TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Process: The process further comprises the crystallization of (I) with a crystallizing solvent. Preferred Components: The aryl bromoalcohol compound (II) is 2-(2-bromophenyl) propan-2-ol or 2-(2-bromophenyl) tetrahydro-2H-pyran. The metal catalyst comprises palladium(II) acetate, trans-diamminedichloropalladium(II), transdiaminedibromopalladium(II), palladium(II) chloride, palladium(II) bromide, palladium(II) iodide, tetrakis(acetonitrile)palladium(II) tetrafluoroborate, bis(acetonitrile)dichloropalladium(II), bis(benzonitrile)palladium(II) chloride, tris(dibenzylideneacetone)dipalladium(0), allylpalladium chloride dimer, palladium(II) trifluoroacetate, palladium(II) acetylacetonate, di- mu -chlorobis(2'-(amino-N)(1,1-rbiphenyl)-2-yl-C)dipalladium(II), sodium tetrachloropalladate(II), and palladium sulfate dihydrate. The first solvent comprises dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, dimethyl sulfoxide, tert-amyl alcohol, propionitrile, cyclopentyl methyl ether, n-butanol, toluene, anisole, diglyme or 1,3-dimethyl-2-imidazolidinone, ethylbenzene, diethoxyethane, and/or phenyl chloride. The first base comprises N,N-dicyclohexylmethylamine, N-ethyldicyclohexylamine, N,N-dimethylcyclohexylamine, dicyclohexylamine, Hunig's base, N,N-diethylbutylamine, tributylamine, 4,4'-trimethylenebis(1-methylpiperidine), 1,2,2,6,6-pentamethylpiperidine, 2,2,6,6-tetramethylpiperidine, 1-ethyl-piperidine, morpholine, sodium bicarbonate, and sodium acetate. The ligand is a phosphine ligand or a carbene ligand. The metal catalyst is a palladium-phosphine complex catalyst comprising bis(tri-o-tolylphosphine) palladium(0), trans-di( mu -acetato)bis(o-(di-o-tolylphosphino)benzyl)dipalladium(II), dichlorobis(tri-o-tolylphosphine)palladium(II), and palladium-phosphine complex of formula (a). The metal catalyst comprises a preformed palladium-carbene complex of formulae (A)-(C). The second base comprises tetramethylguanidine, 1,5-diazabicyclo(4.3.0)non-5-ene, 1,8-diazabicyclo(5.4.0)undec-7-ene, 1,3,4,6,7,8-Hexahydro-1-methyl-2H-pyrimido(1,2-a)pyrimidine, 1,5,7-triazabicyclo(4.4.0)dec-5-ene, cesium carbonate, and 1-ethyl-2,2,4,4,4-pentakis(dimethylamino)-2 lambda 5,4 lambda 5-catenadi(phosphazene). The chiral reducing agent is B-chlorodiisopinocampheylborane. The ruthenium catalyst comprises ruthenium complex of formulae (D)-(H). The ruthenium catalyst is ruthenium(III) chloride((R)-daipena)((R)-dmm-segphos). The third base comprises lithium hydroxide, potassium carbonate, potassium phosphate, potassium tert-butoxide, potassium hydroxide, potassium ethoxide, and potassium methoxide. The second solvent comprises tetrahydrofuran, methanol, ethanol, isopropyl alcohol, 1-butanol, and 2-butanol. The second solvent is a mixture of tetrahydrofuran/methanol, tetrahydrofuran/ethanol, tetrahydrofuran/isopropyl alcohol, tetrahydrofuran/1-butanol, toluene/ethanol, toluene/isopropyl alcohol, and toluene/2-butanol. The crystallizing solvent is toluene, or heptanes.Rx1, Ry1, Rz1 = 1-10C-alkyl, 2-6C-alkenyl, 2-6C-alkynyl, aryl, heteroaryl, or heterocyclyl (all optionally substituted with one or more halo, alkyl or haloalkyl substituents);Ar1 = benzene group of formula (b); andRa1-Re1 = amine, 1-10C alkyl, 2-6C-alkenyl, 2-6C-alkynyl, aryl, heteroaryl, heterocyclyl (all optionally substituted with one or more halo, alkyl or haloalkyl substituents), H, alkyloxy or halo. EXAMPLE - 19 g of Oxoalcohol dissolved in 124 ml of tetrahydrofuran (THF) at 20 degrees C under nitrogen. A base solution was prepared by charging 0.28 g of potassium tert-butoxide and 2.5 ml of ethanol in a separate reactor. A catalyst solution was prepared by dissolving 25 mg of RuCl((R)-daipena)((R)-dmm-Segphos) in 5 ml of THF under nitrogen conditions in a separate reactor. An autoclave was charged with the solution of 19 g of oxoalcohol in 124 ml of THF. The mixture was cooled to -5 degrees C under nitrogen. Potassium tert-butoxide in 2.5 ml of THF was charged. The catalyst solution was added. Autoclave was purged with hydrogen and pressurized to 40 psig. The reaction mixture was agitated until reaction was completed. The batch was charged with 76 ml of toluene and heated to 40 degrees C. Organic layer was washed with water and 1 wt.% aqueous sodium chloride solution. The THF was removed under reduced pressure at 50 degrees C. The 190 ml of toluene was charged. The batch was concentrated to -135 ml total. The batch temperature was adjusted to 48-52 degrees C. Backbone diol was crystallized by slow addition of anti-solvent heptanes at 50 degrees C. The crystalline product was dried at room temperature under vacuum with nitrogen sweep to yield 17.8 g of (I).