NOVELTY - Phthalides effective component is obtained by extracting medicinal materials of rhizoma Chuanxiong, rhizoma Ligustici officinalis, radix Angelicae sinensis, and Angelica acutiloba. It comprises 0.8-8% senkyunolide I, 0.1-3% senkyunolide H, 6-27% sedanolide, 0.02-0.4% n-butylphthalide, 7-70% ligustilide, 0.05-0.3% n-butylidenephthalide, 0.01-2% riligustilide, 0.001-0.5% levistilide A, 3-35% coniferyl ferulate, and 0.1-7% ferulic acid, where total content of effective components is greater than 50%.    USE - The phthalides effective component used for preparing medicine or healthcare food for treating and ameliorating ischemic cardio-cerebrovascular diseases comprising transient ischemic attack, coronary disease, cerebral thrombosis, cerebral infarction, angina, chest tightness, migraine, and myocardial infarction. The medicine is prepared into soft capsules, sublingual tablet, or dropping pills. (all claimed)    ADVANTAGE - The method has quick speed and excellent economical and social benefits and provides phthalides effective component with high yield and controllable quality.    DETAILED DESCRIPTION - An INDEPENDENT CLAIM is included for preparation of phthalides effective component comprising removing impurities from the medicinal materials comprising rhizoma Chuanxiong, rhizoma Ligustici officinalis, radix Angelicae sinensis, and/or A. acutiloba, grinding, conducting ultrasonic extraction method, solvent extraction method, microwave extraction method, solvent reflux extraction method, or supercritical fluid extraction method, concentrating the product to obtain phthalides effective component, adding 0.1-3 times water by volume, completely and uniformly mixing, adding aqueous solvent A, where ratio of water and raw material is 1-2 L:1 kg, extracting the mixture for 1-3 times at 10-40 degrees C, standing the mixture for 2-48 hours to separate the layers, collecting the organic phase and adding anhydrous sodium sulfate to remove the water, obtaining extracting liquid A, or adding aqueous solvent B, where ratio of water and raw material is 1-2 L:1 kg, extracting the mixture for 1-3 times at 10-40 degrees C, standing the mixture for 2-48 hours to separate the layers, collecting the organic phase and adding anhydrous sodium sulfate to remove the water, obtaining extracting liquid B, where solvent A is petroleum ether, n-hexane, n-heptane, and/or mixed solvent of ethyl acetate, dichloromethane, and/or chloroform, and solvent B is ethyl acetate, dichloromethane, and/or chloroform, using normal phase silica gel column to purify the extracting liquid A and/or extracting liquid B, collecting the eluent, and concentrating the eluate to obtain phthalides effective component.