NOVELTY - Fertilizer-medicine double-effect bio-organic fertilizer is claimed. The preparation of the bio-organic fertilizer comprises uniformly mixing fresh livestock and poultry excrement, rice bran and organic fertilizer fermentation agent I, stacking according to a height of 1.2 m, turning the stack when the temperature reaches 70-80 degrees C, after 7 days, adding an organic fertilizer post-cured fermentation agent II in a weight ratio of the fertilizer to the agent as 99: 1, stacking according to the height of 60 cm, turning the stacks when the temperature reaches 50 degrees C, and fermenting for 15 days.    USE - The bio-organic fertilizer is useful for preventing and treating soil-borne diseases of crop (claimed).    ADVANTAGE - The bio-organic fertilizer increases the crop yield, and has significant economic and social benefits.    DETAILED DESCRIPTION - Fertilizer-medicine double-effect bio-organic fertilizer is claimed. The preparation of the bio-organic fertilizer comprises uniformly mixing fresh livestock and poultry excrement, rice bran and organic fertilizer fermentation agent I in the weight ratio of 0.7:0.298:0.002, stacking according to a height of 1.2 m, turning the stack when the temperature reaches 70-80 degrees C, after 7 days, adding an organic fertilizer post-cured fermentation agent II according to a weight ratio of the fertilizer to the agent as 99: 1, stacking according to the height of 60 cm, turning the stacks when the temperature reaches 50 degrees C, and fermenting for 15 days, where the organic fertilizer fermentation agent I is prepared by Pichia burtonii CCTCC AY92055, Aspergillus oryzae CCTCC AF93022 and Bacillus subtilis CICC 10157 according to a colony forming unit number ratio of (0.1-1): (0.1-1): (0.1- 1); and the organic fertilizer post-cured fermentation agent II is prepared by Candida tropicalis CCTCC AY92045, Trichoderma viride CCTCCAF93252, Trichoderma koningii CCTCC AF93251 and Bacillus subtilis CICC 10157 according to a colony forming unit number ratio of (0.1-1): (0.1-1): (0.1-1): (0.1-1).