NOVELTY - A prepared non-polar orlistat intermediate-containing extract is concentrated, cooled, filtered, dried, diluted and crystallized, to obtain orlistat intermediate white crystals. The crystals are dissolved in non-polar solvent, palladium/carbon composite is added, and hydrogenated. The hydrogenated liquid is added to aqueous organic solvent solution, stirred, allowed to standstill, and upper and lower phases are collected. The upper phase is washed, diluted using non-polar solvent, cooled, filtered and crystallized, to obtain orlistat.    USE - Preparation of orlistat (claimed).    ADVANTAGE - The method efficiently and economically provides orlistat with purity of more than 99% and impurity content of less than 0.1%, without causing pollution to environment.    DETAILED DESCRIPTION - A filter aid is added to a fermentation broth, pH of the broth is adjusted to 4-5 using an acid, stirred and filtered. The filter cake is extracted using a polar solvent, stirred and filtered, to obtain solution containing 15-30 g/L orlistat intermediate. Then, deionized water is added to solution to adjust the volume concentration of the aqueous solution to 50-80%. The orlistat intermediate is added to an aqueous solution of organic solvent and non-polar solvent and extracted, to obtain non-polar orlistat intermediate-containing extract. The extract is concentrated to concentration of 100-200 g/L and cooled to less than 5 degrees C, filtered to remove insoluble impurities, dried, diluted to concentration of 50-100 g/L and crystallized, to obtain orlistat intermediate white crystals. The crystals are dissolved in 10-80 g/L non-polar solvent, 5-10 wt.% palladium/carbon composite is added, and hydrogenated at 30-40 degrees C under pressure of 0.3-1 MPa. The hydrogenated liquid is added to aqueous organic solvent solution, stirred, allowed to standstill, and upper and lower phases are collected. The upper phase is washed, diluted using 30-50 g/L non-polar solvent, cooled, filtered and crystallized, to obtain orlistat.