TECHNOLOGY FOCUS - INSTRUMENTATION AND TESTING - Preferred Components: The system further comprises a second separator suitable for separating the biomass into a liquid phase and a solids phase and positioned between the solids outlet of the first auger and the inlet of the second auger, where the second separator is in fluid communication with the solids outlet of the first auger and the inlet of the second auger. The first and/or second separator is a screen, a vibrating screen, or a press. The first and/or second separator is in fluid communication with a filter suitable for separating the liquid phase into a filtrate and retentate. The filter is in fluid communication with the liquid outlet of the first auger and the inlet of the first and/or second auger. The screw transports the solids mass in a direction opposite that of liquid flow inside the auger. The auger is inclined so that the liquid outlet is lower than the solids outlet. The first and/or second auger further comprises additional inlets for adding biomass, solids, or enzymes. The system further comprises at least one additional auger comprising: an inlet in fluid communication with the solids outlet of the first and/or second auger; and a solids outlet, where the at least one additional auger is aligned in series with the first and second augers so that a solid mass is directed through the series. The solids outlet of at least one of the augers is in fluid communication with a third separator suitable for removing liquids from the treated biomass.    TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Method: The method (M1) further comprises: washing the retentate to remove at least a portion of the sugars, thus forming a washed retentate; separating the permeate into a concentrated sugars portion and a liquid portion by reverse osmosis; washing the solids phase to remove at least a portion of the sugars, thus forming a washed solids phase; separating the washed solids phase into a liquid comprising sugars, and solids; and concentrating the solids phase and separating at least a portion of any remaining liquid from the solids, where the method is a batch process or a continuous process. In the method (M1): the washed retentate is further separated into a liquid comprising sugars and solids comprising enzymes; the sugars are further concentrated by reverse osmosis; the liquid phase is separated from the solids phase by a screen, vibrating screen, a press, or a centrifuge; the liquid phase is incubated under conditions suitable to produce sugars; the permeate is separated from the retentate by a filter or membrane; the contacting occurs in an auger; and the conditions suitable to hydrolyze components of the biomass to sugars comprise a counter-current flow so that the liquid phase moves in an opposite direction to the solid phase. The method (M1) further comprises: combining the washed retentate with the biomass or solids phase under conditions where the biomass is converted to sugars; and contacting the solids with additional biomass under conditions suitable to hydrolyze components of the biomass to sugars, where the sugars are fermented under conditions suitable to produce ethanol. The method (M2) further comprises washing the solids phase to remove at least a portion of the sugars, thus forming a washed solids phase, where the washed solids phase is further separated into a second liquid phase and a second solids phase, and the second solids phase is combined with the biomass and/or solids phase, and the second liquid phase is separated into a permeate and a retentate, and the retentate is combined with the biomass and/or solids phase, and the permeate comprises sugars. The method (M2) further comprises separating the liquid phase into a permeate comprising dissolved solids and sugars and a retentate comprising undissolved solids, enzymes, and sugars, by washing the retentate to remove sugars, thus forming a washed retentate, and combining the washed retentate with the biomass or solids phase under conditions, where the biomass is converted to sugars, and the permeate is further separated into a concentrated sugars portion and a liquid portion. Preferred Components: The washed retentate comprises less than 1 wt./vol.% sugars. The biomass comprises a slurry of at least 10% solids. EXAMPLE - Saccharification of corn stover was performed for 15 hours. The material was passed through a hand sieve. The liquid was concentrated using a tangential flow filtration system with a 20 kDa membrane. 40% of the mass of the system was removed from the system through the filter. The solids were recombined with the tangential flow filtration retentate and went through saccharification for an additional 24 hours. In a separate experiment, the tangential flow filtration retentate was washed (1X) to remove additional sugars that would inhibit enzyme activity. The resultant solids were recombined with the washed tangential flow filtration retentate and went through saccharification for an additional 24 hours.