NOVELTY - A valnemulin hydrochloride is synthesized by reacting pleuromutilin tert.-butyl water, p-toluenesulfonyl chloride, and sodium hydroxide solution to obtain 22-0-(4-toluenesulfonyl) oxyacetyl ohmic body strain, reacting sodium ethoxide ethanol solution, dimethyl cysteamine hydrochloride, 14-0-((1-amino-2-methyl-2-yl) acetyl mercapto) ohmic body strain, ethyl acetate, and distilled water, distilling off ethyl acetate to obtain 14-0-((1-amino-2-methylpropane-2-yl) acetyl) mercapto ohmic body strain, reacting potassium hydroxide, D-valine, methylacetoacetate, and benzene or toluene.    USE - Synthesis of valnemulin hydrochloride (claimed).    ADVANTAGE - The synthesis process has high yield, low toxicity, no pollution, and mild reaction and is recyclable.    DETAILED DESCRIPTION - A valnemulin hydrochloride is synthesized by adding pleuromutilin tert.-butyl water and p-toluenesulfonyl chloride, dropwise adding 30-50 wt.% sodium hydroxide (NaOH) solution, reflux-stirring for 20-80 minutes to generate white solid matter, filtering, cooling to room temperature, washing with water and tert.-butyl methyl ether to obtain 22-0-(4-toluenesulfonyl) oxyacetyl ohmic body strain, adding 1-2 wt.% sodium ethoxide ethanol solution to dimethyl cysteamine hydrochloride, stirring at room temperature for 30-90 minutes, cooling reaction system to 2-5 degrees C, adding in synthetic 14-0-((1-amino-2-methyl-2-yl) acetyl mercapto) ohmic body strain, stirring for 2-3 hours, decompressing, distilling ethanol, adding ethyl acetate and distilled water, washing, separating organic phase to wash with saturated ammonium chloride (NH4Cl) solution, separating 2 phases, decompressing, distilling off ethyl acetate to obtain 14-0-((1-amino-2-methylpropane-2-yl) acetyl) mercapto ohmic body strain, mixing solid potassium hydroxide (KOH), D-valine, and methylacetoacetate, refluxing with benzene or toluene for 3-4 hours, evaporating benzene, pouring obtained solid material in tert.-butyl methyl ether, stirring for 1-1.5 hours, filtering, washing filter cake with tert.-butyl methyl ether to obtain methyl D-valine amino acid, suspending obtained methyl D-valine amino acid in dichloromethane, adding N-methyl morpholine, cooling to less than or equal to 0 degrees C by ice, slowly adding isobutyl chloroformate in small amount of dichloromethane, stirring for 30 minutes, adding obtained 14-0-((1-amino-2-methylpropane-2-yl) acetyl) mercapto ohmic body strain, evaporating dichloromethane after 1 hour, adding tert.-butyl methyl ether and distilled water, stirring, adjusting pH to 2 with hydrochloric (HCl) acid, continuously stirring at room temperature for 4-5 hours, separating, washing water with tert.-butyl methyl ether phase, adjusting pH to 8-9 with NaOH, stirring for 20 minutes, separating 2 phases, washing organic phase with water twice, adding distilled water, adjusting pH to 2-3 with HCl, stirring for 15 minutes, separating 2 phases, and vacuum-drying aqueous phase.