TECHNOLOGY FOCUS - INORGANIC CHEMISTRY - Preferred Components: The weak base used in step (a) is selected from triethyl amine, diisipropylethyl amine, pyridine, piperidine, and 1,8-Diazabicyclo(5.4.0)undec-7-ene (preferably diisipropylethyl amine, and piperidine). The salt is used in step (a) is selected from sodium acetate, ammonium acetate, ammonium benzoate, ammonium succinate, and alkyl ammonium acetate (preferably ammonium acetate and sodium acetate). The suitable cyanide source of step (a) and step (b) is selected from lithium cyanide, sodium cyanide potassium cyanide, and trimethylsilyl cyanide (preferably sodium cyanide or potassium cyanide). The base used in step (g) is selected from triethyl amine, diisipropylethyl amine, pyridine, piperidine, 1,8-diazabicyclo(5.4.0)undec-7-ene, 1,4-diazabicyclo(2.2.2)octarie, sodium bicarbonate, potassium bicarbonate, sodium carbonate, potassium carbonate, alkali and alkaline earth metal, and 1-6C alkoxide. The base for hydrolysis in step (h) is selected from alkali or alkaline earth metal hydroxides including lithium hydroxide, sodium hydroxide, potassium hydroxide, calcium hydroxide, magnesium hydroxide, barium hydroxide, and 1-5C quaternary ammonium hydroxide. The suitable hydrogenation catalyst is selected from nickel, palladium, ruthenium and rhodium (preferably nickel and palladium) with or without support and their different chemical forms and grades optionally fresh or recovered or mixture of fresh and recovered catalyst.    TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Method: In the method (M1), the reaction of step (b) preferably carried out at temperature of 45-120 degrees C, preferably 45-110 degrees C and especially is at reflux temperature of the methyl alcohol or ethyl alcohol to reflux temperature of water. The reaction of step (a) and step (c) is carried out preferably at ambient temperature to reflux temperature, especially at reflux temperature. The loading of the compound (V) for the preparation of compound (VI) in step (d) preferably can be selected from 30-300 g per liter of water or water in combination of co-solvent, preferably 50-200 g per liter of water or water in combination of co-solvent whilst especially 60-150 g per liter of water or water in combination of co-solvent. The loading of the genetically modified nitrilase enzyme (Nit 9N562) for the preparation of compound (VI) in step (d) preferably can be selected from 4-25 U per g of compound (V) whilst especially 6-20 U per gram of compound (V). During the preparation of the compound (VI) in step (d), the pH of the solution be kept at 7.2 plus minus 0.8, preferably 7 plus minus 0.5 and can be maintained by a suitable buffer and are well known in the art; one of the most preferred way to achieve is to use a phosphate or acetate buffer or maintain the pH with the addition of suitable acid selected from acetic, citric, tartaric, hydrochloric, sulfuric, and phosphoric acid (preferably hydrochloric acid) and/or a base which is selected from ammonia, mono, di and tri alkyl amine, sodium hydroxide, sodium carbonate, potassium carbonate, sodium bicarbonate and potassium bicarbonate (preferably sodium bicarbonate). The reaction of step (d) is carried out at a temperature of 25-40 degrees C, preferably 28-38 degrees C, especially 30-37 degrees C. During preparation of the compound (VII) the same can be optionally purified by distillation in step (e). The enzymatic enantioselective hydrolysis in step (f) is performed by using hydrolysis enzymes such as esterasees, lipolases and lipases which is selected from Candida Antarctica A, Candida Antarctica B1, Candida Antarctica BY2, Novozymes, Novozye 435, Rhizomucor meihei, Thermomyces lanhginosa, Psendomonas cepecia, Resinase HT, Lipex 100L, Bascillus subtilis, lipase 3.101, lipase 3.102, lipase 3.104, lipase 3.105, lipase 3.106, lipase 3.107, lipase 3.108, lipase 3.109, lipase 3.111, lipase 3.115, lipase 3. 