TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Process: The process (P1) further comprises (e) filtering the aqueous solution to remove solid impurities after step (a) and before step (b). The step (a) is performed by heating the aqueous solution at 40-80 degrees C. The step (b) is followed by cooling the solution to a temperature of below 10 degrees C. The step (e) is followed by seeding the concentrated solution with laquinimod sodium. In process (P2), if insoluble matter in the mixture is determined not to be present below the predetermined amount, the process further comprises: dissolving the batch in water to form an aqueous solution; filtering the aqueous solution to reduce the amount of insoluble matter to below the predetermined amount; and steps (b)-(d) as above per se. Preferred Components: The concentrated solution comprises 1-4 (preferably 1-2) ml of water/g of laquinimod sodium. The anti-solvent is: acetone (preferred), ethanol and/or isopropanol; and added in an amount of 3-15 ml/g of laquinimod sodium. ACTIVITY - Antiinflammatory; Immunosuppressive; Neuroprotective.    MECHANISM OF ACTION - None given.    EXAMPLE - 5-Chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-quinoline-3-carboxylic acid methyl ester (3 g), N-ethylaniline (2-2.88 ml) and heptane (60 ml) were heated and the volatiles (mainly heptane and formed methanol) (32 ml) distilled off during 6 hours and 35 minutes. After cooling to room temperature the crystalline suspension was filtered and the crystals were washed with heptane and dried in vacuum to yield laquinimod acid. Then a solution of 5 M sodium hydroxide was prepared by dilution of a 50 wt.% sodium hydroxide solution (10 g) with sterile water (25 ml). N-ethyl-N-phenyl-1,2-dihydro-4-hydroxy-5-chloro-methyl-2-oxo-quinoline-3-carboxamide (10 g) was suspended in ethanol (150 ml) and the 5 M sodium hydroxide solution was added to pH of 8-12 (5.6 ml). The reaction mixture was stirred for another 30 minutes at ambient temperature. The resulting precipitation was filtered off and rapidly washed twice with ethanol (2x 150 ml). The precipitate was then dried in vacuum over phosphorous pentoxide to give laquinimod sodium. Then the obtained laquinimod sodium (46.7 g) and deionized (500 ml) were introduced into a glass reactor. The mixture was stirred and heated to 50 degrees C until complete dissolution of the solids was observed. The solution was filtered through filter paper and the filter was washed with water (10 ml) and the wash was combined with the filtrate. The resulting solution was introduced into the laboratory reactor equipped with a vacuum distillation system. The solution was concentrated by evaporation under vacuum (35-38 mBar) to a volume of 112 ml. After evaporation, the pressure was adjusted to atmospheric pressure and the jacket temperature was raised to 50 degrees C and acetone (295 g) was added to the batch over 2 hours. Solid crystallization was observed during the acetone addition. The batch was cooled to 2 degrees C and stirred for 12 hours. The solid product was isolated by filtration, washed twice with acetone and dried under vacuum at 35-40 degrees C to obtain recrystallized laquinimod sodium.