NOVELTY - Preparing a bis(chloro-ethyl amine) substituted 1H-benzoimidazole compound (II) comprises either portion-wise adding a bis(hydroxy ethyl amine) substituted 1H-benzoimidazole compound (I) to phosphoryl chloride without solvent, or adding a chlorinating agent to (I) to obtain (II), adding a solubilizer to the obtained reaction mixture, and portion-wise adding an aqueous solution of an inorganic proton acceptor to the reaction mixture.    USE - (II) is useful for treating chronic lymphocytic leukemia and lymphoma. No biological data given.    ADVANTAGE - The process stably and reliably provides (II) with high purity under mild reaction conditions and without using toxic organic solvents, hence safe and ecofriendly.    DETAILED DESCRIPTION - Preparing a bis(chloro-ethyl amine) substituted 1H-benzoimidazole compound of formula (II) comprises either portion-wise adding a bis(hydroxy ethyl amine) substituted 1H-benzoimidazole compound of formula (I) to phosphoryl chloride without solvent, or adding a chlorinating agent to (I) to obtain (II), adding a solubilizer to the obtained reaction mixture, and portion-wise adding an aqueous solution of an inorganic proton acceptor to the reaction mixture, or adding an aqueous solution of crude bis(chloro-ethyl amine) substituted 1H-benzoimidazole hydrochloride compound of formula (III) to water with room temperature or high temperature, agitating the mixture for a first time interval during which (III) begins to precipitate, and further agitating the mixture for a second time interval for another precipitating of (III), where if a mixture with high temperature is used, then the mixture is cooled prior to the agitation of the second time interval at room temperature, and separating the obtained precipitated compound (III), where after the separation step, the process takes place without further recrystallization in an organic solvent.    R1 = alkyl, aryl or alkylaryl;    R2 = alkylene, arylene, alkylarylene or arylalkylene;    Y1, Y2 = O or S; and    Prot = protecting group for carboxylic acid, COSH, CSOH or CSSH.