NOVELTY - Increasing (M1) secretion of a protein from a cell involves providing a mutant cell (C1) or (C2), where the mutant cell (C1) contains inactivating mutations in at least two beta -glucosidase genes, and the mutant cell (C2) contains inactivating mutation in cytokinin response 1 (cre-1) gene in the cell; and contacting the mutant cell with cellulosic biomass, where the cellulosic biomass induces the mutant cell to secrete the protein.    USE - For increasing secretion of a protein from a cell comprising recombinant cell, stable cell line or transiently transfected cell, fungal or yeast cell (preferably filamentous fungus of the Ascomycete or Basidiomycete species, especially Neurospora crassa cells, Aspergillus nidulans cells, Trichoderma reesei cells, Phanerochaete chrysosporium cells, Sporotrichum thermophile (Myceliophthora thermophile) cells, Gibberella zeae cells, Sclerotinia sclerotiorum cells, Botryotinia fuckeliana cells, Aspergillus niger cells, Penicillium chrysogenum cells, Schizophyllum commune cells, Postia placenta cells, Aspergillus oryzae cells, and Acremonium cellulolyticus cells), useful for degradation of lignocellulosic biomass (claimed).    ADVANTAGE - The method facilitates biomass degradation that secretes high levels of active proteins after induction with soluble small molecules, such as cellodextrin.    DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for the following:    (1) increasing secretion (M2) of a protein from a cell involving providing a recombinant cell (C3) or (C4), where the recombinant cell (C3) exhibits reduced expression of at least two beta -glucosidase genes compared to the expression of at least two beta -glucosidase genes in a corresponding non-recombinant cell, and the recombinant cell (C4) exhibits reduced expression of a cre-1 gene compared to the expression of the expression of the cre-1 gene in a corresponding non-recombinant cell; and contacting the recombinant cell with cellulosic biomass, where the cellulosic biomass induces the recombinant cell to secrete the protein;    (2) new mutant cell comprising inactivating mutations in at least two beta -glucosidase genes, where cellulosic biomass induces the cell to secrete higher levels of a protein than a corresponding cell lacking the mutation in at least two beta -glucosidase genes;    (3) new recombinant cell exhibiting reduced expression of at least two beta -glucosidase genes compared to the expression of at least two beta -glucosidase genes in a corresponding non-recombinant cell, where the expression is reduced by siRNA, antisense DNA, quelling, or meiotic silencing, and cellulosic biomass induces the cell to secrete higher levels of a protein than the corresponding non-recombinant cell in which the expression of at least two beta -glucosidase genes is not reduced; and    (4) degradation of biomass involving providing lignocellulosic biomass; providing the mutant cell or recombinant cell, or a cell containing an inactivating mutation in the cre-1 gene; inducing the cell to secrete a protein by contacting the cell with cellulosic biomass; and contacting the induced cell with the lignocellulosic biomass, where the secreted protein degrades the lignocellulosic biomass.