NOVELTY - Synthesis of anti-tumor medicament lonidamine involves mixing dichloroethane, 2,4-dichloro-toluene, N-bromosuccinimide and azobisisobutyronitrile in an organic solvent, washing mother liquor with water, diluting sodium hydroxide solution, obtaining white 1H-indazole-3-carboxylic acid solid, mixing 1H-indazole-3-carboxylic acid and crude ethanol, heating activated carbon, cooling, filtering, drying, obtaining light yellow product, adding glacial acetic acid to the vessel, adding activated carbon, incubating, filtering, liquor cooling and drying.    USE - Synthesis of anti-tumor medicament lonidamine (claimed).    ADVANTAGE - The anti-tumor medicament lonidamine is economically prepared with high yield without polluting the environment, by a simple method.    DETAILED DESCRIPTION - Synthesis of anti-tumor medicament lonidamine involves mixing dichloroethane, 2,4-dichloro-toluene, N-bromosuccinimide and azobisisobutyronitrile in the molar ratio of 1:1.0-1.8:0.08-0.12 in an organic solvent, heating with stirring at 50-80 degrees C, incubating after stopping the reaction for 2-12 hours, cooling to room temperature, filtering, washing mother liquor with water, diluting sodium hydroxide solution, washing saturated sodium sulfite solution for several times, separating organic phase, removing dichloroethane solvent by distillation, obtaining yellow 2,4-dichloro bromide liquid, adding glacial acetic acid and 40-65% aqueous solution with stirring phenylhydrazine, warming to reflux, cooling to heat for 2-8 hours at 10-30 degrees C, precipitating as a yellow solid, filtering, washing, drying, obtaining N-acetyl-phenylhydrazine white, adding N-acetyl-phenylhydrazine, hydroxylamine hydrochloride, anhydrous sodium sulfate and acetic acid in the molar ratio of 1:2-5:6-9:2-4, adding water, heating at 70-100 degrees C, adding N-acetyl-phenylhydrazine for 1-3 times to chloral hydrate, incubating for 10-30 minutes, controlling solution temperature at 40-80 degrees C, cooling at 0-25 degrees C, filtering, washing, drying, obtaining pale yellow N-acetylamino oximino acetanilide, heating concentrated sulfuric acid at 20-70 degrees C, adding N-acetylamino oximino acetanilide, incubating at 50-60 degrees C for 1 hour, slowly warming at 70-100 degrees C, heating for 5-40 minutes, adding reaction to ice-water with certain amount of containers, dropping temperature at 0-40 degrees C, warming to reflux, cooling to room temperature for 1-5 hours, filtering, washing, drying, obtaining pale yellow solid 1H-indazole-3 - carboxylic acid, adding 1H-indazole-3-carboxylic acid and crude isopropyl alcohol in the weight ratio of 1:10-20 to the container, warming to reflux, activating bleaching for 10-30 minutes, processing a pale yellow solid, mixing solid and glacial acetic acid in the weight ratio of 1:10-30, heating to reflux for 10-30 minutes, cooling, filtering, drying, obtaining white 1H-indazole-3-carboxylic acid solid, mixing 1H-indazole-3-carboxylic acid and crude ethanol in the weight ratio of 1:10-60, heating activated carbon to the whole solution, incubating for 15-30 minutes, filtering, adjusting pH of mother liquor with sodium hydroxide solution to 7-8, cooling, filtering, drying, adjusting pH of 18% hydrochloric acid to 2-3, cooling, filtering, drying pale yellow solid, warming to the whole solution, incubating for 10-30 minutes, cooling, filtering, dried, obtaining white solid, obtaining white solid with acetic acid in the weight ratio of 1:10-30, heating to reflux for 10-30 minutes, cooling, filtering, drying, obtianing 1H-indazole-3 white-solid acid, mixing 1H-indazole-3-carboxylic acid and sodium hydroxide in the molar ratio of 1:1-5, adding water, heating with stirring to 70-100 degrees C, dropping solution of 2,4-dichloro-benzyl bromide for 3-10 minutes, raising the temperature at 80-100 degrees C, peforming heat treatment for 2-5 hours as pale yellow solid, adding resulting solid to the flask, adding water, adjusting the pH of solution with 18% hydrochloric acid to 2-3, stirring for 1-3 hours, filtering, drying, obtaining light yellow product, adding glacial acetic acid to the vessel, heating to reflux until the whole solution, adding activated carbon, incubating for 15-40 minutes, filtering, liquor cooling and drying. The molar ratio of phenylhydrazine and glacial acetic acid is 1:2.5-4.5. The molar ratio of concentrated sulfuric acid and oximino acetanilide N-acetylglucosamine is 1:10-40. The molar ratio of 1H-indazole-3-carboxylic acid and 2,4-dichloro-benzyl bromide is 1:1-1.6.