NOVELTY - Coarse powder of caulis sinomenii is dissolved in hydrochloric acid, and hydrochloric acid is added to enable the liquid surface to immerge drug powder for 2 cm. Then, percolated, lime milk is added into the percolating liquid, filtered, hydrochloric acid is added in filtering liquid, extracted, and chloroform layers are washed and concentrated. Hydrochloric acid is dripped to concentrated product, to obtain yellow hydrochloric acid sinomenine crude product. Hydrochloric acid sinomenine crude product is heated and reflown, to obtain hydrochloric acid sinomenine.    USE - Preparation of hydrochloric acid sinomenine.    ADVANTAGE - The method efficiently and economically provides high-yield of hydrochloric acid sinomenine without causing pollution to environment and without using toxic solvents.    DETAILED DESCRIPTION - Coarse powder of caulis sinomenii (100-1000 parts weight) is dissolved in 60-1000 parts volume of 0.1-1 mol/L hydrochloric acid for 0.5-8 hours, filled obtained liquid in a percolating cylinder, and 0.1-1 mol/L of hydrochloric acid is added to enable the liquid surface to immerge the drug powder for 2 cm for 6-48 hours. Then, percolated at speed of 2-6 ml/minutes, and percolation is terminated after 6-24 hours, to obtain the percolating liquid. Lime milk is added into the percolating liquid to adjust the pH to 10.5-12, filtered, hydrochloric acid is added in the filtering liquid to adjust the pH to 7.0-9.5, extracted with chloroform for 2-5 times, and chloroform layers are combined and washed with water until layer becomes neutral. The washed layer is dried using anhydrous sodium sulfate (3-6 weight%), concentrated to recycle the chloroform and crystallized. Hydrochloric acid (6 mol/L) is dripped to the concentrated solution to adjust the pH to 2-4, stirring until the upper suspended solid is dispersed, refrigerated, filtered, filtering liquid is removed, and the filter cake is dried at 60-70 degrees C, to obtain yellow hydrochloric acid sinomenine crude product. Hydrochloric acid sinomenine crude product (5-10 parts weight) is heated and reflown by using 30-120 parts volume of 10-95% ethanol or purified water until the crude product is completely dissolved. Active carbon (4 wt.%) is added to obtained product, heated, reflown for 10-30 minutes, filtered, filtering liquid is concentrated, crystallized, filtered and filtering cake is washed using 95% of ethanol until the filtering liquid is colorless, to obtain hydrochloric acid sinomenine.