NOVELTY - Producing distillate boiling range product involves introducing first and second feed into a reactor having a reactor volume, where reactor volume including a first volume and a separated volume, and second feed including at least 20% by volume of biocomponent feedstock; exposing first feed, in first volume, to hydroprocessing catalyst under hydroprocessing conditions; maintaining physical separation of first and second feed in at least a portion of reactor volume; and exposing second feed, in the separated volume, to a second hydroprocessing catalyst under hydroprocessing conditions.    USE - For producing distillate boiling range product (claimed).    ADVANTAGE - By processing a biocomponent feed in a separate volume, at least some of the additional CO or CO2 production can be avoided, thus allowing for higher overall throughput for a reactor. The feedstocks can be hydroprocessed in the separated volumes to allow multiple types of hydroprocessing conditions and/or feeds to be processed in a single reactor. The reactor configuration where multiple feedstocks remain physically separated can allow the multiple feedstocks to be hydroprocessed without significant chemical interaction between the feedstocks. This can include preventing chemical reactions between a feedstock and/or catalyst outside of the internal reactor structure and the feedstock and/or catalyst within the internal reactor structure. Hydroprocessing a biocomponent feedstock (or a feed containing a biocomponent feed portion) and a mineral feedstock in a reactor while maintaining physical separation of the feeds can overcome some of the challenges in processing the multiple feeds. Physically separating the feedstock containing the biocomponent feed portion from the mineral feedstock for the entire reactor volume can allow the products or effluent from hydroprocessing to also remain separate. This avoids poisoning of the catalyst used to process the mineral feed by the carbon oxides generated from the biocomponent feed. The physical separation also allows the products from the biocomponent feed to pass into a separate product separator. This allows the desirable products from the biocomponent feed to be separated from the by-product gases in a separator suitable for handling higher corrosion conditions.    DETAILED DESCRIPTION - Producing (M1) a distillate boiling range product involves introducing a first feed and a second feed into a reactor having a reactor volume, where the reactor volume including a first volume and a separated volume, and the second feed including at least 20% by volume of a biocomponent feedstock; exposing the first feed, in the first volume, to a first hydroprocessing catalyst under first hydroprocessing conditions to produce a first hydroprocessing effluent; maintaining physical separation of the first feed and the second feed in at least a portion of the reactor volume; and exposing the second feed, in the separated volume, to a second hydroprocessing catalyst under second hydroprocessing conditions to produce a second hydroprocessing effluent.