TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Method: The step of deoxygenating is carried out in the presence of: hydrogen-containing gas and a first catalyst having a neutral catalyst support at first hydroprocessing conditions comprising a reaction temperature of 100-400 degrees C, a pressure of 3204-12410 kPa, a liquid hourly space velocity of 0.25-1 volume of liquid feed/volume of catalyst/hour (V/V/hour), and a hydrogen-containing gas treat rate of 1000-12000 standard cubic feet per barrel (SCF/B); or hydrogen-containing gas and a first catalyst having a neutral catalyst support at modified first hydroprocessing conditions comprising a reaction temperature of 300-420 degrees C, a pressure of 4136-12410 kPa, a liquid hourly space velocity of 0.05-0.25 V/V/Hr, and a hydrogen-containing gas treat rate of 4000-13500 SCF/B. The step of deoxygenating further comprises deoxygenating in the presence of a second catalyst and additional hydrogen-containing gas at second hydroprocessing conditions comprising a reaction temperature of 300-350 degrees C, a pressure of 3549-12410 kPa, a liquid hourly space velocity of 0.5-1.5 V/V/Hr, and a hydrogen-containing gas treat rate of 400-8000 SCF/B. The method further comprises: the step of esterifying the treated biomass-derived pyrolysis oil before the deoxygenating step; removing the ethanol from the low acid biomass-derived pyrolysis oil to produce the esterified biomass-derived pyrolysis oil; treating the biomass-derived pyrolysis oil prior to the esterification step by reducing the solids content of biomass-derived pyrolysis oil; removing the ethanol from the low acid biomass-derived pyrolysis oil prior to the deoxygenating step; and recycling a portion of the low oxygen biomass-derived pyrolysis oil. The step of esterifying comprises esterifying with ethanol in the presence of an esterification catalyst under supercritical or near critical conditions to produce low acid biomass-derived pyrolysis oil. The step of recycling comprises recycling a portion of the low oxygen biomass derived pyrolysis oil comprising partially deoxygenated biomass-derived pyrolysis oil, and/or fully deoxygenated biomass-derived pyrolysis oil, in a ratio of 1.5:1-5:1 of the low oxygen biomass-derived pyrolysis oil to esterified treated biomass-derived pyrolysis oil. EXAMPLE - None given.