TECHNOLOGY FOCUS - INORGANIC CHEMISTRY - Preferred Compounds: The chlorination agent is phosphorus oxychloride, thionyl chloride, phosphorus trichloride, or phosphorus pentachloride.    TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Conditions: 2-Iodo(bromo)-4-methoxy-5-hydroxybenzonitrile and amidine hydrochloride are microwave-reacted at 20-100 degrees C, preferably 70 degrees C, for 0.1-1 hour, preferably 0.5-1 hour, at microwave power of 100-200 W, preferably 150 W, in the presence of catalyst (A) chosen from copper(II) chloride, copper acetate, copper sulfate, copper(I) iodide, cupric oxide, and cuprous oxide, preferably copper(I) iodide, and base (A) chosen from potassium carbonate, cesium carbonate, sodium carbonate, potassium hydroxide, and sodium hydroxide, preferably potassium carbonate. The usage amount of catalyst is 0.1 mol, the usage amount of base is 2 mol, and the usage amount of amidine hydrochloride is 1.2 mol, with respect to 1 mol 2-iodo(bromo)-4-methoxy-5-hydroxybenzonitrile. Alkyl side chain introduction is carried out at 20-100 degrees C, preferably 90 degrees C, by reacting 1.2 mol 4-(3-bromo-propyl)morpholine with respect to 1 mol 6-methoxy-7-hydroxy-quinazolin-4-one for 0.1-1 hour, preferably 0.5-1 hour, at 100-200 W, preferably 150 W, microwave power, in the presence of catalyst (A) and base (A). The usage amount of catalyst is 0.1 mol and the usage amount of base is 2 mol, with respect to 1 mol 6-methoxy-7-hydroxy-quinazolin-4-one. Chlorination is carried out at 60-80 degrees C, preferably 80 degrees C, and 100-200 W, preferably 150 W, microwave power, in the presence of base chosen from dimethylformamide, triethylamine, potassium carbonate, cesium carbonate, sodium carbonate, potassium hydroxide, and sodium hydroxide. The usage amount of chlorination agent is 2 mol and the usage amount of catalyst is 2 mol, with respect to 1 mol 7-methoxy-6-(3-(4-morpholinyl)propoxy)quinazolin-4-one. The final reaction is carried out at 20-100 degrees C, preferably 100 degrees C, for 0.1-1 hour, preferably 0.5-1 hour, and 100-200 W, preferably 150 W, microwave power, in the presence of catalyst (A) and base (A). The usage amount of 3-chloro-4-fluoroaniline is 1.2 mol, the usage amount of catalyst is 0.1 mol, and the usage amount of base is 2 mol, with respect to 1 mol 4-chloro-7-methoxy-6(3-(4-morpholinyl)propoxy)quinazoline. Preferred Compounds: The amidine hydrochloride is formamidine hydrochloride, benzamidine hydrochloride, acetamidine hydrochloride, and/or aliphatic and aromatic amidine hydrochloride.