NOVELTY - A 1,5-substituted thiophenyl-benzimidazol-2-N-methoxycarbonylamino is synthesized by adding substituted thiophenol, anhydrous potassium carbonate, and 2-nitro-5-chloroaniline to N,N-dimethylmethanamide (DMF), performing reflux reaction, evaporating DMF under reduced pressure, pouring residue into ice water, stirring, crystallizing, filtering, washing, obtaining 1st compound, adding 1st compound into methanol, stirring, recovering to room temperature, extracting, concentrating to obtain 2nd compound, reflowing and reacting 2nd compound, cooling to 0 degrees C, filtering, and drying.    USE - Synthesis of 1,5-substituted thiophenyl-benzimidazol-2-N-methoxycarbonylamino (claimed).    ADVANTAGE - Raw material cost is low, operation is simple, yield is high, and pollution is low.    DETAILED DESCRIPTION - A 1,5-substituted thiophenyl-benzimidazol-2-N-methoxycarbonylamino compound of formula (I) is synthesized by adding substituted thiophenol, anhydrous potassium carbonate, and 2-nitro-5-chloroaniline to N,N-dimethylmethanamide (DMF), performing reflux reaction, evaporating DMF under reduced pressure, pouring residue into ice water, stirring, crystallizing, filtering, washing, obtaining compound of formula (II), adding compound of formula (II) into methanol, stirring, adding ammonium chloride, cooling by ice water bath, finishing feeding, recovering to room temperature, finishing reaction, concentrating reaction solution, adding residue into water, extracting with methylene dichloride, washing organic layer with water, drying over anhydrous sodium sulfate, filtering, concentrating to dry and obtain compound of formula (III), reacting thiourea and sodium hydroxide into reaction bottle at 100 degrees C for 40-60 minutes, cooling to room temperature, cooling by ice water bath, dropping methyl chloroformate, reacting under room temperature for 40-60 minutes, recovering, adding 4N hydrochloric acid to adjust pH value to 2-3, adding ethanol solution, reflowing and reacting compound of formula (III), cooling to 0 degrees C, filtering, washing filter cake, and drying.    R=H, F, Cl, Br, or 1-3C alkoxy in which position of substituent is ortho, meta, or para.