NOVELTY - Synthesis of nifuratel comprises reacting epichlorohydrin and sodium thiomethoxide, distilling to obtain 2-(methylthio)-oxirane, heating hydrazine hydrate and 2-(methylthio)-oxirane at 90-95 degrees C, and distilling to obtain 3-methylthio-2-hydroxy-propyl hydrazine; reacting 3-(methylthio)-2-hydroxy-propyl hydrazine and dimethyl carbonate, heating to obtain N-amino-5-methyl-2-(methylthio) oxazolidone; and mixing N-amino-5-methyl-2-(methylthio) oxazolidone and 5-furfural at 15-30 degrees C for 2 hours, filtering, washing the filtrate with ethanol, re-crystallizing, and purifying.    USE - Method for the synthesis of nifuratel (claimed) for treating vaginal infection.    ADVANTAGE - The method uses sodium methoxide, preventing the use of metal sodium, thus ensuring production safety. It is inexpensive, environment-friendly, easy to control, and achieves high yield and stable quality.    DETAILED DESCRIPTION - Synthesis of nifuratel comprises:    (A) placing epichlorohydrin in a reaction bottle, slowly adding sodium thiomethoxide at 0-10 degrees C, stirring at room temperature, reacting for 3 hours, decompressing and distilling, and collecting distillate to obtain 2-(methylthio)-oxirane, where the ratio of epichlorohydrin and sodium thiomethoxide is 1:5;    (B) adding hydrazine hydrate in a three-opening bottle, adding 2-(methylthio)-oxirane at 90-95 degrees C, continuously preserving heat for 2 hours, decompressing and distilling, and collecting distillate to obtain 3-methylthio-2-hydroxy-propyl hydrazine, where the ratio of hydrazine hydrate and 2-(methylthio)-oxirane is 1:1-1.1:1;    (C) reacting 3-(methylthio)-2-hydroxy-propyl hydrazine and dimethyl carbonate, heating to obtain N-amino-5-methyl-2-(methylthio) oxazolidone, where the mol ratio of 3-(methylthio)-2-hydroxy-propyl hydrazine and dimethyl carbonate is 1:1-1:1.2;    (D) hydrolyzing 5-nitrofurfural diacetate and ethanol to obtain 5-furfural, where the mol ratio of ethanol with 5-nitrofurfural diacetate is 1:0.05; and    (E) mixing N-amino-5-methyl-2-(methylthio) oxazolidone and 5-furfural at 15-30 degrees C for 2 hours, standing for 2 hours, filtering, washing the filtrate with ethanol, re-crystallizing, and purifying, where the ratio of N-amino-5-methyl-2-(methylthio) oxazolidone and 5-furfural is 1:1-1:1.05.