TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Method: The method comprises (i) carrying out ring-opening reaction on aqueous sodium hydroxide solution of (III), then washing with methanol, drying by using anhydrous sodium sulfate, and protecting carboxy group to obtain (IV), (ii) carrying out N-substitution reaction of (IV) in an organic solvent, where the organic solvent is a mixed solvent of acetonitrile and methanol, and (iii) dissolving (V) in 1,4-dioxane, then adding aqueous sodium hydroxide solution, and carrying out de-protection reaction to obtain (I). The method comprises (i) stirring (III) with aqueous sodium hydroxide solution, then heating and refluxing until the solution is clear, cooling to room temperature, and filtering to obtain a white solid, then dissolving the white solid in concentrated hydrochloric acid, vacuum extracting to remove water, adding methanol and anhydrous sodium sulfate, stirring, filtering, evaporating the solvent to obtain (IV), (ii) adding (IV) and potassium carbonate into an organic solvent, stirring at room temperature, then adding (II) or its hydrochloride salt in acetonitrile solution, stirring at room temperature to react, then filtering to remove inorganic salt, and evaporating the solvent to obtain (V), and (iii) dissolving (V) in 1,4-dioxane, then adding aqueous sodium hydroxide solution, stirring at room temperature, reacting for a certain time, distilling to remove 1,4-dioxane, extracting obtained solution with petroleum ether, taking aqueous layer, adjusting the pH to 8-9, evaporating the solvent and purifying to obtain (I). The step (i): concentration of aqueous sodium hydroxide solution is 0.1-0.5 g/ml, preferably 0.2 or 0.3 g/ml; the heating temperature is 95-110 degrees C, preferably 100-105 degrees C; concentration of the concentrated hydrochloric acid is 35-40%, preferably is 37%; adding amount of methanol is 40-60 ml, preferably 50 ml; adding amount of anhydrous sodium sulfate is 5-15 g, preferably 10 g; the refluxing time is 4-10 hours, preferably for 6-8 hours; and the stirring time is 6-14 hours, preferably 11-13 hours. The step (ii): the organic solvent is a mixed solvent of acetonitrile and methanol in a volume ratio of 4-11:1, preferably 6:1; the stirring time is 8-16 minutes, preferably 10-15 minutes; and the reaction time is 12-24 hours. The step (iii): the reaction time is 1-5 hours; used amount (in volume) of petroleum ether is equal to the volume of the solution; the extracting time is 1-5 times, preferably 3 times; pH regulator is 1-6 N hydrochloric acid, preferably 2N hydrochloric acid; and the purification is carried out by using gradient flash column chromatography. ACTIVITY - Antiinflammatory; Hepatotropic; Virucide; Anti-HIV.