TECHNOLOGY FOCUS - INORGANIC CHEMISTRY - Preferred Method: The method (M1) involves providing the feedstock of biological origin as a solution in a hydrocarbon solvent. The method (M1) further involves hydroisomerizing the hydrocarbon product. The method (M1) involves contacting the feedstock of biological origin sequentially with the first catalyst in a first zone of the reactor and with the hydrogenation catalyst in a second zone of the reactor. The method (M1) is carried out at a temperature of 300-400 degrees C under H2 partial pressure of 500-800 psig. The method (M1) involves contacting the feed sequentially with the acidic catalyst in a first zone of the reactor and with the hydrogenation catalyst in a second zone of the reactor. The method (M1) is carried out at a temperature of 250-350 degrees C under H2 partial pressure of 500-800 psig. The method (M2) further involves d) hydroisomerizing the hydrocarbon produced by step c). Preferred Base stock: The lube base stock comprises greater than 30 wt.% paraffin (preferably greater than 50 wt.% paraffin), not greater than 10 wt.% 2-ring naphthenic, and not greater than 50 wt.% 1-ring naphthenic. The lube base stock has greater than 25 carbon atoms. The lube base stock has a pour point of less than -10 degrees C. The lube base stock has a viscosity index (VI) greater than 90. The lube base stock has aromatic carbon content of 0.1-10%. The lube base stock has aromatic carbon content of 0.5-10%. Preferred Components: The feedstock of biological origin comprises at least one component selected from fatty acid, fatty acid ester, fatty alcohol, fatty olefin, mono-glyceride, di-glyceride, tri-glyceride, phospholipid and saccharolipid. The hydrothermally stable binder comprises TiO2, ZrO2 or CeO2. The first catalyst comprises a basic material. The first catalyst has a ratio of CO2 chemisorption to NH3 chemisorption of 1-100. The first catalyst is selected from basic clay, alkali impregnated support, and basic metal oxide. The first catalyst comprises a basic catalyst selected from hydrotalcite; basic metal oxide selected from MgO, CaO, BaO, ZnO, MnO2 and K2CO3 supported on SiO2 or ZrO2; K2CO3 supported on TiO2; and La2O3, CeO2, Y2O3, Sm2O3, Pr2O3, La2O3/ZrO2, ZnO/La2O3, Y2O3/ZrO2, CeO2/ZrO2, or La2O3/SiO2. The hydrogenation catalyst comprises a noble metal supported on zeolite. The hydrogenation catalyst comprises a metal hydrogenation component selected from Ni, Co, Pd, Pt, Ru, Rh, Co-Mo, Ni-Mo, Ni-W, and Co-W supported on an inorganic support selected from silica, alumina, titania, zirconia, and zeolite. The hydrogenation catalyst comprises Pt supported on zeolite. The zeolite component of the hydrogenation catalyst comprises a one-dimensional zeolite selected from ZSM-22, ZSM-12, ZSM-23, ZSM-4, ZSM-48 and ZSM-50. The first catalyst is selected from La2O3/ZrO2, La2O3/ZnO and Y2O3/ZrO2, where the hydrogenation catalyst is Pt supported on ZSM-48 or ZSM-48/NiWOx, where the hydrothermally stable binder is selected from TiO2 and ZrO2. The first catalyst comprises an acidic material. The first catalyst has a ratio of CO2 chemisorption to NH3 chemisorption of 0.05-0.5. The first catalyst is selected from acidic clay, alumina, aluminosilicate and metalloaluminophosphate. The first catalyst is selected from acidic metal oxide, mixed metal oxide, WO3/ZrO2, MoO3/ZrO2, zeolite of the faujasite, beta, or MWW family, 10-ring zeolite, 8-ring zeolite, metalloaluminophosphate comprising Si, Ti, Zr, Fe, Co, Ni, Cu, Zn, Y, La, Ce, Pr, Nd, Sm or Gd. The 8- to 10-ring zeolite is selected from MFI, CHA and MOR. The second catalyst comprises a metal hydrogenation component selected from Ni, Co, Pd, Pt, Ru, Rh, Co-Mo, Ni-Mo, Ni-W, and Co-W supported on an inorganic support selected from silica, alumina, titania, zirconia, and zeolite. The second catalyst comprises a hydroisomerization catalyst comprising Pt supported on zeolite. The first catalyst is selected from Montmorillonite, bentonite, and WOx/ZrO2, where the hydrogenation catalyst is selected from Ni or Pd supported on silica or carbon, Co-Mo or Co-W supported on gamma-alumina, and Ni-Mo or Ni-W supported on gamma-alumina, where the hydrothermally stable binder is selected from TiO2 and ZrO2. The first catalyst comprises both a basic material and an acidic material. EXAMPLE - No suitable example given.