NOVELTY - Simulated moving bed chromatographic separation of flurbiprofen enantiomer comprises dissolving flurbiprofen racemate in mobile phase comprising mixed solution of normal hexane and ethanol, pumping into simulated moving bed chromatography (SMBC) system, where the system comprises 4-24 preparative columns divided into four zones, desorbing S-flurbiprofen, adsorbing S-flurbiprofen, desorbing and concentrating, adsorbing R-flurbiprofen, allowing to enter into fourth zone between raffinate outlet and eluent inlet, recycling eluent in zone III, concentrating and recrystallizing enantiomer products.    USE - The method is useful for simulated moving bed chromatographic separation of flurbiprofen enantiomer (claimed).    ADVANTAGE - The method enables continuous production, and high degree of automation and production efficiency.    DETAILED DESCRIPTION - Simulated moving bed chromatographic separation of flurbiprofen enantiomer comprises (a) dissolving flurbiprofen racemate in mobile phase comprising mixed solution of normal hexane and ethanol, such that the concentration is 0-100 g/l, pumping into simulated moving bed chromatography (SMBC) system by a sampling pump, where the chromatography system comprises 4-24 preparative columns divided into four zones, each zone has 1-6 columns located between the first zone eluent inlet and eluent outlet, carrying out desorption of S-flurbiprofen, repeatedly adsorbing S-flurbiprofen between second zone eluent outlet and inlet, desorbing and concentrating, repeatedly adsorbing R-flurbiprofen between the eluent outlet and sample port, allowing to enter into fourth zone between raffinate outlet and eluent inlet, where the eluent in the zone III can be recycled, and third and first zones are separated to prevent the flow of raffinate liquid into R-flurbiprofen in the first zone, where the parameters of the process comprises controlling the elution pump flow rate to be 0-100 ml/minute, pressure to be 0-10 Mpa, sampling pump flow rate to be 0-50 ml/minute, pressure to be 0-10 Mpa, extraction pump flow rate to be 0-100 ml/minute, pressure to be 0-10 Mpa, working temperature to be 20-35 degrees C, the chromatographic column filler is spherical silica particles surface coated with amylose-tris(3,5-dimethylphenyl carbamate) having a granularity of 20-40 mu m, and (b) concentrating the two enantiomers product, recrystallizing to obtain qualified product having a purity of more than 95%.