NOVELTY - Preparing cytidine 5'-diphosphocholine (CDP)-choline (I) and monosodium salt (II), comprises (a) reacting cytidine 5'-monophosphate with morpholine in dicyclohexylcarbodiimide, (b) insitu condensing cytidine 5'-monophosphate morpholidate (III) with phosphorylcholine chloride calcium salt, (c) recovering methanol, (d) dissolving thick semisolid mass of crude (I) in water, (e) adding a calcium precipitating agent to precipitate water insoluble calcium salt, (f) removing the water insolubles, (g) nanofiltration of clear solution and subsequently charcoalizing, and (h) concentrating solution.    USE - The process is useful for preparing (I) (claimed), which is useful for treating Alzheimer's disease, dementia, head trauma, cerebrovascular disease such as stroke, age-related memory loss, Parkinson's disease, and glaucoma. No biological data given.    ADVANTAGE - The process: prepares (II) of (I) with HPLC purity of more than 99.5% using single organic solvent for the reaction and the isolation of crude (I) and without using ion exchange resin for purification; and easily recovers and reuses the solvents in a simple, less time and energy consumption, economical, eco-friendly and industrially feasible manner.    DETAILED DESCRIPTION - Preparing cytidine 5'-diphosphocholine (CDP)-choline of formula (I) and a monosodium salt of formula (II), comprises (a) reacting cytidine 5'-monophosphate with morpholine in presence of dicyclohexylcarbodiimide in methanol at 20-60 degrees C for 3-6 hours to form cytidine 5'-monophosphate morpholidate of formula (III), (b) insitu condensing (III) with phosphorylcholine chloride calcium salt in methanol in presence of hydrochloric acid at 20-60 degrees C for 3-6 hours, (c) recovering the methanol used in the steps (a) and (b) to obtain a thick semisolid mass of crude (I), (d) dissolving or suspending the thick semisolid mass in water and optionally, removing insolubles by filtration, (e) adding a calcium precipitating agent to precipitate water insoluble calcium salt, (f) removing the water insolubles formed in the steps (d) or (e) by filtration to obtain a clear solution, (g) subjecting the clear solution to nanofiltration and subsequently to charcoalization by adjusting the pH to 2-5 to obtain a solution comprising (I), (h) concentrating the solution to obtain a concentrated solution, and (i) optionally, converting the (I) in the concentrated solution into (II), and isolating (II) by adding organic solvent such as alcohol and/or ketone.