NOVELTY - Synthesis of oxadiazole derivatives, involves: 1) reacting 4-piperidine carboxylic acid ethyl ester with benzyl chloroformate; 2) reacting N-carbobenzyloxy-4-piperidine carboxylic acid ethyl ester with hydrazine hydrate; 3) reacting isonicotinic acid/thionyl chloride with 4-picolyl chloride/N-carbobenzyloxy-4-piperidine carboxylic acid hydrazide; 4) reacting 4-(N'-(pyridine-4-carbonyl)-hydrazinocarbonyl)-piperidine-1-carboxylic acid benzyl ester with phosphorus oxychloride; and 5) reacting the benzyl ester in metal catalyst and hydrogen.    USE - For synthesis of oxadiazole derivatives (claimed) used as a medicament for inflammation.    ADVANTAGE - The method uses raw materials of low cost, has low environmental pollution, and has high industrial scale feasibility.    DETAILED DESCRIPTION - Synthesis of oxadiazole derivatives using 4-piperidine carboxylic acid ethyl ester and isonicotinic acid as raw materials, involves: (1) reacting 4-piperidine carboxylic acid ethyl ester under the action of a base in a solvent with benzyl chloroformate to give N-carbobenzyloxy-4-piperidine-carboxylate; (2) reacting N-carbobenzyloxy-4-piperidine carboxylic acid ethyl ester in a solvent with hydrazine hydrate to give N-carbobenzyloxy-4-piperidine carboxylic acid hydrazide; (3) reacting isonicotinic acid and thionyl chloride with 4-picolyl chloride and N-carbobenzyloxy-4-piperidine carboxylic acid hydrazide under the action of a base in a solvent to give 4-(N'-(pyridine-4-carbonyl)-hydrazinocarbonyl)-piperidine-1-carboxylic acid benzyl ester; (4) reacting 4-(N'-(pyridine-4-carbonyl)-hydrazinocarbonyl)-piperidine-1-carboxylic acid benzyl ester with phosphorus oxychloride in a solvent to give 4-(5-pyridin-4-yl-(1,3,4)oxadiazol-2-yl)-piperidine-1-carboxylic acid benzyl ester; and (5) reacting 4-(5-pyridin-4-yl-(1,3,4)oxadiazol-2-yl)-piperidine-1-carboxylic acid benzyl ester under the action of a metal catalyst and hydrogen to give 4-(5-piperidin-4-yl-(1,3,4)oxadiazol-2-yl)-pyridine.