NOVELTY - A multi-axial kneading apparatus (1) comprises chamber (2) where target object is kneaded and liquefied and rotation unit (6) to rotate chamber.    USE - A multi-axial kneading apparatus for enzyme reaction apparatus used for cellulose saccharification apparatus of biomass saccharification apparatus used in ethanol production apparatus (all claimed).    ADVANTAGE - Reaction of unreacted part of kneaded target object can be promoted, unreacted part can be prevented from being deposited in chamber, and reaction of kneaded target object can be completed over a short period of time.    DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for:    (1) enzyme reaction apparatus which has multi-axial kneading apparatus and uses mixture of polysaccharide-containing cellulose and saccharogenic amylase as kneaded target object;    (2) cellulose saccharification apparatus comprising 1st catalytic reaction apparatus which decomposes degradation product generated by enzyme reaction apparatus into glucose using solid acid catalyst;    (3) biomass saccharification apparatus comprising pressurized hot water reaction apparatus which selectively decomposes hemicellulose and makes pressurized hot water act on biomass, solid-liquid-separation device which separates cellulose as solid from process liquid of pressurized hot water reaction apparatus, and cellulose saccharification apparatus which decomposes cellulose separated by solid-liquid separation device into glucose; and    (4) ethanol production apparatus comprising biomass saccharification apparatus, 1st fermentation apparatus which generates ethanol from glucose produced by biomass saccharification apparatus, and 2nd fermentation apparatus which generates ethanol from monosaccharide derived from hemicellulose produced by biomass saccharification apparatus.    DESCRIPTION OF DRAWING(S) - The drawings show a side view and a longitudinal cross-sectional view of the multi-axial kneading apparatus. (Drawing includes non-English language text).    Multi-axial kneading apparatus (1)    Chamber (2)    Shaft (3)    Rotation unit (6)    Kneaded target object (100)