NOVELTY - Positive electrode active material particles contain basic composition containing spinel-type lithium nickel manganese oxide partially substituted with iron and titanium in center region, and low-manganese region containing composition having concentration of manganese less than the basic composition or does not contain manganese, and which covers the outer side of the center region. The operation upper limit electric potential of a positive electrode containing Positive electrode active material particles is 4.5 V or more in metallic lithium standard.    USE - Positive electrode active material particles is used for manufacturing nonaqueous electrolyte secondary battery for vehicle (all claimed) e.g. hybrid vehicle, plug-in hybrid motor vehicle, electric vehicle, fuel cell electric vehicle, electric wheelchair and electric power-assisted bicycle.    ADVANTAGE - The nonaqueous electrolyte secondary battery containing positive electrode active material particles has excellent durability and charging/discharging characteristics.    DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for the following:    (1) manufacture of positive electrode active material particles, which involves preparing raw material particles which set spinel-type lithium nickel manganese oxide partially substituted with iron and titanium as basic composition in center region, and producing positive electrode active material particles using the raw material particles;    (2) nonaqueous electrolyte secondary battery (100), which has positive electrode (10) containing positive electrode active material particles, a negative electrode (20), and a nonaqueous electrolyte (90); and    (3) manufacture of nonaqueous electrolyte secondary battery.    DESCRIPTION OF DRAWING(S) - The drawing shows a sectional view of the nonaqueous electrolyte secondary battery.    Positive electrode (10)    Negative electrode (20)    Separator (40)    Nonaqueous electrolyte (90)    Nonaqueous electrolyte secondary battery (100)