NOVELTY - Preparing esomeprazole sodium comprises: taking and adding (4-methoxy-3,5-dimethyl-pyridin-2-yl)-methanol and toluene in a microwave ultrasonic chemical reactor and then stirring until solution is clear, dripping thionyl chloride under the action of ultrasonic synergistic reaction, filtering the reacted solution, and decompressing the filtrate and drying; adding corresponding intermediate A and methanol and then stirring to dissolve and then separating and decompressing, and removing dichloromethane; and adding obtained intermediate B and toluene and then stirring.    USE - The esomeprazole sodium is useful for treating peptic ulcer and gastroesophageal reflux disease.    ADVANTAGE - The method allows rapid and economical preparation of esomeprazole sodium with high yield and reduced energy consumption in an environmentally friendly manner.    DETAILED DESCRIPTION - Preparing esomeprazole sodium comprises: (1) taking and adding 100 parts by weight (pbw) of (4-methoxy-3,5-dimethyl-pyridin-2-yl)-methanol and 800 pbw of toluene in a microwave ultrasonic chemical reactor and then stirring until the solution is clear, choosing the ultrasonic frequency to 20-30 KHz and the microwave frequency to 2450 MHz, dripping 100 pbw of thionyl chloride under the action of ultrasonic synergistic reaction of ultrasound and microwave, controlling the temperature to 10-30 degrees C, reacting the solution for 10 minutes, filtering the reacted solution, and decompressing the filtrate and then drying to obtain corresponding intermediate A; (2) adding 100 pbw of corresponding intermediate A and 800 pbw of methanol in the ultrasonic microwave chemical reactor and then stirring to dissolve, choosing the ultrasonic frequency to 20-30 KHz and the microwave frequency to 2450 MHz, adding 100 pbw of 20% sodium hydroxide solution under the ultrasonic synergistic reaction of ultrasound and microwave and adding 80 pbw of 2-mercapto-5-methoxybenzimidazole and then refluxing for 10 minutes, adding 100 pbw of 20% sodium hydroxide solution and then refluxing for 20 minutes, adding 800 pbw of methylene dichloride and then separating and decompressing, and removing dichloromethane to obtain corresponding intermediate B; and (3) adding 100 pbw of corresponding intermediate B and 350 pbw of toluene in the ultrasonic microwave chemical reactor and then stirring and dissolving, choosing ultrasonic frequency to 20-30 KHz and the microwave frequency to 2450 MHz, adding 40 pbw of diethyl tartarate, 25 pbw of 4-isopropyl titanate and 1 pbw of water under ultrasonic synergistic reaction of ultrasound and microwave, maintaining the temperature to 50 degrees C and then reacting for 20 minutes, stopping ultrasonic and microwave and then cooling to room temperature and decompressing at 0.02-0.04 MPa, adding 15 pbw of N,N-diisopropyl ethylamine and 50 pbw of hydrogen peroxide isopropyl benzene and then reacting for 30 minutes, adding 600 pbw of 10% ammonia water into the reacted solution, adding 800 pbw of methylene dichloride and dropping glacial acetic acid to adjust the pH value of the solution to 9, adding 800 pbw of dichloromethane and 5% of sodium bicarbonate solution, stirring at room temperature for 30 minutes, separating the dichloromethane layer and then decompressing and evaporating to obtain oily matter, adding 500 pbw of methanol into the oily matter to dissolve and then adding 10 pbw of sodium hydroxide, stirring at room temperature until sodium hydroxide is completely dissolve and then adding 2 pbw of active carbon for decoloring and then filtering, decompressing and evaporating to obtain crude product, adding 1000 pbw of ethanol to the crude product and then stirring to dissolve, adding 5 pbw of active carbon to decolor for 1 hour and then filtering and adding in the ultrasonic microwave chemical reactor, selecting the ultrasonic frequency to 40 KHz and refluxing for 5 minutes, putting the refluxed contents in a spray dryer for supersonic jet drying at a temperature of 30-50 degrees C, a pressure of 0.03-0.05 MPa and a jet speed of 400-800 m/second to obtain the nanometer esomeprazole sodium finished product.