NOVELTY - Preparation of cefpirome hydrohalide intermediate compound (I) involves reacting 7-aminocephalosporanic acid with silanization reaction followed by iodization reaction and reaction with pyridine; and adding oxidizer and hydrochloric acid to iodination obtained product or adding mixed solvent of the organic solvent and water to obtain hydrogen hydroxide of cefopirome intermediate compound.    USE - In the preparation of hydrogen hydroxide of cefopirome intermediate compound (claimed) useful for preparing cefopirome for the treatment of bacterial infection.    ADVANTAGE - The hydrogen hydroxide of cefopirome intermediate compound prepared by the method has high yield, high purity, low production cost, simple operation, little three-waste discharge, easy process and recycle.    DETAILED DESCRIPTION - Preparation of cefopirome hydrohalide intermediate compound of formula (I) involves 1) dissolving 7-aminocephalosporanic in chloromethane solvent using silanization agent to protect amino and carboxyl to obtain trimethylsilyl 3-(acetoxymethyl)-8-oxo-7-(trimethylsilylamino)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate (H1), reacting the compound (H1) with the trimethyliodosilane in presence of bind acid agent at room temperature to obtain trimethylsilyl 3-(iodomethyl)-8-oxo-7-(trimethylsilylamino)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate (H2), reacting the compound (H2) with cyclopentenopyridine at 0-5?0C to obtain 2-((8-oxo-7-(trimethylsilylamino)-2-((trimethylsilyloxy)carbonyl)-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-6,7-dihydro-5H-cyclopenta(c)pyridinium iodide (H3); 2) adding methanol to the compound(H3), stirring the mixture for 10-15 minutes, adding oxidizer which is 0.8-5 times of the molar weight of the trimethyliodosilane in the step 1), adding hydrochloric acid to extract and crystallize, carrying out post treatment to obtain the compound (I); or 3) adding the compound (H3) to the mixed solvent containing organic solvent and water, stirring the mixture for 0.5-5 hours, filtrating the mixture and washing it, performing post treatment to obtain compound (I). The organic solvent is selected from alcohol, ketone, nitrile or amide. The volume ratio of the organic solvent and water is (1-10):1.