TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preparation (Cliamed): Glucosamine hydrochloride and sodium hydroxide are reacted at room temperature for 0.1-2 hours, and obtained product is reacted with methoxybenzaldehyde at room temperature for 2-8 hours, to obtain methoxybenzaldehyde- beta -D-glucosamine Schiff base (A). The compound (A) is reacted with acetic anhydride at 0-40 degrees C for 5-10 hours in presence of pyridine solvent, to obtain methoxybenzaldehyde- beta -D-glucosamine tetraacetate (B). The compound (B) is reacted with acetone in concentrated hydrochloric acid at 0-50 degrees C for 0.5-1 hour, and obtained intermediate compound (C) is reacted with solid phosgene in presence of dichloromethane and saturated sodium bicarbonate two-phase solution at 0-25 degrees C for 0.5-1 hour, to obtain 2-deoxy-2-isocyanate-1,3,4,6-tetraacetyl- beta -D-pyranose (D). The compound (D) is reacted with amine at 0-40 degrees C for 0.5-2 hours, oxalyl chloride is added into dichloromethane solution of obtained intermediate compound (E) under ice-cooling, and refluxed at 0-40 degrees C for 1-6 hours, to obtain acetylglucosamine imidazole-4,5-trione (I). The molar ratio of glucosamine hydrochloride and sodium hydroxide is 1:1-4. The molar ratio of glucosamine hydrochloride and methoxybenzaldehyde is 1:1-2. The molar ratio of compound (A) and acetic anhydride is 1:5-10. The molar ratio of compound (B) and concentrated hydrochloric acid is 1:1.2-2.5. The molar ratio of compound (C) and solid phosgene is 1:0.2-1.5. The molar ratio of compound (D) and amine is 1:1-1.5. The amine is chosen from aniline, chloroaniline, m-chloroaniline, o-chloroaniline, bromoaniline, fluoroaniline, 2,4-dichloro aniline, 3-chloro-4-fluoroaniline, p-toluidine, m-toluidine, o-toluidine, anisidine, m-methoxy aniline, o-anisidine, 3,4,5-trimethoxy aniline, 2,5-dimethoxyaniline, phenetidine, 3-chloro-4-methylaniline, naphthylamine, benzylamine and ethanolamine. The molar ratio of intermediate compound (E) and oxalyl chloride is 1:1-6. ACTIVITY - Antibacterial.