TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Process: The process for manufacturing (VIII) further comprises: reducing (VIII) to obtain substituted 1-(2-(2,4-dimethyl-phenylsulfanyl)-phenyl)-piperazine compounds of formula (IX) or their salts; deprotecting (IX) (when Z1 represents protecting group in (IX)) and converting (IX) to its hydrobromide salt; and converting (IX) (when Z1 represents hydrogen in (IX)) to its hydrobromide salt. Preferred Components: (VIIa) are (2,4-dimethylphenyl)(2-fluorophenyl)sulfane, (2-chlorophenyl)(2,4-dimethylphenyl)sulfane, 1-((2-fluorophenyl)sulfinyl)-2,4-dimethyl benzene, 1-((2-chlorophenyl)sulfinyl)-2,4-dimethyl benzene, 1-((2-fluorophenyl)sulfonyl)-2,4-dimethyl benzene or 1-((2-chlorophenyl)sulfonyl)-2,4-dimethyl benzene. Preferred Definitions:    L1 = F, Cl or Br; and    Z1 = H, trityl, methanesulfonyl, para-toluene sulfonyl or tert-butyloxycarbonyl.    ACTIVITY - Tranquilizer; Antidepressant.    MECHANISM OF ACTION - None given.    SPECIFIC COMPOUNDS - The preparation of 1-(2-((2,4-dimethylphenyl)sulfinyl)phenyl)piperazine of formula (VIIIa), 1-(2-((2,4-dimethylphenyl)sulfonyl)phenyl)piperazine, tert-butyl 4-(2-((2,4-dimethylphenyl)sulfinyl)phenyl)piperazine-1-carboxylate and tert-butyl 4-(2-((2,4-dimethylphenyl)sulfonyl)phenyl)piperazine-1-carboxylate is specifically claimed as (VIII).    EXAMPLE - Mixture of 0.5 g 1-((2-fluorophenyl)sulfinyl)-2,4-dimethyl benzene, 0.87 g piperazine and 0.33 g potassium carbonate in 3 ml dimethyl sulfoxide was stirred at 100 degrees C for 48 hours. The reaction mixture was then cooled to 20 degrees C, 20 ml water was added, and the product was extracted with 15 ml ethyl acetate for 2 times. The combined organic layers were washed with 20 ml of 1 M hydrochloric acid for 2 times. The combined water layers were basified with 5 M sodium hydroxide to pH 12, and the product extracted with 20 ml ethyl acetate for 2 times. The combined organic phases were dried over sodium sulfate and the solvent evaporated. 30 ml Melamine cyanurate was then added, a white precipitate filtered off, washed with 20 ml melamine cyanurate for 2 times, and dried to give 0.45 g 1-(2-((2,4-dimethylphenyl)sulfinyl)phenyl)piperazine.