TECHNOLOGY FOCUS - BIOTECHNOLOGY - Preferred Biomatrix: In the CRB, the biologically active microbes can save their biological activity at least for 14 days in CRB. CRB is in the form of sheet, mat or strip, or individual fibers or floes. It comprises a support structure and/or an effluent splitter. The microbe(s) is(are) selected from Clostridia species, such as Clostridia acetobutylicum, Clostridia butyricum, Clostridia beijerinckii, Clostridia saccharobutylacetonicum, Clostridia saccharobutylicum, and Clostridia saccharoperbutylacetonicum, and Lactobacillus species, such as Lactobacillus plantarum, Lactobacillus brevis, Lactobacillus fermentum, Lactobacillus sanfranciscensis, Lactobacillus buchneri, Lactobacillus collinoides, Lactobacillus rhamnosus and Lactobacillus bulgaricus. Preferred Apparatus: The apparatus further comprises a separate or an integrated cell growing unit (F1) having a feeding device for feeding first substrate (SU1) and an adjusting device for controlling growth conditions of cells of selected microbe(s) in first solution (SO1) in the integrated cell growing unit (F1); a separate or an integrated fermentation adjusting unit (F2) having a feeding device for feeding cells and/or first solution (SO1) from the integrated cell growing unit (F1) and an adjusting device for adjusting condition in second solution (SO2) to favor production of organic solvents and alcohols by cells of selected microbe(s); a separate or an integrated solution recovering unit for recovering third solution (SO3) from the BC comprising organic solvents and alcohols; or a cell return unit for recovering cells, solution and/or fibers originated from the BC, from the substrate (SU1, SU2) and/or from the solution recovering unit, and optionally for returning at least part of those cells to the integrated cell growing unit, to the fermentation adjusting unit, and/or to the BC. Preferred Method: Producing organic solvents and alcohols further comprises growing cells of microbe(s) in first solution (SO1) by feeding first substrate (SU1) and adjusting condition of the first solution (SO1) for optimal growth conditions of cells of microbes; optionally adjusting condition of grown cells in second solution (SO2) to favor production of organic solvents and alcohols by cells of microbes. Amount of cells is controlled by measuring optical density value of the solutions (SO1, SO2, SO3). The substrate (SU1, SU2) is selected from monomeric and oligomeric sugars, substrate originated from wood biomass and lignocellulosic biomass and substrate originated from vegetable peels, such as SSL, POME, and EFB. The growth condition is optimized by controlling the pH value, growth rate, feeding rate, temperature, sugar composition, substrate concentration. EXAMPLE - No example given.