NOVELTY - A system (s1) for reducing non-specific enzyme binding to enhance processing of a lignocellulosic material comprising: a reaction vessel; lignocellulosic feedstock comprising a component selected from hardwood, softwood, or non-wood material; enzyme component including cellulase and/or hemicellulase; and, water. The reaction vessel contains a combination of the lignocellulosic feedstock, the water, and the enzyme component at a pH of 5.2-6.2.    USE - For reducing non-specific enzyme binding to enhance processing of a lignocellulosic material; for enhancing enzymatic saccharification of cellulose; for enhancing enzymatic saccharification of polysaccharides; for producing a biofuel (all claimed).    ADVANTAGE - The system provide economic and process advantages to any process that converts a lignocellulosic biomass into a product using an enzyme. The systems can include a lignosulfonate, with or without a pH of 5.2-6.2, to also reduce non-specific binding and enhance enzymatic activity.    DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for the following: 1) reducing (M1) non-specific binding to enhance processing of a lignocellulosic material involving: obtaining the system (s1); and reacting the combination of the lignocellulosic feedstock, the water, and the enzyme component at pH of 5.2-6.2; 2) a system (s2) for enhancing enzymatic saccharification of cellulose comprising: the reaction vessel; the lignocellulosic feedstock with the proviso that the feedstock does not contain a lignosulfonate; the enzyme component; lignosulfonate additive having a component selected from hardwood, softwood, or non-wood lignin; and water, where, the reaction vessel contains a combination of the lignocellulosic feedstock, the water, the enzyme component, and the lignosulfonate additive; and, the lignocellulosic feedstock is saccharified in the reaction vessel for fermentation; 3) enhancing (M2) enzymatic saccharification of polysaccharides involving: obtaining the system; and, reacting the combination of the lignocellulosic feedstock, the water, the enzyme component, and the lignosulfonate additive at pH of 5.2-6.2 to saccharify the lignocellulosic feedstock; 4) a system (s3) for producing a biofuel comprising: pretreatment vessel containing an aqueous solution of sulfite or bisulfite at a pH of 1-5, the reaction vessel, the lignocellulosic feedstock, enzyme component comprising Trichoderma reesei, lignosulfonate comprising a component selected from hardwood, softwood, or non-wood lignin, water, and fermentation vessel containing a yeast for fermenting the saccharified lignocellulosic feedstock, where, the reaction vessel contains the combination of the lignocellulosic feedstock, the water, the enzyme component, and the lignosulfonate at a pH of 5.2-6.2, where the lignocellulosic feedstock is saccharified in the reaction vessel for fermentation and, the saccharified lignocellulosic feedstock is converted to ethanol in the fermentation vessel and 5) producing (M3) biofuel involving: obtaining the system (s3); pretreating the lignocellulosic feedstock in the pretreatment vessel; reacting the combination of the lignocellulosic feedstock, the water, the enzyme component, and the lignosulfonate at pH of 5.2-6.2 to saccharify the lignocellulosic feedstock; and, fermenting the saccharified lignocellulosic feedstock to create a biofuel.