TECHNOLOGY FOCUS - INORGANIC CHEMISTRY - Preferred Component: The inorganic alkali is sodium bicarbonate, sodium carbonate or sodium hydroxide.    TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Components: The inorganic acid is hydrochloric acid, phosphoric acid or sulfuric acid. The organic base is triethylamine, quinoline, pyridine, dicyclohexylamine or N,N-dimethyl benzylamine. The organic solvent is dichloromethane, chloroform, carbon tetrachloride, acetonitrile or tetrahydrofuran. The silylating agent is trimethylchlorosilane, bromotrimethylsilane, trimethylsilyl iodide, N,O-bis(trimethylsilyl)acetamide or hexamethyl disilazane. The molar ratio of 7( beta )-dichloro-acetamido-3-(1-methyl-1H-tetrazol-5-mercapto methyl)-3-cephem-4-carboxylic acid triethylamine salt and silylating agent is 1:1-3. The halogenating agent is phosphorus pentachloride, phosphorus trichloride, phosphorus oxychloride or sulfone chloride. The molar ratio of 7( beta )-dichloro-acetamido-3-(1-methyl-1H-tetrazol-5-mercapto methyl)-3-cephem-4-carboxylic acid triethylamine salt and organic base is 1:1-2. The molar ratio of 7( beta )-dichloro-acetamido-3-(1-methyl-1H-tetrazol-5-mercapto methyl)-3-cephem-4-carboxylic acid triethylamine salt and halogenating reagent is 1:0.5-2. The oxidizing reagent is methyl lithium, methanol, sodium methoxide or potassium methoxide. The organic acid is formic acid, or acetic acid. The molar ratio of 7( beta )-dichloro-acetamido-3-(1-methyl-1H-tetrazol-5-mercapto methyl)-3-cephem-4-carboxylic acid triethylamine salt and oxidizing agent is 1:10-17. The weight ratio of 7( beta )-dichloro-acetamido-3-(1-methyl-1H-tetrazol-5-mercapto methyl)-3-cephem-4-carboxylic acid triethylamine salt, N,N-dimethylformamide and ethyl acetate is 1:2-10:5-15. The alkylating reagent is trimethylsilyl chloride, trimethylsilyl bromide, trimethylsilyl iodide, N,O-bis(trimethylsilyl)acetamide or hexamethyl disilazane. The molar ratio of 7( beta )-dichloro-acetamido-3-(1-methyl-1H-tetrazol-5-mercapto methyl)-3-cephem-4-carboxylic acid triethylamine salt and silylating reagent is 1:5-8. The weight ratio of 7( beta )-dichloro-acetamido-3-(1-methyl-1H-tetrazol-5-mercapto methyl)-3-cephem-4-carboxylic acid triethylamine salt, purified water and activated carbon is 1:5-10:0.05-0.2. The molar ratio of 7( beta )-dichloro-acetamido-3-(1-methyl-1H-tetrazol-5-mercapto methyl)-3-cephem-4-carboxylic acid triethylamine salt, S-cyanomethyl-isothiourea hydrochloride, lithium methoxide and sodium methoxide is 1:1-4:2-8. The weight ratio of 7( beta )-dichloro-acetamido-3-(1-methyl-1H-tetrazol-5-mercapto methyl)-3-cephem-4-carboxylic acid triethylamine salt, ethyl acetate, purified water, activated carbon, dimethylformamide and cefmetazole amine salt is 1:1-4:5-10:0.05-0.2:0.5-2:0.001-0.005. The weight ratio of cefmetazole amine salts, water and ethyl acetate is 1:5-15:5-15. The weight ratio of cefmetazole amine salts, water, activated carbon, ethyl acetate, methylisobutyl ketone and cefmetazole acid salt is 1:5-15:0.05-0.2:0.5-3:0.5-3:0.001-0.005. The weight ratio of cefmetazole acid, purified water and activated carbon is 1:2-5:0.05-0.2.