NOVELTY - Preparing sinomenine hydrochloride sustained release injection, comprises (i) preparing crude sinomenine hydrochloride by (ia) wetting crude sinomenine hydrochloride with hydrochloric acid, packaging, and percolating, (ib) filtering, extracting, mixing, dehydrating, compressing, and concentrating, and (ic) stirring, cooling, filtering, and drying; (ii) refining sinomenine hydrochloride by heating, dissolving, filtering, concentrating, and crystallizing; (iii) taking bovine albumin or human serum albumin and sinomenine hydrochloride; and (iv) dissolving, spraying, and solidifying.    USE - The method is useful for preparing sinomenine hydrochloride sustained release injection.    ADVANTAGE - The method does not require heating, and cold treatment processes; has high production rate, and simple, and safe mother liquid treatment procedures; and is environmental-friendly.    DETAILED DESCRIPTION - Preparing sinomenine hydrochloride sustained release injection, comprises (i) preparing crude sinomenine by (ia) wetting crude sinomenine hydrochloride (100-1000 parts by wt.) by 0.1-1 mol/l hydrochloric acid (60-1000 parts by vol.) for 0.5-8 hours, packaging in a percolating barrel, then adding hydrochloric acid to cover 2 cm medical power by liquid surface, starting percolation at a speed of 2-6 ml/minute after pouring for 6-48 hours, and stopping percolation after 6-24 hours to obtain a percolating liquid, (ib) adding the percolated liquid to lime milk to adjust the pH to 10.5-12, then filtering, and adding hydrochloric acid to the filtering liquid to adjust the pH to 7-9.5, then extracting by adding chloroform for 2-5 times, then mixing a chloroform layer to wash till the liquid gets neutral, dehydrating by adding anhydrous sodium sulfate (3-6%), then compressing, and concentrating to recover chloroform, and (ic) adding the concentrated liquid dropwise to hydrochloric acid (6 mol/l) to adjust the pH to 2-4, then stirring till the floating solid materials are diffused, then cooling, filtering, and removing the filtered liquid, and drying a filtering cake at 60-70 degrees C to obtain a crude yellow sinomenine hydrochloride; (ii) refining the sinomenine hydrochloride by heating and flowing back crude sinomenine hydrochloride (5-10 parts by wt.) by ethanol (10-95%) or purified water (30-120 parts by vol.), and completely dissolving, then adding activated carbon (4%), and maintaining the temperature and flowing back for 10-30 minutes, then filtering while heating, then concentrating the filtered liquid, cooling, crystallizing, filtering, cleaning the filtering cake by adding ethanol (95%) till the filtered liquid becomes colorless, and obtaining the sinomenine hydrochloride; (iii) taking (in parts by wt.) bovine albumin or human serum albumin (1000-4000) and sinomenine hydrochloride (500-2000); and (iv) taking bovine albumin or human serum albumin and sinomenine hydrochloride, then adding water (80-150 parts by vol.) to the filtered liquid to obtain a clean solution, completely dissolving, spraying, and drying the solution by a spray drier to obtain white powder micro balls, then collecting the micro balls in a drying oven to heat, and solidifying for 2-10 hours at 80-150 degrees C to obtain releasing micro balls, where the inlet temperature is 90-130 degrees C, and the output temperature is 50-90 degrees C, while carrying out spraying and drying.