TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Method: The step (b) in method one comprises either: weighing (in parts by wt.) sinomenine hydrochloride (0.5), sodium chloride (6), and an specific amount of water for injection, mixing and dissolving the sodium chloride in 70% of water for injection to obtain a concentrated solution, then adding sinomenine hydrochloride into the concentrated solution, mixing to dissolve, adding activated carbon for injection (0.1%), mixing and maintaining at 35-45 degrees C for 10 minutes, then filtering out the activated carbon, supplying the water for injection (1000 parts by volume), mixing and examining, filtering with filter element of 0.45 mu m and 0.22 mu m respectively if qualified, and then sampling to measure the pH, content, bacterial endotoxin and visible foreign bodies to comply with the national injection standard, and then sterilizing to obtain the product; or weighing (in parts by wt.) sinomenine hydrochloride (1), sodium chloride (10), and a specific amount of water for injection, mixing and dissolving the sodium chloride in 70% of water for injection to obtain a concentrated solution, then adding sinomenine hydrochloride into the concentrated solution, mixing to dissolve, adding activated carbon for injection (0.2%), mixing and maintaining at 35-45 degrees C for 10 minutes, then filtering out the activated carbon, supplying the water for injection (1000 parts by volume), mixing and examining, filtering with filter element of 0.35 mu m and 0.15 mu m respectively if qualified, and then sampling to measure the pH, content, bacterial endotoxin and visible foreign bodies to comply with the national injection standard, and then sterilizing to obtain the product. The step (b) in method two comprises either: (i) weighing (parts by wt.) sinomenine hydrochloride (0.5), glucose (45) and a specific amount of water for injection, then mixing and dissolving the glucose in 70% of water for injection to obtain a concentrated solution, and adding sinomenine hydrochloride into the solution, mixing to dissolve, then adding activated carbon for injection (0.1%), mixing and maintaining at 35-45 degrees C for 10 minutes, then filtering out the activated carbon, and (ii) adding the water for injection (1000 parts by volume), then mixing, examining, filtering in filter element of 0.45 mu m and 0.22 mu m respectively if qualified, and then sampling to measure the pH, content, bacterial endotoxin and visible foreign bodies to comply with the national standard, and then sterilizing to obtain the product or (i) weighing (parts by wt.) sinomenine hydrochloride (1), glucose (55) and a specific amount of water for injection, then mixing and dissolving the glucose in 60% of water for injection to obtain a concentrated solution, and adding sinomenine hydrochloride into the solution, mixing to dissolve, then adding activated carbon for injection (0.2%), mixing and maintaining at 35-45 degrees C for 10 minutes, then filtering out the activated carbon, and (ii) adding the water for injection (1000 parts by volume), then mixing, examining, filtering in filter element of 0.35 mu m and 0.15 mu m respectively if qualified, and then sampling to measure the pH, content, bacterial endotoxin and visible foreign bodies to comply with the national standard, and then sterilizing to obtain the product. The step (ii) in the method of preparing sinomenine hydrochloride freeze-dried powder injection, comprises either: mixing and dissolving sinomenine hydrochloride (100 parts by wt.) in a specific amount of water for injection, adding activated carbon for injection (0.1%), incubating at 35-45 degrees C for 10 minutes, then filtering out the activated carbon, supplying the water for injection (1000 parts by volume), mixing and examining, filtering with filter element of 0.45 mu m and 0.22 mu m respectively if qualified, and then sampling to measure the pH, content, bacterial endotoxin and visible foreign bodies to comply with the national standard, packaging and then freeze drying to obtain the product; or mixing and dissolving sinomenine hydrochloride (140 parts by wt.) in a specific amount of water for injection, adding activated carbon for injection (0.2%), incubating at 35-45 degrees C for 6 minutes, then filtering out the activated carbon, supplying the water for injection (1000 parts by volume), mixing and examining, filtering with filter element of 0.35 mu m and 0.3 mu m respectively if qualified, and then sampling to measure the pH, content, bacterial endotoxin and visible foreign bodies to comply with the national standard, packaging and then freeze drying to obtain the product. The step (a) in method one and the step (i) in the method of preparing sinomenine hydrochloride freeze-dried powder injection, comprise either: (A) preparing sinomenine hydrochloride crude product: (i) extracting: wetting sinomenine crude powder (500 parts) in 0.5 mol/l of hydrochloric acid (500 parts by volume) for 2 hours, transferring into a percolating tank, adding hydrochloric acid (0.5 mol/l) to cover the medicine powder at 3 cm, soaking for 24 hours, percolating at the rate of 3 ml/minute for 15 hours to obtain the percolate, (ii) extracting: adding lime milk into the percolate to regulate the pH to 11.6, then filtering and adding hydrochloric acid into the filtrate to regulate the pH at 8, extracting with chloroform for 4 times, combining the chloroform layers and washing to neutral state, then adding