113, lipase 3.117, lipase 3.136, A YS Amino, AS Amano, PS AmanoSD, and AK Amano (preferably Candida Antarctica B1 or Candida Antarctica BY2 or Novozyme 435. The loading of enzymes in step (f), is 0.1-5 wt./wt.% compared to the substrate, preferably 0.5-4 wt./wt.% compared to the substrate, especially 1-3 wt./wt.% compared to the substrate. The enzymes in step (f), may be recovered and reused for several times till almost full enzyme activity is retained; while during recycling of enzyme if the activity is less then additional amount of fresh enzyme can be added and the additional amount can be 5-50 wt./wt. with respect to initial enzyme loading, preferably 5-25 wt./wt.% with respect to initial enzyme loading. During the preparation of the compound (VIII) in step (f), the initial pH of the solution be kept at 7.5 plus minus 0.5, preferably 7.2 plus minus 0.2 by using a suitable reagent selected from acetic acid, citric acid, boric acid, ethylenediaminetetraacetic acid, hydrochloric acid, sulfuric acid, triethyl amine, diisopropylamine, pyridine, sodium bicarbonate, potassium bicarbonate, sodium carbonate, potassium carbonate, calcium carbonate, calcium hydroxide, magnesium hydroxide, and/or magnesium oxide. The conversion of the compound (VII) to enantiopure (S)-ester (VIII) in step (f), the pH of the reaction mixture during the progress of the reaction can be allowed to increase slowly of 7-9, preferably 7.5-8.5. The conversion of the compound (VII) to enantiopure (S)-ester (VIII) in step (f), the enzymatic step can optionally be carried out in presence of salts which can be selected from lithium chloride, sodium chloride, potassium chloride, calcium chloride, and/or magnesium chloride or can be generated in situ by neutralization of suitable acid and a suitable base. The enzymatic step (f) is carried out at a temperature of 20-45 degrees C, preferably 25-35 degrees C. The enzymatic step (g) is carried out at a temperature of 25-200 degrees C for 1-60 hours, preferably 50-180 degrees C for 2-24 hours. The step (h) is carried out at a temperature of 10-100 degrees C, preferably 15-60 degrees C, especially 25-50 degrees C. The catalytic hydrogenation in the step (h) is carried out with the hydrogen pressure of 0.5-25 kg/cm2 or equivalent unit (preferably 2-15 kg/cm2 or equivalent units, especially 3-10 kg/cm2). The preparation of pregabalin (I) comprise optional charcoalization of hydrogenation product and isolation of pregabalin by preferably isoelectric focusing at pH of 6.9-7.3, preferably 7-7.2 and crystallization of crude from water and/or 1-5C alcohol. The preparation of pregabalin (I) comprise isolation of pregabalin by isoelectric focusing, where the pH can be adjusted with any inorganic or organic acid such as hydrochloric acid, sulfuric acid, acetic acid, phosphoric acid, formic acid and trifluoroacetic acid (preferably hydrochloric acid or acetic acid). The preparation of pregabalin (I) comprises purification, of pregabalin by crystallization of crude from water and/or 1-5C alcohol and recovering further amount of pure pregabalin (I) by recrystallization of dried mother liquor. The preparation of pregabalin (I) further comprises alternative recovery of pregabalin (I) from the mother liquor preferably as an amino protecting derivative such as tert-butyloxycarbonyl, carboxybenzyl, and trityl (preferably tert-butyloxycarbonyl) can be used and subsequent removal of tert-butyloxycarbonyl group by treatment with acid in a suitable solvent. In the step (h), the preparation of the compound (I) comprises in-situ hydrolysis of the compound (VIII) followed by catalytic hydrogenation while the base strength for hydrolysis preferably can be selected from 0.1-5 N, preferably 0.5-2 N. Preferred Components: The weak organic acid