NOVELTY - Preparing cefixime compound comprises e.g. (i) mixing 7-amido-3-vinylcephalosporanic acid (7-AVCA) and (Z)-2-methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid (MICA) active ester, adding mixed solvent of organic solvent and purified water, carrying out acylation reaction to obtain cefixime methyl ester solution; (ii) mixing with purified water, adding activated carbon, sodium hydrosulfite and EDTA, stirring and filtering; and (iii) adding organic solvent b to cefixime methyl ester aqueous solution, carrying out hydrolysis reaction, filtering, crystallizing, filtering and washing.    USE - The method is useful for preparing cefixime compound (claimed).    ADVANTAGE - The method: utilizes reaction solvent, which can be easily recovered; reduces the environmental pollution and production cost; combines acylation and hydrolysis reactions; has simple operation and short production cycle; improves the yield and purity; and is suitable for large-scale industrial production.    DETAILED DESCRIPTION - Preparing cefixime compound comprises (i) mixing 7-amido-3-vinylcephalosporanic acid (7-AVCA) and (Z)-2-methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid (MICA) active ester, then adding a mixed solvent of organic solvent and purified water according to volume ratio of 1-30:30:1, adjusting the pH with organic alkali to 7-9.5, stirring at -10 degrees C to 40 degrees C, carrying out acylation reaction for 3-7 hours to obtain cefixime methyl ester solution; (ii) mixing cefixime methyl ester solution with purified water, adding activated carbon, sodium hydrosulfite and EDTA into aqueous phase, uniformly stirring to decolor for 0.15-1 hours, and filtering to obtain cefixime methyl ester aqueous solution; and (iii) adding organic solvent b into cefixime methyl ester aqueous solution, quickly adding inorganic alkali solution at -10 degrees C to 30 degrees C for carrying out hydrolysis reaction for 5-30 minutes, adding 1-10 mol/l hydrochloric acid solution for crystallization, adjusting pH to 4-6, adding activated carbon and EDTA for decoloration, filtering, adjusting the pH of the filtrate to 2-3.5 using hydrochloric acid, crystallizing for 2-4 hours, filtering, and washing to obtain cefixime compound.