NOVELTY - Converting biomass to biomass-derived fuels and chemicals, comprises: providing a biomass feed stream; catalytically reacting the biomass feed stream with hydrogen and a deconstruction catalyst at a deconstruction temperature and a deconstruction pressure to produce a product stream comprising a vapor phase, a liquid phase and a solid phase, the vapor phase comprising one or more volatile C2+O1-2 oxygenates; separating the volatile C2+O1-2 oxygenates; and catalytically reacting.    USE - The method is useful for converting biomass to biomass-derived fuels and chemicals (claimed).    ADVANTAGE - The method is highly cost-effective and environment friendly, and efficiently minimizes the number of reaction steps, and thus reactors, necessary to perform the conversion process.    DETAILED DESCRIPTION - Converting biomass to biomass-derived fuels and chemicals, comprises: providing a biomass feed stream comprising a solvent and a biomass component comprising cellulose, hemicellulose or lignin; catalytically reacting the biomass feed stream with hydrogen and a deconstruction catalyst at a deconstruction temperature and a deconstruction pressure to produce a product stream comprising a vapor phase, a liquid phase and a solid phase, the vapor phase comprising one or more volatile C2+O1-2 oxygenates, the liquid phase comprising water and one or more C2+O2+ oxygenated hydrocarbons, and the solid phase comprising extractives; separating the volatile C2+O1-2 oxygenates from the liquid phase and solid phase; and catalytically reacting the volatile C2+O1-2 oxygenates in the presence of a condensation catalyst at a condensation temperature and condensation pressure to produce a C4+ compound comprising a member selected from C4+ alcohol, C4+ ketone, C4+ alkane, C4+ alkene, C5+ cycloalkane, C5+ cycloalkene, aryl, fused aryl, and a mixture. INDEPENDENT CLAIMS are:    (1) a chemical composition comprising a C4+ compound derived from any of the methods;    (2) a gasoline composition comprising a gasoline fraction derived from any of the methods;    (3) a kerosene composition comprising a kerosene fraction derived from any of the methods; and    (4) a diesel composition comprising a diesel fraction derived from any of the methods.