TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Process: (XI) is reduced by using (l1) and base comprising triethylamine, diethylamine, diisopropylethyl amine, diisopropyl amine, pyridine or piperidine. (l1) is lithium diisopropylamide obtained by reacting n-butyl lithium and diisopropyl amine. The process (p1) is performed at a temperature of not less than -10 degrees C to 0 degrees C. The process (p2) is performed at an elevated temperature of 50-60 degrees C to isolate (VII). The resolution is performed at 50-120 degrees C, preferably 80-85 degrees C for 3-5 hours. (X) is reduced by hydrogenating 4,5-dimethoxy-1-cyano-benzocyclobutane at about 60-70 degrees C at 30 bar pressure for 4-6 hours in presence of base comprising ammonia or triethylamine (both preferred), diethylamine, diisopropylamine or diisopropylethylamine. (VIII-A) can be isolated by treating the salt of resolving agent and (VIII-A) with a suitable base like alkali metal hydroxide, carbonates, bicarbonates or hydrides, preferably sodium or potassium hydroxide. (VI) can be converted to stable hydrochloride salt by treating methylated amine as an oil with dry hydrogen chloride gas to adjust pH of 1-3 in mixture of ethyl acetate and ethanol. The step (b1) is preferably carried in organic solvent comprising lower alcohol 1-6C, 2-6C esters, ethers and/or sulfoxide amides, preferably methanol, ethanol, isopropanol, n- propanol, n-butanol, iso-butanol, tert-butanol, ethyl acetate, isopropyl acetate, tert-butyl acetate, n-butyl acetate, tetrahydrofuran, diethyl ether, diisopropyl ether, dioxane, sulfolane or dimethyl sulfoxide, dimethyl formamide or dimethyl acetamide, preferably mixture of dimethyl formamide and ethyl acetate. The ivabradine base is treated with hydrogen chloride gas slowly to adjust pH 1-3 at 5-10 degrees C followed by heating reaction mass to 50-60 degrees C and cooling to ambient temperature. In method (p5) the reaction mixture is heated at 75-80 degrees C followed by cooling to 25-35 degrees C. The acetylation is done with agent like acetyl chloride, acetic acid or acetic anhydride, preferably acetic nhydride. Preferred Components: The first organic solvent is hydrocarbons like toluene, benzene, ethylbenzene, cyclohexane, heptane, ethers like tetrahydrofuran, 2-methyl tetrahydrofuran, or chlorinated hydrocarbons like methylene dichloride, ethylene dichloride, preferably tetrahydrofuran. The second organic solvent is ethyl acetate, isobutyl acetate, isopropyl acetate, toluene, methylene dichloride or ethylene dichloride, preferably methylene dichloride. The 1-8C alcohol is methanol. The polar solvent is 1-4C alcohol, 2-6C ketone, N-methyl pyrrolidone, dimethylformamide or dimethylacetamide, preferably methanol. The organic solvent is methylene dichloride, ethylene dichloride, ethyl acetate, isopropyl acetate, n-butyl acetate, methyl isobutyl ketone, acetone, methanol, ethanol, isopropanol, butanol, tetrahydrofuran or 2-methyltetrahydrofuran, preferably methylene dichloride. The aromatic hydrocarbon is benzene, toluene, xylene or ethyl benzene, preferably toluene. The resolvating agent is N-acetyl-L-glutamine acid, camphorsulfonic acid, tartaric acid, di-benzoyltartaric acid, p-di-toluyltartaric acid, mandelic acid, phenyl glycine, phenylalanine or histaminic acid, preferably N-acetyl-L-glutamic acid or p-di-toluyltartaric acid to obtain (VIII-A). The organic solvent for resolution of racemic amine is 1-8C alcohol, 3-8C ketones, 3-4C esters, ethers and/or water, preferably a mixture of ethanol and water. In step (b1) the base is sodium hydroxide, potassium hydroxide, sodium bicarbonate or potassium bicarbonate, preferably potassium carbonate in presence of catalyst like potassium iodide. In (p4) the solvent is acetonitrile or acetone. In method (p5) the solvent is at least one of acetonitrile, tetrahydrofuran, ethyl acetate or optionally mixture with water. In method (p6): the organic solvent is dimethylformamide, dimethylacetamide, N-methyl pyrrolidone, methanol, ethanol, pyridine, acetone or isopropanol preferably pyridine; the elevated temperature is 60-90 degrees C, preferably 80 degrees C; the hydrocarbon solvent is toluene, xylene, cyclohexane or ethylbenzene etc, preferably toluene and temperature at 110 degrees C; the solvent is methylene dichloride, ethylene dichloride, ethyl acetate, n-butyl acetate, isopropyl acetate or butanol preferably methylene dichloride; and the organic solvent is mixture of acetic acid and methylene dichloride. ACTIVITY - Cardiant; Vasotropic; Antianginal.    MECHANISM OF ACTION - None given.    EXAMPLE - 1 Kg 3-(2-Bromo-4,5-dimethoxyphenyl)propanenitrile and 2 l tetrahydrofuran (THF) were taken in flask. The reaction mixture was treated with 4.08 Kg n-butyl lithium and 1.492 Kg diisopropylamine solution in 2 l THF at -20 degrees C. The reaction mixture was stirred at -10 degrees C for 30 minutes. The reaction mixture was treated with 0.8 Kg ammonium chloride solution in 2.5 l water at -15 degrees C to 10 degrees C. The aqueous layer was extracted with 2 l methylene dichloride at 0-10 degrees C and stirred for 30 minutes. The separated organic layer was combined with THF layer and treated with 0.24 l hydrochloric acid in 1.76 l water at 25 degrees C. The organic layer was distilled under vacuum at 40-50 degrees C. The residue was treated with 1 l methanol and heated at 60 degrees C for 30 minutes. The reaction mixture was cooled to 5 degrees C to isolate product. The product was washed with methanol and dried to obtain 4,5-dimethoxy-1-cyano-benzocyclobutane (71%).