TECHNOLOGY FOCUS - INORGANIC CHEMISTRY - Preferred Components: The transition metal compound is selected from copper(I) chloride, copper(II) bromide, copper(I) oxide, copper(II) oxide, copper(I) acetate, copper(II) triflate, and/or copper(II) carbonate. The base is selected from cesium carbonate, cesium chloride, cesium fluoride and/or cesium iodide (preferably cesium carbonate). The oxidation agent in step (c6) is selected from sodium perborate hydrate, hydrogen peroxide, sodium hypochlorite, sodium percarbonate, sodium bromate, potassium bromate, sodium chlorate, potassium chlorate, and/or Oxone (RTM: oxidizing agent). The metal compound is preferably selected from a cobalt(II) compound, a cobalt(III) compound, an iron(III) compound, iron(II) compound and a manganese(II) compound (preferably cobalt(II) bromide, iron(III) acetylacetonate, cobalt(III) acetylacetonate, cobalt(II) acetyacetonate and manganese(II) acetylacetonate). The Grignard compound is of formula R6MgX.R6=1-6C alkyl.    TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Method: The step (a1) is a transition metal catalyzed process, particularly a transition metal catalyzed process using a catalyst comprising a transition metal compound and at least one ligand; or is a transition metal free catalyzed process, particularly a transition metal free catalyzed process using a base and at least one ligand. In the step (b1), the intermediate (III) is converted to the intermediate (I) by an amination process. The amination process involves (c2) reacting the intermediate (III) with an organo-zinc compound and/or an organo-magnesium compound in a suitable solvent, and (c3) reacting with an electrophilic aminating reagent in a suitable solvent; (c4) reacting the intermediate (III) with a halo-boron agent and/or a bifluoride agent, and (c5) reacting with an azide aminating reagent; and (c6) reacting the intermediate (III) with an oxidation agent in a suitable solvent to obtain intermediate of formula (IV), and (c7) reacting the intermediate (IV) with an aminating agent to obtain the intermediate (I). The step (c7) is a transition metal catalyzed process, particularly a transition metal catalyzed process using a catalyst comprising a transition metal compound and optionally at least one ligand, where the transition metal compound is selected from a gold compound (preferably Au/TiO2), a rhodium compound (preferably asterisk Cp RhCl2dimer), an iron compound (preferably FeBr3, FeCl3), an iridium compound (asterisk asterisk asterisk preferably IrCl(cod)2dimer, Cp IrCl2dimer, Cp IrBr2dimer or Cp IrCl2dimer), and a ruthenium compound (preferably Ru(p-cymene)Cl2dimer, Ru(p-cymene)Cl2dimer, Ru(p-cymene)Cl2dimer or Ru3CO12); or an acid catalyzed process, where the acid is selected from Bronsted acids. In the step (b2), the metal catalyzed cross-coupling process is carried out using a catalyst comprising a metal compound. Preferred Components: The Bronsted acids are selected from trifluoromethanesulfonic acid (HOTf), methanesulfonic acid, chlorsulfonic acid p-toluenesulfonic acid (PTSA), 2,5-dinitrobenzenesulfonic acid (DNBSA), sulfuric acid or dodecylbenzenesulfonic acid (DBSA), and particularly HOTf. ACTIVITY - Antidiabetic. No biological data given.    MECHANISM OF ACTION - Dipeptidyl peptidase IV (DPP-IV) inhibitor.    SPECIFIC COMPOUNDS - Preparation of 11 compounds is specified as the intermediate (I), e.g. 3-amino-4-(2,4,5-trifluoro-phenyl)-butyric acid methyl ester (IA), 3-benzyloxyamino-4-(2,4,5-trifluoro-phenyl)-butyric acid methyl ester, 3-(toluene-4-sulfonylamino)-4-(2,4,5-trifluoro-phenyl)-butyric acid methyl ester, 3-benzoylamino-4-(2,4,5-trifluoro-phenyl)-butyric acid methyl ester, and 3-(benzyl-(1-phenyl-ethyl)-amino)-4-(2,4,5-trifluoro-phenyl)-butyric acid methyl ester. 4 Compounds are specifically claimed as the intermediate (III), i.e. 3-dimethylboranyl-4-(2,4,5-trifluoro-phenyl)-butyric acid methyl ester (IIIA), 3-diethylboranyl-4-(2,4,5-trifluoro-phenyl)-butyric acid methyl ester, 3-(4,4,5,5-tetramethyl-(1,3,2)dioxaborolan-2-yl)-4-(2,4,5-trifluoro-phenyl)-butyric acid methyl ester and 3-benzo(1,3,2)dioxaborol-2-yl-4-(2,4,5-trifluoro-phenyl)-butyric acid methyl ester.    EXAMPLE - To a solution of methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(2,4,5-trifluorophenyl)butyric acid methyl ester (358 mg) in anhydrous tetrahydrofuran (THF) (5 ml) under nitrogen, was slowly added CH3MgCl (3 M in THF, 666 mu l) and the solution was stirred for 1 hour at 0 degrees C. Then aqueous ammonium hydroxide (25% aqueous solution, 224 mu l) and dry THF (3 ml) were added following by slow addition of sodium hypochlorite (15% aqueous solution, 1.32 ml) for in situ generation of chloramines (NH2Cl). The reaction mixture was stirred for 30 minutes at 0 degrees C, then slowly heated to room temperature and vigorously stirred for 20 hours. Aqueous HCl (1 M, 5 ml) was added, the mixture was extracted with tert-butylmethyl ether (MTBE) (30 ml) and organic phase was separated from the aqueous in separating funnel. Afterward aqueous NaOH (5 M, 5 ml) was added to the acidic aqueous layer and gently extracted with MTBE (3 times with 30 ml). The combined organic layers were dried over Na2SO4 and solvent was evaporated under reduced pressure. The obtained crude reaction mixture (135 mg, 54% yield) was analyzed with HPLC and 3-amino-4-(2,4,5-trifluoro-phenyl)-butyric acid methyl ester was confirmed with HPLC-MS analysis.