TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Method: The treating is performed under continuous flow conditions. The depressurizing is facilitated by a pressure let down device in the reactor vessel, where: the reaction mixture is pressurized to a maximum pressure prior to or during the treating; and prior to the depressurizing facilitated by the pressure let down device, the product mixture is pressurized at less than 98%, preferably less than 50% of the maximum pressure. The sequestering of the organic and/or inorganic matter by the solid substrate comprises adsorbing the organic matter and/or inorganic matter onto a surface of the solid substrate, or absorption of the organic matter and/or inorganic matter into the solid substrate. The treating is performed under conditions of continuous flow and the slurry has a flow velocity of above 0.01 cm/second, preferably 2 cm/second. The method further comprises: separating the solid substrate from the product mixture after the cooling and depressurizing, and recycling the solid substrate into a second slurry or second reaction mixture comprising organic matter feedstock; separating oil from the product and recycling the oil into a second slurry or second reaction mixture comprising organic matter feedstock. The treating comprises treating the reaction mixture at 250-400 degrees C (preferably 320-360 degrees C) and a pressure of 100-300 bar, preferably 220-250 bar. The depressurizing and cooling of the product mixture occurs simultaneously or separately. Preferred Components: The substrate is inert or substantially inert at the reaction temperature and pressure. The solid substrate is a carbonaceous material comprising at least 50 wt.%, preferably at least 90 wt.% carbon. The solid substrate is: one of coals, anthracitic coal, meta-anthracite, anthracite, semi-anthracite, bituminous coal, sub-bituminous coal, lignite (i.e. brown coal), coking coal, coal tar, coal tar derivatives coal char, coke, high temperature coke, foundry coke, low and medium temperature coke, pitch coke petroleum coke, coke oven coke, coke breeze, gas coke, brown coal coke, semi coke, charcoal, pyrolysis char, hydrothermal char, carbon black, graphite fine particles, amorphous carbon, carbon nanotubes, carbon nanofibers and/or vapor-grown carbon fibers; a non-carbonaceous material comprising no 10%, preferably no carbon; or one of ash, fly ash, a mineral, calcium carbonate, calcite, a silicate, silica, quartz, an oxide, a metal oxide, an insoluble or substantially insoluble metal salt, iron ore, a clay mineral, talc, gypsum, carbonates of magnesium, carbonates of calcium and magnesium, limestone, dolomite, hydroxides of calcium, hydroxides of magnesium, oxides of calcium, oxides of magnesium, hydrogen carbonates of calcium, hydrogen carbonates of magnesium, kaolinite, beatofrite, illite, zeolites, calcium phosphate, hydroxyapatite and/or phyllosilicates. The solid substrate: is provided in the form of a powder or a slurry comprising the powder; and is present in the reaction mixture at more than 0.5%, preferably more than 30 wt.%, or at less than 0.5 wt.% or less than 50 wt.%. The organic matter feedstock is: lignocellulosic matter comprising at least 10% of lignin, at least 35% of cellulose and at least 20% of hemicellulose; or wood. The reaction mixture comprises more than 10 wt.%, preferably more than 40 wt.%, of the organic matter. The organic matter feedstock is provided in the form of a liquid slurry comprising some or all of the solvent. The reaction mixture further comprises: 5-60 wt.%, preferably less than 10 wt.% of an oil additive that is mixed with the feedstock and/or solvent prior to the treating, and is one of paraffinic oil, gas-oil, crude oil, synthetic oil, coal-oil, bio-oil, shale oil, kerogen oil, mineral oil, white mineral oil, aromatic oil, tall oil, distilled tall oil, plant or animal oils, fats and their acidic forms and/or esterified forms; a catalyst additive that is mixed with the feedstock and/or solvent prior to the treating, where the catalyst additive is added to the reaction mixture after the reaction mixture reaches the reaction temperature and pressure, and is one of a base catalyst, an alkali metal hydroxide catalyst, a transition metal hydroxide catalyst, sodium hydroxide, potassium hydroxide, sodium carbonate, potassium carbonate, an acid catalyst, a solid acid catalyst, an alkali metal formate catalyst, a transition metal catalyst, a transition metal formate catalyst, a supported transition metal catalyst, a reactive carboxylic acid catalyst, a transition metal catalyst, a sulfide catalyst, a noble metal catalyst, a water-gas-shift catalyst, sodium formate, potassium formate, and/or sodium hydroxide. The catalyst is provided in a slurry comprising the organic matter feedstock, and the catalyst is 1-30 wt.%, preferably less than 5 wt.% of the organic matter in the reaction mixture. The reaction mixture comprises the organic matter feedstock and the solid substrate at a ratio of 1:1, 3:2, 2:1, 3:1, 4:1, 5:1, 6:1, 8:1, 10:1, 20:1 or 30:1. The solid substrate constitutes at least 1%, preferably at least 50% of the total combined mass of the solid substrate and organic matter feedstock (e.g. lignocellulosic matter) in the reaction mixture. The solvent is an aqueous solvent, an oil solvent, or a mixture of an aqueous solvent and an oil solvent. The oil solvent or the mixture of the aqueous solvent and the oil solvent comprises crude tall oil and/or distilled tall oil. The oil solvent is recycled from a bio-product produced by the method. The solid substrate solvent is recycled from a bio-product produced by the method. The aqueous solvent comprises water, or water and an alcohol. The alcohol is one of ethanol and/or methanol. Prior to and/or after the treating, the reaction mixture comprises 3-30 wt.% of alcohol. The bio-product comprises an oil component having a gross calorific value of at least 32 MJ/kg. The bio-product comprises a compound comprising waxes, aldehydes, carboxylic acids, carbohydrates, phenols, furfurals, alcohols, ketones, resins, resin acids, compounds structurally related to resin acids, alkanes, alkenes, fatty acids, fatty acid esters, sterols, sterol-related compounds, furanic oligomers, cyclopentanones, cyclohexanones, alkyl- and alkoxy-cyclopentanones, alkyl- and alkoxy-cyclohexanones, cyclopenteneones, alkyl- and alkoxy-cyclopentenones, aromatic compounds, naphthalenes, alkyl- and alkoxy-substituted naphthalenes, cresols, alkyl- and alkoxy phenols, alkyl- and alkoxy-catechols; alkyl- and alkoxy-dihydroxybezenes, alkyl- and alkoxy-hydroquinones, indenes, and/or indene derivatives. EXAMPLE - No suitable example given.