NOVELTY - A multi-raffinate simulated moving bed (SMB) process for separation of ethanol and butanediol from aqueous biomass effluent stream involves: a) passing biomass effluent stream to pretreatment zone including naturation zone and filtration zone to provide SMB feed stream; b) passing SMB feed stream and mobile phase desorbent stream to SMB zone; c) passing a portion of primary raffinate stream to regeneration zone to provide secondary raffinate stream; and d) passing extract stream to a product recovery zone to separate and recover ethanol and butanediol products from extract stream.    USE - As multi-raffinate simulated moving bed (SMB) process for separation of ethanol and butanediol from an aqueous biomass effluent stream from a fermentor (claimed).    ADVANTAGE - Increasing the number of raffinate streams alone or in combination with a hot regeneration zone within the simulated moving bed (SMB) cycle can significantly reduce the capital and operating costs associated with the incorporation of the SMB process in a complex for the production of ethanol and butanediol from biofermentation effluent. The process is useful for removing water from dilute aqueous mixtures of organic compounds comprising ethanol in dilute concentration in water and produced by fermentation, biomass extraction, biocatalytic and enzymatic processes which are not economically recoverable by conventional distillation methods. The simulated moving bed process which incorporates an integrated liquid and vapor regeneration steps in the SMB cycle to provide additional raffinate streams. The integrated vapor regeneration sequence employs streams such as steam, heated azeotropic ethanol, and superheated ethanol vapor to significantly reduce the capital and reduce the operating cost of the SMB complex and reduce the possibility of contaminating the fermentor. The use of ethanol as the desorbent combined with employing a superheated ethanol vapor to desorbs the SMB adsorbent beds undergoing regeneration in the SMB cycle, or by using an azeotropic mixture of ethanol and water as the desorbent combined with using steam to desorbs the adsorbent beds undergoing regeneration can significantly reduce capital cost and operating costs of the complex by elimination of an external distillation column to purify the desorbent.    DETAILED DESCRIPTION - A multi-raffinate simulated moving bed (SMB) process for separation of ethanol and butanediol from an aqueous biomass effluent stream from a fermentor, where the biomass effluent stream comprises water, ethanol, butanediol, acetic acid, and suspended solids, and the multi-raffinate simulated moving bed has SMB zone containing a desorption zone, a rectification zone, an adsorption zone, and at least one regeneration zone, involves: a) passing the aqueous biomass effluent stream to a pretreatment zone including a naturation zone and a filtration zone to provide SMB feed stream; b) passing the SMB feed stream at an effective feed temperature and a mobile phase desorbent stream at an effective desorbent temperature to the SMB zone, where the mobile phase desorbent stream comprises 1-3C alcohol, SMB zone contains several adsorbent beds (81-88) each adsorbent bed having a top and a bottom, and the regeneration zone comprises at least one of the adsorbent beds containing a stationary phase adsorbent selected from fluorinated carbon adsorbent and a modified 18C silica gel, and each of the adsorbent beds of the desorption zone, rectification zone, adsorption zone are disposed in a serial configuration, the bottom of each adsorbent bed is in fluid communication with the top of the i+1 adsorbent bed, to provide an extract stream comprising ethanol and butanediol withdrawn from the desorption zone and a primary raffinate stream withdrawn from the adsorption zone, c) passing at least a portion of the primary raffinate stream to at least one regeneration zone to provide at least one secondary raffinate stream; and, d) passing the extract stream to a product recovery zone to separate and recover ethanol and butanediol products from the extract stream.    DESCRIPTION OF DRAWING(S) - The figure shows a schematic view of the flow diagram of liquid phase simulated moving bed separation zone for 8 adsorbent bed arrangement for purification of ethanol and butanediol.    Adsorbent beds (81-88)