NOVELTY - Preparing Katarantin in airlift bioreactor, involves: making reactor by setting important units in main reactor equipped with glass; sterilizing airlift bioreactor in an autoclave; filling bioreactor with inoculum of Catharanthus roseus cell cultures; entering air with aerator or air pump into bioreactor, cleaning air entering the tube; and observing content of the resulting katarantin performed at various aeration and heavy inoculum.    USE - For preparing Katarantin in airlift bioreactor (claimed) which is used to prepare anti-cancer compounds.    ADVANTAGE - The obtained Katarantin reduces the prize of cancer chemotherapy. Use of airlift bioreactor is suitable to reduce energy for aeration; has good control mechanism in the industrial-scale production of secondary metabolites; allows constantly setting the conditions at each phase of growth and development of plant cells; and provides ease of handling culture such as inoculation and saves time.    DETAILED DESCRIPTION - Preparing Katarantin in airlift bioreactor, involves: a) making reactor by setting important units in the main reactor equipped with a glass filter having diameter of 2.5 cm3 and grain porosity (pore 16-40 pm), where the top of the column bioreactor having a height of 7 cm is equipped with a drain plug inoculum or cells and duct air spend all closed with threaded lid and heat resistant, air duct with silicone hose (heat-resistant); b) sterilizing airlift bioreactor in an autoclave large sequential or connected; c) filling bioreactor with inoculum of Catharanthus roseus cell cultures with varying weight; d) entering the air with aerator or air pump into the bioreactor, where the reactor previously cleaned and dried using air filters, air filter nested or 2 stages, cleaning the air entering the tube and can not be returned because of set up with a kleb made of glass before it goes into the filter in the column to be used by the vinca cells in the bioreactor; and e) observing content of the resulting katarantin performed at various aeration and heavy inoculum.