NOVELTY - Malic acid sunitinib is synthesized by adding bi-acid ester to acetic acid, adding dropwise aqueous solution of sodium nitrite, allowing components to react, adding zinc powder, refluxing, pouring into ice water, filtering, washing by water, drying to obtain 3,5-dimethyl-1H-pyrrole-di-2,4-dicarboxylic bi-acid ester, dissolving 3,5-dimethyl-1H-pyrrole-di-2,4-dicarboxylic bi-acid ester in inorganic alkali aqueous solution, pouring mixture into ice water, adjusting pH value of mixture, performing solid separation, filtering, washing by water, and drying.    USE - Synthesis of malic acid sunitinib (claimed).    ADVANTAGE - Synthesis has high product yield and purity, reduced reaction steps, mild reaction, and recyclable reaction solvent, reduces reaction cost, and is environment-friendly, convenient, and low-cost.    DETAILED DESCRIPTION - Malic acid sunitinib is synthesized by adding bi-acid ester to acetic acid, adding dropwise aqueous solution of sodium nitrite, allowing components to react, adding zinc powder, refluxing, pouring into ice water, filtering, washing by water, drying to obtain 3,5-dimethyl-1H-pyrrole-di-2,4-dicarboxylic bi-acid ester, dissolving 3,5-dimethyl-1H-pyrrole-di-2,4-dicarboxylic bi-acid ester in inorganic alkali aqueous solution, pouring mixture into ice water, adjusting pH value of mixture, performing solid separation, filtering, washing by water, drying to obtain 3,5-dimethyl-1H-pyrrol-4-acid butyloxycarbonyl-2-carboxylic acid, dissolving 3,5-dimethyl-1H-pyrrole-4-acid butyloxycarbonyl-2-carboxylic acid into dimethylformamide (DMF), refluxing, adding activated carbon to decolor mixture, cooling, filtering, adding phosphorus trihalide to DMF, allowing to react, adding filtrate, pouring into ice water, adjusting pH value through alkali aqueous solution to obtain 2,4-di-5-formyl-1H-pyrrole-3-carboxylic acid bi-ester, dissolving 2,4-di-5-formyl-1H-pyrrole-3-carboxylic acid bi-ester in acid nitrile, 5-fluoro-indol-2-one, and bi-amine, continuously reacting, cooling, filtering, drying to obtain sunitinib, dissolving sunitinib into alcohol, adding malic acid, dissolving components completely, decompressing and removing alcohol, and crystallizing.