TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Process: The process (P1) for preparation of the compound (Ib) involves: reacting thiazole-5-carboxylic acid compound of formula (IIb) or its salt with the compound (III). The process (P1) for preparation of 2-amino-thiazole-5-carboxylic acid (2-chloro-6-methyl-phenyl)-amide (Ic) involves: reacting thiazole-5-carboxylic acid compound of formula (IIc) or its salt with the compound (III). The process (P1) for preparation of 2-(6-chloro-2-methyl-pyrimidin-4-ylamino)-thiazole-5-carboxylic acid (2-chloro-6-methyl-phenyl)-amide (Id) involves: reacting thiazole-5-carboxylic acid compound of formula (IId) or its salt with the compound (III). The reaction of the compound (IIa) or its salt with the compound (III) is performed in at least one solvent at 15-40 degrees C. The compound (III) is prepared in situ by combining 2-chloro-6-methylaniline with ethyl magnesium bromide in at least one solvent at -10 to 10 degrees C. Preferred Components: The solvent is selected from water, aromatic hydrocarbons, esters, halogenated hydrocarbons, ketones, ethers and/or polar aprotic solvents. The ester is selected from ethyl acetate, n-propyl acetate, isopropyl acetate, and n-butyl acetate. The aromatic hydrocarbon is selected from toluene and xylene. The halogenated hydrocarbon is selected from dichloromethane, chloroform, and 1,2-dichloroethane. The ketone is selected from acetone and methyl ethyl ketone. The ether is selected from diethyl ether and tetrahydrofuran. The polar aprotic solvent is selected from N,N-dimethylformamide, N,N-dimethylacetamide, dimethylsulfoxide, acetonitrile, and N-methylpyrrolidone. The ratio of methanol and water in aqueous methanol is 1:1. The volume of aqueous methanol is 2-15 times more than the weight of tert-butyl(5-((2-chloro-6-methylphenyl) carbamoyl)-1,3-thiazol-2-yl)carbamate (Ib). ACTIVITY - Cytostatic. No biological data given.    MECHANISM OF ACTION - Cyclic protein tyrosine kinase inhibitor.    SPECIFIC COMPOUNDS - Preparation of 3 compound i.e. tert-butyl(5-((2-chloro-6-methylphenyl)carbamoyl)-1,3-thiazol-2-yl)carbamate of (Ib), 2-amino-thiazole-5-carboxylic acid (2-chloro-6-methyl-phenyl)-amide (Ic), and 2-(6-chloro-2-methyl-pyrimidin-4-ylamino)-thiazole-5-carboxylic acid (2-chloro-6-methyl-phenyl)-amide (Id) are specified as (Ia).    EXAMPLE - 3.87 g Magnesium turnings were charged into a flask. 15 ml Tetrahydrofuran was added to the flask. A solution of 16 g ethyl bromide in 60 ml tetrahydrofuran was prepared and 10 ml of this solution was slowly charged to the flask. 30 mg Iodine was added to the reaction mixture and stirred at 25-32 degrees C for 5 minutes. The mixture was warmed to 27 degrees C and the remaining amount of ethyl bromide was added slowly over 30 minutes. The mixture was heated to gentle reflux for 30 minutes and was then cooled to 0 degrees C. 22.86 g 2-Chloro-6-methylaniline was added drop-wise at 0 degrees C and the temperature of the reaction mixture was slowly raised to 20-25 degrees C. 10 g Ethyl 2-((tert-butoxycarbonyl)amino)-1,3-thiazole-5-carboxylate dissolved in 60 ml tetrahydrofuran was slowly added to the reaction mixture over 30 minutes. The reaction mixture was stirred for 3 hours. The reaction mixture was poured slowly into 200 ml 25% ammonium chloride solution with stirring. 200 ml Ethyl acetate was added and stirred for 30 minutes, filtered. After work up, tert-butyl (5-((2-chloro-6-methylphenyl)carbamoyl)-1,3-thiazol-2-yl) carbamate (Ib) (10.22 g) was obtained.