TECHNOLOGY FOCUS - INORGANIC CHEMISTRY - Preferred Compositions: The pH adjusting agent is 37.5 mass% concentrated hydrochloric acid.    TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Compositions: 1-7 carbon-containing alkyl is methyl, ethyl, propyl, heptyl, isopropyl, isopentyl, or 3-pentyl, halo alkyl is dichloromethyl, 1-chloroethyl, 1-bromoethyl, 2-chloroethyl, thiol is thiomethyl, 2-thioethyl, or 1-thioethyl, aminoalkyl is aminomethyl, aminoethyl, or aminopropyl, substituted phenoxymethylene is 2-4-monosubtituted phenoxymethylene or 2,4-dichlorophenoxymethylene, and substituted phenyl is 2-4-monosubstituted phenyl, 2-5-disubstituted phenyl, or 2-hydroxy-3,5-dinitrophenyl. 2-4-monosubtituted phenoxymethylene is halophenoxymethylene or 4-methoxyphenoxymethylene, 2-4-monosubstituted phenyl us hydroxyphenyl, nitrophenyl, alkylphenyl, 4-halophenyl, or aminophenyl, and 2-5-disubstituted phenyl is 3,5-dimethylphenyl, 3,5-dinitrophenyl, 2,4-dinitrophenyl, 2-hydroxy-5-sulfonyl phenyl, or 2,4-dibromophenyl. Hydroxyphenyl is 4-hydroxyphenyl or 2-hydroxyphenyl, nitrophenyl is 4-nitrophenyl or 3-nitrophenyl, 4-halophenyl is 4-fluorophenyl, 4-chlorophenyl, or 4-bromophenyl, aminophenyl is 3-aminophenyl or 4-aminophenyl, alkylphenyl is 4-ethylphenyl, 3-ethylphenyl, 4-methylphenyl, or 3-methylphenyl, and halophenoxymethylene is 2-chloro-oxymethylene, 3-chlorophenyloxymethylene, 4-fluorophenyloxymethylene, 4-bromophenyloxymethylene, or 4-iodophenoxymethylene. Amount of ethanol is 4-5 L per 1 mol of 2-substituted benzimidazole. Preparation: (Claimed) 1-carboxymethyl-2-substituted benzimidazole is prepared by mixing 2-substituted benzimidazole and potassium chloroacetate with molar ratio of 1:1-1.5, dissolving in ethanol, adding water, mixing to obtain solution, heating at 75-82 degrees C while stirring, monitoring reaction completion, cooling to room temperature, adjusting pH to 1-2 in ice bath to precipitate solid, and purifying solid product. Preferred Processes: Reaction completion is monitored through thin layer chromatography using mixed ethyl acetate and petroleum ether with volume ratio of 1:3. Cooling is carried out by natural cooling. Purification is carried out by filtration and recrystallization using ethanol and water with volume ratio of 1:1. ACTIVITY - Cytostatic.