TECHNOLOGY FOCUS - INORGANIC CHEMISTRY - Preferred Composition: The alkaline compound is chosen from metal hydride, metal carbonate, metal hydroxide, metal amide and metal alkoxide. The metal hydride is lithium hydride, sodium hydride or potassium hydride. The metal carbonate is sodium carbonate, potassium carbonate or cesium carbonate. The metal hydroxide is sodium hydroxide, potassium hydroxide or lithium hydroxide. The metal amide is lithium amide, sodium amide or potassium amide. The metal alkoxide is sodium methoxide, sodium ethoxide, sodium isopropyl alcohol or tertiary butyl alcohol.    TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Process: The method further involves adding a basic additive chosen from lithium hydroxide, triethylamine and iisopropylethylamine, during preparation of compound (IV). Preferred Composition: The catalyst is chosen from cinchona alkaloid derivatives. The molar ratio of compound (II), compound (III) and catalyst (V) is 1:1.2:(0.05-0.08). The acid catalyst is protonic acid (a) or Lewis acid. The protonic acid (a) is chosen from methanesulfonic acid, p-toluenesulfonic acid, benzenesulfonic acid and camphorsulfonic acid. The Lewis acid is chosen from boron trifluoride ether solution, stannous chloride and titanium tetrachloride. The molar ration of compound (IV) and acid catalyst is 1:0.047. The molar ratio of compound (VI), 4,6-dimethyl-2-methylsulfonyl pyridine and alkaline compound is 1:(1.1-1.2):(2.5-2.8). The molar ratio of compound (VII) and alkaline compound is 1:(2-5.5). The protonic acid (b) is chosen from hydrochloric acid, sulfuric acid and methanesulfonic acid. The reaction medium is chosen from ether solvent, halogenated alkane solvent, alcohol solvent, ester solvent, 5-8C hydrocarbon solvent, amide solvent and nitrile solvent. The ether solvent is diethyl ether, methyl tert-butyl ether, 1,4-dioxane, tetrahydrofuran, ethylene glycol monomethyl ether, ethylene glycol dimethyl ether, ethylene glycol monoethyl ether or ethylene glycol diethyl ether. The halogenated alkyl solvent is methylene dichloride, chloroform or 1,2-dichloroethane. The alcohol solvent is methanol, ethanol, isopropanol, n-propanol, n-butanol, tert-butyl alcohol or glycol. The ester solvent is ethyl acetate, methyl acetate, isobutyl acetate or ethyl formate. The 5-8C hydrocarbon solvent is pentane, n-hexane, n-heptane, toluene or xylene. The amide solvent is N,N-dimethylformamide or N,N-dimethylacetamide. The nitrile solvent is acetonitrile or propionitrile. The molar ratio of basic additive and benzophenone is 1:(2.5-6).