NOVELTY - Polypeptide having one or more substitution corresponding to e.g. Thr89Cys/Tyr, Val187Met/Gln/Cys/Gly/Tyr, Ala191Ile/Lys/Asp/CYs/Glu/Asn/Trp/Arg/Pro, Tyr214Leu/Pro, Gln215Asp/Glu/Ser/Met/Leu/Cys/Phe/Ala, Ile218Trp, Ile222Gly/Tyr/Met/Pro/Ser/Trp, Tyr226Met/Thr/Pro/Gln, Gln338Arg/Ile/Asp/Glu/Phe/Gly/Pro, Met339Tyr/Glu/Asn, Gln341Val/Tyr/Ser/His, or Trp479Ser/Ile/Phe/Asp/Glu/His/Met/Asn/Arg/Thr/Tyr of SEQ ID NO: 59 is new, where the polypeptide is member of the major facilitator superfamily (MFS).    USE - The polypeptide is useful for the degradation of a lignocellulosic or hemicellulosic material to produce a fermentation product such as ethanol, butanol, lactic acid, di-terpene, glycosylated di-terpene, plastic, organic acid, solvent, animal feed supplement, pharmaceutical, vitamin, amino acid, enzyme and chemical feedstock (all claimed). The fermentation product further includes 3-hydroxy-propionic acid, acrylic acid, acetic acid, succinic acid, citric acid, malic acid, fumaric acid, 1,3-propane-diol, ethylene, glycerol, beta -lactam antibiotic, cephalosporin, solvents, fuels including biofuels and biogas, organic polymers, and an industrial enzyme such as protease, cellulase, amylase, glucanase, lactase, lipase, lyase, oxidoreductases, transferase and xylanase, where the lignocellulosic or hemicellulosic material includes e.g. orchard primings, chaparral, mill waste, urban wood waste, municipal waste, logging waste, forest thinnings, short-rotation woody crops, industrial waste, wheat straw, oat straw, rice straw, barley straw, rye straw, flax straw, soy hulls, rice hulls, rice straw, corn gluten feed, oat hulls, sugar cane, corn stalks, corn cobs, corn husks, switch grass, soybean stems, sugar beet pulp, seed hulls, cellulosic animal wastes, lawn clippings, cotton, seaweed, softwood, hardwood, poplar, pine, shrubs, grasses, wheat, wheat straw, sugar cane bagasse, corn, corn husks, and corn hobs.    ADVANTAGE - The polypeptide has altered pentose transport activity, xylose transport activity, and sugar specificity, improved capacity for transport of xylose and reduced activity for transport of glucose.    DETAILED DESCRIPTION - Polypeptide having one or more substitution corresponding to Thr89Cys/Tyr, Val187Met/Gln/Cys/Gly/Tyr, Ala191Ile/Lys/Asp/CYs/Glu/Asn/Trp/Arg/Pro, Tyr214Leu/Pro, Gln215Asp/Glu/Ser/Met/Leu/Cys/Phe/Ala, Ile218Trp, Ile222Gly/Tyr/Met/Pro/Ser/Trp, Tyr226Met/Thr/Pro/Gln, Gln338Arg/Ile/Asp/Glu/Phe/Gly/Pro, Met339Tyr/Glu/Asn, Gln341Val/Tyr/Ser/His, Gln342Asn/His/Arg/Cys/Phe/Gly/Ile/Lys/Leu/Pro/Ser/Thr/Trp, Leu343Tyr/Gln/Ile/Cys/Glu/Lys/Asn/Pro/Ser, Asn346Gly/Ile, Asn347Ser/Leu/Lys/Gly/Thr/Val, Tyr350Glu/Ser/Gln, Gly373Arg/Lys/Leu/Met/Tyr, Asn376Lys/Gln/Ala/Cys/Asp/Glu/Ile/Met/Pro, Thr380Tyr/Gly/Met/Ala/Ser/Asp/Glu/Ile/Lys/Leu/Trp, Ser383Tyr/Trp/Val/Cys/Glu/Ile/Leu/Gln/Arg, Phe446His/Asp/Ile, Thr448/Arg/Lys/His/Asp/Glu/Trp, T449F/His/Ala/Gly/Ile/Leu/Pro/Gln/Val, Thr451Trp/Tyr/Ser, Trp455Asp/Lys/Glu/Pro/Gln, Asn478Gln/Ile/Phe/Gly, or Trp479Ser/Ile/Phe/Asp/Glu/His/Met/Asn/Arg/Thr/Tyr of SEQ ID NO: 59 is new, where the polypeptide is member of the major facilitator superfamily (MFS). INDEPENDENT CLAIMS are included for:    (1) polynucleotide having at least 50% identity to SEQ ID NO: 56, encoding the polypeptide;    (2) nucleic acid construct comprising the polynucleotide;    (3) host cell transformed with the nucleic acid construct; and    (4) degradation of lignocellulosic or hemicellulosic material, comprising contacting the lignocellulosic or hemicellulosic material with an enzyme composition to obtain one or more sugar and fermenting the produced sugar to give a fermentation product, where the fermentation is conducted with a transformed host cell.