TECHNOLOGY FOCUS - BIOTECHNOLOGY - Preferred Method: The concentration of immobilized biological enzyme is 10-15 g/l. The immobilized biological enzyme is obtained by (i) immersing carrier in composite enzyme solution at 10-15 degrees C, slightly shaking for 3-5 minutes, and refrigerating at 4 degrees C for 2-28 hours, and (ii) adding carrier to 2.5-5% glutaraldehyde solution in a ratio of 1:20-40 (g/ml), performing crosslinking reaction at 15-25 degrees C for 2 hours, removing carrier, and rinsing carrier in acetic acid sodium acetate solution (pH 5-5.5) for several times. The composite enzyme solution comprises antibiotic-degrading enzyme and enzymes involved in antibiotic biosynthetic late period. The total activity of the enzyme at pH 6 is 2000-3000 U/mg. The carrier is bacterial cellulose film, chitosan, polyacrylonitrile-based activated carbon fiber or bio-carbon fiber. The immobilized activated sludge is prepared by (i) adjusting pH to 6-6.5 of wastewater with quicklime, treating pharmaceutical wastewater by coagulation and sedimentation, and adding glucose (in g) (3-10), ammonium sulfate (1-2) and potassium dihydrogen sulfate (1-2) as exogenous nutrients to treated water, (ii) mixing returned sludge of sewage treatment aerobic segment with domesticated wastewater in a volume ratio of 1:4-5, increasing CODCr value by 10-15% every day, performing intermittent aeration, and aerating for 5-6 hours (every 1-2 hours), when biomass of ciliates including Vorticella and Epistylis is 40-45% of total biomass, and metazoans including rotifers and nematodes appear, and thus domestication is completed, and (iii) fixing of activated sludge by polyethylene (PVA)-boric acid embedding fixation method. The embedding fixation method involves heating PVA (in parts mass) (71) and distilled water (45-50) at 90 degrees C water bath until PVA is substantially dissolved, adding sodium alginate (0.1-0.15), silica (2-2.5) and calcium carbonate (0.2-0.4), heating to completely dissolve, cooling to 30-40 degrees C, adding activated sludge (35-45), stirring sufficiently, adding saturated boric acid solution until pH to 6-7, crosslinking at 4 degrees C for 15-25 hours in refrigerator, maintaining at room temperature for 3-5 hours, and rinsing with physiological saline.