TECHNOLOGY FOCUS - BIOTECHNOLOGY - Preferred Strain: The isolated, biologically pure hemiascomycetes yeast strain comprises as metabolic pathways for the catabolism of fatty acid (i) at least one FOX2 independent peroxisomal beta -oxidation pathway (ii) at least one FOX2 dependent peroxisomal beta -oxidation pathway, and (iii) one FOX2 dependent mitochondrial beta -oxidation pathway, where the strain still does grow on fatty acid carbon source when rendered non functional for the FOX2 gene. The isolated strain is selected from strains of the genus Candida, Debaryomyces, Clavispora, Metschnikowia, Kluyveromyces, Lodderomyces, Pichia, Hansenula, Lipomyces, Yarrowia, and Geotrichum; where strain of the genus Candida is preferably selected among C. tropicalis, C. parapsilosis, C. orthopilosis, C. metapsilosis, C. norvegensis, C. antartica, C. dubliniensis, C. haemulonii, C. kefyr, C. krusei, C. lusitaniae, C. maltosa, and C. oleophila; and most preferably belongs to the species Candida lusitaniae or Clavispora lusitaniae; where strain of the genus Debaryomyces is preferably selected among D. hansenii and D. castelli; yeasts of the genus Clavispora include C. lusitaniae and C. opuntiae; where strain of the genus Metschnikowia is preferably M. pulcherrima, where strain of the genus Kluyveromyces is preferably selected among K. lactis, K. marxianus, K. yarrowii, and K. wickerhamii; where strain of the genus Lodderomyces is preferably L. elongisporus; where strain of the genus Pichia is preferably selected among P. guilliermondii, P. anomala, P. fabianii, P. kluyveri, P. norvegensis, P. ohmeri, P. pastoris and P. angusta; where strain of the genus Hansenula is preferably selected among H. polymorpha; where strain of the genus Lipomyces is preferably selected among L. starkeyi, L. orientalis, L. yarrowii, and L. japonica; where strain of the genus Yarrowia is preferably Y. lipolytica; where strain of the genus Geotrichum is preferably selected among G. candidum, G. clavatum, and G. fici. One or more pathways are disrupted or enhanced by at least one genetic modification, preferably by at least one or more genetic mutations, total or partial gene deletions or excisions, gene disruptions or integrations, and/or gene duplications. The isolated strain comprises one or more genetic modifications that disrupt or enhance the mitochondrial FOX2 dependent pathway and/or the peroxisomal FOX2 dependent pathway, preferably at least one more genetic modification of the FOX2 gene, such as preferably a total or partial gene deletion, excision, disruption insertion or integration within the FOX2 gene, or most preferably where FOX2 gene is rendered non functional by insertion of another gene of an unrelated metabolic pathway and/or by an antibiotic resistance gene (ABR). FOX2 gene is enhanced and the strain comprises one or more duplication of the FOX2 gene comprising a defined nucleotide sequence of 3628 bp (SEQ ID NO: 1), given in the specification. FOX2 gene is rendered non functional by insertion of another gene of an unrelated metabolic pathway and/or by an ABR. The isolated strain further comprises a partial or total deletion or a genetic modification of the Peroxisomal ABC-transporter 1 (PXA1) gene, or further comprising a genetic modification of the Enoyl-CoA Hydratase 1 (ECH1) gene and/or of the Delta 9-desaturase (OLE2) gene. The strain comprises genetic mutation and specific mutants are selected from (a) fox2 Delta ; (b) pxa1 Delta ; (c) fox2 Delta , pxa1 Delta ; (d) ole2 Delta ; (e) ole2 Delta , fox2 Delta ; (f) ole2 Delta , pxa1 Delta ; (g) ole2 Delta , fox2 Delta , pxa1 Delta ; (h) ech1 Delta ; (i) ech1 Delta Delta fox2 Delta ; (j) ech1 Delta , pxa1 Delta ; (k) ech1 Delta , fox2 Delta , pxa1 Delta ; (l) ole2 Delta , ech1 Delta ; (m) ole2 Delta , ech1 Delta , fox2 Delta ; and (n) ole2 Delta , ech1 Delta , pxa1 Delta . Preferred Method: In the method of producing commodity chemicals, the suitable medium comprises carbon source and is enriched one or more substrates chosen among palmitic acid, oleic acid, ricinoleic acid, or vegetable oil, and where the vegetable oil is preferably selected among sunflower oil, castor oil, coconut oil, Massoi bark oil, and/or their hydrolysates. EXAMPLE - No suitable example given.