NOVELTY - An oxazole ketone is synthesized by dissolving raw material 5-fluoro-2-hydroxybenzaldehyde under nitrogen protection in solvent, adding acid binding agent, stirring uniformly, adding bromine acetamide, stirring at room temperature until reaction is complete, filtering, concentrating filtrate to obtain 1st compound, dissolving 1st compound under protection of nitrogen in solvent, heating to 100-140 degrees C, stirring until reaction is complete, separating, purifying reaction liquid to obtain 2nd compound, and adding 3-(4-chlorobutyl)-5-cyanoindole, catalyst, alkali, and 2nd compound in solvent.    USE - Synthesis of oxazole ketone for synthesis of vilazodone salt (claimed).    ADVANTAGE - Production process is simple and environment-friendly and has high product yield and purity, and product has good quality.    DETAILED DESCRIPTION - An oxazole ketone of formula (III) is synthesized by dissolving raw material 5-fluoro-2-hydroxybenzaldehyde under nitrogen protection in solvent, adding acid binding agent, stirring uniformly, adding bromine acetamide, stirring at room temperature until reaction is complete, filtering, concentrating filtrate to obtain compound of formula (I), dissolving compound of formula (I) under protection of nitrogen in solvent, heating to 100-140 degrees C, stirring until reaction is complete, separating, purifying reaction liquid to obtain compound of formula (II), adding 3-(4-chlorobutyl)-5-cyanoindole, catalyst, alkali, and compound of formula (II) under protection of nitrogen in solvent, refluxing and stirring for 14-18 hours to react completely, slowly adding water, stirring to separate out solid, filtering alkaline aqueous solution, and washing filter cake. An INDEPENDENT CLAIM is included for synthesis of vilazodone salt of formula (IV) which involves dissolving oxazole ketone of formula (III) in organic solvent, heating to dissolve completely, stirring and slowly adding acid, reacting fully, separating out solid, cooling and filtering, washing, and drying.    HX=hydrochloric acid, sulfuric acid, hydrobromide, acetic acid, tartaric acid, maleic acid, fumaric acid, oxalic acid, citric acid, phosphoric acid, trifluoroacetic acid, formic acid, succinic acid, mandelic acid, methanesulfonic acid, p-toluenesulfonic acid, benzoic acid, p-nitrobenzoic acid, and hydroxybenzoic acid.    DESCRIPTION OF DRAWING(S) - The drawing shows a graph of oxazole ketone liquid phase chromatograph.