TECHNOLOGY FOCUS - INORGANIC CHEMISTRY - Preferred Method: The method involves performing the decarboxylation and nitration reaction at 0-100 degrees C, using a reducing agent such as zinc, iron, magnesium, acetic acid, hydrochloric acid, palladium on carbon/hydrazine hydrate, magnesium/hydrazine, iron/hydrazine hydrate, palladium on carbon/hydrogen, diazotization reagent such as sodium nitrite, potassium nitrite, nitro butane, and acid such as hydrochloric acid, sulfuric acid, phosphoric acid and acetic acid, and dithio carbonate reagent such as alkyl xanthate. The method utilizes the basic catalyst such as potassium carbonate, sodium carbonate, sodium hydroxide, potassium hydroxide, sodium hydride, potassium or sodium alkoxides, and catalyst such as cuprous iodide, and copper iodide.    TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Components: The compound (I) is 3,4,5-trimethoxy-1-((3-amino-4-nitrophenyl) thio) benzene, 3,4,5-trimethoxy-1-((3-acetamido-4-nitrophenyl) thio) benzene, 3,4,5-trimethoxy-1-((3-nitro-4-methoxyphenyl) thio) benzene, 3,4,5-trimethoxy-1-((3-amino-4 methoxyphenyl) thio) benzene, 3,4,5-trimethoxy-1-((3-fluoro-4-methoxyphenyl) thio) benzene, 3,4, 5-dimethoxy-1-((4-ethoxy-phenyl) thio) benzene, 3,4,5-dimethoxy-1-((4-methoxyphenyl) thio) benzene, 5-dimethoxy-2-((3,4-dimethoxyphenyl)thio) benzene, 3-((3,4,5 trimethoxyphenyl) thio) benzo-thiophene-2-carboxylic acid methyl, 2-fluorenyl methoxy amide-3-acetoxy-N-(2-methoxy-5-(3,4,5-trimethoxyphenyl) thio)-propionamide, 2-amino-3-hydroxy-N-(2-methoxy-5-(3,4,5-trimethoxyphenyl) thio) propanamide, or 3,4,5-dimethoxy-1-((4-methoxyphenyl) thio) benzene. Preferred Method: The method utilizes iodo reaction solvent such as ethanol, methanol, isopropanol, ethylene glycol and other alcohols, benzene, toluene, acetone, tetrahydrofuran, dioxane, N, N-dimethylformamide, pyridine, dimethyl sulfoxide, dichloromethane, chloroform, dichloroethane or its mixed solvents. Preferred Definitions:    R1-R4=hydroxyl, amino group, amine substituted to its corresponding ester, carboxylate, sulfonate esters, amides, peptides or its organic or inorganic salt derivatives;    R5-R8=H, halo, hydroxy, amino, methyl, ethyl, benzyl, alkoxy, nitro, acyloxy or amide;and    R11-R18=H, halo, hydroxy, amino, substituted amino, cyano, alkyl or alkoxy.