NOVELTY - Azelaic acid dimethyl vinyl ester and glucose are dissolved in anhydrous pyridine, alkaline protease is added, reacted, separated and purified, to obtain glucose vinyl ester. Then, N-isopropyl acrylamide is added into glucose vinyl ester, initiator and solvent are added, reacted under nitrogen blanket, stirred, and polymerized, to obtain glucose vinyl ester/isopropyl acrylamide copolymer. To the product polycaprolactone is added, stirred, and resulted product is dried, to obtain glucose vinyl ester/isopropyl acrylamide copolymer nanoparticles.    USE - Preparation of glucose azelaic acid vinyl ester/isopropyl acrylamide copolymer nanoparticles used as drug carrier.    ADVANTAGE - The glucose azelaic acid vinyl ester/isopropyl acrylamide copolymer nanoparticles having improved biocompatibility are prepared by simple, economical and environmentally-friendly method.    DETAILED DESCRIPTION - Azelaic acid dimethyl vinyl ester and glucose provided in molar ratio of 1-4:1 is dissolved in anhydrous pyridine, alkaline protease is added, reacted at 40-60 degrees C for 3-5 days, separated and purified, to obtain glucose vinyl ester. Then, N-isopropyl acrylamide is added into glucose vinyl ester, initiator and solvent are added, reacted at 55-60 degrees C under nitrogen blanket, stirred for 3-8 hours, and polymerized, to obtain glucose vinyl ester/isopropyl acrylamide copolymer. To the resulted product polycaprolactone is added, and stirred, to obtain glucose vinyl ester/isopropyl acrylamide copolymer electronic fuel injection solution. The resulted product is dried, to obtain glucose vinyl ester/isopropyl acrylamide copolymer nanoparticles. The mass volume ratio of alkaline protease and anhydrous pyridine is 0.5-1.5 g:50-100 mL. The molar ratio of N-isopropyl acrylamide and glucose vinyl ester is 1-50:1. The amount of initiator and glucose vinyl ester/isopropyl acrylamide copolymer is 0.2-2 %mass. The amount of glucose vinyl ester/isopropyl acrylamide copolymer and polycaprolactone in glucose vinyl ester/isopropyl acrylamide copolymer electronic fuel injection solution is 3-30 %mass. The molar ratio of glucose vinyl ester/isopropyl acrylamide copolymer and polycaprolactone is 1:1.