TECHNOLOGY FOCUS - INORGANIC CHEMISTRY - Preferred Components: The inorganic bases are selected from alkali metal carbonates selected from potassium carbonate, sodium carbonate, and cesium carbonate; alkali metal bicarbonates selected from sodium bicarbonate, and potassium bicarbonate; alkali metal hydroxides selected from sodium hydroxide, potassium hydroxide, barium hydroxide, and lithium hydroxide; metal hydrides, metal alkoxides selected from sodium methoxide, sodium ethoxide, and potassium tert butoxide; metal amides or liquor ammonia. The diazotizing agent used in step (b) is selected from resin nitrite; metal nitrite selected from sodium nitrite, potassium nitrite, silver nitrite, aluminum nitrite, lithium nitrate, rubidium nitrite, and cesium nitrite; organic nitrites selected from isoamyl nitrite, isopentyl nitrite, and methyl nitrite. The aqueous acid used in step (d) is inorganic acid selected from hydrochloric acid, hydrobromic acid, sulfuric acid, hydrobromic acid in acetic acid, boron and trifluoride in ether.    TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Components: The solvent used in steps (a), (b), (c) and (d) is selected from esters selected from ethyl acetate, and isopropyl acetate; aliphatic hydrocarbons selected from cyclohexane, n-hexane, n-heptane, and pentane; aromatic hydrocarbons selected from toluene, xylene, and naphthalene; halogenated aliphatic hydrocarbons selected from dichloromethane, chloroform, and ethylene dichloride; dialkylformamides selected from dimethyl formamide; ethers selected from methyl tertiary butyl ether, di-isopropyl ether, di-ethyl ether, dimethyl ether, and methyl butyl ether; cyclic ethers selected from tetrahydrofuran, and 1,4-dioxane; substituted cyclic ethers selected from 2-methyl tetrahydrofuran; alcohols selected from methanol, ethanol, n-propanol, iso-propanol, n-butanol, iso-butanol, n-pentanol, ethylene glycol, and diethylene glycol; ketones selected from acetone, methyl ethyl ketone, and methyl isobutyl ketone; dialkylsulfoxides selected from dimethyl sulfoxide; dialkylacetamides selected from N,N,-dimethyl acetamide; nitrites selected from acetonitrile, and propionitrile; ionic liquids, hexamethylphosphorous triamide, hexamethylphosphoramide; and/or water. The base used in step (a), and (c) is selected from organic bases and inorganic bases. The organic bases are selected from primary amines such as methylamine, ethanolamine aniline, propyl amine, 2-propyl amine, butyl amine, and 2-amino ethanol; secondary amines selected from N,N-diisopropyl amine, dimethylamine, diethyl amine, N-methyl propyl amine, pyrrole, and methylethanolamine; tertiary amines selected from triethylamine, N,N-dimethyl aniline, N,N-diisopropyl ethyl amine, trimethyl amine, pyridine, pyrimidine, and N,N-dimethylethyl amine; tetraalkylammonium and phosphonium hydroxides; metal alkoxides and amides; and metal silanoates. The catalyst used in step (a) and (c) is organic, inorganic catalyst or phase transfer catalyst selected from 1,8-diazabicycloundec-7-ene (DBU); 1,5-diazabicyclo(4.3.0)non-5-ene (DBN); dimethylaminopyridine; alkali metal iodide selected from potassium iodide, lithium iodide and sodium iodide, iodine, p-toluene sulfonic acid, and tertiary alkyl ammonium halide. The acid used in step (b) is an organic acid selected from formic acid, acetic acid, propanoic acid, trifluoroacetic acid, perchloric acid, and paratoluene sulfonic acid. The aqueous acid used in step (d) is organic acid selected from formic acid, acetic acid, propanoic acid, trifluoroacetic acid, perchloric acid, oxalic acid, fumaric acid, maleic acid, and paratoluene sulfonic acid. The solvent used for extraction of the compound (iii), the solvent used for purification of compound (iii) or the solvent used for extraction of ticagrelor compound (I), comprises of esters such as ethyl acetate, isopropyl acetate or methyl acetate, aliphatic hydrocarbons such as n-heptane, iso-octane, n-hexane or cyclohexane, aromatic hydrocarbons such as toluene, xylene or naphthalene, ethers such as diisopropyl ether or diethyl ether, cyclic ethers such as tetrahydrofuran or 2-methyl tetrahydrofuran, alcohol such as methanol, ethanol, isopropanol or iso-butanol, ketone such as acetone or ethyl methyl ketone, nitriles, ionic liquids and/or halogenated aliphatic hydrocarbons such as methylene dichloride, ethylene dichloride or chloroform. The solvent used for purification of ticagrelor compound (I) is selected from alkyl acetate selected from ethyl acetate, and isopropyl acetate; aliphatic hydrocarbons selected from cyclohexane, n-hexane, n-heptane, and pentane; aromatic hydrocarbons selected from toluene, xylene, and naphthalene; halogenated aliphatic hydrocarbons selected from dichloromethane, chloroform, and ethylene dichloride; dialkylformamides selected from dimethyl formamide; ethers selected from methyl tertiary butyl ether, di- isopropyl ether, di-ethyl ether, di-methyl ether, and methyl butyl ether; cyclic ethers selected from tetrahydrofuran, and 1,4-dioxane; substituted cyclic ethers such selected from 2-methyl tetrahydrofuran; alcohols selected from methanol, ethanol, n-propanol, iso-propanol, n-butanol, iso-butanol, n-pentanol, ethylene glycol, and diethylene glycol; esters; ketones selected from acetone, methyl ethyl ketone, and methyl isobutyl