TECHNOLOGY FOCUS - BIOTECHNOLOGY - Preferred Microorganism: The inhibitor molecule is glucose or a glucose analog. The genetic modification comprises a mutation in one or more genes, where at least one of the one or more genes encodes a propionyl-Coenzyme A (CoA) carboxylase, a two component AraC family transcriptional regulator, or a ROK family glucokinase, a homolog of Cphy3487, a dihydrolipoamide dehydrogenase, a binding-protein-dependent transport systems inner membrane component, an ABC transporter related protein, a homolog of Cphy0056, a TetR family transcriptional regulator, an AraC-like protein, a glycosyl transferase 36, a diaminopimelate epimerase, an oxidoreductase domain-containing protein, a homolog of Cphy2965, a desulfoferrodoxin ferrous iron-binding region, a homolog of Cphy1063, an AraC family transcriptional regulator, a phage tape measure protein, a D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein, or an HD superfamily phosphohydrolase-like protein. One or more fermentation end-products comprise one or more alcohols, where the one or more alcohols comprise ethanol. The biomass comprises hemicellulosic or lignocellulosic material. The microorganism can hydrolyze and ferment hemicellulosic and lignocellulosic material. The microorganism is a Clostridium species. The increased cellulase synthesis is characterized by a larger clearing zone when the microorganism is grown on a phosphoric acid-swollen cellulose (PASC) agar plate in comparison to a non-genetically modified microorganism of the same species. The clearing zone is measured after staining with Congo-Red. The clearing zone is measured according to a radius, diameter, area, or volume of the clearing zone. The increased cellulase synthesis is characterized in a fluorescent cellulase activity assay. The fluorescent cellulase activity assay comprises 4-methylumbilliferone (4Mu) substrates, where the 4Mu substrates comprise glucopyranoside, cellobioside, or their combination. The fluorescent cellulase activity assay shows a 5-10 fold increase in cellulase activity for the microorganism in comparison to the microorganism of the same species without the genetic modification. The increased cellulase synthesis is characterized by an increased level of cellulase coding mRNA or increased level of cellulase protein. The inhibitor molecule is glucose or a glucose analog. The genetic modification comprises a mutation in EVEN SEQ ID NOS: 2-40, may be found at ftp://ftp.wipo.int/pub/published_pct_sequences/publication, or their combination. The genetic modification comprises a mutation in one or more genes. The mutation reduces an activity, stability, or expression level of a protein encoded by at least one of the one or more genes. The mutation increases an activity, stability, or expression level of a protein encoded by at least one of the one or more genes. At least one of the one or more genes is a homolog of a gene from Table 4, given in the specification. At least one of the one or more genes is from Table 4. At least one of the one or more genes is a ROK family glucokinase. The mutation is in the carbohydrate biding pocket of the ROK family glucokinase. At least one of the one or more genes is a two component AraC family transcriptional regulator, where the two component AraC family transcriptional regulator controls the expression of one or more genes encoding an ABC transporter protein. At least one of the one or more genes is a propionyl-CoA carboxylase. One or more genes comprises a combination of genes as indicated in Table 4. The microorganism can hydrolyze and ferment hemicellulosic and lignocellulosic material. The microorganism is a bacteria, a yeast, or another fungus. The microorganism is a Clostridium species, where the microorganism is C. phytofermentans, Clostridium sp. Q.D., or its variant, and where the microorganism is C. phytofermentans Q.17, Q.18, Q.19, or Q.20. The microorganism is deposited under NRRL Accession Number B-50447, NRRL Accession Number B-50448, NRRL Accession Number B-50449, or NRRL Accession Number B-50450. The microorganism produces more of at least one the one or more fermentation end-products from the biomass than a microorganism of the same species without the genetic modification. The microorganism produces 10-100% more of at least one of the one or more fermentation end-products from the biomass than a microorganism of the same species without the genetic modification. One or more fermentation