TECHNOLOGY FOCUS - INORGANIC CHEMISTRY - Preferred Components: The base is selected from sodium carbonate, potassium carbonate, sodium bicarbonate, potassium bicarbonate, sodium hydroxide, potassium hydroxide, lithium hydroxide, ammonia, aqueous ammonia, triethylamine, diisopropylamine, or N-methylmorpholine, preferably aqueous ammonia.    TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Components: The chiral acid is selected from L-tartaric acid, mandelic acid, lactic acid, camphoric acid, di-para-toluoyl-L-tartaric acid (L-DTTA), dibenzoyl-L-tartaric acid monohydrate (L-DBTA), L-malic acid, L-2-chloromandelic acid, or camphorsulfonic acid, preferably L-tartaric acid. The ketone solvent is selected from acetone, ethyl methyl ketone, diethyl ketone, and/or methyl isobutyl ketone, preferably methyl isobutyl ketone. ACTIVITY - Thrombolytic. No biological data given.    MECHANISM OF ACTION - Adenosine diphosphate (ADP)-induced platelet aggregation inhibitor.    EXAMPLE - 225 ml Liquid ammonia (NH3) was slowly added until the pH of the reaction mixture was 7.5 at 0-2 degrees C. The layers were separated. The aqueous layer was extracted with 2x 300 ml dichloromethane. The combined dichloromethane was washed with 300 ml water. Dichloromethane was distilled from the organic layer under vacuum at 45 degrees C to obtain (+)-methyl-2-amino-2-(2-chlorophenyl)acetate. The 8.4 g (+)-methyl-2-amino-2-(2-chlorophenyl)acetate, 14.4 g 2-(thiophen-2-yl)ethyl para-toluenesulfonate, 10.8 g sodium bicarbonate, 0.4 g lithium bromide, 1.35 g tetra-n-butylammonium bromide and 45 ml acetonitrile were charged into a round bottom flask at 26 degrees C. The reaction mass was heated to 79 degrees C and stirred for 30 hours. The reaction mass was cooled to 26 degrees C. 45 ml Toluene and 45 ml water were added to the reaction mass at 26 degrees C and stirred for 10 minutes, the layers were separated, the aqueous layer was extracted with 15 ml toluene. The combined toluene layer was washed with 45 ml water. The toluene layer was evaporated under vacuum at 53 degrees C to obtain (+)- alpha -(2-thien-2-yl)-ethyl amino)- alpha -(2-chlorophenyl)methyl acetate or its salt. The 100 g (+)- alpha -(2-thien-2-yl)-ethyl amino)- alpha -(2-chlorophenyl)methyl acetate hydrochloride and 500 ml formaldehyde solution were charged into a round bottom flask at 26 degrees C. The reaction mass was stirred at the same temperature for 24 hours. The reaction mass was filtered. The reaction mass was charged into a round bottom flask at 26 degrees C. The reaction mass was cooled to 10 degrees C. The 500 ml dichloromethane was added to the reaction mass. The aqueous solution of sodium carbonate (15 grams sodium carbonate in 500 ml water) was slowly added until the pH of the reaction mixture was 7.5 at 10-12 degrees C. The layers were separated. The aqueous layer was extracted with 500 ml dichloromethane. The combined organic layer was washed with 300 ml water. Dichloromethane was distilled from the organic layer at 45 degrees C to obtain Clopidogrel free base (yield: 98.7 g).