NOVELTY - Fabricating composition of polymers, copolymers, terpolymers and tetrapolymer soluble and/or insoluble in water of cyclodextrin, preferably alpha-cyclodextrin, beta-cyclodextrin, and/or gamma-cyclodextrin and their derivatives, comprises: introducing a crosslinking agent and cyclodextrin or its mixture of two or three different cyclodextrin, in a reaction chamber, with or without catalyst, to obtain a reaction mixture; agitating the reaction mixture; applying microwaves on the reaction mixture to obtain soluble and insoluble composition; and successively washing.    USE - The composition is useful in the form of a powder, tablets, gelcapsules, granules, microgranules, cream, emulsion, preferably oil-in-water or water-in oil or multiple emulsion, solution, colloidal solution or suspension (claimed). The process is useful for the preparation of the composition, which is useful in the field of pharmacy, human medicine, veterinary medicine, chemistry, separation chemistry, environment, electronics, biology, diagnosis, plant health, functional food, food, cosmetics and nutraceuticals in the field of molecular fingerprints.    ADVANTAGE - The process provide the composition with: improved stability and bioavailability; high solubility and non-crystalline amorphous structure; high yield; and improved mechanical property. The process is simple to implement on an industrial scale and easy to carried out, eco-friendly and inexpensive.    DETAILED DESCRIPTION - Fabricating composition of polymers, copolymers, terpolymers and tetrapolymer soluble and/or insoluble in water of cyclodextrin, preferably alpha-cyclodextrin, beta-cyclodextrin, and/or gamma-cyclodextrin and their derivatives, comprises: introducing a crosslinking agent or its mixture of crosslinking agent in the form of solid, suspension and cyclodextrin or its mixture of two or three different cyclodextrin and/or their derivatives in the form of solid or a suspension, in a reaction chamber, with or without catalyst, to obtain a reaction mixture; agitating the reaction mixture for a duration of 1-180 minutes, preferably 3 minutes; applying microwaves on the reaction mixture for 5 seconds to 72 hours, preferably 1.5 minutes, with an determined irradiation energy of 1-1000 watts, preferably 100 watts and at a temperature of 140 degrees C, for obtaining most of the soluble composition or at 170 degrees C for obtaining most of the insoluble composition; and successively washing the obtained solid residue with three volumes of 20 ml of water and with two volumes of 50 ml of ethanol, drying the solid residue resulting from washing at a temperature of 70 degrees C to obtain the insoluble composition, filtering and dialyzing the first fraction of 60 ml of washing water using a membrane, and drying the filtrate or dialyzate by spray drying, atomization or lyophilization to obtain the soluble composition. An INDEPENDENT CLAIM is included for the composition obtained by the process, comprising the crosslinking agent ( greater than or equal to 20 wt.%, preferably greater than or equal to 50 wt.%).