NOVELTY - Solid-phase synthesis of buserelin involves coupling ethylamino-based carrier resin (I) with fluorenylmethyloxycarbonyl-Pro-hydroxyl compound and removing protecting group, coupling obtained product with fluorenylmethyloxycarbonyl-Arg(amino acid side chain protecting group)-hydroxyl compound, coupling resultant product with other amino acid of buserelin peptide chain, acid-cracking obtained product to remove carrier resin, and hydrogenating obtained product to remove amino acid side chain protecting groups.    USE - Solid-phase synthesis of buserelin (claimed).    ADVANTAGE - The buserelin is economically synthesized with high yield and stability under mild conditions, by simple and environmentally-friendly process.    DETAILED DESCRIPTION - Solid-phase synthesis of buserelin involves coupling ethylamino-based carrier resin of formula (I) for solid-phase peptide synthesis with fluorenylmethyloxycarbonyl-Pro-hydroxyl compound and removing protecting group to obtain amine-Pro-ethylamino-based carrier resin, coupling the amine-Pro-ethylamino-based carrier resin with fluorenylmethyloxycarbonyl-Arg(amino acid side chain protecting group)-hydroxyl compound to obtain amine-Arg(amino acid side chain protecting group)-Pro-ethylamino-based carrier resin, coupling other amino acid of buserelin peptide chain to obtain Pyr-His(amino acid side chain protecting group)-Trp(amino acid side chain protecting group)-Ser(PG4)-Tyr(amino acid side chain protecting group)-D-Ser(tert-butyl)-Leu(amino acid side chain protecting group)-Arg(PGl)-Pro-ethylamino-based carrier resin, carrying out acid cracking process and removing carrier resin to obtain full-protection peptide (Pyr-His(amino acid side chain protecting group)-Trp(amino acid side chain protecting group)-Ser(amino acid side chain protecting group)-Tyr(amino acid side chain protecting group)-D-Ser(tert-butyl)-Leu(amino acid side chain protecting group)Arg(amino acid side chain protecting group)-Pro-ethylamine), and hydrogenating full-protection peptide to remove amino acid side chain protecting groups.    A=polymer.