TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Composition: The palladium catalyst has ligand chosen from monodentate neutral phosphine ligand, bidentate neutral phosphine ligand, neutral ( pi ) ligand, monovalent anionic ligand, bivalent anionic ligand, monodentate neutral amine ligand, bidentate neutral amine ligand, neutral nitrile ligand, and neutral sulfinyl ligand. The palladium catalyst is coordinated palladium complex in which the palladium has valency of 0 or 2. The organic alkali metal salt is organic lithium salt. The bidentate neutral phosphine ligand is 1,2-bis (diphenylphosphino)ethane, 1,3-bis(diphenylphosphino)propane, 1,4-bis(diphenylphosphino)butane or 1,1'-bis(diphenylphosphino)ferrocene. The monodentate neutral phosphine ligand is tri-n-butylphosphine, tri-t-butylphosphine or triphenylphosphine. The neutral ( pi ) ligand is benzene, cyclobutadiene or cyclooctadiene. The monovalent anionic ligand is methyl, phenyl, hexamethyl cyclopentadienyl, pentamethyl cyclopentadienyl, allyl, cyclopentadienyl, alkoxy, fluorine, chlorine, bromine, iodine, carboxylate, acetylacetonate, trifluoromethane sulfonate, 1,3-bis(2,6-di-isopropyl phenyl)-4,5-dihydroimidazole-2-lidene, 1,3-bis(2,6-di-isopropyl phenyl)imidazole-2-lidene or 1,3-bis(2,4,6-trimethyl phenyl)imidazole-2-lidene.The bivalent anionic ligand is phthalocyanine, naphthalocyanine or porphyrin. The monodentate neutral amine ligand is ammonia, pyridine or 3-chloropyridine. The bidentate neutral amine ligand is N,N,N',N'-tetramethylethylenediamine, 1,10-phenanthroline phosphorus or 2,2'-bipyridyl. The neutral nitrile ligand is acetonitrile or benzonitrile. The neutral sulfinyl ligand is 1,2-bis(phenylsulfinyl)ethane. The content of palladium catalyst is 0.01-50 mol% with respect to total amount of monohalogenated 3-substituted thiophene. The content of organic alkali metal salt is 0.1-10 equivalent with respect to 1 equivalent of monohalogenated 3-substituted thiophene. The polar aprotic organic solvent is N,N-dimethylformamide, N,N-diethyl formamide, N,N-dibutyl formamide, N,N-diisopropyl formamide, N,N,N',N'-tetramethyl azodicarboxamide, N,N-dimethyl thioformamide, bis(diethyl thiocarbamoyl)disulfide, bis(dimethyl thiocarbamoyl)disulfide, tetramethyl thiuram monosulfide, 1-cyclohexyl-2-pyrrolidone, 1-ethyl-2-pyrrolidone, 1-octyl-2-pyrrolidone, 1-vinyl- 2-pyrrolidone, 1,1-carbonyl-dipiperidine, 1,3-dimethyl-3,4,5,6-tetrahydro-2-(1H)pyrimidinone, N,N,N',N'-tetra-isobutyl urea and/or N,N,N',N'-tetramethylurea, preferably N,N-dimethylformamide and/or N,N,N',N'-tetramethylurea. The monohalogenated 3-substituted thiophene is 2-halogenated 3-substituted thiophene of formula (I).R=linear or branched 1-12C alkyl, linear or branched 1-12C alkoxy, 2-12C alkenyl, 2-12C alkynyl or 3-12C cycloalkyl;andX=halo.