl pyrrolidone, diethylene glycol monomethyl, diethylene glycol monoethylether, and/or dipropylene glycol diethyl ether. The palladium catalytic agent is metal palladium, palladium acetic acid, palladium chloride, palladium dichloride (acetonitrile), palladium trifluoroacetic acid, tri(dibenzylidene acetone) di-palladium, dipentene propyl group palladium chloride, and/or di-(dibenzylidene acetone) palladium. The organic phosphine ligand is triphenylphosphine, tricyclic group phosphine, tri-tert-butyl phosphine, 2-dicyclohexyl phosphine-2,4,6-tri-isopropyl biphenyl, 2-(dicyclohexyl phosphine) biphenyl, 2-dicyclohexyl phosphine-2-(N,N-dimethyl amino-group) biphenyl, 9,9-dimethyl-4,5-bi-(diphenyl phosphine) xanthene, 9,9-dimethyl-4,5-bi(di-tert-butyl phosphine group) xanthene, 2- dicyclohexyl phosphine-2', 6'-diisopropyl oxygroup-1,1'-biphenyl, ( plus minus )-2,2'-bi-(toluene)-1,1'-biphenyl, ( plus minus )-2,2'-bi-(p-toluenesulfonic phosphine group)-1,1'-biphenyl, and/or 1,1'-bi(diphenyl phosphine) ferrocene. The strong base is potassium tert-butoxide, sodium tert-butoxide, and/or potassium ethoxide. The halogenated methane is chloromethane, methyl bromide, methyl iodide, trifluoromethane sulfonic acid methyl ester, and/or p-toluene sulfonic acid methyl ester. Preferred Method: The reaction is conducted at 120-160 degrees C for 16-24 hours. The compound (II) is heated and backflow to generate hydrolysis reaction in strong acid aqueous solution. The strong acid is twice to five times of substance quantity of compound. The concentration of strong acid is 1-3 mol/liter in concentration of hydrogen ion. The reaction is conducted at 100-150 degrees C for 5-15 hours. The compound shown in the formula (II) is heated and backflow in strong base aqueous solution with presence of solvent alcohol, and protonized by strong acid to obtain ibuprofen. The strong base is twice to five times of substance quantity of the compound. The concentration of strong acid is 1-3 mol/liter in concentration of hydrogen ion. The volume of cosolvent alcohol is 1/10-1/2 of that of strong base aqueous solution. The use quantity of strong acid is 1.2-1.5 times of that of strong base. The reaction is conducted at 100-150 degrees C for 5-15 hours. A compound of formula (IV) and halogenated methane are dissolved in a solvent to react with strong base hydride presence to generate compound (II).X=Cl, Br, I, trifluoromethanesulfonic acid base, or p- toluenesulfonic acid group.