NOVELTY - Preparation of sinomenine hydrochloride sustained-release tablets involves preparing sinomenine hydrochloride from caulis sinomenii by percolation, cation-exchange resin or macroporous adsorption resin column elution, and refining; and mixing (pts. wt.) sinomenine hydrochloride (50-70), hydroxypropyl methylcellulose (80-90), pregelatinized starch (70-90) and microcrystalline cellulose (80-90) for 20-40 minutes, adding (pts. wt.) magnesium stearate (1-2) and silica gel powder (1-2), continuously mixing for 1-5 minutes, discharging material, tableting, coating, and packing with aluminum.    USE - Method for preparing sinomenine hydrochloride sustained-release tablets (claimed).    ADVANTAGE - Sinomenine hydrochloride extraction method adopts cation-exchange resin or macroreticular resin adsorption instead of traditional benzene and chloroform extraction processes; has high extraction yield; overcomes toxic hazards and environment pollution caused by high dosage of organic solvent; reduces organic solvent treatment process and environmental protection facility investment; and is simple and convenient to operate, safe to operating personnel, and environment friendly. The extracted and separated sinomenine hydrochloride has higher purity and no solvent residues, thus, reducing potential harm to human body.    DETAILED DESCRIPTION - Preparation of sinomenine hydrochloride sustained-release tablets involves:    (A) wetting caulis sinomenii coarse powder (100-1000 pts. wt.) with hydrochloric acid (HCl) (0.1-1 mol/L, 60-1000 pts. vol.) for 0.5-8 hours, putting in displacement tank, adding HCl (0.1-1 mol/L, 2 cm higher than powder level) and soaking for 6-48 hours, and percolating at 2-5 ml/minute for 6-24 hours; processing percolation solution through cation-exchange resin (preferably 001x 2.5, 001x 4 resin) or 152 resin (preferably macroporous adsorption resin) column with diameter-to-height ratio of 1:8-12 (preferably 1:10) at 2-5 (preferably 3) times column volume/hour, stopping the process when silicotungstic acid test solution detects precipitate in effluent and thin-layer chromatography detects no alkaloid spots, eluting with purified water until eluent is colorless, immersing cation-exchange resin in 8-15 (preferably 10%) ammonia solution or immersing 152 resin in 3-10 (preferably 5%) HCl solution for 12 hours, eluting cation-exchange resin with ammonia-ethanol (pH=8-11) or eluting 152 resin with 3-10 (preferably 5%) HCl solution at 2-5 bed volume/hour, detecting precipitate in eluent via silicotungstic acid test solution and stopping elution when no precipitation is detected, combining eluent, neutralizing to pH 6-8 with HCl or ammonia, desalting, concentrating, and drying to obtain sinomenine hydrochloride crude product; and heating and refluxing crude product (5-10 pts. wt.) with 10-95% (preferably 40-80%) ethanol or purified water (30-120 pts. vol.), adding active carbon (3-6, preferably 4 wt.%), preserving heat for 10-30 minutes, filtering while hot, concentrating filtrate, cooling, crystallizing, filtering, and washing filter cake with 75-95% ethanol until colorless to obtain sinomenine hydrochloride; and    (B) mixing (pts. wt.) sinomenine hydrochloride (50-70, preferably 60), hydroxypropyl methylcellulose (80-90, preferably 87.4), pregelatinized starch (70-90, preferably 80) and microcrystalline cellulose (80-90, preferably 86.6) for 20-40 (preferably 3) minutes, adding (pts. wt.) magnesium stearate (1-2, preferably 1.6) and silica gel powder (1-2, preferably 1.6), continuously mixing for 1-5 (preferably 3) minutes, discharging material, tableting, coating, and packing with aluminum.