ketone; dialkylsulfoxides selected from dimethyl sulfoxide; dialkylacetamides selected from N,N-dimethyl acetamide; nitrites selected from acetonitrile, and propionitrile; ionic liquids, hexamethylphosphorous triamide, hexamethylphosphoramide and/or water. Preferred Method: The isolation of compound (iii) from reaction mass of step (a) involves: i) extracting the compound (iii) from the reaction mass with solvent; ii) washing the organic layer of step (i) with water; iii) decolorizing the organic layer of step (ii) with activated charcoal; iv) concentrating the organic layer of step (iii) to obtain the residue comprising the compound (iii); v) optionally, purifying the compound (iii) obtained in step (iv) by crystallization using solvent to obtain solid, or acid-base treatment to obtain solid, or crystallization in combination with acid-base treatment to obtain solid. The isolation of compound (iii) from reaction mass of the step (a) can also be performed by: ia) isolating compound of formula (iii) from the reaction mass; iia) drying the compound (iii) obtained from step (ia); iiia) crystallizing the dried compound (iii) using solvent to obtain purified compound (iii) as solid. The isolation of compound (I) from reaction mass of step (d) involves: ib) extracting the ticagrelor compound (I) from the reaction mass with solvent, iib) washing the organic layer of step (ib) with water, iiib) decolorizing the organic layer of step (iib) with activated charcoal, ivb) concentrating the organic layer of step (iiib) to obtain the residue comprising the compound (I), vb) optionally, purifying the ticagrelor compound (I) obtained in step (ivb) by crystallization using solvent to obtain solid, or acid-base treatment to obtain solid, or crystallization in combination with acid-base treatment to obtain solid. The isolation of compound (I) from reaction mass of step (d) can also be performed by: ic) isolating ticagrelor (I) from the reaction mass; iic) drying the ticagrelor (I) obtained from step (ic); iiic) crystallizing the dried ticagrelor compound (I), using solvent to obtain purified compound (I) as solid. ACTIVITY - Anticoagulant; Thrombolytic; Antianginal; Vasotropic; Cardiant.    MECHANISM OF ACTION - P2Y12 purinoceptor antagonist. No biological data given.    EXAMPLE - To a mixture of 50 g 4,6-dichloro-2-(propylthio)-5-pyrimidinamine in 500 ml ethylene glycol, 84.82 g 2-(((3aR,4S,6R,6aS)-6-amino-2,2- dimethyltetrahydro-3aH-cyclopenta(d)(1,3)-dioxol-4-yl)oxy)-1-ethanol, L-tartaric acid (1:1) was added 5 g 1,8-bicyclo (5.4.0)undec-7-ene, followed by addition of 122.12 g diisopropyl ethylamine at 20-25 degrees C. Reaction mixture was heated at 120-125 degrees C stirred and maintained at same temperature for 2-3 hours, until completion of reaction. After workup, 2-(((3aR,4S,6R,6aS)-6-((5-amino-6-chloro-2-(propylthio)-4-pyrimidinyl)amino)-2,2-dimethyltetrahydro-3aH-cyclopenta(d)(1,3)dioxol-4-yl)oxy)-1-ethanol (A1) was obtained. To a solution of 9.11 g para-toluene sulfonic acid and 50 ml water was added 20 g resin nitrite and the solution stirred for 10-15 minutes, followed by addition of 10 g (A1) in 50 ml acetonitrile. The reaction mass was stirred for 60-90 minutes at room temperature. The progress of reaction was monitored by HPLC. After workup, 2-(((3aR,4S,6R,6aS)-6-(7-chloro-5-(propylthio)-3H-(1,2,3) triazolo(4,5-d)pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta(d)(1,3)dioxal-4-yl)oxy)-1-ethanol (A2) as an oil was obtained. To the solution of 10 g (A2) in 200 ml acetonitrile was added 7.50 g trans-(1R,2S)-2-(3,4-difluorophenyl) cyclopropanamine (2R)-2-hydroxy-2-phenylethanoate, followed by addition of 6.46 g anhydrous potassium carbonate under stirring at 25-30 degrees C and maintained for 2-3 hours. After workup, 2-(((3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-diflurophenyl)-cyclopropyl)amino)-5-(propylthio)-3H-(1,2,3)triazolo(4,5-d)pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta(d)(1,3)dioxal-4-yl)oxy)-1-ethanol (A3) was obtained. 10 g (A3) was dissolved in 100 ml methylene dichloride and the solution was stirred for 10-15 minutes to the same solution was added 3.33 g concentrated hydrochloric acid and reaction mass was stirred for stirred for 60-90 minutes. The progress of reaction was monitored by HPLC. After completion of reaction, 150 ml purified water was charged to the reaction mass, solution was basified to pH 8-9 using sodium hydroxide solution, stirred, and layers were separated. Methylene dichloride layer was washed using 100 ml purified water and then 10% sodium chloride solution. After workup, 8 g (1S,2S,3R,5S)-3-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-(1,2,3)-triazlo(4,5-d)pyrimidin-3-yl)-5-(2-hydroxyethoxy) cyclopentane-1,2-diol (ticagrelor) as oil was obtained. To the same oil 40 ml ethyl acetate was added, the solution was stirred and heated to 50-55 degrees C followed by addition of 50 ml n-heptane and the solution was maintained at same temperature for 30 minutes. The resulting solution was gradually cooled to room temperature and further cooled and maintained at 0-5 degrees C, for 30-40 minutes. Obtained solid was filtered, washed with pre-chilled 8 ml n-heptane, sucked dried and dried at 50-55 degrees C to give pure white crystalline solid of 8 g ticagrelor with HPLC purity of 98.2% by area.