end-products comprise one or more alcohols. One or more fermentation end-products comprise ethanol. The biomass comprises cellulosic, hemicellulosic, or lignocellulosic material. The microorganism produces a higher saccharification yield from the biomass than a microorganism of the same species without the genetic modification. An isolated, mutated or genetically modified microorganism is characterized by deregulated cellulase activity. An isolated bacterium is selected from C. phytofermentans Q.17, C. phytofermentans Q.18, C. phytofermentans Q.19, or C. phytofermentans Q.20. The bacterium can hydrolyze polysaccharides in the presence of a repressor molecule, where the polysaccharides are comprised of hexose or pentose sugars. The bacterium is deposited under NRRL Accession Number B-50447, NRRL Accession Number B-50448, NRRL Accession Number B-50449, or NRRL Accession Number B-50450. The bacterium can utilize cellulose or xylose as its sole carbon source. The bacterium produces alcohol dehydrogenase. The alcohol dehydrogenase reduces acetaldehyde into ethanol. The ethanol is produced at greater than 90% theoretical yield from biomass. The polysaccharides comprise a portion of a biomass. A high-yielding mutant of C. phytofermentans that produces ethanol at a rate of over 45g/l from biomass. Preferred Method: Producing one or more fermentation-end products comprises (a) providing a biomass in a media; (b) contacting the biomass with a first isolated microorganism, the microorganism comprising a genetic modification that enables the microorganism to synthesize more cellulases in the presence of an inhibitor molecule than a microorganism of the same species without the genetic modification; and (c) allowing sufficient time for the microorganism to produce the one or more fermentation end-products from the biomass. One or more fermentation end-products is one or more alcohols. One or more alcohols comprise ethanol. The method further comprises contacting the biomass with a second microorganism, where the second microorganism is a fungal strain or yeast strain. The microorganism produces more of at least one of the fermentation end-products with the genetic modification than without the genetic modification. Producing a fermentation end-product comprises (a) culturing a medium comprising a non-recombinant or recombinant Q.17, Q.18, Q.19 or Q.20 biocatalyst for a period of time under conditions suitable for production of a fermentation end-product by the Q.17, Q.18, Q.19 or Q.20 biocatalyst; and (b) harvesting a fermentation end-product from the medium. The fermentation end-product is a chemical, a biofuel, an alcohol, or ethanol. The medium comprises a cellulosic and/or lignocellulosic material. The cellulosic or lignocellulosic material is not enzymatically treated with a sufficient quantity of enzymes to convert more than 15% of the cellulosic or lignocellulosic material to simple sugars within 24 hours. The cellulosic or lignocellulosic material is pretreated by pretreatments selected from acid, steam explosion, hot water treatment, alkali, catalase, and a detoxifying or chelating agent. A second biocatalyst is added to the medium. In the method of fermenting a biomass material, polysaccharides comprise a portion of a biomass selected from corn stover, bagasse, lignocellulosic, hemicellulosic material, algae, fruit peels, oat hulls, modified crop plants, pectin containing material, starch, wood, algae, distiller's grains, switchgrass, paper, and paper pulp sludge. The biomass is pretreated. The biomass is pretreated to make polysaccharides more available to the biocatalyst. The biomass is pretreated by pretreatments selected from acid, steam explosion, hot water treatment, alkali, catalase, and a detoxifying or chelating agent. A fermentation end-product is produced. In the method of hydrolyzing and fermenting a carbonaceous biomass, the biomass is contacted by a C. phytofermentans Q.17, Q.18, Q.19 or Q.20 bacterium for a period long enough to produce ethanol at greater than 70-90% theoretical yield from the carbonaceous biomass. The method further comprises maintaining a temperature of 30-40 degrees C, preferably 35-39 degrees C. The contacting is in a medium with a pH of 5.5-7.5. The bacterium uses biomass as a major carbon source. The bacterium is deposited under NRRL Accession Numbers B-50447, B-50448, B-50449, or B-50450. The bacterium is genetically-modified. EXAMPLE - No suitable example given.