NOVELTY - An epinastine hydrochloride is prepared by reacting 6-chloromethyl-11-dihydro-dibenzo(b,e) azepine and N-fluorenylmethoxycarbonyl chloride group in organic solvent with presence of acid-binding agent to generate intermediate compound, carrying out reduction reaction and de-protection reaction of obtained intermediate compound with de-protecting agent to obtain 6-aminoethyl-6,11-dihydro-5H-dibenzo (b,e) azepine, carrying out cyclization of obtained compound product and bromine cyanide ring to generate epinastine hydrobromide, and neutralizing epinastine hydrobromide with alkali.    USE - Preparation of hydrochloric acid (claimed).    ADVANTAGE - The preparation is simple, more environment-friendly, and easy, has easy to obtain raw materials, high yield, and less by-products, avoids side reaction, obtains good product purity, and does not need high pressure container and special device.    DETAILED DESCRIPTION - An epinastine hydrochloride is prepared by reacting 6-chloromethyl-11-dihydro-dibenzo(b,e) azepine and N-fluorenylmethoxycarbonyl chloride group in organic solvent with presence of acid-binding agent to generate intermediate compound in which acid binding agent is triethylamine, pyridine, methylamine, dimethylamine, sodium methoxide, sodium ethoxide, sodium hydroxide, sodium carbonate, sodium bicarbonate, potassium hydroxide, potassium carbonate, or potassium bicarbonate, and organic solvent is 1-6 carbon-containing lower alcohol or ether, dichloromethane, chloroform, or acetonitrile, carrying out reduction reaction and de-protection reaction of obtained intermediate compound with de-protecting agent to obtain 6-aminoethyl-6,11-dihydro-5H-dibenzo (b,e) azepine in which de-protecting agent is weak alkaline reagent, such as piperidine, methylamine, and/or dimethylamine, carrying out cyclization of obtained compound product and bromine cyanide ring to generate epinastine hydrobromide, and neutralizing epinastine hydrobromide with alkali in which synthesis route is described in formula (A)..