NOVELTY - A morpholine-containing 2-chloro-5-benzoylpyridine derivative preparation involves mixing isonicotinic acid, hydrogen peroxide and sodium tungstate, adding phosphorus oxychloride, chlorinating, diluting yellow viscous residue, mixing solvent and dimethyl formamide, performing Friedel-Crafts acylation, dropwise adding thionyl chloride, distilling, adding solvent and Lewis acid, adding tert-butyl compound, reacting with 1-morpholinoethanone and strong base, adding aromatic ketone, acyl morpholine and solvent, and performing aldol condensation to obtain 1-morpholinoethanone derivative.    USE - Method for preparing morpholine-containing 2-chloro-5-benzoylpyridine derivative (claimed).    ADVANTAGE - The method reduces cost and suitable for industrial production.    DETAILED DESCRIPTION - A morpholine-containing 2-chloro-5-benzoylpyridine derivative is prepared by mixing isonicotinic acid, hydrogen peroxide and sodium tungstate, adding water, stirring, heating, reacting, cooling, filtering, washing with water, drying, adding phosphorus oxychloride, chlorinating, dissolving, heating, diluting yellow viscous residue, stirring, dropwise adding water, cooling to room temperature, filtering, washing with water, drying to obtain 2-chloro-isonicotinic acid, mixing solvent and dimethyl formamide, performing Friedel-Crafts acylation, stirring, heating, dropwise adding thionyl chloride, heating, decompressing, distilling to obtain light yellow transparent liquid, adding solvent and Lewis acid, stirring, cooling, adding tert-butyl benzene, pouring in ice bath, stirring, extracting water, washing with aqueous sodium hydroxide, separating organic layer, drying, extracting solvent to obtain crude product, crystallizing, filtering, drying at room temperature to obtain light yellow crystals, reacting with 1-morpholinoethanone and strong base, adding aromatic ketone, acyl morpholine and solvent, heating, reacting, cooling to room temperature, washing with diluted hydrochloric acid, drying, extracting solvent, performing aldol condensation to obtain 1-morpholinoethanone derivative, adding solvent, stirring, heating, adding acid, reacting, cooling, washing, drying, extracting solvent, and drying.