TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Method: The method (M1) preferably involves: method M2: introducing a first feed and a second feed into a reactor having a reactor volume, where the reactor volume including a first volume and a separated volume; exposing the first feed, in the first volume, to a first hydroprocessing catalyst under first hydroprocessing conditions to produce a first hydroprocessing effluent; maintaining physical separation of the first feed and the second feed in at least a portion of the reactor volume; exposing the second feed, in the separated volume, to a second hydroprocessing catalyst under second effective hydroprocessing conditions to produce a second hydroprocessing effluent; and recycling at least a portion of effluent from the reactor to form at least one of the first feed or the second feed, where at least one of the first feed and the second feed comprising less than 50 wt.% of recycled effluent; or method M3: introducing a first feed and a second feed into a reactor having a reactor volume, where the first feed having a nitrogen content that differs from a nitrogen content of the second feed by at least 100 weight parts per million (wppm); exposing the first feed, in the reactor volume, to a first hydroprocessing catalyst under first hydroprocessing conditions to produce a first hydroprocessing effluent; maintaining physical separation of the first feed and the second feed in at least a portion of the reactor volume; and exposing the second feed, in the reactor volume, to a second hydroprocessing catalyst under second hydroprocessing conditions to produce a second hydroprocessing effluent. In the methods, the physical separation of the first feed and the second feed are maintained for the entire reactor volume. The second hydroprocessing conditions include hydrodeoxygenation conditions, and the second hydroprocessing effluent comprises a liquid effluent with an oxygen content of less than 3 wt.%. The second hydroprocessing effluent is separated to form a gas phase effluent and a liquid effluent, and the method further involves: mixing the liquid effluent with a mineral feed to form a mixed feed; and hydroprocessing the mixed feed. The separation of the first feed and the second feed is maintained in the reactor volume until the first feed is downstream from at least one catalyst bed. The second hydroprocessing effluent is combined with the first feed and/or the first hydroprocessing effluent after a final hydroprocessing stage in the reactor volume and prior to leaving the reactor. In (M2), the second hydroprocessing catalyst comprises a dewaxing catalyst, and the second hydroprocessing conditions include catalytic dewaxing conditions. The first feed comprises less than 50 wt.% of the recycled effluent, and the recycled effluent comprises at least a portion of the second hydroprocessing effluent. The second feed includes an oxygen content of at least 3 wt.%. In (M3), the separation of the first feed and the second feed is maintained in the reactor volume until the first feed is downstream from at least one flow distributor; or from at least one catalyst bed. Preferred Components: The first feed is a naphtha boiling range feed. The oxygen content of the second feed is greater than 3 wt.%. The first feed has a basic nitrogen content of at least 50 wppm. The recycled effluent comprises at least a portion of the first hydroprocessing effluent and at least a portion of the second hydroprocessing effluent. In (M3), the feed has a basic nitrogen content that differs from the basic nitrogen content of the second feed by at least 50 wppm. At least a portion of the second feed comprises a biocomponent feedstock. EXAMPLE - No suitable example given.