NOVELTY - Microemlusion-based gel preparation comprises Tripterygium wilfordii, surfactant, co-surfactant, oil phase and a aqueous phase; and gel matrix. The surfactant is polysorbate, caprylic/capric acid polyethylene glycol esters, polyoxyethylene fatty acid esters and/or polyoxyethylene fatty alcohol ethers. The co-surfactant is ethanol, isopropanol, 1,2-propylene glycol, glycerin, polyethylene glycol 400 and/or ethanol. The oil phase is oleic acid, isopropyl myristate and/or isononyl ethylhexyl ester. The gel matrix is poloxamer.    USE - Used as microemlusion-based gel preparation (claimed).    ADVANTAGE - The preparation of microemlusion-based gel: has reliable and simple processes, consumes less energy and does not cause pollution. Compared with the common Tripterygium wilfordii emulsifiable paste, the microemlusion-based gel preparation obtained by the method can obviously improve a unit-area accumulative penetration amount, has a certain slow release effect, reduces the frequency and an amount of administration, is convenient for administration and does not pollute clothing.    DETAILED DESCRIPTION - Microemlusion-based gel preparation comprises: 0.02 wt.% Tripterygium wilfordii, 10-35 wt.% surfactant, 1-10 wt.% co-surfactant, 3-12 wt.% oil phase and a aqueous phase (balance amount); and 8-20 wt.% gel matrix. The surfactant is polysorbate, caprylic/capric acid polyethylene glycol esters, polyoxyethylene fatty acid esters and/or polyoxyethylene fatty alcohol ethers. The co-surfactant is ethanol, isopropanol, 1,2-propylene glycol, glycerin, polyethylene glycol 400 and/or ethanol. The oil phase is oleic acid, isopropyl myristate and/or nonanoic acid ethylhexyl ester. The gel matrix is poloxamer. An INDEPENDENT CLAIM is also included for preparing the microemlusion-based gel preparation, comprising: (i) uniformly mixing surfactant and co-surfactant at room temperature, adding oil phase, and ultrasonically mixing, adding Tripterygium wilfordii extract to the above mixture, ultrasonically mixing, adding distilled water make the total volume to 100 pts. volume, magnetically stirring until clear and transparent to obtain yellow opalescent bluish microemulsion; and (ii) evenly sprinkling the microemulsion on the gel matrix, allowing to stand overnight, and vacuum degassing to obtain the product.