TECHNOLOGY FOCUS - BIOLOGY - Preferred Components: The enzyme is immobilized enzyme comprising penicillin acylase or immobilized alpha -amino-acid ester hydrolase. The penicillin acylase is PGK400 and PGK450.    TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Processes: The esterification reaction temperature is - 25 to 20 degrees C, and the agent for esterification is diphenyl carbinol, diphenyl diazomethane, p-nitrobenzyl bromide or p-methoxy benzyl chloride; the absorbing alkali comprises triethylamine, pyridine, 2,6-dimethyl pyridine, 2-methyl pyridine and/or N-methyl morpholine; the acyl halide for esterification is methylsulfonylchloride and methylsulfonylbromide; the reaction solvent for esterification is halohydrocarbon solvent comprising dichloromethane, trichloromethane and/or 1,2-dichloromethane. The oxidization reaction temperature is - 25 to 30 degrees C, and oxidant is peracetic acid and hydrogen peroxide; the reaction solvent is halohydrocarbon solvent; generating compound 32 by open loop reaction at 45-110 degrees C; the reaction agent is trimethyl phosphate and/or triethyl phosphate; the reaction solvent is aprotic solvent comprising n-hexane, petroleum ether, cyclohexane and/or toluene; and eliminating solvent in reaction utilizing evaporation. The method further comprises crystallizing compound 32 with crystallizing solvent of protic solvent comprising methanol, ethanol, n-propyl alcohol, isopropanol, n-butyl alcohol or isobutanol; processing ozonization reaction at - 70 to 20 degrees C, with reaction comprising halohydrocarbon solvent, protic solvent and/or aprotic solvent; generating compound 33 by reduction reaction at - 45 to 20 degrees C, with reducing agent comprising trimethyl phosphate and/or triethyl phosphate; and crystallizing compound 33 with crystallizing solvent. The esterification reaction temperature is - 25 to 20 degrees C, with agent for esterification comprising diphenyl carbinol, diphenyl diazomethane, p-nitro benzyl bromide or p-methoxy benzyl chloride; bromination reaction temperature is - 35 to 10 degrees C, with bromination agent comprising bromine or N-bromosuccinimide; generating compound 34 by cyclization reaction at 0-35 degrees C, with acid for cyclization comprising sulfuric acid, hydrochloric acid or phosphoric acid, and solvent comprising halohydrocarbon solvent and protic solvent. The reduction reaction temperature is - 70 to 30 degrees C, with reducing agent comprising sodium borohydride, potassium borohydride, palladium carbon or sodium borohydride and potassium borohydride, solvent comprising protic solvent or halohydrocarbon solvent; esterification reaction temperature is - 25 to 10 degrees C; the acyl halide for esterification is methylsulfonylchloride and/or methylsulfonylbromide; the absorbing alkali comprises triethylamine, pyridine, 2,6-dimethyl pyridine, 2-methyl pyridine and/or N-methyl morpholine; the reaction solvent is halohydrocarbon solvent; generating 7-ANCA compound 35 with protective group by elimination reaction at - 45 to 10 degrees C; and eliminating halohydrocarbon solvent in reactant by evaporation. The method further comprises crystallizing 7-ANCA compound 35 with protective group. The reaction temperature is 5-40 degrees C, at pH 5.5-8.5, reaction solvent comprising water, boric acid buffer salt water solution, and phosphoric acid buffer salt water solution, and stirring at 20-30 revolutions/minute.