NOVELTY - 3-(Tert-butoxy)-2-((4-ethyl-2,3-dioxopiperazin-1-yl)carbonylamino)butanoic acid is provided and added to methylene dichloride for 1-10 times, and cooled at 0 degrees C. The obtained compound is added to 8.175 times volume isopropanol and cooled, solid is filtered and collected, and dried, to obtain crude product. Ethyl acetate is added and pulped for 4 hours, precipitate is filtered and collected, and dried, to obtain cefbuperazone crude product. The obtained crude product is purified, to obtain celbuprazone sodium.    USE - Manufacture of cefbuperazone sodium (claimed).    ADVANTAGE - The cefbuperazone sodium is economically manufactured with high yield without polluting the environment.    DETAILED DESCRIPTION - 3-(Tert-butoxy)-2-((4-ethyl-2,3-dioxopiperazin-1-yl)carbonylamino)butanoic acid is provided and added to methylene dichloride for 1-10 times, and cooled at 0 degrees C. The solution of 0.1 times volume oxalyl chloride and 0.0025 times volume N,N-dimethylformamide is provided and reacted for 30-180 minutes, removed to the solid, then obtained compound is added to 2.5 times volume methylene dichloride, dissolved in the solvent, and repeated for 3 times, to obtain 3-(tert-butoxy)-2-((4-ethyl-2,3-dioxopiperazin-1-yl)carbonylamino)butanoyl chloride. The obtained compound is provided, and added to the dichloromethane for 10 times under nitrogen, and cooled at 50 degrees C. The obtained compound is added to 125 times by weight methoxy cephalosporin compound and 0.5 times pyridine, and reacted for 8-24 hours at room temperature. The reaction is finished and temperature is raised at 0 degrees C, washed using sodium bicarbonate, hydrochloric acid and saturated salt, and organic phase is collected. Anhydrous sodium sulfate is added for 125 times, organic phase is collected and dried, to obtain diphenylmethyl 7-(3-(tert-butoxy)-2-((4-ethyl-2,3-dioxopiperazin-1-yl)carbonylamino)butanamido)-7-methoxy-3-(((1-methyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate crude product. The obtained compound is added to 8.175 times volume isopropanol until the solution is clear and naturally cooled for 16 hours, solid is filtered and collected, water content is controlled to 1% and dried, to obtain diphenylmethyl 7-(3-(tert-butoxy)-2-((4-ethyl-2,3-dioxopiperazin-1-yl)carbonylamino)butanamido)-7-methoxy-3-(((1-methyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate. The obtained compound is added to 10 times anisole under ice-water cooling at 0 degrees C, solution of 10 times volume trifluoroacetic acid is added, naturally dropped to room temperature, reaction is stirred for 30 minutes at 30 degrees C and solvent is removed. Ethyl acetate is added and pulped for 4 hours, precipitate is filtered and collected, and dried, to obtain cefbuperazone crude product. The obtained crude product is purified, to obtain celbuprazone sodium.