TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Method: The method comprises: (i) dissolving 31-32.6 g chlorosulfonic acid in 30 ml chloroform while stirring for 20 minutes, and cooling to less than or equal to 20 degrees C to obtain solution of chlorosulfonic acid in chloroform; (ii) dissolving 40 g of thymol in 200 ml chloroform while stirring and cooling to 20-25 degrees C, then adding 0.5 g anhydrous sodium sulfate, dropping chlorosulfonic acid-chloroform solution slowly at 20-25 degrees C for 2-3 hours, then reacting at 25-30 degrees C for 30 minutes, adding 40 ml deionized water and 10 ml 5% alkali solution while stirring for 20 minutes at 25-30 degrees C, allowing the reaction mixture to stand for 15 minutes, and separating aqueous layer; (iii) adding 20 ml deionized water and carrying out steam distillation, where rate of water addition is close to the speed of the distillate fraction, then maintaining the system volume at constant and distilling off the chloroform completely, cooling to below 25 degrees C, filtering, washing the filtrate with cold water, and drying completely to obtain 58.3-58.6 g light yellow solid sulfonated thymol product; (iv) dissolving 20-22.5 g sodium dichromate dihydrate in 100 ml water, adding 25 ml 97% concentrated sulfuric acid while stirring, diluting to 200 ml and cooling to 0 degrees C to obtain chromic acid solution; (v) dissolving 50 g sulfonated thymol product in 200 ml dichloromethane, dropping chromic acid solution within 10 minutes, cooling and stirring for 30 minutes, allowing to stand for 15 minutes, separating aqueous layer, adding 20 ml 5% alkali solution to the organic layer, washing twice with 50 ml water, and removing the aqueous layer; and (vi) adding 20 ml deionized water into the system, and carrying out steam distillation, where rate of water addition is close to the speed of the distillate fraction, then maintaining the system volume at constant and evaporating water and solvent by vacuum distillation, allowing the distillate to pass through a condenser jacket at 35-40 degrees C, and then through a receiving flask at 50-55 degrees C with water bath, where the distillation temperature is maintained at 85-90 degrees C, then heating to 60-65 degrees C and keeping for 30 minutes, separating organic layer using a separating funnel, cooling and solidifying at room temperature and vacuum degree of -0.09 MPa, and drying for 4 hours to obtain an orange brown powder of thymoquinone. Preferred Components: The molar ratio of thymol and chlorosulfonic acid is 1:1-1.05 and the molar ratio of chlorosulfonic acid and sodium dichromate dihydrate is 1:0.4-0.45. ACTIVITY - Angiogenesis inhibitor.