NOVELTY - Simulated moving bed chromatographic resolution of ranolazine enantiomer comprises dissolving racemic ranolazine in methanol and introducing into simulated moving bed chromatography (SMBC) separation system using cellulose tris(3,5-dimethylphenylcarbamate) as filler and methanol as mobile phase. The enantiomer products are concentrated and recrystallized to obtain purity of greater than or equal to 98%.    USE - Method for simulated moving bed chromatographic resolution of ranolazine enantiomer (claimed).    ADVANTAGE - The method has high degree of automation and high production efficiency.    DETAILED DESCRIPTION - Simulated moving bed chromatographic resolution of ranolazine enantiomer involves using SMBC separation system having elution pump flow rate of 0-1000 ml/minute (preferably 1000 ml/minute) and pressure of 0-10 MPa, injection pump flow rate of 0-50 ml/minute (preferably 50 ml/minute) and pressure of 0-10 MPa, extraction pump flow rate of 0-100 ml/minute (preferably 100 ml/minute) and pressure of 0-10 MPa, operating temperature of 25-30 degrees C (preferably 50 degrees C), stationary phase comprising cellulose tris(3,5-dimethylphenylcarbamate) with particle size of 10-30 mu m, and mobile phase comprising methanol. Racemic ranolazine is dissolved in methanol at 0-100g/ml (preferably 100 g/ml) and introduced into the chromatographic system via the injection pump. The chromatographic system comprises 4-24 columns divided into four areas, each having 1-6 supports. In the first area located between eluent inlet and eluate outlet, R-ranolazine desorption is achieved. In the second area located between eluate outlet and raffinate inlet, R-ranolazine is repeatedly adsorb, desorb, and concentrated. In the third area located between raffinate inlet and outlet, S-ranolazine is obtained. In the fourth area located between raffinate outlet and eluent inlet, the eluent is recycled into the first area while S-ranolazine is collected. The enantiomer products are concentrated and recrystallized to obtain purity of greater than or equal to 98%.