TECHNOLOGY FOCUS - INORGANIC CHEMISTRY - Preferred Components: In the step (a), the inorganic alkali is one or more sodium hydroxide, potassium hydroxide, lithium hydroxide, cesium hydroxide, calcium hydroxide, barium hydroxide, sodium carbonate, potassium carbonate, lithium carbonate, cesium carbonate and ammonium carbonate; and the amount of the inorganic alkali is 1-20 times of the molar amount of (II). In the step (b), the inorganic alkali is one or more sodium hydroxide, potassium hydroxide, lithium hydroxide, cesium hydroxide, calcium hydroxide, barium hydroxide, sodium carbonate, potassium carbonate, lithium carbonate, cesium carbonate, ammonium carbonate, sodium bicarbonate, potassium bicarbonate and ammonium bicarbonate; and the amount of the inorganic alkali is 1-20 times of the molar amount of (II).    TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Process: The step (a) and (b) are carried out in the presence of an organic solvent and in the presence of inorganic alkali. The temperature for hydrolyzing reaction is carried out at 20-100 degrees C. The hydrolyzing reaction is performed until the detection reaction is completely ended. The temperature for salifying reaction is 0-50 degrees C and the time for salifying reaction is 1-12 hours. (II) is prepared by performing aminolysis reaction between (R)-indan-1-yl-amine and trifluoroacetate compound of formula (CF3CO2R1) (VII).R1 = 1-5C alkyl, preferably methyl, ethyl or propyl.Preferred Components: The organic solvent in the step (a) is amides and/or dimethylsulfoxide. The amides are one or more N,N-dimethylformamide, N,N-dimethyl acetamide, N-methyl-pyrrolidone and N,N,N,N,N,N-hexamethylphosphoramide. The organic solvent in the step (b) is alcohols and/or ethers. The alcohols are one or more methanol, ethanol, propanol, isopropanol, butanol and trifluoroethanol. The ethers are one or more tetrahydrofuran, dioxane, n-butyl ether and methyl tertiary-butyl ether. The amount of methanesulfonic acid is 1-1.5 times of the molar amount of (IV). The solvent for salifying reaction is one or more ethyl acetate, ethanol, ethanol, ether, and isopropyl ether. The amount of 3-chloro-propyne or 3-bromo-propyne in the step (a) is 1-20 times of the molar amount of (II). The amount of (VII) is 1-20 times of the molar amount of (R)-indan-1-yl-amine. ACTIVITY - Antiparkinsonian.    MECHANISM OF ACTION - None given.