NOVELTY - Synthesizing Sprycel (RTM: Dasatinib), comprises: e.g. adding tetrahydrofuran, pyridine and 2-chloro-6-methylaniline in a reaction bottle and then stirring and cooling, dropping (E)-3-acryloyl chloride, recovering to room temperature and reacting for 2-4 hours, reducing the temperature after the reaction is finished, adjusting the pH value of the solution to 3-5 using hydrochloric acid and then concentrating and drying the residue, adding toluene to the residue and then freezing, crystallizing and filtering, and washing the filter cake using ice toluene and then drying.    USE - The method is useful for synthesizing Sprycel (RTM: Dasatinib) (claimed).    ADVANTAGE - The method allows economical synthesis of Sprycel (RTM: Dasatinib) with high yield in an eco-friendly manner.    DETAILED DESCRIPTION - Synthesizing Sprycel (RTM: Dasatinib), comprises: (1) adding tetrahydrofuran, pyridine and 2-chloro-6-methylaniline in a reaction bottle and then stirring and cooling to 0-5 degrees C, dropping (E)-3-acryloyl chloride, recovering to room temperature and reacting for 2-4 hours, reducing the temperature after the reaction is finished, adjusting the pH value of the solution to 3-5 using 1 mole/l of hydrochloric acid and then concentrating and drying the residue, adding toluene to the residue and then freezing, crystallizing and filtering, and washing the filter cake using ice toluene and then drying to obtain compound II; (2) adding water into the reaction bottle containing sodium bromate and then stirring and adding 2 mole/l of sulfuric acid to adjust the pH value to 1, adding compound II and then dissolving in acetonitrile solution and cooling to 10 degrees C, slowly dropping 2 mole/l of sodium bisulfite aqueous solution, recovering to room temperature after finishing dropping and reacting for 3-5 hours, extracting the reaction liquid by ether after the reaction is finished, washing an organic layer with sodium sulfite water solution and then concentrating and drying to obtain compound III crude product, adding compound III crude product, water and 1,4-dioxane into the reaction bottle and then stirring and adding thiourea, heating, refluxing and reacting for 2-4 hours, cooling to room temperature after the reaction is finished, adding ammonia water to adjust the pH value of the reaction solution to 8-9 and then cooling, crystallizing and filtering, and washing the filter cake using ice water and then drying to obtain the compound IV; (3) adding 4,6-di-chloro-2-methylpyridine, diisopropylamine and methylene dichloride in the reaction bottle and then stirring and adding 1-(2-piperazine), stirring at room temperature for overnight and then filtering, washing the filter cake with methylene dichloride, combining the filtrate, concentrating until it is dry, recrystallizing the residue using ethyl acetate and petroleum ether to obtain white solid compound V; and (4) adding compound IV, compound V, potassium carbonate, cuprous iodide and dimethylformamide in the reaction bottle and then stirring at 90 degrees C and reacting for overnight, cooling to room temperature and then filtering, pouring the filtrate into the water and stirring for 10-30 minutes, filtering and drying the filter cake using 80% of ethanol aqueous solution and then adding water and heating to 60-70 degrees C, cooling to room temperature and then crystallizing and filtering, and washing the filter cake by 50% ice ethanol aqueous solution and then drying to obtain white solid water Sprycel (RTM: Dasatinib) compound.