TECHNOLOGY FOCUS - ORGANIC CHEMISTRY - Preferred Process: The process of preparing (V) by adding (II) at 0-100 degrees C, preferably 20-30 degrees C to a suspension of magnesium formed with a solvent, or adding the starting materials (II) and (III) parallelly to the suspension of magnesium formed with a mixture of toluene and tetrahydrofuran, or using in the Grignard reaction a mixture of tetrahydrofuran and toluene in a 10-20 (preferably 15-20) fold volume, or methyl-tetrahydrofuran in a 5-15 (preferably 5-10) fold volume, related to the starting material (III), or adding a solution of (III) formed with tetrahydrofuran to the reaction mixture, or using tetrahydrofuran in a 1-10 (preferably 4-6) fold volume, related to (III), or reacting magnesium in a 10-20 (preferably 15-20) fold volume, related to the starting material (III), of a tetrahydrofuran-toluene mixture of a volume ratio of 2:12, preferably 1:9, with (II) at room temperature, adding to the reaction mixture parallelly with the formation of the Grignard compound (III) in a molar amount of 0.7-1.1 mole, preferably 0.85-0.95 mole, related to the benzyl chloride, where the addition step is been completed stirring the reaction mixture at 40-60 degrees C, preferably 40-45 degrees C for a further period of 0.5-3 hours, preferably 1-2 hours, cooling the reaction mixture, adding diluted hydrochloric acid, separating the organic phase, washing the organic phase, drying, and optionally evaporating, or reacting magnesium at room temperature in a 5-15 (preferably 5-10) fold volume of 2-methyl-tetrahydrofuran, related to the starting material (III), with (II), where the formation of the Grignard compound has been completed by adding (III) at 0.7-1.1 (preferably 0.85-0.95) mole, related to (II), to the reaction mixture, stirring the reaction mixture at 40-60 degrees C, preferably 40-45 degrees C for 0.5-3 hours, preferably 1-2 hours, cooling the reaction mixture, adding diluted hydrochloric acid, separating the organic phase, washing the organic phase, drying, and optionally evaporating. Preferred Components: The intermediate (V) is halogenated, preferably brominated or chlorinated, which is (V1a), which is subjected to reaction with: 5,6,7,7a-tetrahydro-4H-thieno(3,2-c)pyridin-2-one (VIII) or its acid addition salt, preferably with a salt formed with para-toluene-sulfonic acid, and acylating the formed 5-(2-cyclopropyl-1-(2-fluoro-phenyl)-2-oxo-ethyl)-5,6,7,7a-tetrahydro-4H-thieno(3,2-c)pyridin-2-one (IX); or a silyloxy derivative of formula (V1b), removing the silyl protecting group from the formed 1-cyclopropyl-2-(2-fluorophenyl)-2-(2-(silyloxy)-6,7-dihydrothieno(3,2-c)pyridin-5(4H)-yl)ethanone of formula (VIc) to obtain (IX), and subjecting (IX) to acylation; or 4,5,6,7-tetrahydro-thieno(3,2-c)pyridin-2-yloxy of formula (VId), and converting O-alkyl the formed 5-(2-cyclopropyl-1-(2-fluoro-phenyl)-2-oxo-ethyl)-4,5,6,7-tetrahydro-thieno(3,2-c)pyridin-2-yloxy of formula (V1e) into an O-acyl group; or acetic acid 4,5,6,7-tetrahydro-thieno(3,2-c)pyridin-2-yl ester; or 2-thiophen-2-yl-ethylamine, subjecting the formed 1-cyclopropyl-2-(2-fluoro-phenyl)-2-(2-thiophen-2-yl-ethylamino)-ethanone to ring closure, oxidizing and acylating the formed 1-cyclopropyl-2-(6,7-dihydro-4H-thieno(3,2-c)pyridin-5-yl)-2-(2-fluoro-phenyl)-ethanone to obtain (IX), and if necessary converting (V) into a salt. The mixture contains 5-20 (preferably 8-18) vol.% of tetrahydrofuran. The methyl-tetrahydrofuran is 2-methyl-tetrahydrofuran.X1a = Cl or Br;R1a-R3a = 1-4C alkyl, preferably dimethyl-tert-butyl-silyloxyl; andR1b = alkyl. ACTIVITY - Thrombolytic.    MECHANISM OF ACTION - None given.    EXAMPLE - No suitable example given.