NOVELTY - Preparation of nebivolol hydrochloride (I) involves reacting 2-((R)-2,2-dimethyl-(1,3)dioxolan-4-yl)-6-fluoro-chroman-4-one with hydrogen, reacting the obtained (R)-1-(6-fluoro-chroman-2-yl)-ethane-1,2-diol (III) with triphenylphosphine to give 6-fluoro-2-oxiranyl-1-benzopyran compounds (IVa) and (IVb), reacting compound (IVa) with benzylamine, reacting the obtained (R)-2-(benzylamino-methoxy)-1-((S)-6-fluoro-chroman-2-yl)-ethanol with compound (IVb) to give a compound (Va) and converting compound (Va) into nebivolol.    USE - Preparation of nebivolol hydrochloride.    ADVANTAGE - The method enables preparing nebivolol hydrochloride with easy material source and at low cost and at mild reaction conditions without pollution to environment.    DETAILED DESCRIPTION - Preparation of nebivolol hydrochloride (I) comprises reacting 1-(5-fluoro-2-hydroxy-phenyl)-ethanone with copper bromide, reacting the obtained 2-bromo-1-(5-fluoro-2-hydroxy-phenyl)-ethanone with triphenylphosphine, reacting the obtained (2-(5-fluoro-2-hydroxy-phenyl)-2-oxo-ethyl)-triphenyl-phosphonium bromide with D-glyceraldehyde acetonide in the presence of sodium bicarbonate, reacting the obtained 3-(2,2-dimethyl-(1,3)dioxolan-4-yl)-1-(5-fluoro-2-hydroxy-phenyl)-propenone with lithium hydroxide, reacting the obtained 2-((R)-2,2-dimethyl-(1,3)dioxolan-4-yl)-6-fluoro-chroman-4-one with hydrogen in the presence of palladium on carbon and acetic acid, reacting the obtained (R)-1-(6-fluoro-chroman-2-yl)-ethane-1,2-diol (III) with triphenylphosphine in diethyl azodicarboxylate to give 6-fluoro-2-oxiranyl-1-benzopyran compounds of formula (IVa) and (IVb), reacting compound (III) with benzalkonium chloride, reacting the obtained (R)-2-benzyloxy-1-(6-fluoro-chroman-2-yl)-ethanol with tosyl chloride, reacting the obtained toluene-4-sulfonic acid (R)-2-benzyloxy-1-(6-fluoro-chroman-2-yl)-ethyl ester with potassium carbonate to give 6-fluoro-2-oxiranyl-1-benzopyran compounds of formula (IVc) and (IVd), reacting compound (IVa) with benzylamine, reacting the obtained (R)-2-(benzylamino-methoxy)-1-((S)-6-fluoro-chroman-2-yl)-ethanol with compound (IVb) to give (R)-2-(benzyl-((R)-2-((S)-6-fluoro-1-benzopyran-2-yl)-2-hydroxy-ethyl)-amino)-1-((R)-6-fluoro-1-benzopyran-2-yl)-ethanol (Va), reacting compound (IVb) with benzylamine and reacting the obtained (R)-2-(benzylamino-methoxy)-1-((R)-6-fluoro-chroman-2-yl)-ethanol with compound (Va) to give compound (Va), reacting compound (IVc) with benzylamine and reacting the obtained (S)-2-(benzylamino-methoxy)-1-((S)-6-fluoro-chroman-2-yl)-ethanol with compound (IVd) to give (S)-2-(benzyl-((S)-2-((R)-6-fluoro-1-benzopyran-2-yl)-2-hydroxy-ethyl)-amino)-1-((S)-6-fluoro-1-benzopyran-2-yl)-ethanol (Vb), reacting compound (IVd) with benzylamine and reacting the obtained (S)-2-(benzylamino-methoxy)-1-((R)-6-fluoro-chroman-2-yl)-ethanol with compound (IVc) to give compound (Vb), converting compounds (Va) or (Vb) into nebivolol and converting nebivolol into nebivolol hydrochloride.