NOVELTY - Making at least 4 carbon containing (C4+) compound comprises: providing water and a biomass-derived water soluble oxygenated hydrocarbon comprising a hydrocarbon in an aqueous liquid and/or vapor phases, catalytically reacting the oxygenated hydrocarbon with hydrogen in the presence of a deoxygenation catalyst comprising a support and e.g. rhenium, at a deoxygenation temperature of 100-400 degrees C, and pressure of 72-1300 psig, to provide a reaction stream comprising water and oxygenates, and catalytically reacting the oxygenates in presence of an acid catalyst comprising e.g. alumino silicate.    USE - The method is useful for making C4+ compound including C4+ alcohol, C4+ ketone, C4+ alkane, C4+ alkene, C5+ cycloalkane, C5+ cycloalkene, aryl and/or fused aryl, preferably benzene, toluene, xylene, ethyl benzene, paraxylene, metaxylene, orthoxylene or 9C aromatics; and for preparing gasoline composition (all claimed), where the compounds are useful as fuels from biomass resources, such as ethanol, methanol, biodiesel, Fischer-Tropsch diesel, and gaseous fuels.    ADVANTAGE - The method provides the biofuels that do not depend on microorganisms, enzymes or other expensive and delicate manufacturing processes, and with lower energy consumption. The hydrocarbon fuels having a greater amount of energy content than ethanol. The condensation catalyst can be regenerated multiple times without a significant loss of performance.    DETAILED DESCRIPTION - Making at least 4 carbon containing (C4+) compound comprises: providing water and a biomass-derived water soluble oxygenated hydrocarbon comprising a hydrocarbon in an aqueous liquid phase and/or a vapor phase, catalytically reacting the oxygenated hydrocarbon with hydrogen in the liquid and/or vapor phase, in the presence of a deoxygenation catalyst comprising a support and a member consisting of rhenium, copper, iron, rubidium, platinum, palladium, nickel, tungsten, molybdenum, silver, tin, and/or their alloys, at a deoxygenation temperature of 100-400 degrees C, and a deoxygenation pressure of 72-1300 psig, to provide a reaction stream comprising water and two or more oxygenates having two or more carbon atoms and one or two oxygen atoms, and catalytically reacting the oxygenates in the vapor phase in the presence of an acid catalyst comprising a member of an alumino silicate, zirconia, tungstated aluminosilicate, tungstated zirconia, tungstated alumina, tungstated titania, a heteropolyacid and/or an acid modified resin, at a condensation temperature and condensation pressure to produce the C4+ compound. An INDEPENDENT CLAIM is included for a gasoline composition derived by the method as above per se, and distilling the product stream to provide the gasoline composition having a boiling point of less than 150 degrees C.