TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Processes: Synthesis of anacetrapib intermediate includes dissolving 3,5-bis(trifluoromethyl)bromobenzene of formula (1) with Weinrib amide of formula (2) in anhydrous anaerobic treatment solvent A1, cooling at 5-15 degrees C, slowly dropping isopropylmagnesium chloride solution, warming at 15-25 degrees C for 1 night, cooling at 5-15 degrees C, quenching with acid J, extracting with organic solvent B, drying using toluene azeotrope with water, concentrating under reduced pressure to obtain Boc-protected ketone of formula (3) in which mass ratio of 3,5-bis(trifluoromethyl)bromobenzene of formula (1):Weinrib amide of formula (2) is 1.26-1.9:1 and molar ratio of isopropylmagnesium chloride:3,5-bis(trifluoromethyl)bromobenzene of formula (1) is 1.5-2, dissolving Boc-protected ketone of formula (3), ruthenium(II) catalyst, and base G in solvent A1, degassing oxygen at room temperature, stirring, adding proton supply agent H, heating at 30-40 degrees C, monitoring reaction using thin-layer chromatography (TLC), concentrating under reduced pressure to half of original volume, adding solvent A1, diluting with solvent C, washing organic phase with hydrochloric acid and saturated and aqueous sodium bicarbonate, washing with water, drying, filtering organic phase, distilling off solvent under reduced pressure to obtain crude product, recrystallizing with mixed solvent E to obtain (1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-Boc-aminopropanol of formula (4) in which mass ratio of catalyst:Boc-protected ketone of formula (3) is 10-10000:1, molar ratio of base G:Boc-protected ketone of formula (3) is 2-4:1, volume ratio of proton supply agent H:Boc-protected ketone of formula (3) is 100:1, and volume-to-mass ratio of solvent A:Boc-protected ketone of formula (3) is 5-20 g:1 ml, dissolving (1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-Boc-aminopropanol of formula (4) in solvent D, placing in ice-water bath, slowly adding base I, stirring at less than or equal to 25 degrees C, monitoring reaction using TLC, quenching with acid J at less than or equal to 25 degrees C, separating organic layer, washing organic layer with diluted hydrochloric acid, concentrating under reduced pressure, and recrystallizing residue with mixed solvent F to obtain 5-(3,5-bis(trifluoromethyl)phenyl) methyl-1,3-oxazolidin-2-one of formula (A) in which molar ratio base I:(1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-Boc-aminopropanol of formula (4) is 1-2:1, base I amount is equal to acid J, and volume-to-mass ratio of solvent D:(1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-Boc-aminopropanol of formula (4) is 5-20:1. Drying process is performed by using anhydrous sodium sulfate, anhydrous magnesium sulfate, or toluene azeotrope with water. Preferred Compositions: Organic solvent B is ethyl acetate, methylene chloride, tert.-butyl ether, or toluene. Solvent A1 is tetrahydrofuran, 2-methyltetrahydrofuran, diethyl ether, dioxane, methylene chloride, or toluene. Acid J is 0.5-6 N hydrochloric acid, formic acid, or acetic acid. Organic solvent C is isopropyl acetate, ethyl acetate, or heptane. Base G is alkali-soluble organic solvent e.g. triethylamine, 1,8-diazabicycloundec-7-ene, 1,4-diazabicyclo-2.2.2-octane, or morpholine. Proton supply agent H is formic acid, ammonium formate, or isopropyl alcohol. Mixed solvent E is methanol, ethanol, isopropanol, and/or water. Organic solvent D is toluene, tetrahydrofuran, dioxane, and/or isopropanol. Base I is inorganic base e.g. potassium hydroxide, sodium hydroxide, or sodium hydrogensulfite. Mixed solvent F is toluene, methanol, ethanol, isopropanol, hexane, or n-heptane.