NOVELTY - Synthesis of acetic acid cyproterone by dehydrogenation involves: taking 17 alpha-hydroxyl progesterone, absolute ethyl alcohol and triethyl orthoformate as raw material, carrying out etherification reaction at 38-42 degrees C, in a weight ratio of 1:1.2-2:0.4-0.8, after finishing reaction, carrying out acid-base neutralization to acidic; adding toluene as reaction solvent to the obtained product, to protect nitrogen, and then adding a chlorine-cyano benzoquinone to dehydrogenation reaction, carrying out filtering, concentrating and drying.    USE - For synthesis of acetic acid cyproterone by dehydrogenation (claimed).    ADVANTAGE - The method uses the efficient one-pot cooking synthesis method, with product yield of more than 80-83%, shortened reaction period, improves the labor productivity, reduces the device investment and use type; uses small amount of the solvent, which reduces the environment pollution and reduces the production cost of the factory.    DETAILED DESCRIPTION - Synthesis of acetic acid cyproterone by dehydrogenation involves: taking 17 alpha-hydroxyl progesterone, absolute ethyl alcohol and triethyl orthoformate as raw material, carrying out esterification reaction at 38-42 degrees C, where the weight ratio of 17a-hydroxyl progesterone, absolute ethyl alcohol and triethyl orthoformate is 1:1.2-2:0.4-0.8, after finishing reaction, carrying out acid-base neutralization to acidic; adding toluene as reaction solvent to the obtained product to protect N2, and then adding a chlorine-cyano benzoquinone to dehydrogenation reaction which is carried out at 85-90 degrees C, where the weight ratio of cyano benzoquinone and 17a-hydroxy progesterone is 0.8-1.6:1, carrying out filtering, concentrating and drying after the reaction is finished to obtain the acetic acid cyproterone dehydrogenation. In the step, etherification reaction, adding p-toluene sulfonic acid pyridine salt as catalyst, according to the p-toluene sulfonic acid pyridine salt and 17a-hydroxy progesterone to the weight ratio of 0.01-0.05:1. After reducing the temperature to less than 25 degrees C, and then adding triethylamine to neutralize to pH value is 7-8.