anhydrous sodium sulfate (3%) to dehydrate, and vacuum concentrating to recycle chloroform, and (iii) crystallizing: dripping hydrochloric acid (6 mol/l) to regulate the pH to 3, and mixing until the floating solids disperse, then cooling, filtering, discarding the filtrate, drying the filter cake at 65 degrees C to obtain yellow sinomenine hydrochloride crude product, and (B) refining process of sinomenine hydrochloride: heating and refluxing sinomenine hydrochloride crude product (7 parts) in 75% ethanol or pure water (60 parts by volume respectively) until completely dissolved, then adding activated carbon (4% by wt.) and refluxing for 20 minutes, filtering when it is hot, and concentrating the filtrate, cooling, crystallizing and filtering, washing the filter cake with ethanol (95%) until the filtrate is colorless to obtain sinomenine hydrochloride; or (A) preparing sinomenine hydrochloride crude product: (i) extracting: wetting sinomenine crude powder (400 parts) in 0.3 mol/l of hydrochloric acid (320 parts by volume) for 3.5 hours, transferring into a percolating tank, adding hydrochloric acid (0.3 mol/l) to cover the medicine powder at 4 cm, soaking for 6 hours, percolating at the rate of 6 ml/minute for 8 hours to obtain the percolate, (ii) extracting: adding lime milk into the percolate to regulate the pH to 11.3, then filtering and adding hydrochloric acid into the filtrate to regulate the pH at 8.5, extracting with chloroform for 2 times, combining the chloroform layers and washing to neutral state, then adding anhydrous sodium sulfate (5%) to dehydrate, and vacuum concentrating to recycle chloroform, and (iii) crystallizing: dripping hydrochloric acid (6 mol/l) to regulate the pH to 4, and mixing until the floating solids disperse, then cooling, filtering, discarding the filtrate, drying the filter cake at 62 degrees C to obtain yellow sinomenine hydrochloride crude product, and (B) refining process of sinomenine hydrochloride: heating and refluxing sinomenine hydrochloride crude product (10 parts) in 95% ethanol or pure water (120 parts by volume respectively) until completely dissolved, then adding activated carbon (4% by wt.) and refluxing for 25 minutes, filtering when it is hot, and concentrating the filtrate, cooling, crystallizing and filtering, washing the filter cake with ethanol (95%) until the filtrate is colorless to obtain sinomenine hydrochloride; or (A) preparing sinomenine hydrochloride crude product: (i) extracting: wetting sinomenine crude powder (200 parts) in 0.2 mol/l of hydrochloric acid (900 parts by volume) for 3.5 hours, transferring into a percolating tank, adding hydrochloric acid (0.8 mol/l) to cover the medicine powder at 4 cm, soaking for 15 hours, percolating at the rate of 4 ml/minute for 20 hours to obtain the percolate, (ii) extracting: adding lime milk into the percolate to regulate the pH to 11.3, then filtering and adding hydrochloric acid into the filtrate to regulate the pH at 9, extracting with chloroform for 2 times, combining the chloroform layers and washing to neutral state, then adding anhydrous sodium sulfate (5%) to dehydrate, and vacuum concentrating to recycle chloroform, and (iii) crystallizing: dripping hydrochloric acid (6 mol/l) to regulate the pH to 4, and mixing until the floating solids disperse, then cooling, filtering, discarding the filtrate, drying the filter cake at 62 degrees C to obtain yellow sinomenine hydrochloride crude product, and (B) refining process of sinomenine hydrochloride: heating and refluxing sinomenine hydrochloride crude product (8 parts) in 50% ethanol or pure water (12 parts by volume respectively) until completely dissolved, then adding activated carbon (4% by wt.) and refluxing for 25 minutes, filtering when it is hot, and concentrating the filtrate, cooling, crystallizing and filtering, washing the filter cake with ethanol (95%) until the filtrate is colorless to obtain sinomenine hydrochloride; or (A) preparing sinomenine hydrochloride crude product: (i) extracting: wetting sinomenine crude powder (800 parts) in 0.8 mol/l of hydrochloric acid (300 parts by volume) for an hour, transferring into a percolating tank, adding hydrochloric acid (0.2 mol/l) to cover the medicine powder at 5 cm, soaking for 36 hours, percolating at the rate of 5 ml/minute for 8 hours to obtain the percolate, (ii) extracting: adding lime milk into the percolate to regulate the pH to 11.3, then filtering and adding hydrochloric acid into the filtrate to regulate the pH at 7, extracting with chloroform for 5 times, combining the chloroform layers and washing to neutral state, then adding anhydrous sodium sulfate (6%) to dehydrate, and vacuum concentrating to recycle chloroform, and (iii) crystallizing: dripping hydrochloric acid (6 mol/l) to regulate the pH to 2, and mixing until the floating solids disperse, then cooling, filtering, discarding the filtrate, drying the filter cake at 68 degrees C to obtain yellow sinomenine hydrochloride crude product, and (B) refining process of sinomenine hydrochloride: heating and refluxing sinomenine hydrochloride crude product (6 parts) in 80% ethanol or pure water (40 parts by volume respectively) until completely dissolved, then adding activated carbon (4% by wt.) and refluxing for 15 minutes, filtering when it is hot, and concentrating the filtrate, cooling, crystallizing and filtering, washing the filter cake with ethanol (95%) until the filtrate is colorless to obtain sinomenine hydrochloride.