TECHNOLOGY FOCUS - INORGANIC CHEMISTRY - Preferred Composition: The alkali is inorganic base chosen from potassium carbonate, sodium carbonate, cesium carbonate, sodium hydroxide, potassium hydroxide, sodium methoxide, sodium ethoxide, sodium tert-butoxide, potassium tert-butoxide, lithium tertbutoxide, sodium hydroxide, calcium hydroxide and lithium diisopropylamide. The reducing agent is metal reducing agent including palladium, nickel, ruthenium, rhodium, iron, zinc, magnesium and aluminum. The metal salt of the aromatic nucleophilic substitution reaction is metal halide including sodium chloride, potassium chloride, lithium chloride, sodium bromide, potassium bromide, lithium bromide, fluoro-sodium hydroxide, potassium fluoride and lithium fluoride.    TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Process: The aromatic nucleophilic substitution reaction is carried out by adding malonate (III) in a reaction bottle, adding alkali and solvent (a), heating to 25-60 degrees C, stirring, cooling to room temperature, adding raw material halogenated ortho-nitroaniline (II) containing a substituent group, re-heating to 25-160 degrees C, stirring until the reaction is complete, heating to 110-180 degrees C, using byproduct metal salt of the aromatic nucleophilic substitution reaction used as a promoter for the ester group removal reaction, removing ester group, cooling to room temperature, adding solvent (b) and reducing agent, and heating to 60-150 degrees C. Preferred Composition: The solvent (a) is water or organic solvent. The organic solvent comprises toluene, benzene, methylene dichloride, ether, tetrahydrofuran, acetone, methyl alcohol, dimethyl sulfoxide, N,N-dimethyl formamide, N,N-dimethyl acetamide and hexamethylphosphoric triamide. The amount of solvent (a) is 1-50 mL/per mmol of substituent ortho halo nitrobenzene. The solvent (b) is alcohol solution, and acetic acid or hydrochloric acid solution. Preferred Property: The molar ratio of halogenated ortho-nitroaniline (II) containing a substituent group, malonate (III), alkali and reducing agent is 1:1-10:1-10:1-10.