TECHNOLOGY FOCUS - BIOTECHNOLOGY - Preferred Method: The method further comprises: densifying the reduced recalcitrance lignocellulosic material prior to wet milling; adding an enzyme to the lignocellulosic material before, during or after wet milling; and adding a microorganism to the lignocellulosic material or a sugar derived from the lignocellulosic material, where the microorganism is added after wet milling has been completed, and the microorganism converts the lignocellulosic feedstock or sugar to the product. In the method: the recalcitrance of the lignocellulosic material has been reduced by irradiating the lignocellulosic material, where irradiating comprises exposing the material to an electron beam, delivering a dose of at least 5 Mrad to the lignocellulosic material; wet milling is performed using a rotor/stator head, where the rotor and stator include nesting rings of teeth, the stator comprises at least two concentric rings of teeth, and the rotor comprises a ring of teeth configured to fit between adjacent rings of teeth of the stator; wet milling is performed using many rotor/stator heads, at a shear rate of 30000-50000/second, and is performed in-line; and a jet mixer is applied during wet milling, and the jet mixer is operated during conversion of the feedstock or sugar to the product. Preferred Components: The lignocellulosic material is wood, particle board, sawdust, agricultural waste, sewage, silage, grasses, rice hulls, bagasse, cotton, jute, hemp, flax, bamboo, sisal, abaca, straw, wheat straw, corn cobs, corn stover, switchgrass, alfalfa, hay, coconut hair, seaweed and/or algae. In the method: the clearance between the rotor and stator is 0.01-0.25 inches (0.25-6.4 mm); and the spacing between the teeth in each ring of teeth is 0.1-0.3 inch (2.5-7.6 mm). In the wet milling system (S1): the biomass comprises a lignocellulosic material; the recalcitrance of the lignocellulosic material has been reduced by irradiating the lignocellulosic material, where irradiating comprises exposing the material to an electron beam; and the wet mill comprises the rotor/stator head. The wet milling system (S1) further comprises a jet mixer disposed in the fluid. In the system (S2), the jet head and wet mill are disposed within the tank. EXAMPLE - No suitable example given.