TECHNOLOGY FOCUS - INORGANIC CHEMISTRY - Preferred Components: The chlorinating agents are selected from thionyl chloride, phosphorus trichloride, phosphorus penta chloride, phosphorus oxychloride, or oxalyl chloride.    TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Components: The solvents (S1) are selected from chlorinating includes but are not limited to aromatic hydrocarbons such as toluene, xylene, n-hexane, n-heptane and cyclohexane; halogenated hydrocarbons such as dichloromethane, ethylenedichloride and chloroform; ether solvents such as 1,4-dioxane, tetrahydrofuran and methyl t-butyl ether; and/or aprotic polar solvents such as N,N-dimethylformamide (DMF), dimethylsulfoxide (DMSO) and dimethylacetamide (DMA). The bases (B1) are selected from organic bases such as triethyl amine, diisopropylethylamine, and pyridine; inorganic bases such as sodium carbonate, potassium carbonate, sodium bicarbonate and potassium bicarbonate; and/or alkali metal hydroxides such as sodium hydroxide, potassium hydroxide, caustic soda in solid form or in form of aqueous solution of differing concentration. The base (B2) is selected from inorganic bases such as alkali metal hydroxides and carbonates; and organic bases such as triethylamine, dicyclohexylamine, diisopropylethylamine, morpholine, and ammonium hydroxide. The acid is selected from inorganic acids such as hydrochloric acid, sulfuric acid, and phosphoric acid; and organic acids such as acetic acid, methanesulfonic acid, oxalic acid or formic acid. The solvent (S2) selected is acetonitrile. The aceylating agents are selected from sodium acetate, acetyl chloride, or isopropenyl acetate. ACTIVITY - Antiarthritic; Antirheumatic; Immunosuppressive; Neuroprotective. No biological data given.    MECHANISM OF ACTION - Tyrosine kinase inhibitor.    EXAMPLE - A round bottom flask was charged with cyanoacetic acid (100 g) and phosphorus pentachloride and tetrahydrofuran (300 ml) and the reaction mixture was stirred at room temperature for 4 hours. 4-trifluoromethyl aniline (161 g) dissolved in tetrahydrofuran (100 ml) was slowly added to the reaction mixture and stirred for completion of reaction. The resultant reaction mass was cooled and separated solid was filtered and washed with slurry of isopropanol and cyclohexane and dried under reduced pressure to afford 2-cyano-N-(4-(trifluoromethyl)phenyl)acetamide. A round bottom flask was charged with 2-cyano-N-(4-(trifluromethyl)phenyl)acetamide (100 g), sodium hydroxide (70 g) and dimethyl formamide was added and the reaction mixture was stirred for 30 minutes. Isopropenyl acetate (60 ml) was added slowly and the resultant mixture was stirred for about 4-5 hours at room temperature. After completion of the reaction, the resulting reaction mixture was diluted with water and acidified with conc. HCl solution and stirred for solid separation. After workup, teriflunomide (yield: 101 g, purity by HPLC: 95%), was obtained.