NOVELTY - The method comprises condensing chiral epichlorohydrin in a presence of acetone and Lewis acid, cooling a system to -40 degrees C to 30 degrees C, dripping chiral epichlorohydrin as a main raw material and insulating and reacting at -40 degrees C to 30 degrees C after dripping after the reaction, recovering the temperature to 5-30 degrees C, adding saturated alkaline solution to stop reaction, extracting and distributing liquid to obtain chiral 3-chloro-1,2-propanediol acetonide, where the mole ratio of the main material chiral epichlorohydrin to acetone is 1:1.5-6.    USE - The chiral glycerol acetonide is useful: as solvent for oil, dye, cellulose derivative, polymer solvent, adhesive, wax and chlorine compound and as stabilizer, solution of ethane as disposable lithium battery, silk finishing agent and sealing glue; as important organic synthesis intermediate, in food medicine and chemical industry; for synthesizing some chiral medicine and chiral molecule as a chiral-inducing monomer; and for preparing the hypoglycemic agent for correcting hyperglycemia and hyperlipidemia and metabolism, sugar, protein and fat normal metabolism.    ADVANTAGE - The method provides chiral glycerol acetonide with higher reaction purity yield, in a simple and environmental friendly-manner.    DETAILED DESCRIPTION - The method comprises condensing chiral epichlorohydrin in a presence of acetone and Lewis acid, cooling a system to -40 degrees C to 30 degrees C, dripping chiral epichlorohydrin as a main raw material and insulating and reacting at -40 degrees C to 30 degrees C after dripping after the reaction, recovering the temperature to 5-30 degrees C, adding saturated alkaline solution to stop reaction, extracting, distributing liquid to obtain chiral 3-chloro-1,2-propanediol acetonide, where the mole ratio of the main material chiral epichlorohydrin to acetone is 1:3-5, the mole ratio of main material chiral epichlorohydrin to Lewis acid is 1:0.08-0.03 and the mole ratio of the main material Lewis acid to alkali is 1:0.2-0.6, substituting the raw material in a presence of polar solvent and chiral 3-chloro-1,2-propanediol acetonide, adding ester compound of formula (RCOOX) (A), reacting after heating up to 130-150 degrees C, after reaction, adding water and ester solvents to extract, separate and condense to obtain an ester compound of chiral glycerol acetonide, where the dosage ratio of chiral 3-chloro-1,2-propanediol acetonide to polar solvent is 1 g/4-6 ml, the mole ratio of chiral 3-chloro-1,2-propanediol acetonide to halide is 1:1-3, the mole ratio of chiral 3-chloro-1,2-propanediol acetonide to (A) is 1:1-3, the dosage ratio of chiral 3-chloro-1,2-propanediol acetonide to water is 1 g/7-10 ml and the dosage ratio of chiral 3-chloro-1,2-propanediol acetonide to ester solvent is 1 g/8-12 ml; hydrolyzing the raw material in a presence of non-polar solvent and ester compound of chiral 3-chloro-1,2-propanediol acetonide, adding 20% inorganic alkaline solution, and reacting after insulating for 20-40 degrees C, after reaction, separating, extracting, condensing, and rectifying to obtain a final product chiral glycerol acetonide, where the dosage ratio of ester compound of chiral glycerol acetonide to non-polar solvent is 1 g/1-3 ml and the mole ratio of ester compound of chiral glycerol acetonide to inorganic alkali is 1:1-3.    R = H, 2-3C alkane, para-chlorobenzyl group or p-nitrodiphenyl group; and    X = K or Na.