TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Method: The step of combining the first feedstock portion involves combining the first feedstock portion with the heated organic liquid stream and hydrogen-rich gas stream to form the first heated diluted pyoil feed stream prior to the step of contacting the first heated diluted pyoil feed stream with the first deoxygenating catalyst. The hydrogen-rich gas stream comprises a hydrogen-rich recycle gas stream, and the method further involves passing the hydrogen-rich recycle gas stream through a heater to heat the hydrogen-rich recycle gas stream prior to the step of combining the first feedstock portion with the heated organic liquid stream and the hydrogen-rich gas stream. The heated organic liquid stream comprises a heated recycle organic liquid stream. The method (m1) further involves passing a recycle organic liquid stream through a heater to form the heated recycle organic liquid stream prior to the step of combining the first feedstock portion with the heated organic liquid stream and the hydrogen-rich gas stream to form the first heated diluted pyoil feed stream; combining the recycle organic liquid stream and the hydrogen-rich recycle gas stream to form a combined recycle stream, and where the step of passing involves passing the combined recycle stream through the heater to form a heated combined recycle hydrogen-containing organic liquid stream, and where the step of combining the first feedstock portion involves combining the first feedstock portion with the heated combined recycle hydrogen-containing organic liquid stream to form the first heated diluted pyoil feed stream. The step of combining the first feedstock portion involves forming the first heated diluted pyoil feed stream having a second temperature of 100-300 degrees C. The step of combining the first feedstock portion involves combining the first feedstock portion with the heated organic liquid stream that comprises a heated co-feed organic liquid stream. The step of combining the first feedstock portion involves combining the first feedstock portion with the heated co-feed organic liquid stream that comprises alcohols, ethers and/or phenolic compounds. The step of contacting the first heated diluted pyoil feed stream involves contacting the first heated diluted pyoil feed stream with the first deoxygenating catalyst at a reaction zone temperature of 100-350 degrees C. The step of combining the second feedstock portion involves forming the second heated diluted pyoil feed stream having a third temperature of 120-350 degrees C. The step of contacting the second heated diluted pyoil feed stream involves contacting the second heated diluted pyoil feed stream with the second deoxygenating catalyst at a reaction zone temperature of 160-360 degrees C. The method involves separating a low-oxygen pyoil effluent and optionally selectively heating to form a low-oxygen pyoil product stream, a heated recycle organic liquid stream, and a hydrogen-rich recycle gas stream, where the step of separating involves forming the heated recycle organic liquid stream having a second temperature of 150-400 degrees C. The first feedstock portion is combined with the heated recycle organic liquid stream at a predetermined pyoil to recycle oil ratio of 1:5 to 1:40, where the predetermined pyoil to recycle oil ratio is defined by a pyoil mass flow rate of the first feedstock portion to a recycle oil mass flow rate of the heated recycle organic liquid stream. The step of combining the first feedstock portion involves combining the first feedstock portion with the heated recycle organic liquid stream and a hydrogen-rich gas stream that comprises the hydrogen-rich recycle gas stream, where the first feedstock portion is combined with the hydrogen-rich gas stream at a predetermined pyoil to hydrogen ratio of 1:1 to 1:5, and where the predetermined pyoil to hydrogen ratio is defined by a pyoil mass flow rate of the first feedstock portion to a hydrogen-rich gas mass flow rate of the hydrogen-rich gas stream. The step of dividing involves dividing the feedstock stream into the portions including a third feedstock portion, and where the method further involves combining the third feedstock portion with a second intermediate low-oxygen pyoil effluent to form a third heated diluted pyoil feed stream; and introducing the third heated diluted pyoil feed stream to a third reaction zone that contains a third deoxygenating catalyst and that is operating at third hydroprocessing conditions effective to form the low-oxygen pyoil effluent. The step of dividing involves dividing the feedstock stream to form the first feedstock portion having a first pyoil mass flow rate of 10-35% of the feedstock stream, the second feedstock portion having a second pyoil mass flow rate of 15-35% of the feedstock stream, and the third feedstock portion having a third pyoil mass flow rate of 15-50% of the feedstock stream. The first deoxygenating catalyst, the second deoxygenating catalyst, or the third deoxygenating catalyst is a more active and/or increased quantity of catalyst than the other of the first deoxygenating catalyst, the second deoxygenating catalyst, or the third deoxygenating catalyst, and where the method further involves operating the first reaction zone, the second reaction zone, or the third reaction zone that is associated with the more active and/or increased quantity of catalyst at a reaction zone temperature less than the other of the first reaction zone, the second reaction zone, or the third reaction zone.