TECHNOLOGY FOCUS - INORGANIC CHEMISTRY - Preferred Components: The alkaline catalyst in first step is selected from lithium piperazine, lithium N-methyl piperazine, or lithium pyrrole. The base in second step is selected from triethylamine, pyridine, sodium carbonate, potassium carbonate, sodium hydroxide, potassium hydroxide, lithium hydroxide, calcium carbonate, cesium carbonate or DMAP and mol ratio of compound (III):alkali:hydroxyl protecting group is 1:1.2-1.5:1-1.2. The hydroxyl protecting group in second step is selected from benzyl, dimethyl silicon, tertiary butyl methyl, isopropyl, para-methoxybenzyl, benzhydryl, para-methoxy benzyl, 2-methoxy methyl, 2-allyl, acetyl, benzoyl, or butyl acyl group. The base in third step is selected from triethylamine, pyridine, sodium carbonate, potassium carbonate, sodium hydroxide, potassium hydroxide, lithium hydroxide, calcium carbonate, cesium carbonate or DMAP. The reducing agent in fourth step is selected from palladium on carbon, 5% of 7.5% palladium on carbon, 10% palladium on carbon, or concentrated hydrochloric acid or Raney nickel. The base in fifth step is selected from triethylamine, pyridine, sodium carbonate, potassium carbonate, sodium hydroxide, potassium hydroxide, lithium hydroxide, calcium carbonate, cesium carbonate or 4-dimethyl amino pyridine (DMAP).    TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Method: In the first step, reaction temperature is 100-120 degrees C. Preferred Components: The organic solvent in first step is selected from pyridine, 2-methyl pyridine, 4-methyl pyridine, or 2,6-dimethyl pyridine. The solvent in second step is organic solvent selected from acetone, N,N-dimethyl formamide, acetonitrile, toluene, methylene dichloride, dimethyl sulfoxide, and/or tetrahydrofuran. The organic solvent in third step is selected from chloroform, acetone, N,N-dimethyl formamide, acetonitrile, toluene, dichloromethane, dimethyl sulfoxide, ethyl acetate, ethanol, methanol or isopropyl alcohol. The phase transfer catalyst in third step is selected from benzyl triethyl ammonium chloride (TEBA), tetrabutyl ammonium bromide, tetrabutyl ammonium chloride, tetrabutyl ammonium bisulfate (TBAB), trioctyl methyl ammonium chloride, dodecyl trimethyl ammonium chloride, tetradecyl trimethyl ammonium chloride, 18-crown-6, 15-crown-5, cyclodextrin or PEG2000. The organic solvent in fourth step is selected from acetone, acetonitrile, toluene, methylene dichloride, dimethyl sulfoxide, ethyl acetate, ethanol, methanol, isopropyl alcohol or tetrahydrofuran. ACTIVITY - Antilipemic.