TECHNOLOGY FOCUS - BIOTECHNOLOGY - Preparation (Claimed): Production of cellobiohydrolase variant involves either method M1: cultivating a host cell comprising the polynucleotide (A2) under conditions suitable for expression of the variant, and optionally recovering the variant; method M2: cultivating a transgenic plant or a plant cell comprising a polynucleotide encoding the variant under conditions conducive for production of the variant, and optionally recovering the variant; or method M3: introducing into a parent cellobiohydrolase, an alteration at, at least one position corresponding to positions 197, 198, 199, and 200 of the mature polypeptide of (SEQ ID NO: 2), where the alteration at the position corresponding to positions 197, 198, and 200 is a substitution and the alteration at the position corresponding to position 199 is a deletion, and the variant has cellobiohydrolase activity, and optionally recovering the variant. Preferred Variant: The parent cellobiohydrolase is selected from: (a) a polypeptide having at least 60% sequence identity to the mature polypeptide of (SEQ ID NO: 2), (SEQ ID NO: 8), as available on WIPO website, (SEQ ID NO: 10), as available on WIPO website, (SEQ ID NO: 12), as available on WIPO website, (SEQ ID NO: 14), as available on WIPO website, (SEQ ID NO: 16), as available on WIPO website, (SEQ ID NO: 18), as available on WIPO website, (SEQ ID NO: 20), as available on WIPO website, or (SEQ ID NO: 22), as available on WIPO website; (b) a polypeptide encoded by a polynucleotide that hybridizes under low stringency conditions with the mature polypeptide coding sequence of (SEQ ID NO: 1), as available on WIPO website, (SEQ ID NO: 3), as available on WIPO website, (SEQ ID NO: 4), as available on WIPO website, (SEQ ID NO: 7), as available on WIPO website, (SEQ ID NO: 9), as available on WIPO website, (SEQ ID NO: 11), as available on WIPO website, (SEQ ID NO: 13), as available on WIPO website, (SEQ ID NO: 15), as available on WIPO website, (SEQ ID NO: 17), as available on WIPO website, (SEQ ID NO: 19), as available on WIPO website, or (SEQ ID NO: 21), as available on WIPO website; or their full-length complements; (c) a polypeptide encoded by a polynucleotide having at least 60% identity to the mature polypeptide coding sequence of (SEQ ID NO: 1), (SEQ ID NO: 3), (SEQ ID NO: 4), (SEQ ID NO: 7), (SEQ ID NO: 9), (SEQ ID NO: 11), (SEQ ID NO: 13), (SEQ ID NO: 15), (SEQ ID NO: 17), (SEQ ID NO: 19), or (SEQ ID NO: 21); (d) the mature polypeptide of (SEQ ID NO: 2), (SEQ ID NO: 8), (SEQ ID NO: 10), (SEQ ID NO: 12), (SEQ ID NO: 14), (SEQ ID NO: 16), (SEQ ID NO: 18), (SEQ ID NO: 20), or (SEQ ID NO: 22); and (e) a fragment of the mature polypeptide of (d), which has cellobiohydrolase activity. The sequences not defined here may be found at ftp://ftp.wipo.net/pub/published pct sequences/publication. The variant comprises a substitution at a position corresponding to position 197 or 198 (where the substitution is with Ala); a substitution at a position corresponding to position 200 (where the substitution is with Ala, Gly, or Trp); and a deletion at a position corresponding to position 197. The variant comprises at least one alteration selected from Asn197Ala, Asn198Ala, Ala199asterisk, and Asn200Ala,Gly,Trp at positions corresponding to the mature polypeptide of (SEQ ID NO: 2). The parent is a hybrid or chimeric polypeptide in which the carbohydrate binding domain of the parent is replaced with a different carbohydrate binding domain or a fusion protein in which a heterologous carbohydrate binding domain is fused to the parent. ACTIVITY - Plant protectant. No biological data is given.    MECHANISM OF ACTION - None given.    EXAMPLE - No suitable example given.