TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Components: Strain of transformed microorganism is selected from Acanthospermum small of the milky spore Cunninghamella blakesleana AS 3.970, AS 3.153, AS 3.910, AS 3.954, AS 3.2016, AS 3.2017, AS 3.2018, AS 3.3401, or Acanthospermum small of the milky spore Cunninghamella echinulata AS 3.154, AS 3.952, AS 3.953, AS 3.1969, AS 3.1970, AS 3.1971, AS 3.1977, AS 3.1978, AS 3.1979, AS 3.1980, AS 3.1981, AS 3.1987, AS 3.1988, AS 3.1989, AS 3.1990, AS 3.2000, AS 3.2004, AS 3.2005, AS 3.2006, AS 3.2011, AS 3.2015, AS 3.2473, AS 3.2474, AS 3.2475, AS 3.2716, AS 3.400, or small of milky Actinomucor elegans or Cunninghamella elegans AS 3.156, AS 3.1207, AS 3.1659, AS 3.2028, AS 3.2031, AS 3.2032, AS 3.2033, AS 3.2041, AS 3.2476, AS 3.2477, AS 3.2717, AS 3.3402, AS 3.2476, milky CFCC 5029, or Cunninghamella echinulata var. elegans teleomorph ATCC 9245, ATCC 8688a, ATCC 8983, Cunninghamella echinulata var. echinulata teleomorph ATCC 11585a, ATCC 36190, ATCC 11585b, ATCC9244, Cunninghamella echinulata var. elegans teleomorph ATCC 11064, ATCC 10028a, Cunninghamella elegans ATCC 36112, ATCC 26269, ATCC 10028b, Aspergillus niger AS 3.40, AS 3.315, AS 3.316, AS 3.350, AS 3.429, AS 3.739, AS 3.879, AS 3.939, AS 3.940, AS 3.1858, AS 3.2931, AS 3.3882, AS 3.3883, AS 3.4303, AS 3928, AS 3.4304, AS 3.4309, AS 3.4463, AS 3.4304, AS 3.4523, Aspergillus flavus, Acanthospermum fine hair spore, Alternaria alternatas or micro-purple Penicillium janthinellum. Combined elicitor has three group but at least two groups contain group A. Group A contains A1 is alpha-cyclodextrin, A2 is beta-cyclodextrin, A3 is 2, 6-dimethyl-beta-cyclodextrin, A4 is hydroxypropyl beta-cyclodextrin, A5 is methylated-beta-cyclodextrin, A6 is hydroxyethyl-beta-cyclodextrin, A7 is glucose-beta-cyclodextrin, A8 is sulfobutyl-beta-cyclodextrin, A9 is gamma-cyclodextrin or A10 is carboxymethyl-beta-cyclodextrin. Group B contains B1 is methyl jasmonate, B2 is salicylic acid, B3 is chitosan, B4 is jasmonic, B5 is fungal derived polysaccharides, B6 is beta-glucan, B7 is glutathione, B8 is beta-glucan 2-hydroxyethyl jasmine, B9 is brassinolide, B10 is ester, B11 is chitin or B12 is small milky trichoderma. C group contains C1 is carbamazepine, C2 is modafinil, C3 is nevirapine, C4 is rifampicin, C5 is Hypericum perforatum, C6 is isoniazid, C7 is insulin, C8 is omeprazole, C9 is phenobarbital, C10 is prednisone, C 11 is prednisolone, C12 is dexamethasone, C13 is betamethasone, C14 is beclomethasone,C15 is betamethasone valerat, C16 is dexamethasone acetate, C17 is 9-fluoro-16 alpha -methyl 11 beta ,17-dihydroxy-3-oxygen and 1,4 diene-17 beta -carboxylic acid. Chromatographic column is agilent ZORBAX (RTM: Microparticulate column packing for HPLC) eclipse XDB columns-C18. Preferred Definitions:    R1=methyl.    ACTIVITY - Cytostatic; Anti-HIV; Antiinflammatory; Hepatotropic; Virucide; Neuroprotective; Nootropic; Antiparkinsonian; Anticonvulsant; Vulnerary.    SPECIFIC COMPOUNDS - 20 Celastrol derivatives are specifically claimed, e.g.6-hydroxy tripterine, 7-hydroxy tripterine, 6,7-dihydroxy tripterine, 23-hydroxy tripterine, 6,23-dihydroxy tripterine of formula (III).