NOVELTY - Producing middle distillates from at least one feedstock from renewable sources comprises hydrotreating the feedstock with at least a hydrotreatment catalyst at a temperature of 120-450 degrees C, at a pressure of 1-10 MPa, and at a hourly space velocity of 0.1-10 hours-1 and in the presence of hydrogen/feedstock ratio of 50-3000 Nm3 and hydroisomerization of obtained effluent with at least one hydroisomerization catalyst at a temperature of 120-450 degrees C, at a pressure of 1-10 MPa and at a hourly space velocity of 0.1-10 hours-1 and in the presence of hydrogen/feedstock ratio of 50-3000 Nm3.    USE - The process is useful for producing middle distillates from at least one feedstock from renewable sources (claimed), preferably diesel and kerosene type.    ADVANTAGE - The process reduces global warming potential and greenhouse gas emissions. The catalyst has improved catalytic performance.    DETAILED DESCRIPTION - Producing middle distillates from at least one feedstock from renewable sources comprises: hydrotreating the feedstock with at least a hydrotreatment catalyst at a temperature of 120-450 degrees C, at a pressure of 1-10 MPa, and at a hourly space velocity of 0.1-10 hours-1 and in the presence of hydrogen/feedstock ratio of 50-3000 Nm3 of hydrogen/m3 of feedstock; and hydroisomerization of obtained effluent with at least one hydroisomerization catalyst at a temperature of 120-450 degrees C, at a total pressure of 1-10 MPa and at a hourly space velocity of 0.1-10 hours-1 and in the presence of hydrogen/feedstock ratio of 50-3000 Nm3 of hydrogen/m3 of feedstock, where the catalyst, comprises, in the oxide form, at least one metal from group VIB and/or at least one metal from group VIII of the periodic table, present in the form of at least one polyoxometalate of formula (HhXxMmOy)(q-), the polyoxometalate is present within an oxide based mesostructured matrix of at least one element Y1 comprising silicon, aluminum, titanium, zirconium, gallium and/or cerium, the matrix has a pore size of 1.5-50 nm and amorphous wall thickness of 1-30 nm, and the catalyst is sulfurized prior to use in the process.    X = P, Si, B, Ni or Co;    M = one or more element comprising Mo, W, Ni or Co;    h = 0-12;    x = 0-4;    m = 5-12 or 18;    y = 17-72; and    q = 1-20.