NOVELTY - Use of nitric oxide (NO) donor for preventing or treating arterial insufficiency and cardiac arrhythmia, and suppressing negative effects associated with arterial insufficiency treatment, is claimed, where the NO donor is administered in an intermitting manner to induce arteriogenesis. The NO donor is glyceryl trinitrate (GTN) in a solid preparation containing 0.05-2 wt.% GTN, at least one diluent, one carrier material and at least one substance that reduces the volatility of GTN, where the substance is a non-volatile ester stabilizer having a melting point of not higher than 60 degrees C.    USE - The NO donor is useful for: preventing or treating an arterial insufficiency, which is due to a partial or complete occlusion of an arterial vessel, or due to the deposition of material in the blood vessels, or due to an external or internal compression of an artery, and is a vascular disease, atherosclerosis, ischemic disease, chronic arterial disease, coronary arterial insufficiency, cerebral arterial insufficiency, peripheral arterial insufficiency, intestinal arterial insufficiency, urogenital arterial insufficiency, nerval artery insufficiency, scleroderma, or central retinal artery insufficiency; preventing or treating cardiac arrhythmia; and suppressing negative effects associated with arterial treatment of any arterial insufficiency which is which is anti-arteriogenic or inhibiting arteriogenesis (all claimed). Test details are described but no results given.    ADVANTAGE - The NO donor is safe, short acting and effectively induced arteriogenesis even if they are not administered constantly but in a manner where plasma levels are only elevated for a short time, and shows a higher pro-arteriogenic effect than a long acting nitrate. The NO donor acts as a biomimetic when applied in an intermitting manner. The solid preparation of NO donor: exhibits highly prolonged shelf life and improved stability as compared with conventional GTN preparations; can be produced without the use of volatile and flammable solvents, thus eliminating the energy-intensive drying steps and elaborate solvent recovery processes.