TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Compound: The short chain amine is amino, hydrazino, ethylenediamine, diethylenetriamine, piperidinyl, piperazinyl, or 4-piperidinyl-piperidine. Preparation (claimed): The derivative (I) is prepared by connecting all-trans retinoic acid and short chain amine through amide bond, where molecular weight of short chain amine is 20-200. Preferred Preparation: The derivative (I) is prepared by reacting all-trans retinoic acid with N-hydroxysuccinimide to obtain pyrrolidine compound of formula (VII); and reacting compound (VII) with short chain amine to obtain (I), where short chain amine is ammonia, hydrazine, ethylenediamine, diethylenetriamine, piperidine, piperazine, or 4-piperidinyl-piperidine. The method comprises mixing all-trans retinoic acid with N-hydroxysuccinimide; adding tetrahydrofuran; mixing to obtain mixed solution; dissolving dicyclohexylcarbodiimide into tetrahydrofuran; obtaining tetrahydrofuran solution of dicyclohexylcarbodiimide; putting mixed solution into ice bath; dropwise adding tetrahydrofuran solution of dicyclohexylcarbodiimide into the mixed solution; after dropwise addition, drawing out from the ice bath; stirring for 8-16 hours at 15-25 degrees C; filtering to obtain filtrate; passing the filtrate through column; purifying the filtrate to obtain (VII), where developing solvent used is ethyl acetate and triethylamine at 16-24:1 volume ratio; adding the reaction product and short chain amine into tetrahydrofuran; reacting for 8-16 hours at 15-35 degrees C; spin drying tetrahydrofuran; adding dichloromethane; washing with water and saturated salt water; spin drying dichloromethane; adding tetrahydrofuran; precipitating with water; and freezing to obtain (I); or dissolving the reaction product into N,N'-dimethylformamide; obtaining the reaction liquid; dropwise adding the reaction liquid into N,N'-dimethylformamide containing short chain amine; after finishing dropwise addition, reacting for 8-16 hours at 15-35 degrees C; adding ethyl acetate; washing with water and saturated salt water; drying with anhydrous sodium sulfate; and spin drying the solvent to obtain (I). ACTIVITY - Cytostatic.    SPECIFIC COMPOUNDS - 6 Compounds (I) are specifically claimed, e.g. compounds of formulae (Ia)-(Ie).