NOVELTY - A penicillin fermentation liquid treatment process involves cooling original penicillin fermentation liquid having wet solid content of 30-32% at 10-15 degrees C; putting into ceramic membrane filter of sealed ceramic membrane crossflow filtration system for filtering; 2) during process, when the wet solid content of penicillin fermentation liquid is increased to original wet solid content of 1.8-2 times, carrying out dialysis for original fermentation solution using 2 times of weight of water, nano-filter concentrating and dehydrating obtained low titer ceramic membrane filtrate.    USE - As penicillin fermentation liquid treatment process (claimed).    ADVANTAGE - The method uses ceramic cross-flow filtration system to replace the traditional or drum of the plate-and frame filter, the yield is improved, also can save the subsequent refining, crystallizing and preparing penicillin, changes waste into valuable, solves the problem that the penicillin fungus dreg of environmental pollution and treatment cost.    DETAILED DESCRIPTION - A penicillin fermentation liquid treatment process involves cooling original penicillin fermentation liquid having wet solid content of 30-32% at 10-15 degrees C; putting into ceramic membrane filter (20-500 nm) of sealed ceramic membrane crossflow filtration system, filtering at a pressure of 0.350.45 MPa, and membrane pressure of 0.130.2MPa under filtering conditions by high-valence ceramic membrane filtrate; 2) during the process, when the wet solid content of the penicillin fermentation liquid is increased to original wet solid content of 1.8-2 times, carrying out dialysis for the original fermentation solution using 2 times of the weight of the water, nano-filter concentrating and dehydrating the obtained low titer ceramic membrane filtrate till the titer concentration and ceramic film concentration same, 3) continuously adding dialysis of 2 times of the weight of the water into the original fermentation solution to obtain extremely low titer ceramic membrane filtrate containing, low 500-800U titer of penicillin fermentation solution indigo naturalis, filtering; accommodating ceramic membrane filtration system trapped bacteria residue; converting the resulting high titers of ceramic membrane filtrate into 6-aminopenicillanic acid (6APA) by conversion or oxidation, ring expansion, preparation of 7-amino deacetoxy cephalosporanic acid (7-ADCA) cleavage; and collecting fungus dreg engineering bacteria by adding decomposition bacteria.