NOVELTY - Synthesis of cefotetan disodium involves preparing chloroacetyl methoxy cephalosporin (I) and catalyst solution (II), adding obtained solution (G) and butanone, mixing, adding concentrated hydrochloric acid, mixing solution (C), adding 157 mL water and 33 g sodium chloride, stirring the resultant product, adding organic phase (A), adding ethanol and charcoal, mixing, filtering resultant product, adding 53 g sodium ethylhexanoate, stirring the resultant product, crystallizing, filtering the resultant product, washing with methyl ethyl ketone and ethanol, and vacuum drying.    USE - Synthesis of cefotetan disodium used in pharmaceutical field.    ADVANTAGE - The cefotetan disodium is economically and environmentally-friendly manufactured.    DETAILED DESCRIPTION - Synthesis of cefotetan disodium involves adding 620 mL methylene chloride and 110 g 7( beta )-amino-7( alpha )-methoxy-3-((1-methyl-1H-tetrazol-5-yl)thiomethyl)-3-cephem-4-carboxy-diphenylmethyl ester, stirring, cooling to -10 degrees C, adding 22 g pyridine, dripping 27.8 g acetyl chloride, then stirring the resultant product, adding 620 mL purified water, 33 g sodium chloride and 44 mL of 37% hydrochloric acid, stirring the resultant product to obtain solution (A), adding 620 mL purified water, 33 g sodium chloride and 11 mL of 37% hydrochloric acid, stirring the resultant product to obtain solution (B), adding 330 mL purified water and 25 g sodium chloride, then stirring the resultant product to obtain solution (C), adding 11 g activated carbon, mixing the resultant product, filtering, then concentrating the filtrate to obtain oil (a), adding 160 mL methanol, concentrating the resultant product under reduced pressure to obtain oil (B), adding 440 mL methanol, controlling the temperature to 22-25 degrees C, stirring the resultant product for 4 hours, cooling the resultant product, filtering and washing with 200 mL methanol, vacuum drying the resultant product to obtain chloroacetyl methoxy cephalosporin (I), adding 240 mL anisole into a reactor, stirring under nitrogen, cooling, adding 95 g aluminum chloride, cooling the resultant product, stirring for 30 minutes, adding 440 mL dichloromethane, cooling the resultant product to obtain catalyst solution (II), adding 1000 mL dichloromethane to a reactor, 110 g chloroacetyl methoxy cephalosporin (I), cooling to -10 degrees C, adding obtained catalyst solution (II), stirring the resultant product for 1 hour, adding 850 mL purified water, 850 mL acetone and 70 mL of 37% hydrochloric acid, mixing the resultant product to obtain mixture (D), adding 750 mL purified water and 60 g sodium chloride to the resultant product, stirring to obtain solution (E), adding 5% sodium bicarbonate solution, stirring the resultant product to obtain solution (F), then adding 900 mL ethyl acetate, cooling the resultant product, adding 13.5% hydrochloric acid, stirring, adjusting pH to 1 to obtain organic phase (A), adding 9 g activated carbon, stirring the resultant product, filtering and concentrating under reduced pressure to obtain oil (C), adding 130 mL ethanol and 380 mL isopropanol, stirring the resultant product, dissolving sodium ethylhexanoate and isopropanol, reacting at 20-25 degrees C for 3 hours, cooling, filtering the resultant product, washing the resultant product with 70 mL ethanol to obtain mixture (G), vacuum drying the resultant product to obtain sodium chloroacetyl methoxy cephalosporin, then adding 650 mL water into a reactor, stirring the resultant product, cooling, adding obtained component (I), adding 55 g sodium, stirring the resultant product, adding sodium hydrogen carbonate in which pH value is adjusted to 7.5, adding mixture (B) and 720 mL water, cooling, adding the resultant product with 4-carboxy-3-hydroxy-5-mercapto isothiazolyl solution and 35.3 g sodium bicarbonate, introducing carbon dioxide gas, reacting the resultant product for 30 minutes, adding 0.5 g ethylenediaminetetraacetic acid, stirring the resultant product, maintaining pH to 7.8, stirring the resultant product for 85 hours, adding 15% diluted hydrochloric acid in which pH is adjusted to 4.5, stirring, adding activated aluminum oxide wet product, stirring for 1 hour, filtering, adding 5 g activated carbon to the filtrate, mixing, filtering the resultant product, adding 380 g sodium chloride and 525 mL tetrahydrofuran, stirring the resultant product, adding solution (F), adding 275 mL tetrahydrofuran, mixing the resultant product, adding solution (G) and 450 mL butanone, mixing, adding concentrated hydrochloric acid in which pH is adjusted to 2, mixing solution (C), adding 157 mL water and 33 g sodium chloride, stirring the resultant product, adding organic phase (A), adding ethanol and charcoal, mixing, filtering the resultant product, adding 53 g sodium ethylhexanoate, dissolving the resultant product in ethanol solution, stirring the resultant product, crystallizing, filtering the resultant product, washing the cake with methyl ethyl ketone and ethanol, and vacuum drying.