NOVELTY - Kanamycin B is dissolved in water, then isopropanol, di-tert-butyl dicarbonate and sodium carbonate are added and reacted, to obtain 5-nitro-butyloxycarbonyl-kanamycin B. Obtained product is dissolved in tetrahydrofuran, water is added, 1-phthaloyl-3-hydroxybutyryl-oxa-phthalimide is added and reacted, to obtain hydroxybutanamide compound. Hydrochloric acid is added without separating and reacted, to obtain 1-nitro-(L-4-phthaloyl-2-hydroxybutyryl)dibekacin. Obtained product is provided in ethanol, hydrazine hydrate is added and refluxed, to obtain arbeksein.    USE - Production of arbeksein (claimed).    ADVANTAGE - The arbeksein is economically produced with high yield without polluting the environment, by simple method.    DETAILED DESCRIPTION - Kanamycin B is dissolved in water, then isopropanol, di-tert-butyl dicarbonate and sodium carbonate are added, and reacted at 20-60 degrees C for 3-24 hours, to obtain 5-nitro-butyloxycarbonyl-kanamycin B. The obtained product and 1,1-di-methoxyl cyclohexane are added using p-methylbenzene sulfonic acid as a catalyst and N,N-dimethyl formamide as solvent, and reacted at 20-60 degrees C for 6-24 hours, to obtain 5-nitro-butyloxycarbonyl-4'',6''-oxa-cyclohexylidene-kanamycin B. The obtained product and benzoyl chloride are added using pyridine as solvent, and reacted at -10 degrees C to 60 degrees C for 1-7 hours using one-pot feeding method without separating. Then alpha -toluenesulfonyl chloride is added, and reacted for 1-7 hours, to obtain 2'',3''-2-oxa-benzoyl-5-nitro-butyloxycarbonyl-4'',6''-oxa-cyclohexylidene-4'-oxa-benzylsulfonylkanamycin B. Methanol as solvent is provided, obtained product and sodium methoxide are added, and reacted at 10-60 degrees C for 1-7 hours, to obtain 3',4'- beta -epoxy-5-nitro-butyloxycarbonyl-4'',6''-oxa-cyclohexylidene-kanamycin B. The obtained product, n-butyl potassium xanthate and triethyl phosphate are added using pyridine as a solvent, and reacted at 60-140 degrees C for 1-7 hours, to obtain 3',4'-dideoxy-3'-alkene-5-nitro-butyloxycarbonyl-4'',6''-oxa-cyclohexylidene-kanamycin B. The obtained product and hydrochloric acid are added using methanol as solvent, and then reacted at 20-60 degrees C for 1-7 hours, to obtain 3',4'-dideoxy-3'-alkene-kanamycin B. The obtained product and palladium/C catalyst are added using acetic acid aqueous solution as solvent, and then hydrogen is provided to perform hydrogenation, and reacted at room temperature for 24-72 hours, to obtain (2R,5R,6R)-4-amino-2-(((2S,4S,6R)-4,6-diamino-3-(((6S)-3-amino-6-(aminomethyl)oxan-2-yl)oxy)-2-hydroxycyclohexyl)oxy)-6-(hydroxymethyl)oxane-3,5-diol. The obtained product which is dibekacin is provided in acetonitrile, then hexamethyl disilazane and trimethyl chlorosilane are added, refluxed at 60-90 degrees C for 2 hours, to obtain silicyl dibekacin. gamma -Phthaloyl-( alpha )-hydroxybutyricacid, N-hydroxy phthalimide and N,N-dicyclohexylcarbimide are added in tetrahydrofuran, reacted at 0-60 degrees C for 1 hour, to obtain 1-phthaloyl-3-hydroxybutyryl-oxa-phthalimide. The obtained product is dissolved in tetrahydrofuran, then water is added, 1-phthaloyl-3-hydroxybutyryl-oxa-phthalimide is added, and reacted at 0-30 degrees C for 1 hour, to obtain N-((1R,3S,5S)-5-amino-2-(((2R,5R,6R)-4-amino-5-hydroxy-6-(hydroxymethyl)-3-methyloxan-2-yl)oxy)-4-(((6S)-3-amino-6-(aminomethyl)oxan-2-yl)oxy)-3-hydroxycyclohexyl)-4-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)-2-hydroxybutanamide. Hydrochloric acid is added without separating, and then reacted for 1 hour, to obtain 1-nitro-(L-4-phthaloyl-2-hydroxybutyryl)dibekacin. 1-Nitro-(L-4-phthaloyl-2-hydroxybutyryl) dibekacin obtained is provided in ethanol, hydrazine hydrate is added until the pH value is 11, and then refluxed at 90 degrees C for 2 hours, to obtain arbeksein.