used in step (a) is selected from benzoic acid, succinic acid maleic acid, fumaric acid, phthalic acid, and acetic acid. The suitable solvent in step (a) is selected from ethyl acetate, dichloro methane, chloroform, methyl tert-butyl ether, cyclohexane, and toluene (preferably cyclohexane or toluene). The organic solvent in step (b) and step (c) is selected from water, ethyl alcohol, methyl alcohol, isopropyl alcohol, n-butyl alcohol, tetra hydrofuran, dioxane, dimethylformamide, dimethyl sulfoxide, dimethylacetamide, methyl tert-butyl ether, and cyclohexane (preferably methyl alcohol, ethyl alcohol and/or water). The alcohol (R3OH) in step (e) is selected from methyl alcohol, ethyl alcohol, isopropyl alcohol, n-propyl alcohol, n-butyl alcohol, cyclopentanol and cyclohexanol. The alkyl halide (R3X) in step (e) is selected from 1-5C alkyl halides including methyl iodide, ethyl chloride, ethyl bromide, ethyl iodide, n-propyl bromide, isopropyl chloride, and isopropyl bromide. The acid catalyst or reagent in step (e) is selected from hydrochloric acid, sulfuric acid, thionyl chloride, trimethylsilyl chloride, methanesulfonic acid, paratoluene sulfonic acid, benzene sulfonic acid, trifluoromethanesulfonic acid, Lewis acid or strongly acidic sulfonated resins well known in the art (preferably hydrochloric acid, sulfuric acid, paratoluene sulfonic acid, and trimethyl silyl chloride). The organic solvent in step (f) is selected from water, methyl alcohol, ethyl alcohol, isopropyl alcohol, n-butyl alcohol, isobutyl alcohol, acetone, methyl isobutyl ketone, acetonitrile, methyl tert-butyl ether, tetrahydrofuran, 2-methyl tetrahydrofuran, 1,4-dioxane, and dimethyl sulfoxide (preferably water, 1,4-dioxane, and dimethyl sulfoxide). The organic solvent in step (g) is selected from water, methyl alcohol, ethyl alcohol, isopropyl alcohol, n-propyl alcohol, n-butyl alcohol, isobutyl alcohol, tertiary butyl alcohol, cyclohexanol, toluene, monochlorobenzene, dichlorobenzene, tetrahydrofuran, 2-methyl tetrahydrofuran, 1,4-dioxane, dimethylformamide, dimethyl amine, dimethyl sulfoxide, and sulfolane. The organic solvent in step (h) is selected from water, methyl alcohol, ethyl alcohol, isopropyl alcohol, n-propyl alcohol, n-butyl alcohol, isobutyl alcohol, tertiary butyl alcohol, cyclohexanol, toluene, monochlorobenzene, dichlorobenzene, tetra hydrofuran, dioxane, and/or dimethylformamide. ACTIVITY - CNS-Gen.; Anticonvulsant; Analgesic; Tranquilizer. No biological data is given.    MECHANISM OF ACTION - None given.    EXAMPLE - To a clean 400 ml autoclave, 10 g 3-cyano-5-methyl hexanoic acid methyl ester was dissolved in 100 ml methanol at 25 degrees C. A solution of 2.85 g potassium hydroxide was added and the reaction mass temperature was kept below 25 degrees C. It was stirred at 20-25 degrees C for 1.5 hours. 3 g Raney Ni) was added. The autoclave was closed properly and started stirring. The air inside the autoclave was replaced by purging nitrogen gas twice. It was pressurized 10 kg/cm2 of hydrogen gas and release to atmosphere twice to remove nitrogen gas. The stirring was initiated with 500 revolutions per minute (RPM) at 30 degrees C and hydrogen gas pressure of 10 kg/cm2. The hydrogenation was continued till almost full conversion (checked by HPLC). The catalyst was filtered through celite or any other suitable bed and washed wit 25 ml methanol (MeOH) water. The catalyst was recovered for reuse. The filtrate was adjusted to pH 7-7.4 by using approximately 5 ml glacial acetic acid. The methanol was recovered under reduced pressure at 40 degrees C. The reaction mass was cooled to 0-5 degrees C for 1 hour. The solid was filtered on a Buchner funnel using vacuum. The wet cake washed with 15-20 ml of chilled isopropyl alcohol and suck dried for 30 minutes to obtain 5.17 g (Yield: 55%) racemic prgabalin was obtained.