NOVELTY - Pramoxine hydrochloride is prepared by adding morpholine and 1-bromo-3-chloropropane into weakly alkaline solution and reacting for 4-6 hours in hot water bath of 55-65 degrees C to obtain intermediate N-(3-chloropropyl)morpholine; adding anhydrous ethanol and sodium hydroxide, then adding 4-butoxyphenol and N-(3-chloropropyl)morpholine, heating and refluxing for 24-26 hours to obtain oily substance; and adding hydrochloric acid into the oily substance, adding toluene, extracting with ethyl acetate, separating organic phase, and concentrating upper solution to obtain pramoxine hydrochloride.    USE - Method of preparing pramoxine hydrochloride (claimed).    ADVANTAGE - The method does not need chlorination, has reduced production steps and cost and simple operation process, avoids environmental pollution, and is suitable for large-scale industrial production.    DETAILED DESCRIPTION - Preparation of pramoxine hydrochloride comprises:    (A) dissolving strong alkaline weak acid salt into water to obtain weakly alkaline solution, then adding morpholine and 1-bromo-3-chloropropane into the weak alkaline solution, stirring for 30-40 minutes, reacting for 4-6 hours at constant temperature in hot water bath of 55-65 degrees C, reopening water bath to cool to room temperature, standing to divide into layers at room temperature, taking the upper layer of oily substance to carry out rectification to obtain intermediate N-(3-chloropropyl)morpholine, where weight ratio of morpholine, 1-bromo-3-chloropropane and strong alkaline weak acid salt is 1:1.57-2:0.52-1.27;    (B) adding anhydrous ethanol and sodium hydroxide into a reaction kettle, stirring and dissolving, then adding 4-butoxyphenol and N-(3-chloropropyl)morpholine into the reaction kettle, heating and refluxing for 24-26 hours, cooling to room temperature, filtering, and concentrating the filtrate till flowing no alcohol to obtain oily substance, where weight ratio of N-(3-chloropropyl) morpholine and 4-butoxyphenol is 1:0.9-1.3; and    (C) adding 20% hydrochloric acid into the oily substance, adjusting pH to 2-3, adding toluene with stirring and uniformly mixing, then standing, separating the organic phase at upper layer (the lower layer is water layer), adding 20% sodium hydroxide solution to adjust pH to 9-10, and then adding ethyl acetate and water to extract for 2 times, taking the upper solution to concentrate to obtain pramoxine hydrochloride, dissolving the pramoxine hydrochloride in ethanol, then adding 30% hydrochloric acid to adjust pH to 1-3, then freezing to crystallize, centrifuging, and filtering to obtain pramoxine hydrochloride.