TECHNOLOGY FOCUS - INORGANIC CHEMISTRY - Preferred Components: The metal oxide or amide has the structure of formula (M(Y1)n) (IV). The silane hydride is of formula (H-Si(R11)(R12)(R13)) (III) or (R1-(Si(R0(i)2)(R1(i)3)-O)m-R4) (II).M = a metal;n = an integer equal to the valency of the metal;Y1 = OR0(k) or NR0(k)R1(k); andk = 1-n, such that for each value of k, and each of R0(k) and R1(k) is other than 1-10C hydrocarbon chain;R11-R13 = H, 1-8C alkyl, phenyl, 1-5C alkoxy, halo or -(CH2)p-SiR14R15R16;p = 0-5;R14, R15, R16 = H, 1-18C alkyl or 1-5C alkoxyl group;m = 1-500, preferably 1-100;i = 1-m;R0(i)2, R1(i)3 = H, 1-5C alkyl, 1-5C alkoxyl or OSiR5R6R7;R5, R6, R7 = H, 1-5C alkyl or 1-5C alkoxyl;R1 = H, 1-5C alkyl or 1-5C alkoxyl group;R4 = 1-5C alkyl or -SiR5aR6aR7a or -OSiR5aaR6aaR7aa; andR5a, R6a, R7a, R5aa, R6aa, R7aa = H, 1-5C alkyl, 1-5C alkoxyl group.Provided that at least one of R1, R0(i)2, R1(i)3, R5, R6, R7, R5a, R6a, R7a, R5aa, R6aa, R7aa is H.    TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Process: The cyclization is intramolecular cyclization. In the process, at least 0.1 equivalents of metal oxide or amide compound are used. Preferred Components: The compound comprising at least two nitrile functions undergoes a reductive alkylation. The compound comprises two nitrile functions. The compound is nitrile compound of formula (NC-(A(a))b-CN) (I).b = 1-7;a = 1-(b);A(a) = O, S, NR2(a) or CR0(a)R1(a); orA(a)A(a) = C(Raa)=C(R(a+1)) or C triple bond C;R0(a), R1(a), R(a+1) = H, OH, 1-6C hydrocarbon chain (optionally interrupted by O, S and/or NR2(a)-), aryl, or heteroaryl comprising 5-10 atoms, CHO, C(O)G1, C(O)OG1, C(O)NG2G3 or NG2G3;G1 = 1-6C hydrocarbon chain;G2, G3 = H, 1-6C hydrocarbon chain or amino-protecting group;R2(a) = H, amine protecting group, 1-6C hydrocarbon chain (optionally interrupted by O and/or S), or aryl or heteroaryl comprising 5-10 atoms.Provided that R0(a), R1(a) and R2(a) are optionally together to form a ring. EXAMPLE - Polymethylhydrosiloxane (1 ml) and tetraisopropoxytitanium (IV) (1.3 ml) were added to a sealed tube comprising (1-cyanomethyl-cyclopropyl)-acetonitrile (500 mg) in anhydrous toluene (4.3 ml) under argon atmosphere. The mixture was then heated to 100 degrees C overnight (15 hours) to obtain 1-cyanomethylcyclopropyl-acetonitrile A. The mixture was cooled to room temperature, transferred in flask and diluted with toluene. The solution was then acidified using an aqueous solution of 1M hydrochloric acid (20 ml) and the crude mixture was concentrated under reduced pressure. The resulting solid was then filtered and washed with pentane. the residue was then dissolved in chloroform and filtered. The filtrate was finally concentrated under reduced pressure to produce 1-aza-spiro(2,5)octane was isolated in the form of hydrochloride salt (85%).