TECHNOLOGY FOCUS - BIOLOGY - Preferred Components: The substrate is chosen from wood, wood pulp, wood chips, sawdust, hardwood, softwood, newsprint, cardboard, paper pulp, corn fiber, corn grain, corn cobs, corn husks, corn stover, grasses, wheat, wheat straw, barley, barley straw, oat straw, oat hulls, hay, rice, rice straw, switchgrass, cord grass, rye grass, Miscanthus, reed canarygrass, waste paper, paper, fruit pulp, vegetable pulp, distillers grain, rice hulls, rice straw, cotton, hemp, flax, sisal, sugarcane bagasse, sugarcane straw, beet pulp, Sorghum, soy, soybean stover, canola straw, flowers, and their suitable mixtures.    TECHNOLOGY FOCUS - BIOTECHNOLOGY - Preferred Cell: The Myceliophthora fungal cell is M.thermophila fungal cell. Preferred Composition: The cellulose comprises pretreated lignocellulose. The enzyme mixture comprises a cell-free mixture. At least one fermentable sugar comprises glucose. At least one fermentable sugar comprises cellobiose. The enzyme mixture comprises at least one inhibitor of the two or more cellulose hydrolyzing enzymes. The enzyme mixture comprises at least one cellulase enzyme chosen from endoglucanases (EGs), beta -glucosidases (BGLs), type 1 cellobiohydrolases (CBH1s), type 2 cellobiohydrolases (CBH2s), and/or glycoside hydrolase 61s (GH61s), and/or variants of the cellulase enzyme. The cellulase enzyme is an enzyme that is endogenous to the Myceliophthora fungal cell. The enzyme mixture comprises at least one beta -glucosidase. The enzyme mixture comprises at least one cellobiose dehydrogenase. The cellobiose dehydrogenase (CDH) comprises CDH1 and/or CDH2. Preferred Method: The method further involves using at least one cellulase enzyme and/or at least one additional enzyme. The enzyme mixture is subjected to a purification process to selectively remove one or more glucose and/or cellobiose oxidizing enzymes from the enzyme mixture. The purification process comprises selective precipitation to separate the glucose and/or cellobiose oxidizing enzymes from other enzymes present in the enzyme mixture. The enzyme mixture comprises at least one inhibitor of the cellobiose oxidizing enzyme. At least 80%, 85% or 90% of the cellulose hydrolyzed by the enzyme mixture is present in the form of cellobiose and/or glucose. The method is conducted in a reaction volume of at least 10,000 liters. The method further involves fermenting at least one fermentable sugar to at least one end product. The method for producing at least one fermentable sugar and the fermentation of at least one fermentable sugar are conducted in a simultaneous saccharification and fermentation process. The enzyme mixture comprises at least one inhibitor of the two or more cellulose hydrolyzing enzymes. EXAMPLE - No suitable example given.