TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Process: In the process (P1): the first stage is a hydrotreatment stage; the first stage and the second stage are housed within the same hydrotreater reactor; the entire liquid and gaseous effluent from the first stage is passed through to the second stage; the pressure in the hydrotreater reactor is 1500-2000 psig; the first stage and the second stage are housed in different reactors; the feedstream is heated by an exothermic reaction upon entry into the hydrotreater of the second stage; the feedstream prior to entry into the hydrotreater in the second stage is exposed to hydrogen to generate an exothermic reaction without deoxygenating the reactive species in the feedstream; a reactive species is added to the feedstream, where the heat generated by the addition of the added reactive species causes at least part of the increase in temperature needed for the second stage; the pressure in the hydrotreater reactor housing the first stage is 500-1000 psig and the pressure in the hydrotreater reactor housing the second stage is 500-2000 psig; the feedstream introduced into the first stage or second stage is heated in a controlled pretreatment heat exchanger; the temperature at the entry of the first stage is 120-350 degrees F; the temperature of the feedstream entering the second stage does not exceed 500 degrees F; the space velocity within the first stage is 0.5-6; greater than 80%, preferably greater than 95% of oxygen has been removed from the feedstream exiting the second stage; the temperature at the exit of the second stage is 650-850 degrees F; the space velocity within the second stage is less than 5; the bio-oil containing feedstream is separated into bio-oil and an aqueous phase prior to step (a); the step (a) occurs in a slurry bed reactor or a fixed bed reactor; the step (b) occurs in a fixed bed reactor; the solids are separated from the slurry prior to step (b); the bio-oil containing feedstream is separated into bio-oil and an aqueous phase between step (a) and step (b); at least a portion of the solids are removed from the bio-oil prior to step (a); the removal of the at least a portion of the solids from the bio-oil occurs in a desalter, settler and/or separator; the bio-oil is subjected to fractionation to produce bio-naphtha; the fractionation occurs prior to step (a); at least a portion of the bio-naphtha is blended with the bio-oil containing feedstream; and at least a portion of the organic reactive molecules is subjected to a condensation reaction in step (a). In the process (P2): the first stage is a hydrotreatment stage; the pressure in the first stage and the pressure in the second stage are the same, where the first stage and the second stage are housed in the same hydrotreater reactor or in separate hydrotreater reactors; the pressure in the first stage does not exceed 1000 psig; the space velocity within the first stage is 1-6, and the space velocity within the second hydrotreatment stage is less than 2; the bio-oil or pyrolysis oil originates from a biomass converted feedstream; the biomass converted feedstream is separated into bio-oil and an aqueous phase prior to introducing the bio-oil into the first stage; the bio-oil is subjected to fractionation prior to prior to step (a1); the bio-naphtha is separated from the bio-oil during fractionation and at least a portion of the separated bio-naphtha is blended with the biomass converted feedstream; and at least a portion of the organic reactive molecules are subjected to a condensation reaction in step (a1). In the process (P3): the first stage is a hydrotreatment stage; the first stage and the second stage are housed in the same hydrotreater reactor or in separate hydrotreater reactors; and at least a portion of the organic reactive molecules are subjected to a condensation reaction in step (a2). Preferred Components: The reactive species is an olefin or an alcohol. In the process (P1), the amount of organic reactive molecules deoxygenated in the first stage is less than 5%, preferably less than 0.1%. The feedstream is a bio-oil containing feedstream. The ratio of the specific gravities of the oil phase to the aqueous bio-oil phase is less than 1. The first stage reactor contains a catalyst comprising nickel molybdenum alloy, cobalt molybdenum alloy or nickel tungsten alloy, sulfided transition metals, reduced metals and noble metals, or a catalyst having an acid functionality such as a silica-alumina, sulfated oxide and/or supported phosphoric acids. The sulfided transition metals comprise sulfided nickel molybdenum alloy and sulfided cobalt molybdenum alloy. EXAMPLE - No suitable example given.