TECHNOLOGY FOCUS - INORGANIC CHEMISTRY - Preferred Components: Step (b) in which: the reducing agent is sodium borohydride, lithium aluminum hydride, lithium tri-sec-butylboronhydride, diisobutyl aluminum hydride or red aluminum. Step (d) in which the metal catalyst is palladium, platinum, platinum(III) oxide or rhodium and reaction pressure is 1-5atm. Step (e) in which alkali acid-binding agent of alkylation reaction is sodium carbonate, potassium carbonate, sodium bicarbonate, triethylamine, diisopropylethylamine or 1,8-diazabicycloundec-7-ene.    TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Method: The method comprises (a) subjecting (II) and (III) at ratio of 1:1-3 to intermolecular cyclization in presence of acid in an isopropyl acetate solvent to obtain (IV), and reacting (IV) with hydrochloric acid to form salt and then converting transformational configuration of obtained salt to obtain (V), (b) reducing (V) to alcohol and then esterifying obtained alcohol with 3,5-bis(trifluoromethyl)benzoyl chloride at molar ratio of 1:1-2 to obtain (VI) and recrystallizing by using alcohol solvent, (c) reacting (VI) with dimethyltitanocene at molar ratio of 1:1-10 in tetrahydrofuran to obtain crude product (VII), (d) subjecting (VII) to reduction hydrogenation in presence of metal catalyst to obtain (VIII) and purifying of (VIII) with acid to form salt, and (e) alkylating the purified intermediate (VIII) to obtain (I). Step (a) in which: the reaction temperature is 35-150 degrees C and reaction time is 1-24 hours; intermediate (IV) is reacted with hydrochloric acid to form salt, which is converted into isomer simultaneously at temperature of 50-100 degrees C and reaction time of 1-24 hours, preferably intermediate (IV) is reacted for 12 hours at 70 degrees C in saturated isopropyl acetate hydrogen chloride solution, then cooling and filtering, where the reaction solvent is ethyl acetate, isopropyl acetate or propyl acetate. Step (b) in which: the reduction reaction temperature is -78 to 25 degrees C; intermediate (V) is reduced to alcohol by using lithium tri-sec-borohydride as reducing agent at -78 degrees C in anhydrous tetrahydrofuran; and reacting obtained alcohol with acid chloride at temperature of 0-50 degrees C in presence of alkali acid-binding agent and to obtain ester, where the alkali acid-binding agent is triethylamine, diisopropylethylamine, sodium carbonate, potassium carbonate or 1,8-diazabicycloundec-7-ene. Step (c) in which: reaction temperature is 50-150 degrees C and reaction time is 1-12 hours; and reaction is carried out in toluene and refluxing for 10 hours. Step (e) in which alkylation reaction is carried out in dimethylformamide solution using potassium carbonate as alkali acid-binding agent and reacting at room temperature for 5 hours. Step (d) in which reduction hydrogenation reaction is carried out in mixed solution containing ethyl acetate and isopropanol at volume ratio of 3:1 in presence of 10% palladium/carbon as catalyst, and hydrogenating for 5 hours at 3 atmospheric pressure. Preferred Components: Step (a) in which, the acid is hydrochloric acid, sulfuric acid, p-toluenesulfonic acid or acetic acid. Step (b) in which, the alcohol solvent is isopropanol (preferred), methanol, ethanol, or n-propanol.